Occult medullary carcinoma of thyroid: an unusual clinical and pathologic presentation.

Abstract:

:High calcitonin levels noted on a totally healthy 49-year-old man participating in a calcitonin control project led to a presumptive diagnosis of medullary carcinoma. Complete thyroid studies augmented by selective catheterization and quantitative calcitonin studies confirmed the clinical impression of medullary carcinoma. Surgery was recommended and a total thyroidectomy was performed. On gross examination no nodules or tumefactions were palpable. Histopathology showed diffuse C-cell hyperplasia in the midst of which a C-cell tumor and micromedullary carcinoma of the thyroid were found. Morphologically the full spectrum of changes from focal C-cell hyperplasia through the stages of diffuse and nodular hyperplasia to the final development of medullary carcinoma are demonstrated by light and electron microscopy. The patient's postoperative course was benign and for the subsequent three years he had continued asymptomatic with normal calcitonin levels.

journal_name

Cancer

journal_title

Cancer

authors

White IL,Vimadalal SD,Catz B,Van de Velde R,LaGanga T

doi

10.1002/1097-0142(19810315)47:6<1364::aid-cncr2820

subject

Has Abstract

pub_date

1981-03-15 00:00:00

pages

1364-8

issue

6

eissn

0008-543X

issn

1097-0142

journal_volume

47

pub_type

杂志文章

相关文献

CANCER文献大全
  • The diagnostic value of the hemoccult as a screening test in patients taking anticoagulants.

    abstract::The value of a 3-day Hemoccult II test in the diagnosis of colorectal disease in patients receiving anticoagulant therapy was studied. The influence of rehydration and nonrehydration of the slide was investigated, as well as the reproducibility of positive tests. Eight hundred forty-nine patients on anticoagulant ther...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841215)54:12<3054::aid-cncr282

    authors: Kewenter J,Svanvik J,Svensson C,Wållgren K

    更新日期:1984-12-15 00:00:00

  • Ovarian epithelial tumors of borderline malignancy. A clinical and pathologic study of 109 cases.

    abstract::One hundred nine cases of ovarian tumors of low malignant potential (borderline tumors) diagnosed at Stanford University Medical Center from 1958 to 1982 were reviewed. The patients ranged in age from 10 to 79 years (mean, 40.5 years). The histologic types and corresponding stages of these neoplasms were 73 serous (St...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19861101)58:9<2052::aid-cncr2820

    authors: Bostwick DG,Tazelaar HD,Ballon SC,Hendrickson MR,Kempson RL

    更新日期:1986-11-01 00:00:00

  • Kaposi's sarcoma in immunosuppression. Possibly the result of a dual viral infection.

    abstract::Kaposi's sarcoma of the gingiva and skin developed in an HIV-negative renal transplant patient while he was receiving cyclosporine therapy. The Kaposi's sarcoma developed shortly after the patient had an acute infection with cytomegalovirus (CMV). Electron microscopy of the tumor's established cell line showed two typ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900201)65:3<492::aid-cncr28206

    authors: Siegal B,Levinton-Kriss S,Schiffer A,Sayar J,Engelberg I,Vonsover A,Ramon Y,Rubinstein E

    更新日期:1990-02-01 00:00:00

  • Adrenocortical carcinoma: clinical and laboratory observations.

    abstract:BACKGROUND:The clinical features and natural history of adrenocortical carcinoma are highly dependent on the type of center reporting their experience. Observations from oncology services suggest a high incidence of nonfunctioning tumors, whereas reports from endocrine clinics emphasize excessive corticoid and androgen...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Wajchenberg BL,Albergaria Pereira MA,Medonca BB,Latronico AC,Campos Carneiro P,Alves VA,Zerbini MC,Liberman B,Carlos Gomes G,Kirschner MA

    更新日期:2000-02-15 00:00:00

  • Behavioral and psychosocial cancer research. Building on the past, preparing for the future.

    abstract::This report identifies five general conclusions that emerged from the Second Workshop on Methodology in Behavioral and Psychosocial Cancer Research. These conclusions address diverse topics, including a focus on areas other than methodology; an emphasis on the transfer of technology and knowledge to applied settings; ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910201)67:3+<865::aid-cncr2820

    authors: Burish TG

    更新日期:1991-02-01 00:00:00

  • The clinical significance of large cells in bone marrow in patients with chronic lymphocytic leukemia.

    abstract:BACKGROUND:Patients with chronic lymphocytic leukemia (CLL) that transforms to Richter syndrome (RS) frequently show atypical lymphocytes in bone marrow; however, a diagnosis of RS requires confirmation of the presence of sheets of large cells in bone marrow or lymph nodes. METHODS:In this study, the authors evaluated...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20251

    authors: Ma Y,Mansour A,Bekele BN,Zhou X,Keating MJ,O'Brien S,Giles FJ,Albitar M

    更新日期:2004-05-15 00:00:00

  • Secondary hematologic neoplasm after intravesical chemotherapy for superficial bladder carcinoma.

    abstract::Two cases are reported of patients who developed a hematologic malignancy several years after intravesical chemotherapy of superficial bladder cancer with etoglucid, doxorubicin, and mitomycin C. In one patient, karyotypic abnormalities (-5, 7q-) typical of a therapy induced malignancy were associated with rapid progr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900101)65:1<23::aid-cncr282065

    authors: Sonneveld P,Kurth KH,Hagemeyer A,Abels J

    更新日期:1990-01-01 00:00:00

  • Increased secretion of interleukin-6 in malignant mesothelioma cells from a patient with marked thrombocytosis.

    abstract:BACKGROUND:A high prevalence of thrombocytosis in malignant mesothelioma has been reported, although its pathogenesis remains unknown. METHODS:The case of a patient with marked thrombocytosis in peritoneal malignant mesothelioma is reported. To investigate the cytokines responsible for thrombocytosis in this patient, ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19921015)70:8<2105::aid-cncr2820

    authors: Higashihara M,Sunaga S,Tange T,Oohashi H,Kurokawa K

    更新日期:1992-10-15 00:00:00

  • A prospective study of immune responsiveness in human melanoma. I. Assessment of initial pretreatment status with stage of disease.

    abstract::The clinical findings in 262 patients with melanoma were correlated with an assessment of their cellular-mediated immunity by delayed-type hypersensitivity (DTH) skin tests, by lymphocyte blastogenesis, and by leukocyte enumerations. Patients with systemic metastases (stage IV) and those with evidence of tumor burden ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197806)41:6<2165::aid-cncr282041

    authors: Pritchard DJ,Ritts RE Jr,Taylor WF,Miller GC

    更新日期:1978-06-01 00:00:00

  • Patterns of relapse of N2 nonsmall-cell lung carcinoma patients treated with preoperative chemotherapy: should prophylactic cranial irradiation be reconsidered?

    abstract:BACKGROUND:Although it induces a relevant reduction in the risk of both visceral metastases and locoregional recurrences, the combination of chemotherapy and surgery only marginally improves the survival of patients with Stage IIIA(N2) (International Union Against Cancer staging and classification system) nonsmall-cell...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Andre F,Grunenwald D,Pujol JL,Girard P,Dujon A,Brouchet L,Brichon PY,Westeel V,Le Chevalier T

    更新日期:2001-06-15 00:00:00

  • Detection of prostate carcinoma with contrast-enhanced sonography using intermittent harmonic imaging.

    abstract:BACKGROUND:The purpose of this study was to assess prostate carcinoma detection and discrimination of benign from malignant prostate tissue with contrast-enhanced ultrasonography. METHODS:In all, 301 subjects referred for prostate biopsy were evaluated with contrast-enhanced sonography using continuous harmonic imagin...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21440

    authors: Halpern EJ,Ramey JR,Strup SE,Frauscher F,McCue P,Gomella LG

    更新日期:2005-12-01 00:00:00

  • Causes of death in long-term survivors of head and neck cancer.

    abstract:BACKGROUND:Survivors of head and neck squamous cell carcinoma (HNSCC) face excess mortality from multiple causes. METHODS:We used the population-based Surveillance, Epidemiology, and End Results (SEER) cancer registry data to evaluate the causes of death in patients with nonmetastatic HNSCC diagnosed between 1992 and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28588

    authors: Baxi SS,Pinheiro LC,Patil SM,Pfister DG,Oeffinger KC,Elkin EB

    更新日期:2014-05-15 00:00:00

  • Friendships and relationships: Sacramento AANCART's best practice.

    abstract::The best practice of Sacramento's Asian American Network for Cancer Awareness Research and Training program is friendships and relationships. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21510

    authors: Shimizu R,Chen MS Jr,Snipes KP,Chan A,Wilson GR,Chong JL,Bal DG

    更新日期:2005-12-15 00:00:00

  • Randomized, placebo-controlled trial of Saforis for prevention and treatment of oral mucositis in breast cancer patients receiving anthracycline-based chemotherapy.

    abstract:BACKGROUND:Oral mucositis (OM) is a frequent complication of mucotoxic cancer therapy, causing significant oral pain, increased infection risk, and impaired functioning. The efficacy and safety of Saforis (glutamine) powder in UpTec for oral suspension was evaluated for the prevention and treatment of OM. METHODS:Thre...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.22384

    authors: Peterson DE,Jones JB,Petit RG 2nd

    更新日期:2007-01-15 00:00:00

  • Molecular mechanisms of osteolytic bone metastases.

    abstract:BACKGROUND:Breast carcinoma commonly metastasizes to the skeleton in patients with advanced disease to cause bone destruction and the associated pain, hypercalcemia, fracture, and nerve-compression syndromes. In this scenario, the bone destruction is mediated by the osteoclast. Tumor-produced parathyroid hormone-relate...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(20000615)88:12+<2892::aid-cncr2>

    authors: Guise TA

    更新日期:2000-06-15 00:00:00

  • Medullary carcinoma of the breast. An unusual cytologic finding in cyst fluid aspirates.

    abstract::Cystic medullary carcinoma of the breast is unusual. This report describes five patients with medullary carcinoma who presented clinically with a breast cyst. Fine-needle aspiration biopsy (NAB) was performed as part of the initial physical examination and the retrieved cyst fluid was examined cytologically. Four of t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900115)65:2<277::aid-cncr28206

    authors: Howell LP,Kline TS

    更新日期:1990-01-15 00:00:00

  • The impact of chemotherapy on Leydig cell function in long term survivors of germ cell tumors.

    abstract:BACKGROUND:Because patients with germ cell tumors expect an additional life span of around 50 years after successful treatment, attention is now focused on potential long term toxicity. Limited data are available on Leydig cell function in long term survivors. METHODS:The authors measured testosterone, sex hormone bin...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010401)91:7<1297::aid-cncr1132

    authors: Gerl A,Mühlbayer D,Hansmann G,Mraz W,Hiddemann W

    更新日期:2001-04-01 00:00:00

  • The prognostic value of histologic subtypes in primary extremity liposarcoma.

    abstract::Patients with a localized primary liposarcoma of the extremity who were treated in Memorial Sloan-Kettering Cancer Center between 1968 and 1978 were studied. The prognosis of patients with extremity liposarcoma was analyzed according to histopathologic subtypes. A system of five subtypes was used; well-differentiated,...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891001)64:7<1514::aid-cncr2820

    authors: Chang HR,Hajdu SI,Collin C,Brennan MF

    更新日期:1989-10-01 00:00:00

  • Small cell astrocytoma: an aggressive variant that is clinicopathologically and genetically distinct from anaplastic oligodendroglioma.

    abstract:BACKGROUND:Small cell glioblastoma (GBM) is a variant with monomorphous, deceptively bland nuclei that often is misdiagnosed as anaplastic oligodendroglioma. METHODS:To elucidate its clinicopathologic and genetic features, the authors studied 71 adult patients (median age, 57 years), including 22 patients who were ide...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20625

    authors: Perry A,Aldape KD,George DH,Burger PC

    更新日期:2004-11-15 00:00:00

  • Second-line chemotherapy for recurrent carcinoma of the ovary.

    abstract::Despite relatively high response rates to chemotherapy for ovarian carcinoma, most patients eventually will have progressive disease that will require additional therapy. Most efforts to study such second-line or "salvage" chemotherapy have been single-arm trials of small numbers of patients, which report widely varia...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.2820710422

    authors: Thigpen JT,Vance RB,Khansur T

    更新日期:1993-02-15 00:00:00

  • Atypical squamous cells of undetermined significance: a comparative review of original and automated rescreen diagnosis of cervicovaginal smears with long term follow-up.

    abstract:BACKGROUND:There is an increasing number of articles regarding the long term follow-up of Papanicolaou (Pap) smears with the diagnosis of atypical squamous cells of undetermined significance (ASCUS). Much controversy exists regarding the management of patients with this diagnosis. In a prior study in 1992, the authors ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19971225)81:6<348::aid-cnc

    authors: Stastny JF,Remmers RE,London WB,Pedigo MA,Cahill LA,Ryan M,Frable WJ

    更新日期:1997-12-25 00:00:00

  • Measuring response to BCR-ABL inhibitors in chronic myeloid leukemia.

    abstract::In patients with chronic myeloid leukemia (CML), the hallmark Philadelphia chromosome is the marker of disease that can be detected by conventional metaphase cytogenetics, fluorescence in situ hybridization, or polymerase chain reaction. The current "gold standard" of treatment response is cytogenetic response. Cytoge...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.26280

    authors: Radich JP

    更新日期:2012-01-15 00:00:00

  • Measuring financial toxicity as a clinically relevant patient-reported outcome: The validation of the COmprehensive Score for financial Toxicity (COST).

    abstract:BACKGROUND:Cancer and its treatment lead to increased financial distress for patients. To the authors' knowledge, to date, no standardized patient-reported outcome measure has been validated to assess this distress. METHODS:Patients with AJCC Stage IV solid tumors receiving chemotherapy for at least 2 months were recr...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30369

    authors: de Souza JA,Yap BJ,Wroblewski K,Blinder V,Araújo FS,Hlubocky FJ,Nicholas LH,O'Connor JM,Brockstein B,Ratain MJ,Daugherty CK,Cella D

    更新日期:2017-02-01 00:00:00

  • Carboplatin, methotrexate, and vinblastine in the treatment of patients with advanced urothelial cancer. A phase II trial.

    abstract:BACKGROUND:A Phase II study with carboplatin, methotrexate, and vinblastine (CAMV) was conducted with patients who had advanced urothelial cancer to investigate the activity and toxicity of carboplatin when used in combination chemotherapy. METHODS:Thirty-six patients with advanced urothelial cancer were treated with ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19940401)73:7<1932::aid-cncr2820

    authors: Boccardo F,Pace M,Guarneri D,Canobbio L,Curotto A,Martorana G

    更新日期:1994-04-01 00:00:00

  • Use of p63 for distinction of glandular versus squamous lesions in cervicovaginal specimens.

    abstract:BACKGROUND:Differentiating primary glandular from high-grade squamous intraepithelial lesions (HSIL) that involve endocervical glands is not an uncommon diagnostic problem in liquid-based gynecological cytology. Squamous and atypical glandular cell lesions may show similar cytomorphologic features. The aim of this stud...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22419

    authors: Garcia MT,Acar BC,Jorda M,Gomez-Fernandez C,Ganjei-Azar P

    更新日期:2007-02-25 00:00:00

  • Elevations in serum alpha-fetoprotein levels in patients with chronic hepatitis B.

    abstract::In a retrospective analysis of 166 patients with chronic hepatitis B followed for up to 8 years, 22 patients had 29 episodes of elevations in serum alpha-fetoprotein (AFP) levels. Twenty-five episodes were due to a transient exacerbation of the underlying hepatitis and 11 of these episodes were followed by a loss of h...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891115)64:10<2117::aid-cncr282

    authors: Di Bisceglie AM,Hoofnagle JH

    更新日期:1989-11-15 00:00:00

  • Factors influencing survival of children with nonmetastatic neuroblastoma.

    abstract::A randomized study was designed to determine the effect of intermittent oral cyclophosphamide on the rate of metastases in children with localized and regional neuroblastoma. Secondary objectives of the study were to determine the value of the proposed staging system, to measure the influence of the peripheral lymphoc...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(197608)38:2<661::aid-cncr2820380

    authors: Evans AE,Albo V,D'Angio GJ,Finklestein JZ,Leiken S,Santulli T,Weiner J,Hammond GD

    更新日期:1976-08-01 00:00:00

  • A pathologic study of childhood lymphoma in Taiwan with special reference to peripheral T-cell lymphoma and the association with Epstein-Barr viral infection.

    abstract::The authors retrospectively reviewed the clinicopathologic and immunologic features of 65 consecutive cases of childhood lymphoma reported between 1980 and 1989. Southern blot hybridization was also performed in 23 cases to study their association with Epstein-Barr virus (EBV) and human T-cell leukemia virus type 1 (H...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19911101)68:9<1954::aid-cncr2820

    authors: Lee SH,Su IJ,Chen RL,Lin KS,Lin DT,Chuu WM,Lin KS

    更新日期:1991-11-01 00:00:00

  • Analysis of factors related to the occurrence of chronic disseminated candidiasis in patients with acute leukemia in a non-bone marrow transplant setting: a follow-up study.

    abstract:BACKGROUND:Chronic disseminated candidiasis (CDC) is a serious complication of treatment in patients with acute leukemia. Although some general risk factors are known to predispose to systemic fungal infections, few studies have addressed the relevance of certain clinical and laboratory features in patients with CDC. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010915)92:6<1349::aid-cncr1457

    authors: Sallah S,Wan JY,Nguyen NP,Vos P,Sigounas G

    更新日期:2001-09-15 00:00:00

  • Chronic myeloid leukemia among patients with a history of prior malignancies: A tale of dual survivorship.

    abstract:BACKGROUND:Some patients with chronic myeloid leukemia (CML) have a history of previous malignancies. To the authors' knowledge, outcomes for CML diagnosed in these patients have not been well described. The current study was conducted to determine the outcome of patients with CML and a history of prior malignancies. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30362

    authors: Koller PB,Kantarjian HM,Nogueras-Gonzalez GM,Jabbour E,Verstovsek S,Borthakur G,Estrov Z,Wierda WG,Garcia-Manero G,Ferrajoli A,Ravandi F,O'Brien SM,Cortes JE

    更新日期:2017-02-15 00:00:00