Quality assurance for interventions in clinical trials. Multicenter data monitoring, data management, and analysis.

abstract：BACKGROUND:The poor prognosis reported for patients with high-grade glial neoplasms indicates a need for the development of multimodality therapeutic approaches. The addition of chemotherapy has contributed variably to increased survival. The objective of the current study (Southwest Oncology Group [SWOG] 9016) was to ...

journal_title：Cancer

authors： Blumenthal DT,Rankin C,Eyre HJ,Livingston RB,Spence AM,Stelzer KJ,Rushing EJ,Berger MS,Rivkin SE,Cohn AL,Petersdorf SH

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:For patients with stage III through IVB head and neck squamous cell carcinoma (HNSCC), concurrent high-dose cisplatin plus radiation therapy is a widely accepted standard of care. HNSCC tumors that express high levels of vascular endothelial growth factor have been associated with a worse prognosis, and beva...

journal_title：Cancer

authors： Fury MG,Lee NY,Sherman E,Lisa D,Kelly K,Lipson B,Carlson D,Stambuk H,Haque S,Shen R,Kraus D,Shah J,Pfister DG

更新日期：2012-10-15 00:00:00

abstract：BACKGROUND:The objective of this study was to assess the racial and ethnic disparities in outcomes and their association with process-of-care measures for elderly Medicare recipients with localized prostate cancer. METHODS:The Surveillance, Epidemiology, and End Results-Medicare databases for the period from 1995 to 2...

journal_title：Cancer

authors： Jayadevappa R,Chhatre S,Johnson JC,Malkowicz SB

更新日期：2011-06-01 00:00:00

abstract：:The authors performed immunohistochemical and cytogenetic studies in a 73-year old man with malignant angioendotheliomatosis. The patient was referred for evaluation of fever of unknown origin, hepatic failure, and neurologic deterioration. Examination of a muscle biopsy revealed numerous, noncohesive atypical mononuc...

journal_title：Cancer

authors： Molina A,Lombard C,Donlon T,Bangs CD,Dorfman RF

更新日期：1990-08-01 00:00:00

abstract：BACKGROUND:Capecitabine with oxaliplatin (CAPOX) has previously demonstrated clinical activity in patients with small bowel adenocarcinoma (SBA) and ampullary adenocarcinoma (AAC). Herein, the authors conducted a phase 2 trial to evaluate the benefit of adding bevacizumab to CAPOX. METHODS:In this phase 2, single-arm,...

journal_title：Cancer

authors： Gulhati P,Raghav K,Shroff RT,Varadhachary GR,Kopetz S,Javle M,Qiao W,Wang H,Morris J,Wolff RA,Overman MJ

更新日期：2017-05-15 00:00:00

abstract：BACKGROUND:Preclinical studies have demonstrated that the inhibition of the PI3K/Akt/mTOR pathway restores gefitinib sensitivity in resistant cancer cell lines. A phase 1 study was conducted of the combination of everolimus, an mTOR inhibitor, and gefitinib to determine a daily dose of everolimus with gefitinib in pati...

journal_title：Cancer

authors： Milton DT,Riely GJ,Azzoli CG,Gomez JE,Heelan RT,Kris MG,Krug LM,Pao W,Pizzo B,Rizvi NA,Miller VA

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:Primary myelofibrosis (PMF) and overlap myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are clonal hematopoietic disorders that share similar clinical features and molecular abnormalities, such as the Janus kinase 2 (JAK2) valine to phenylalanine mutation at codon 617 (V617F) and the tet methylcytosin...

journal_title：Cancer

authors： Bejanyan N,Tiu RV,Raza A,Jankowska A,Kalaycio M,Advani A,Chan J,Saunthararajah Y,Mooney L,Maciejewski JP,Sekeres MA

更新日期：2012-08-15 00:00:00

abstract：BACKGROUND:The objective of this study was to investigate the patterns of recurrence, various prognostic factors, and the role of radioiodine in the treatment of patients with follicular thyroid carcinoma (FTC). METHODS:The clinical outcomes of 215 patients with FTC who were treated at a single institution were analyz...

journal_title：Cancer

authors： Chow SM,Law SC,Mendenhall WM,Au SK,Yau S,Yuen KT,Law CC,Lau WH

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Sequential systematic biopsies after radiotherapy (RT) for prostate carcinoma were evaluated with respect to radiation effect, tumor differentiation, and prostate specific antigen (PSA) staining, and these histopathologic parameters were correlated with local outcome. METHODS:Since 1990, transrectal ultraso...

journal_title：Cancer

authors： Crook JM,Bahadur YA,Robertson SJ,Perry GA,Esche BA

更新日期：1997-01-01 00:00:00

abstract：:In 230 cases of chronic lymphocytic leukemia (CLL), marker analysis was performed with rosette techniques and a panel of xeno-antisera. A monoclonal B-cell proliferation was found in the majority of cases (94%). In most cases, the B-cells carried IgM, with or without IgD. Cytoplasmic immunoglobulin-inclusion bodies we...

journal_title：Cancer

authors： van der Reijden HJ,van der Gaag R,Pinkster J,Rümke HC,van't Veer MB,Melief CJ,von dem Borne AE

更新日期：1982-12-15 00:00:00

abstract：:The reports of 240 gallium scans on 165 patients with Hodgkin's disease were reviewed to compare results with higher doses with those in earlier studies that employed lower doses. Tracer concentrations in specific sites were correlated with radiologic and pathologic reports and with the clinical courses of the patient...

journal_title：Cancer

authors： Hagemeister FB,Fesus SM,Lamki LM,Haynie TP

更新日期：1990-03-01 00:00:00

abstract：:Of 209 Hodgkin's disease patients treated at least 6 months with a five-drug combination of induction chemotherapy and having a complete remission, four patients developed acute myelogenous leukemia (AML) as a second malignant neoplasm. The overall relative risk for development of AML is 185.0 (P less than 0.05) and t...

journal_title：Cancer

authors： Bartolucci AA,Liu C,Durant JR,Gams RA

更新日期：1983-12-15 00:00:00

abstract：:Plasma carcinoembryonic antigen (CEA) levels were studied in all available members of 17 families in which a presumed sporadic retinoblastoma had occurred. In 9 of the 17 families, close relatives of the patient had elevated CEA levels in the absence of demonstrable disease; this we have termed the "CEA family syndrom...

journal_title：Cancer

authors： Felberg NT,Michelson JB,Shields JA

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:At the time of diagnosis of colorectal carcinoma, 2-3% of patients are likely to be harboring brain metastases, and another 10% of patients will develop brain lesions during the course of their disease. The purpose of this study was to examine the clinical course of a group of patients with metastatic brain ...

journal_title：Cancer

authors： Wroński M,Arbit E

更新日期：1999-04-15 00:00:00

abstract：:From November 1987 to April 1989, 1000 women 40 years or older underwent screening vaginal sonography at the University of Kentucky Medical Center (Lexington, KY). Patients included in this investigation were all asymptomatic and had no known pelvic abnormalities. Each ovary was measured in three planes and ovarian vo...

journal_title：Cancer

authors： van Nagell JR Jr,Higgins RV,Donaldson ES,Gallion HH,Powell DE,Pavlik EJ,Woods CH,Thompson EA

更新日期：1990-02-01 00:00:00

abstract：:Three cases of carcinoid tumor arising in the trachea are reported and contrasted with carcinoids arising in bronchi and carcinoids in general. Only eleven other documented examples of tracheal carcinoids are found in the English literature. The true prevalence of carcinoids primary in the trachea cannot be accurately...

journal_title：Cancer

authors： Briselli M,Mark GJ,Grillo HC

更新日期：1978-12-01 00:00:00

abstract：:For men diagnosed with clinically localized prostate cancer, definitive therapy with radical prostatectomy, external beam radiation therapy, or brachytherapy offers a high chance of cure. Currently, there are insufficient data to recommend 1 treatment approach over another, leaving physicians and patients to decide ba...

journal_title：Cancer

authors： Nguyen CT,Zelefsky MJ,Kattan MW

更新日期：2009-07-01 00:00:00

abstract：:The authors estimated cancer risk among 589 patients hospitalized with Crohn's disease between 1960-1976 by calculating the ratios of observed number of cancers (O) in our hospital sample to the expected number of cancers (E) based on the age- and sex-specific cancer rates of a standard population. The authors then co...

journal_title：Cancer

authors： Greenstein AJ,Sachar DB,Smith H,Janowitz HD,Aufses AH Jr

更新日期：1981-12-15 00:00:00

abstract：BACKGROUND:Accelerated radiotherapy (RT) represents a promising method with which to improve the treatment outcome in patients with head and neck carcinoma. However, its applicability to elderly patients has not been well established. This study assessed treatment toxicities, patient compliance, and oncologic results i...

journal_title：Cancer

authors： Allal AS,Maire D,Becker M,Dulguerov P

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:An association between laryngopharyngeal reflux (LPR) and laryngeal carcinoma has been suggested, but remains unproven. The current pilot study was performed to determine the incidence of LPR among patients with early laryngeal carcinomas or dysplasia and to examine the associations between levels of LPR and...

journal_title：Cancer

authors： Lewin JS,Gillenwater AM,Garrett JD,Bishop-Leone JK,Nguyen DD,Callender DL,Ayers GD,Myers JN

更新日期：2003-02-15 00:00:00

abstract：BACKGROUND:The reason for the thermal abnormality associated with some breast cancers is unclear. We previously reported that a thermographic abnormality is associated with tumor size and lymph node involvement. Despite this association, we were unable to demonstrate an independent association between an abnormal therm...

journal_title：Cancer

authors： Sterns EE,Zee B,SenGupta S,Saunders FW

更新日期：1996-04-01 00:00:00

abstract：:This study characterized the fine structure of melanosomes in melanocytes of the dysplastic nevi in six cases with lentiginous melanocytic dysplasia and one case with epithelioid-cell melanocytic dysplasia, and compared that structure with those of common melanocytic nevi and malignant melanoma. It was found that: fin...

journal_title：Cancer

authors： Takahashi H,Horikoshi T,Jimbow K

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND:Recommendations for pretreatment evaluation and treatment of cervical cancer have significantly evolved over the last decade because of the results of multiple randomized studies comparing the addition of platin-based chemoradiation as well as the widespread dissemination and use of imaging modalities. This ...

journal_title：Cancer

authors： Trimble EL,Harlan LC,Gius D,Stevens J,Schwartz SM

更新日期：2008-08-15 00:00:00

abstract：:In a county hospital, 217 patients were operated on for suspected cancer of the pancreas (186 patients) and periampullary structures (31 patients). The surgeons' philosophy was to avoid biopsy of the pancreas whenever possible, they often performed radical resection based on clinical judgment alone (8% of the resectio...

journal_title：Cancer

authors： Lee YT

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:Only five cases of basaloid squamous cell carcinoma (BSCC), a rare tumor of head and neck, have been reported to involve the floor of mouth. METHODS:Clinicopathologic and immunohistochemical features of eight BSCC of floor of mouth were studied to evaluate the significance of the basaloid features. RESULTS...

journal_title：Cancer

authors： Coppola D,Catalano E,Tang CK,Elfenbein IB,Harwick R,Mohr R

更新日期：1993-10-15 00:00:00

abstract：:Aspergillus infection can be a major cause of morbidity in immunocompromised patients, especially when there is pulmonary involvement. Diagnosis of aspergillosis is often complicated by the varied clinical presentation and compromised medical status of such patients. Four cases of head and neck Aspergillus infections ...

journal_title：Cancer

authors： Schubert MM,Peterson DE,Meyers JD,Hackman R,Thomas ED

更新日期：1986-03-15 00:00:00

abstract：BACKGROUND:The AKT inhibitor MK-2206 at a dose of 60 mg every other day was evaluated in gastric/gastroesophageal junction cancers. METHODS:Patients who had progressed after first-line treatment were eligible. Pertinent eligibility criteria included adequate organ function, a fasting serum glucose level ≤ 150 mg/dL, a...

journal_title：Cancer

authors： Ramanathan RK,McDonough SL,Kennecke HF,Iqbal S,Baranda JC,Seery TE,Lim HJ,Hezel AF,Vaccaro GM,Blanke CD

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Nonionizing radiation, such as radiofrequency field and near infrared laser, induces thermal cytotoxicity in cancer cells treated with gold nanoparticles. Quantum dots are fluorescent semiconducting nanoparticles that were hypothesized to induce similar injury after radiofrequency field irradiation. METHODS...

journal_title：Cancer

authors： Glazer ES,Curley SA

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:The objective of this study was to determine the potential economic implications resulting from using exemestane (EXE), a new steroidal, irreversible aromatase inactivator, compared with megestrol acetate (MA) in patients with advanced breast carcinoma. METHODS:The model used the clinical results from the m...

journal_title：Cancer

authors： Hillner BE,Radice D

更新日期：2001-02-01 00:00:00

abstract：BACKGROUND:Selective neck dissection (SND) is a mainstay of head and neck cancer treatment. A common sequela is shoulder syndrome from spinal accessory nerve (SAN) trauma. Extensive dissection in neck levels 2 and 5 leads to SAN dysfunction. However, it is not known whether limited level 2 dissection reduces SAN injury...

journal_title：Cancer

authors： Dziegielewski PT,McNeely ML,Ashworth N,O'Connell DA,Barber B,Courneya KS,Debenham BJ,Seikaly H

更新日期：2020-04-01 00:00:00