Abstract:
BACKGROUND:All edemas result from an imbalance between capillary filtration and tissue (lymph) drainage. This basic approach was adopted to investigate mechanisms for chronic arm edema following breast carcinoma treatment. METHODS:A review of causes of lymphedema is presented plus the traditional pathophysiology of breast carcinoma related lymphedema (postmastectomy edema; PME). A summary of recent research that explored capillary filtration as a surrogate for lymph flow in the steady state is presented. RESULTS:A reduced interstitial protein concentration (relative to plasma) argues against lymphatic obstruction. Evidence exists that total arm blood flow (in some patients) and vascular bed size are increased in PME. CONCLUSIONS:The primary insult to the axillary lymphatic system by surgery and radiotherapy presumably is the root cause of PME; however, there is strong evidence to suggest that hemodynamic factors are contributory to the chronic swelling.
journal_name
Cancerjournal_title
Cancerauthors
Mortimer PSdoi
10.1002/(sici)1097-0142(19981215)83:12b+<2798::aidsubject
Has Abstractpub_date
1998-12-15 00:00:00pages
2798-802issue
12 Suppl Americaneissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19981215)83:12B+<2798::AIDjournal_volume
83pub_type
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