Abstract:
:High calcitonin levels noted on a totally healthy 49-year-old man participating in a calcitonin control project led to a presumptive diagnosis of medullary carcinoma. Complete thyroid studies augmented by selective catheterization and quantitative calcitonin studies confirmed the clinical impression of medullary carcinoma. Surgery was recommended and a total thyroidectomy was performed. On gross examination no nodules or tumefactions were palpable. Histopathology showed diffuse C-cell hyperplasia in the midst of which a C-cell tumor and micromedullary carcinoma of the thyroid were found. Morphologically the full spectrum of changes from focal C-cell hyperplasia through the stages of diffuse and nodular hyperplasia to the final development of medullary carcinoma are demonstrated by light and electron microscopy. The patient's postoperative course was benign and for the subsequent three years he had continued asymptomatic with normal calcitonin levels.
journal_name
Cancerjournal_title
Cancerauthors
White IL,Vimadalal SD,Catz B,Van de Velde R,LaGanga Tdoi
10.1002/1097-0142(19810315)47:6<1364::aid-cncr2820subject
Has Abstractpub_date
1981-03-15 00:00:00pages
1364-8issue
6eissn
0008-543Xissn
1097-0142journal_volume
47pub_type
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