Turcot's syndrome. Flow cytometric analysis.

Abstract:

:Turcot's syndrome is a rare, genetically transmittable disease in which patients with colonic polyposis (possibly complicated by the progression to adenocarcinoma) have malignant central nervous system neoplasms. Dominant, recessive, and sporadic cases have been described. A 26-year-old man is reported with no relevant family history who had intermittent abdominal discomfort in 1986. Sigmoidoscopy revealed numerous polyps, several of which showed carcinomatous change. Dukes' Stage C colorectal carcinoma was diagnosed. Treatment consisted of total colectomy with construction of a Koch's pouch. He remained well for 3 years until onset of headache, nausea, and vomiting. Computed tomographic scan disclosed a large, circumscribed, enhancing, right frontoparietal mass. After craniotomy and partial resection, histologic review disclosed anaplastic astrocytoma. He received cranial radiation therapy, 6000 cGy, by parallel opposed ports to the tumor bed, and carmustine 200 mg/m2 intravenously every 8 weeks. Flow cytometric DNA analysis was done on the paraffin-embedded archival material from the patient's normal colon, colonic adenocarcinoma, and anaplastic astrocytoma. DNA histograms revealed diploid distributions in all three samples. The G2/M fraction of the astrocytoma was elevated at 16%, and the S-phase fraction of the colonic adenocarcinoma was 19.4%.

journal_name

Cancer

journal_title

Cancer

authors

Newton HB,Rosenblum MK,Malkin MG

doi

10.1002/1097-0142(19911001)68:7<1633::aid-cncr2820

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

1633-9

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

68

pub_type

杂志文章

相关文献

CANCER文献大全
  • Current status of the treatment of epidermoid cancer of the vulva.

    abstract::Epidermoid cancer accounts for 81% of the malignancies of the vulva. Although the etiology has not been delineated, chronic vulvitis is associated with cancer in almost one-third of the patients. The staging system should utilize the most precise and accurate parameters delineated for improved treatment. A new staging...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197607)38:1<587::aid-cncr2820380

    authors: Krupp P,Bohm JW,Lee FY,Collins JH

    更新日期:1976-07-01 00:00:00

  • Occult papillary thyroid carcinoma at autopsy in La Plata, Argentina.

    abstract::Although clinically evident thyroid carcinoma is not a frequent neoplasm (incidence 2.7 per 100,000 persons in La Plata, Argentina), occult carcinomas are present in a high proportion of the population, but there are marked differences along geographical lines. The purpose of the present study is to establish the prev...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890715)64:2<547::aid-cncr28206

    authors: Ottino A,Pianzola HM,Castelletto RH

    更新日期:1989-07-15 00:00:00

  • Imaging hepatic neoplasms.

    abstract::The various radiologic methods used in the detection of hepatic lesions in the oncologic patient are discussed. The advantages and disadvantages of each imaging technique as well as a new diagnostic approach are also discussed. With the rapid technological advances made in cross-sectional imaging, the authors believe ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Bernardino ME,Lewis E

    更新日期:1982-12-01 00:00:00

  • A double-blind comparison of the efficacy of two dose regimens of oral granisetron in preventing acute emesis in patients receiving moderately emetogenic chemotherapy.

    abstract:BACKGROUND:The purpose of this study was to define an optimal administration schedule of granisetron for patients receiving moderately emetogenic chemotherapy by comparing the antiemetic efficacy and safety of 2 mg of the drug administrated orally. METHODS:In this double-blind, randomized, parallel study, 2-dose regim...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/(SICI)1097-0142(19960701)78:1<144::AID-CNC

    authors: Ettinger DS,Eisenberg PD,Fitts D,Friedman C,Wilson-Lynch K,Yocom K

    更新日期:1996-07-01 00:00:00

  • Prostaglandin-E-producing hepatocellular carcinoma with hypercalcemia.

    abstract::An autopsy case of prostaglandin E-producing hepatocellular carcinoma with hypercalcemia is presented in this article. A 72-year-old man showed high serum calcium levels (14.2 to 17.3 mg/100 ml) and hypophosphatemia. The plasma level of immunoreactive parathyroid hormone was below the normal range. Administration of o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880501)61:9<1813::aid-cncr2820

    authors: Ikeda T,Tozuka S,Hasumura Y,Takeuchi J

    更新日期:1988-05-01 00:00:00

  • Time to the initiation of adjuvant chemotherapy does not impact survival in patients with resected pancreatic cancer.

    abstract:BACKGROUND:Surgical resection with adjuvant chemotherapy is the standard of care for patients with pancreatic cancer, but to the authors' knowledge, little is known regarding the temporal relationship between chemotherapy initiation and survival. The current study analyzed the impact of time to the initiation of adjuva...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30163

    authors: Mirkin KA,Greenleaf EK,Hollenbeak CS,Wong J

    更新日期:2016-10-01 00:00:00

  • A unique pattern of proto-oncogene abnormalities in ovarian adenocarcinomas.

    abstract::Twelve cases of ovarian adenocarcinoma were studied for alterations in proto-oncogenes, and a unique pattern of altered ras proto-oncogenes was observed. Amplification of ras-Ki was found in three of seven ovarian tumors and amplification of ras-Ha in one of 12. In contrast, ras-Ha amplification was not found in any o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881015)62:8<1573::aid-cncr2820

    authors: Zhou DJ,Gonzalez-Cadavid N,Ahuja H,Battifora H,Moore GE,Cline MJ

    更新日期:1988-10-15 00:00:00

  • Preventable and mitigable adverse events in cancer care: Measuring risk and harm across the continuum.

    abstract:BACKGROUND:Patient safety is a critical concern in clinical oncology, but the ability to measure adverse events (AEs) across cancer care is limited by a narrow focus on treatment-related toxicities. The objective of this study was to assess the nature and extent of AEs among cancer patients across inpatient and outpati...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30916

    authors: Lipitz-Snyderman A,Pfister D,Classen D,Atoria CL,Killen A,Epstein AS,Anderson C,Fortier E,Weingart SN

    更新日期:2017-12-01 00:00:00

  • Concurrent vinblastine and radiation therapy in bladder cancer.

    abstract:BACKGROUND:Since mid-1987, 29 patients with invasive transitional cell carcinoma of the urinary bladder (T1-3 N0-X M0) were treated with concurrent radiation therapy (RT) (target dose [TD], 62-66 Gy) 1.8-2.0 Gy/day for 5 days a week with a break in the middle of treatment of 2-3 weeks and vinblastine weekly 2 mg/5-12 h...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19921215)70:12<2885::aid-cncr282

    authors: Kragelj B,Jereb B,Kragelj L,Stanonik M

    更新日期:1992-12-15 00:00:00

  • Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods.

    abstract::Grilled or fried meat and fish contain various mutagenic heterocyclic amines, and structures of at least 19 compounds have already been determined. Among these, 10 have been examined for long term carcinogenicity, all proving to be positive. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), for example, preferen...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940801)74:3+<1063::aid-cncr282

    authors: Nagao M,Ushijima T,Wakabayashi K,Ochiai M,Kushida H,Sugimura T,Hasegawa R,Shirai T,Ito N

    更新日期:1994-08-01 00:00:00

  • Risk-directed therapy for childhood acute lymphoblastic leukemia. Results of the Associazione Italiana Ematologia Oncologia Pediatrica '82 studies.

    abstract:BACKGROUND:In 1982, the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) started its third-generation study, aiming to improve previous results obtained by AIEOP '79 study and to deliver a standardized treatment to most Italian children with acute lymphoblastic leukemia (ALL). METHODS:We treated 902 child...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/1097-0142(19931015)72:8<2517::aid-cncr2820

    authors: Vecchi V,Aricò M,Basso G,Ceci A,Madon E,Mandelli F,Masera G,Massimo L,Pession A,Zanesco L

    更新日期:1993-10-15 00:00:00

  • A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis.

    abstract::Ninety-two cases of granulosa cell tumor of the ovary have been studied. The clinical and pathologic data from this group were similar to that obtained in previous series. Because of the long natural history of many granulosa cell tumors, crude death rates over a relatively short period give little indication of the t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197501)35:1<231::aid-cncr2820350

    authors: Fox H,Agrawal K,Langley FA

    更新日期:1975-01-01 00:00:00

  • Combination versus successive single agent chemotherapy in lymphocytic lymphoma.

    abstract::Fifty-three patients with advanced lymphocytic lymphoma were randomly assigned to treatment with the combination cyclophosphamide, vincristine, and prednisone (CVP) or the same agents used successively in maximal doses (C-V-P). Complete remissions occurred in 68% with CVP and 48% with C-V-P. For patients with nodular ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(197801)41:1<23::aid-cncr28204101

    authors: Kennedy BJ,Bloomfield CD,Kiang DT,Vosika G,Peterson BA,Theologides A

    更新日期:1978-01-01 00:00:00

  • Acinic cell carcinomas arising in salivary glands: a clinicopathologic study.

    abstract::Fifty-one cases of acinic cell carcinoma (ACC) arising in major and minor salivary glands are reported (primary sites: parotid 37, submandibular, six, and oral cavity, eight.) These lesions usually produced painless slowly growing masses. Of 49 patients with follow-up information, 17 (35%) developed local recurrences ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197910)44:4<1434::aid-cncr282044

    authors: Perzin KH,LiVolsi VA

    更新日期:1979-10-01 00:00:00

  • Surgical management of soft tissue sarcomas of the hand and foot.

    abstract:BACKGROUND:Soft tissue sarcomas of the hand and foot present unique management challenges. The purpose of the current study study was to determine oncologic outcome, particularly with respect to factors affecting local recurrence, distant recurrence, and disease-specific survival. METHODS:A retrospective study was per...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10750

    authors: Lin PP,Guzel VB,Pisters PW,Zagars GK,Weber KL,Feig BW,Pollock RE,Yasko AW

    更新日期:2002-08-15 00:00:00

  • Cardiac metastases.

    abstract::The authors found metastases to the heart in 10.7% of 1029 autopsy cases in which a malignant neoplasm was diagnosed. The lung was the commonest primary site (36.4%) and adenocarcinoma was the most frequent cell type (36.4%) of neoplasms metastatic to heart. Nonepithelial tumors accounted for 22.7% of cardiac metastas...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900315)65:6<1456::aid-cncr2820

    authors: Klatt EC,Heitz DR

    更新日期:1990-03-15 00:00:00

  • Serum sialyltransferase and fucosyltransferase activities in patients with bronchial carcinoma.

    abstract::Serum sialyltransferases and fucosyltransferases measured by an affinity adsorbent technique were studied in 27 exactly defined patients with malignant pulmonary diseases. Fourteen patients with benign pulmonary diseases and 56 with benign surgical diseases were used as controls. Enzyme activities were expressed as am...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831101)52:9<1679::aid-cncr2820

    authors: Ronquist G,Nou E

    更新日期:1983-11-01 00:00:00

  • A possible association between ionizing radiation and pituitary adenoma: a descriptive study.

    abstract:BACKGROUND:Despite the recognition of ionizing radiation as a causal risk factor for a variety of solid tumors (including brain tumors), to date, such an association with pituitary adenoma (PA) has not been demonstrated. METHODS:To evaluate a possible association between past exposure to radiation and the occurrence o...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.10667

    authors: Juven Y,Sadetzki S

    更新日期:2002-07-15 00:00:00

  • Results with chemotherapy comprised of cyclophosphamide, doxorubicin, vincristine, and prednisone followed by radiotherapy with or without prechemotherapy surgical debulking for patients with bulky, aggressive lymphoma.

    abstract:BACKGROUND:The authors performed a case-control analysis of local control, progression free survival, and overall survival in patients with Stage I-II aggressive lymphomas measuring > or = 7 cm in greatest dimension who were treated initially with or without surgical debulking: All patients then received cyclophosphami...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10260

    authors: Wilder RB,Romaguera JE,Tucker SL,Ha CS,Hess MA,Cabanillas F,Cox JD

    更新日期:2002-02-01 00:00:00

  • Prospects for monoclonal antibody therapy of leukemia and lymphoma.

    abstract::The development of monoclonal antibodies has led to renewed interest in the use of antibodies to treat malignant disease. Unfortunately, treatment with unmodified antibodies has been disappointing. Therapy with unmodified antibodies has been limited by the failure of host effector mechanisms to eliminate antibody-coat...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19860715)58:2+<584::aid-cncr2820

    authors: Badger CC,Bernstein ID

    更新日期:1986-07-15 00:00:00

  • Focal, high dose, and fractionated modified stereotactic radiation therapy for lung carcinoma patients: a preliminary experience.

    abstract:BACKGROUND:Stereotactic radiation therapy is highly effective in the treatment of small brain metastases, regardless of the histology. This suggests that small extracranial malignancies may be curable with similar radiation therapy. The authors developed a novel treatment unit for administering such therapy. METHODS:T...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19980315)82:6<1062::aid-cn

    authors: Uematsu M,Shioda A,Tahara K,Fukui T,Yamamoto F,Tsumatori G,Ozeki Y,Aoki T,Watanabe M,Kusano S

    更新日期:1998-03-15 00:00:00

  • Adjuvant chemotherapy for advanced nasopharyngeal carcinoma in childhood.

    abstract::Seven children with advanced nasopharyngeal carcinoma younger than 20 years of age diagnosed between 1975 and 1986 (inclusive) were treated with a uniform adjuvant chemotherapy regimen, which consisted of vincristine (1.5 mg/m2; day 1), doxorubicin (45 mg/m2; day 1), 5-fluorouracil (8 mg/kg; days 1 through 5), and cyc...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19890515)63:10<1922::aid-cncr282

    authors: Kim TH,McLaren J,Alvarado CS,Wyly JB,Crocker I,Winn K,Singhapakdi S,Ragab A

    更新日期:1989-05-15 00:00:00

  • Patterns of failure after total laryngectomy for glottic carcinoma.

    abstract::The 136 patients who underwent total laryngectomy as the primary treatment for squamous cell carcinoma of the glottis at the Mayo Clinic in 1970 through 1981 were followed by retrospective record review for at least 4 years or until death, local recurrence, neck recurrence, or delayed neck metastasis. Cancer recurred ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890701)64:1<143::aid-cncr28206

    authors: Foote RL,Buskirk SJ,Stanley RJ,Grambsch PM,Olsen KD,DeSanto LW,Earle JD,Weiland LH

    更新日期:1989-07-01 00:00:00

  • Central nervous system prophylaxis in adults with acute lymphoblastic leukemia: current and emerging therapies.

    abstract::Central nervous system (CNS) recurrence continues to be a significant complication in the treatment of adult patients with acute lymphoblastic leukemia (ALL). Preventing CNS recurrence has been a therapeutic challenge and has not been addressed critically in many clinical trials. Adult studies modeled on childhood ALL...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.25008

    authors: Jabbour E,Thomas D,Cortes J,Kantarjian HM,O'Brien S

    更新日期:2010-05-15 00:00:00

  • Prolactin and pituitary gonadotropin values and responses to acute luteinizing hormone-releasing hormone (LHRH) challenge in patients having long-term treatment with a depot LHRH analogue.

    abstract::Sixty patients with advanced prostatic carcinoma were treated with monthly subcutaneous injections of a depot formulation of goserelin, a luteinizing hormone-releasing hormone (LHRH) analogue (Zoladex, ICI Pharma, Destelbergen, Belgium). All patients were regularly evaluated with measurements of luteinizing hormone (L...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910201)67:3<557::aid-cncr28206

    authors: Mahler C,Verhelst J,Chaban M,Denis L

    更新日期:1991-02-01 00:00:00

  • Primary leptomeningeal B-cell lymphoma in a 8-year-old child.

    abstract::A case of primary leptomeningeal B-cell lymphoma in an 8-year-old, previously healthy child is described. The child was found to have hypogammaglobulinemia, and the Epstein-Barr virus genome was identified in cultured tumor cells despite blood serology being negative for the virus. The patient was treated with cycloph...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19901015)66:8<1856::aid-cncr2820

    authors: Hayani A,Venger BH,Rouah E,Laurent JP,Mahoney DH,McClain KL

    更新日期:1990-10-15 00:00:00

  • Curative radiotherapy in the malignant lymphomas.

    abstract::The clinical experience and technologic improvements of the past 40 years are briefly summarized in terms of their contributions to the present optimistic and aggressive approach to the treatment of malignant lymphoma. The reasoning behind the large-field moderately high-dose technique that has evolved is reviewed and...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(196810)22:4<752::aid-cncr2820220

    authors: Nobler MP

    更新日期:1968-10-01 00:00:00

  • Changes in guinea pig plasma cyclic nucleotide levels during the development of a transplantable leukemia.

    abstract::Plasma levels of cyclic AMP and cyclic GMP were determined in 35 guinea pigs for up to 9 days following subcutaneous passage of L2C leukemia cells. Twenty guinea pigs into which normal syngeneic guinea pig thymocytes were passaged served as controls. Cyclic AMP levels in plasma showed little change and were only eleva...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840101)53:1<79::aid-cncr282053

    authors: Wood PJ,Pao G,Cooper A

    更新日期:1984-01-01 00:00:00

  • Intraoperative photodynamic therapy for retroperitoneal sarcomas.

    abstract::A pilot study was done to determine the feasibility of adjuvant photodynamic therapy (PDT) in recurrent retroperitoneal sarcomas. Ten patients, who had recurrences after conventional methods of treatment, had repeated resections of the tumor and intraoperative photodynamic treatment to the tumor bed. The methods and e...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880315)61:6<1248::aid-cncr2820

    authors: Nambisan RN,Karakousis CP,Holyoke ED,Dougherty TJ

    更新日期:1988-03-15 00:00:00

  • Severity of reduced bone mineral density and risk of fractures in long-term survivors of childhood leukemia and lymphoma undergoing guideline-recommended surveillance for bone health.

    abstract:BACKGROUND:Survivors of childhood leukemia/lymphoma are at increased risk for reduced bone mineral density (BMD). The authors sought to determine the frequency of reduced BMD detected by off-therapy surveillance, factors associated with reduced BMD, and the association of reduced BMD with fractures. METHODS:This cross...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32512

    authors: Bloomhardt HM,Sint K,Ross WL,Rotatori J,Ness K,Robinson C,Carpenter TO,Chow EJ,Kadan-Lottick NS

    更新日期:2020-01-01 00:00:00