Malignant struma ovarii. Light and electron microscopic study.

Abstract:

:Malignant struma ovarii is a very rare tumor, consisting of a struma ovarii with malignant change. Only 17 examples with metastases have previously been reported. We present a case which involved both ovaries and produced multiple metastases. Microscopy and ultrastructure were identical to a mixed papillary and follicular carcinoma of the thyroid gland. Characteristic ultrastructural features of malignant struma ovarii are: microvilli on the surface and in the cytoplasmatic vacuoles; oncocytic transformation of cytoplasm of some cells; and presence of electron dense, granular and crystalline material (colloid) in the follicles and vacuoles. The patient's thyroid was normal. We conclude that malignant struma ovarii can only be diagnosed wheb a carcinoma arising in the thyroid gland can be excluded. Ultrastructure examination may provide useful diagnostic features separating malignant struma ovarii from strumal carcinoid and serous adenocarcinoma.

journal_name

Cancer

journal_title

Cancer

authors

Pardo-Mindan FJ,Vazquez JJ

doi

10.1002/1097-0142(19830115)51:2<337::aid-cncr28205

subject

Has Abstract

pub_date

1983-01-15 00:00:00

pages

337-43

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

51

pub_type

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