Outcomes in adolescents and young adults with Hodgkin lymphoma treated on US cooperative group protocols: An adult intergroup (E2496) and Children's Oncology Group (COG AHOD0031) comparative analysis.

Abstract:

BACKGROUND:There is no clear consensus between pediatric and adult providers about the treatment of adolescents and young adults (AYAs) with Hodgkin lymphoma (HL). METHODS:Failure-free survival (FFS) and overall survival (OS) were compared between 114 patients ages 17 to 21 years with HL who were treated on the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Intergroup adult E2496 study and 391 similarly patients ages 17 to 21 years with HL who were treated on the pediatric Children's Oncology Group (COG) AHOD0031 study. RESULTS:Comparing AYAs from the COG and E2496 studies, there were no significant differences in extralymphatic disease, anemia, or hypoalbuminemia. More AYAs in the E2496 trial had stage III and IV disease (63% vs 29%; P < .001) and B symptoms (63% vs 27%; P < .001), and fewer had bulk disease (33% vs 77%; P < .001). More AYAs on the COG trial received radiotherapy (76% vs 66%; P = .03), although in smaller doses. E2496 AYA The 5-year FFS and OS rates were 68% and 89%, respectively in the E2496 AYAs and 81% and 97%, respectively, in the COG AYAs, indicating a statistically superior compared in the COG AYAs (P = .001). In stratified multivariable analyses, E2496 AYAs had worse FFS than COG AYAs in all strata except patients who had stage I and II HL without anemia. Propensity score analysis (based on stage, anemia, and bulk disease) confirmed inferior FFS for E2496 AYAs compared with COG AYAs (P = .004). On the E2496 study, FFS was significantly divergent across age groups (P = .005), with inferior outcomes for those ages 17 to 21 years versus 22-44 years. There was no difference across age on the COG study. CONCLUSIONS:Younger AYA patients with HL appear to have better outcomes when treated on a pediatric trial than patients of similar age on an adult trial. Prospective studies examining these differences are warranted. Cancer 2018;124:136-44. © 2017 American Cancer Society.

journal_name

Cancer

journal_title

Cancer

authors

Henderson TO,Parsons SK,Wroblewski KE,Chen L,Hong F,Smith SM,McNeer JL,Advani RH,Gascoyne RD,Constine LS,Horning S,Bartlett NL,Shah B,Connors JM,Leonard JI,Kahl BS,Kelly KM,Schwartz CL,Li H,Friedberg JW,Friedman D

doi

10.1002/cncr.30979

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

136-144

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

124

pub_type

杂志文章

相关文献

CANCER文献大全
  • Predictive and prognostic roles of ribonucleotide reductase M1 in resectable pancreatic adenocarcinoma.

    abstract:BACKGROUND:Ribonucleotide reductase M1 (RRM1) is an important molecule in different types of cancer. The objective of this study was to evaluate the predictive roles of RRM1 in the survival of patients with resectable pancreatic adenocarcinoma who received treatment with gemcitabine or nongemcitabine adjuvant therapy. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27715

    authors: Xie H,Jiang W,Jiang J,Wang Y,Kim R,Liu X,Liu X

    更新日期:2013-01-01 00:00:00

  • Polymorphisms in CYP1A1 and breast carcinoma risk in a population-based case-control study of Chinese women.

    abstract:BACKGROUND:Cytochrome P450 1A1 (CYP1A1) is involved in the 2-hydroxylation of estrogen, the hormone that plays a critical role in the etiology of breast carcinoma. METHODS:The authors evaluated common polymorphisms in the CYP1A1 gene in relation to breast carcinoma risk in a large population-based case-control study a...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/cncr.21056

    authors: Boyapati SM,Shu XO,Gao YT,Cai Q,Jin F,Zheng W

    更新日期:2005-06-01 00:00:00

  • Access, insurance, and personpower.

    abstract::This presentation will focus on the issues of access to care, insurance, and personpower in pediatric oncology. The invitation to participate in this workshop was addressed to me as former Chairman of the Section of Hematology/Oncology of the American Academy of Pediatrics and current Chairman of the sub-board of Pedi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930515)71:10+<3290::aid-cncr28

    authors: Gilchrist GS

    更新日期:1993-05-15 00:00:00

  • Social needs and health-related quality of life among African American cancer survivors: Results from the Detroit Research on Cancer Survivors study.

    abstract:BACKGROUND:Social needs may affect cancer survivors' health-related quality of life (HRQOL) above and beyond sociodemographic and cancer-related factors. The purpose of this study was to estimate associations between social needs and HRQOL. METHODS:Results included data from 1754 participants in the Detroit Research o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33286

    authors: Hastert TA,McDougall JA,Strayhorn SM,Nair M,Beebe-Dimmer JL,Schwartz AG

    更新日期:2021-02-01 00:00:00

  • The role of chemotherapy for node-negative breast cancer.

    abstract::Approximately 25% of women with early stage breast cancer and negative axillary nodes will eventually die of metastatic disease. Some studies have shown a recurrence rate of 40% or more at 10 years in this relatively good prognostic group. The incidence of breast cancer continues to increase approximately 1% per year ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Cooper MR

    更新日期:1991-03-15 00:00:00

  • Hemolytic uremic syndrome after high dose chemotherapy with autologous stem cell support.

    abstract:BACKGROUND:Chemotherapy intensification may lead to new forms of toxicity such as hemolytic uremic syndrome. METHODS:Three patients are described who developed this complication 4 to 6 months after high dose chemotherapy followed by autologous stem cell support. The literature on this subject is reviewed. RESULTS:One...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19951201)76:11<2338::aid-cncr282

    authors: van der Lelie H,Baars JW,Rodenhuis S,van Dijk MA,de Glas-Vos CW,Thomas BL,van Oers RH,von dem Borne AE

    更新日期:1995-12-01 00:00:00

  • The clinical significance of large cells in bone marrow in patients with chronic lymphocytic leukemia.

    abstract:BACKGROUND:Patients with chronic lymphocytic leukemia (CLL) that transforms to Richter syndrome (RS) frequently show atypical lymphocytes in bone marrow; however, a diagnosis of RS requires confirmation of the presence of sheets of large cells in bone marrow or lymph nodes. METHODS:In this study, the authors evaluated...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20251

    authors: Ma Y,Mansour A,Bekele BN,Zhou X,Keating MJ,O'Brien S,Giles FJ,Albitar M

    更新日期:2004-05-15 00:00:00

  • Levamisole in primary breast cancer. A controlled study in conjunction with l-phenylalanine mustard.

    abstract::Between September 1976 and May 1980, 135 patients with operable breast cancer and positive axillary nodes received l-phenylalanine mustard, adjunct to surgery, 0.15 mg/kg for five days, six weekly, and were randomised prospectively to levamisole 150 mg for three days, two weekly, or a placebo. Treatment was continued ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19830601)51:11<1992::aid-cncr282

    authors: Kay RG,Mason BH,Stephens EJ,Arthur JF,Hitchcock GC,Trindall PL,Rodgers R,Mullins P

    更新日期:1983-06-01 00:00:00

  • Use of carcinoembryonic antigen in small cell lung cancer. Prognostic value and relation to the clinical course 1.

    abstract::Carcinoembryonic antigen (CEA) was measured in 147 patients at diagnosis of small cell lung cancer; 17% of patients with limited disease and 51% with extensive disease had an abnormal CEA level (greater than 10 ng/ml). The median level was higher in extensive than in limited disease (11 ng/ml and 5.8 ng/ml, respective...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870615)59:12<2047::aid-cncr282

    authors: Laberge F,Fritsche HA,Umsawasdi T,Carr DT,Welch S,Murphy WK,Chiuten DF,Dhingra HM,Farha P,Spitzer G

    更新日期:1987-06-15 00:00:00

  • Disparities in access to care at high-volume institutions for uro-oncologic procedures.

    abstract:BACKGROUND:Socioeconomic status represents an established barrier to health care access. Age, sex, and race may also play a role. The authors examined whether these affect the access to high-volume hospitals for uro-oncologic procedures in the United States. METHODS:Within the Nationwide Inpatient Sample (NIS), the au...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27440

    authors: Trinh QD,Sun M,Sammon J,Bianchi M,Sukumar S,Ghani KR,Jeong W,Dabaja A,Shariat SF,Perrotte P,Agarwal PK,Rogers CG,Peabody JO,Menon M,Karakiewicz PI

    更新日期:2012-09-15 00:00:00

  • The Reach to Recovery program.

    abstract::The diagnosis of breast cancer brings with it significant psychosocial concerns and questions. Part of providing comprehensive care for a woman with breast cancer requires the physician to be aware of the Reach To Recovery Program, which is a peer modeling program provided by the American Cancer Society. The women who...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.2820741324

    authors: Rinehart ME

    更新日期:1994-07-01 00:00:00

  • Primary lymphoma of the central nervous system. Computerized tomography scan characteristics and treatment results for 12 cases.

    abstract::A retrospective analysis of 12 patients with primary central nervous system non-Hodgkin's lymphoma seen from 1958 to 1980 was carried out with emphasis on diagnostic evaluation and treatment results. Computerized tomography (CT) scans were found to be the most valuable diagnostic tool both for initial evaluation as we...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19831201)52:11<1993::aid-cncr282

    authors: Mendenhall NP,Thar TL,Agee OF,Harty-Golder B,Ballinger WE Jr,Million RR

    更新日期:1983-12-01 00:00:00

  • Supratentorial gangliogliomas: histopathologic grading and tumor recurrence in 184 patients with a median follow-up of 8 years.

    abstract:BACKGROUND:Supratentorial gangliogliomas (GGs) are rare tumors of the central nervous system and are commonly associated with chronic seizures. To date, only case reports and small series of patients with short-term follow-up have been available for the assessment of the potential of GGs to recur and progress. METHODS...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20332

    authors: Luyken C,Blümcke I,Fimmers R,Urbach H,Wiestler OD,Schramm J

    更新日期:2004-07-01 00:00:00

  • 111Indium-bleomycin breast and axilla imaging.

    abstract::111Indium-Bleomycin (111In-Blm), a new radiopharmaceutical, was administered intravenously to 37 patients with benign and malignant breast lesions. Early and delayed images of both the breasts and axillae were made, and results were correlated with physical examination, histopathology of the excised lesion, mammograph...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197601)37:1<36::aid-cncr28203701

    authors: Silverstein MJ,Verma RC,Greenfield L,Morton DL

    更新日期:1976-01-01 00:00:00

  • Adenocarcinoma of the proximal colon. Sites of initial dissemination and patterns of recurrence following surgery alone.

    abstract::Seven hundred ninety-five patients were adenocarcinomas of the proximal colon were reviewed. Two hundred forty-five patients presented with disseminated disease at the time of diagnosis, and were analyzed to identify mechanisms and sites of disease spread. Five hundred fifty patients underwent radical resection, and w...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840115)53:2<360::aid-cncr28205

    authors: Russell AH,Tong D,Dawson LE,Wisbeck W

    更新日期:1984-01-15 00:00:00

  • Thin-needle aspiration biopsy: the diagnosis of head and neck tumors revisited.

    abstract::Results of 567 thin-needle aspiration biopsies of head and neck lesions are reviewed. Cases included lymph nodes, salivary glands, thyroid, soft tissue and bone lesions. For the entire series, 17 patients had unsatisfactory aspirations. There were 12 false negative reports and 4 false positive reports, rates of 2.1% a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197904)43:4<1541::aid-cncr282043

    authors: Frable WJ,Frable MA

    更新日期:1979-04-01 00:00:00

  • Serous borderline tumors of the ovary with noninvasive peritoneal implants.

    abstract:BACKGROUND:The authors conducted this study to update their experience with patients who have ovarian serous borderline tumors with noninvasive peritoneal implants, with the objectives of gaining additional insight into the biologic behavior of these tumors and understanding better the effects of postoperative treatmen...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19981115)83:10<2157::aid-c

    authors: Gershenson DM,Silva EG,Tortolero-Luna G,Levenback C,Morris M,Tornos C

    更新日期:1998-11-15 00:00:00

  • Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy.

    abstract::Since June 1978, 57 patients with primary osteogenic sarcoma of an extremity were treated with high-dose methotrexate (HDMTX) and citrovorum factor rescue (CFR), Adriamycin, and the combination of bleomycin, cyclophosphamide and dactinomycin (BCD) given for 4-16 weeks prior to definitive surgery. Histologic examinatio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820315)49:6<1221::aid-cncr2820

    authors: Rosen G,Caparros B,Huvos AG,Kosloff C,Nirenberg A,Cacavio A,Marcove RC,Lane JM,Mehta B,Urban C

    更新日期:1982-03-15 00:00:00

  • Low-molecular weight forms of cyclin E differentiate ovarian carcinoma from cells of mesothelial origin and are associated with poor survival in ovarian carcinoma.

    abstract:BACKGROUND:The authors recently reported on the role of cyclin E in differentiating ovarian/primary peritoneal carcinoma from malignant peritoneal mesothelioma using gene expression arrays. In the current study, they analyzed the expression of low-molecular weight (LMW) forms of cyclin E in ovarian carcinoma, malignant...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22918

    authors: Davidson B,Skrede M,Silins I,Shih IeM,Trope CG,Flørenes VA

    更新日期:2007-09-15 00:00:00

  • A double-blind comparison of the efficacy of two dose regimens of oral granisetron in preventing acute emesis in patients receiving moderately emetogenic chemotherapy.

    abstract:BACKGROUND:The purpose of this study was to define an optimal administration schedule of granisetron for patients receiving moderately emetogenic chemotherapy by comparing the antiemetic efficacy and safety of 2 mg of the drug administrated orally. METHODS:In this double-blind, randomized, parallel study, 2-dose regim...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/(SICI)1097-0142(19960701)78:1<144::AID-CNC

    authors: Ettinger DS,Eisenberg PD,Fitts D,Friedman C,Wilson-Lynch K,Yocom K

    更新日期:1996-07-01 00:00:00

  • Cardiovascular disease in survivors of hematopoietic cell transplantation.

    abstract::Hematopoietic cell transplantation (HCT) is increasingly offered as a curative option for many patients with hematologic malignancies. Improvements in HCT strategies and supportive care have resulted in a growing number of long-term survivors. However, these survivors are at an increased risk of developing long-term d...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.28444

    authors: Armenian SH,Chow EJ

    更新日期:2014-02-15 00:00:00

  • Radiation therapy at the end of life in patients with incurable nonsmall cell lung cancer.

    abstract:BACKGROUND:Receipt of chemotherapy at the end of life (EOL) is considered an indicator of poor quality of care for medical oncology. The objective of this study was to characterize the use of radiotherapy (RT) in patients with nonsmall cell lung cancer (NSCLC) during the same period. METHODS:Treatment characteristics ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27401

    authors: Kapadia NS,Mamet R,Zornosa C,Niland JC,D'Amico TA,Hayman JA

    更新日期:2012-09-01 00:00:00

  • Clinical and biochemical effects in vivo of monoclonal antitumor antibody in Verner-Morrison's syndrome.

    abstract:BACKGROUND:Monoclonal antibodies have not been evaluated in metastasizing endocrine tumors, even though these lesions may induce severe morbidity of hormone excess in absence of considerable tumor burden. METHODS:A murine monoclonal antibody of the IgG2a subtype was generated by immunization with dispersed tumor cells...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19940301)73:5<1346::aid-cncr2820

    authors: Juhlin C,Papanicolaou V,Arnberg H,Klareskog L,Lörelius LE,Rastad J,Oberg K,Akerström G

    更新日期:1994-03-01 00:00:00

  • Acute myelogenous leukemia as a second malignant neoplasm following the successful treatment of advanced Hodgkin's disease.

    abstract::Of 209 Hodgkin's disease patients treated at least 6 months with a five-drug combination of induction chemotherapy and having a complete remission, four patients developed acute myelogenous leukemia (AML) as a second malignant neoplasm. The overall relative risk for development of AML is 185.0 (P less than 0.05) and t...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19831215)52:12<2209::aid-cncr282

    authors: Bartolucci AA,Liu C,Durant JR,Gams RA

    更新日期:1983-12-15 00:00:00

  • Gianturco expandable wire stents in the treatment of superior vena cava syndrome recurring after maximum-tolerance radiation.

    abstract::Two patients with superior vena cava syndrome (SVCS) recurring after maximum-tolerance radiation were treated by placing a Gianturco expandable wire stent (GEWS) into the obstructed superior vena cava. The SVCS symptoms rapidly disappeared and good short-term (6 months) palliation was achieved. GEWS placement is a pro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870915)60:6<1243::aid-cncr2820

    authors: Rösch J,Bedell JE,Putnam J,Antonovic R,Uchida B

    更新日期:1987-09-15 00:00:00

  • The impact of treatment factors on local control in T2-T3 anal carcinomas treated by radiotherapy with or without chemotherapy.

    abstract:BACKGROUND:This study was conducted to investigate the influence of therapeutic parameters on local control (LC) in the sphincter-conserving treatment of T2-T3 anal carcinoma. METHODS:From 1976 to 1993, 137 patients with anal carcinoma classified as T2 (85 patients) or T3 (52 patients) were treated curatively by radio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19970615)79:12<2329::aid-c

    authors: Allal AS,Mermillod B,Roth AD,Marti MC,Kurtz JM

    更新日期:1997-06-15 00:00:00

  • Idiopathic giant cell myocarditis after autologous hematopoietic stem cell transplantation and interleukin-2 immunotherapy: a case report.

    abstract:BACKGROUND:Interleukin-2 (IL-2) is used in the treatment of solid tumors and hematologic malignancies. Sudden death is a rare complication of IL-2 treatment. METHODS:A patient with lymphoma underwent chemoradiotherapy myeloablation and autologous stem cell transplantation. The stem cells were cultured in IL-2 (6000 IU...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19980915)83:6<1231::aid-cn

    authors: Truica CI,Hansen CH,Garvin DF,Meehan KR

    更新日期:1998-09-15 00:00:00

  • Adenoid cystic carcinoma of the salivary gland. Sustained complete response to chemotherapy.

    abstract::A patient developed widely metastatic adenoid cystic carcinoma of the parotid gland after several local recurrences. A complete regression of pleural, pulmonary parenchymal, cutaneous, and bone metastases was seen following therapy with 5-fluorouracil, Adriamycin, and mitomycin C. This is the second complete response ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830215)51:4<589::aid-cncr28205

    authors: Budd GT,Groppe CW

    更新日期:1983-02-15 00:00:00

  • Malignant clear cell acrospiroma.

    abstract::The histologic features of a malignant clear cell acrospiroma were those of infiltrative local growth, frequent mitoses and angiolymphatic invasion. The histochemical and ultrastructural findings were similar to those reported for benign clear cell acrospriomas. Amputation of the leg and regional node dissection were ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197802)41:2<641::aid-cncr2820410

    authors: Headington JT,Niederhuber JE,Beals TF

    更新日期:1978-02-01 00:00:00

  • Evaluation of fluorescence polarization of human blood lymphocytes (SCM test) in the diagnosis of cancer.

    abstract::Fluorescence polarization was performed on 82 individuals: 32 patients with malignant diseases, 30 apparently healthy individuals, and 20 patients with nonmalignant diseases. The blood lymphocytes from these cases were isolated and challenged with cancer basic protein (CaBP). Stimulation occurred in the majority of th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800901)46:5<1164::aid-cncr2820

    authors: Schnuda ND

    更新日期:1980-09-01 00:00:00