Outcomes in adolescents and young adults with Hodgkin lymphoma treated on US cooperative group protocols: An adult intergroup (E2496) and Children's Oncology Group (COG AHOD0031) comparative analysis.


BACKGROUND:There is no clear consensus between pediatric and adult providers about the treatment of adolescents and young adults (AYAs) with Hodgkin lymphoma (HL). METHODS:Failure-free survival (FFS) and overall survival (OS) were compared between 114 patients ages 17 to 21 years with HL who were treated on the Eastern Cooperative Oncology Group-American College of Radiology Imaging Network Intergroup adult E2496 study and 391 similarly patients ages 17 to 21 years with HL who were treated on the pediatric Children's Oncology Group (COG) AHOD0031 study. RESULTS:Comparing AYAs from the COG and E2496 studies, there were no significant differences in extralymphatic disease, anemia, or hypoalbuminemia. More AYAs in the E2496 trial had stage III and IV disease (63% vs 29%; P < .001) and B symptoms (63% vs 27%; P < .001), and fewer had bulk disease (33% vs 77%; P < .001). More AYAs on the COG trial received radiotherapy (76% vs 66%; P = .03), although in smaller doses. E2496 AYA The 5-year FFS and OS rates were 68% and 89%, respectively in the E2496 AYAs and 81% and 97%, respectively, in the COG AYAs, indicating a statistically superior compared in the COG AYAs (P = .001). In stratified multivariable analyses, E2496 AYAs had worse FFS than COG AYAs in all strata except patients who had stage I and II HL without anemia. Propensity score analysis (based on stage, anemia, and bulk disease) confirmed inferior FFS for E2496 AYAs compared with COG AYAs (P = .004). On the E2496 study, FFS was significantly divergent across age groups (P = .005), with inferior outcomes for those ages 17 to 21 years versus 22-44 years. There was no difference across age on the COG study. CONCLUSIONS:Younger AYA patients with HL appear to have better outcomes when treated on a pediatric trial than patients of similar age on an adult trial. Prospective studies examining these differences are warranted. Cancer 2018;124:136-44. © 2017 American Cancer Society.






Henderson TO,Parsons SK,Wroblewski KE,Chen L,Hong F,Smith SM,McNeer JL,Advani RH,Gascoyne RD,Constine LS,Horning S,Bartlett NL,Shah B,Connors JM,Leonard JI,Kahl BS,Kelly KM,Schwartz CL,Li H,Friedberg JW,Friedman D




Has Abstract


2018-01-01 00:00:00














  • Epidermal Langerhans' cell densities influence survival in mycosis fungoides and Sézary syndrome.

    abstract::Because Langerhans' cells (LC) (CD1a-positive epidermal cells) have been discussed to be involved in the pathogenesis of mycosis fungoides and Sézary syndrome, the authors examined the influence of densities of Langerhans' cells and, concurrently, of other phenotypes retrospectively on survival of 35 patients. Cell de...


    pub_type: 杂志文章


    authors: Meissner K,Michaelis K,Rehpenning W,Löning T

    更新日期:1990-05-01 00:00:00

  • Trends, patterns, and outcomes in the management of malignant colonic polyps in the general population of the United States.

    abstract:BACKGROUND:Colonoscopic screening has increased detection of malignant colonic polyps (MPs). The goal of this study was to analyze trends and patterns in the surgical treatment of MPs and to assess outcomes as measured by lymph node retrieval and patient survival. METHODS:The Surveillance, Epidemiology, and End Result...


    pub_type: 杂志文章


    authors: Wasif N,Etzioni D,Maggard MA,Tomlinson JS,Ko CY

    更新日期:2011-03-01 00:00:00

  • Prostate cancer risk in the Swedish AMORIS study: the interplay among triglycerides, total cholesterol, and glucose.

    abstract:BACKGROUND:In a cohort including 5112 prostate cancer (pCa) patients, the authors investigated associations among triglycerides (TG), total cholesterol (TC), and pCa while taking into account glucose. METHODS:A cohort (n = 200,660) based on 4 groups of men, according to age at cohort entry, with TG, TC, and glucose me...


    pub_type: 杂志文章


    authors: Van Hemelrijck M,Garmo H,Holmberg L,Walldius G,Jungner I,Hammar N,Lambe M

    更新日期:2011-05-15 00:00:00

  • Clinical characteristics of 45 patients with invasive pulmonary aspergillosis: retrospective analysis of 1711 lung cancer cases.

    abstract:BACKGROUND:: Invasive aspergillosis (IA) is a common complication in patients with hematologic malignancies. Patients with solid tumors also are at risk for IA because they may develop neutropenia as a result of chemotherapy and radiotherapy. However, studies of IA in patients with solid tumors are rare. In this study,...


    pub_type: 杂志文章


    authors: Yan X,Li M,Jiang M,Zou LQ,Luo F,Jiang Y

    更新日期:2009-11-01 00:00:00

  • External beam irradiation and the combination of cisplatin and carmustine followed by carmustine alone for the treatment of high-grade glioma: a phase 2 Southwest Oncology Group trial.

    abstract:BACKGROUND:The poor prognosis reported for patients with high-grade glial neoplasms indicates a need for the development of multimodality therapeutic approaches. The addition of chemotherapy has contributed variably to increased survival. The objective of the current study (Southwest Oncology Group [SWOG] 9016) was to ...


    pub_type: 杂志文章,多中心研究


    authors: Blumenthal DT,Rankin C,Eyre HJ,Livingston RB,Spence AM,Stelzer KJ,Rushing EJ,Berger MS,Rivkin SE,Cohn AL,Petersdorf SH

    更新日期:2008-08-01 00:00:00

  • Radical nephrectomy surgical outcomes in the University HealthSystem Consortium Data Base: Impact of hospital case volume, hospital size, and geographic location on 40,000 patients.

    abstract:BACKGROUND:We sought to determine the impact of radical nephrectomy case volume, hospital size, and geographic region on immediate surgical outcomes for patients undergoing radical nephrectomy in academic centers across the country. METHODS:The University HealthSystem Consortium (UHC) Clinical Data Base was queried fo...


    pub_type: 杂志文章


    authors: Mitchell RE,Lee BT,Cookson MS,Barocas DA,Duke Herrell S,Clark PE,Smith JA,Chang SS

    更新日期:2009-06-01 00:00:00

  • Stratification of risk factors in renal cell carcinoma.

    abstract::One hundred fifteen patients underwent surgical treatment of renal cell carcinoma. Survival time was analyzed by statistical regression methods in order to determine the joint significance of stage, using both the Robson and TNM classifications, histologic grade, cell type, and demographic features of the patient samp...


    pub_type: 杂志文章


    authors: Selli C,Hinshaw WM,Woodard BH,Paulson DF

    更新日期:1983-09-01 00:00:00

  • Review of four cases of childhood hepatic angiosarcoma--elevated environmental arsenic exposure in one case.

    abstract::Four cases of childhood hepatic angiosarcoma (HAS), representing the malignant form of infantile hemangioendothelioma, are described. The morphologic appearance of childhood HAS differs from the adult form in the following features: the associated presence of benign infantile hemangioendothelioma; the presence of dyso...


    pub_type: 杂志文章


    authors: Falk H,Herbert JT,Edmonds L,Heath CW Jr,Thomas LB,Popper H

    更新日期:1981-01-15 00:00:00

  • Measuring financial toxicity as a clinically relevant patient-reported outcome: The validation of the COmprehensive Score for financial Toxicity (COST).

    abstract:BACKGROUND:Cancer and its treatment lead to increased financial distress for patients. To the authors' knowledge, to date, no standardized patient-reported outcome measure has been validated to assess this distress. METHODS:Patients with AJCC Stage IV solid tumors receiving chemotherapy for at least 2 months were recr...


    pub_type: 杂志文章


    authors: de Souza JA,Yap BJ,Wroblewski K,Blinder V,Araújo FS,Hlubocky FJ,Nicholas LH,O'Connor JM,Brockstein B,Ratain MJ,Daugherty CK,Cella D

    更新日期:2017-02-01 00:00:00

  • Changing trends. An overview of breast cancer incidence and mortality.

    abstract::The incidence of breast cancer rose about 1% per year between 1940 and 1980 according to data in the Connecticut Tumor Registry. A sharp increase of 32% was reported between 1980 and 1987 in the Surveillance, Epidemiology and End Results Program of the National Cancer Institute. Data from this program shows that the i...


    pub_type: 杂志文章


    authors: Garfinkel L,Boring CC,Heath CW Jr

    更新日期:1994-07-01 00:00:00

  • The treatment of chronic lymphocytic leukemia with COP chemotherapy.

    abstract::Since single drug therapy of chronic lymphocytic leukemia (CLL) has not resulted in prolonged remissions of advanced disease, we initiated a program of combination chemotherapy, COP (cycloposphamide, vincristine sulfate, prednisone) for CLL patients with increasing adenopathy, spenomegaly, and/or signs of marrow failu...


    pub_type: 杂志文章


    authors: Liepman M,Votaw ML

    更新日期:1978-05-01 00:00:00

  • Treatment capacity required for full-scale implementation of lung cancer screening in the United States.

    abstract:BACKGROUND:Full-scale implementation of lung cancer screening in the United States will increase detection of early stages. This study was aimed at assessing the capacity required for treating those cancers. METHODS:A well-established microsimulation model was extended with treatment data from the National Cancer Data...


    pub_type: 杂志文章


    authors: Blom EF,Ten Haaf K,Arenberg DA,de Koning HJ

    更新日期:2019-06-15 00:00:00

  • Combination chemotherapy and radiation therapy in the treatment of metastatic osteogenic sarcoma.

    abstract::Fourteen patients with 16 metastatic ostogenic sarcoma lesions were treated with high-dose methotrexate (HDMTX) with citrovorum factor rescue (CFR), adriamycin, and pulse high-dose cyclophosphamide combined with radiation therapy. Thirteen of 16 lesions responded. Responses consisted of relief of pain (6/6 patients) i...


    pub_type: 杂志文章


    authors: Rosen G,Tefft M,Martinez A,Cham W,Murphy ML

    更新日期:1975-03-01 00:00:00

  • The radiographic diagnosis and treatment of paraneoplastic central nervous system disease.

    abstract::Paraneoplastic nervous system syndromes are being identified with increasing frequency because of greater physician awareness and the availability of serodiagnostic tests for some syndromes. Frequently, paraneoplastic syndromes develop in the setting of an indolent, limited stage, or otherwise occult malignancy. As a ...


    pub_type: 杂志文章,评审


    authors: Glantz MJ,Biran H,Myers ME,Gockerman JP,Friedberg MH

    更新日期:1994-01-01 00:00:00

  • Prognostic evaluation of DNA flow cytometric and histopathologic parameters of colorectal cancer.

    abstract:BACKGROUND:The clinical value of DNA flow cytometry of colorectal cancer is unclear. The purpose of this retrospective study was to evaluate the relationship between tumor flow cytometry, histopathologic parameters, and survival. METHODS:Flow cytometry was performed on paraffin embedded specimens from 653 patients who...


    pub_type: 杂志文章


    authors: Tang R,Ho YS,You YT,Hsu KC,Chen JS,Changchien CR,Wang JY

    更新日期:1995-11-15 00:00:00

  • Infiltration of dendritic cells in relation to tumor invasion and lymph node metastasis in human gastric cancer.

    abstract::The infiltration of dendritic cells determined in 210 patients with gastric carcinoma was investigated from the standpoint of tumor invasion, lymph node metastasis, and prognosis. Dendritic cell infiltration was graded as "slight" and "marked." The 39% frequency in the marked infiltration group at the mucosal stage di...


    pub_type: 杂志文章


    authors: Tsujitani S,Kakeji Y,Watanabe A,Kohnoe S,Maehara Y,Sugimachi K

    更新日期:1990-11-01 00:00:00

  • Transcatheter arterial chemoembolization or chemoinfusion for unresectable intrahepatic cholangiocarcinoma: clinical efficacy and factors influencing outcomes.

    abstract:BACKGROUND:The role of transcatheter arterial chemoembolization (TACE) or transcatheter arterial chemoinfusion (TACI) for unresectable intrahepatic cholangiocarcinoma (ICC) has recently been questioned. The aim of the study was to evaluate the clinical efficacy of TACE or TACI in patients with unresectable ICC and to i...


    pub_type: 杂志文章


    authors: Kim JH,Yoon HK,Sung KB,Ko GY,Gwon DI,Shin JH,Song HY

    更新日期:2008-10-01 00:00:00

  • Prognostic impact of discordant results from cytogenetics and flow cytometry in patients with acute myeloid leukemia undergoing hematopoietic cell transplantation.

    abstract:BACKGROUND:Cytogenetics and multicolor flow cytometry (MFC) are useful tools for monitoring outcome of treatment in acute myeloid leukemia (AML). However, no data are available regarding the meaning of results when the 2 tests do not agree. METHODS:The authors of this report analyzed 1464 pairs of concurrent cytogenet...


    pub_type: 杂志文章


    authors: Fang M,Storer B,Wood B,Gyurkocza B,Sandmaier BM,Appelbaum FR

    更新日期:2012-05-01 00:00:00

  • The fine structure of astroblastoma.

    abstract::An astroblastoma in the cerebrum was investigated with the electron microscope. A distinctive feature of the tumor was the radial arrangement of astrocytic cells around the blood vessels. The blood vessels in the tumor commonly exhibited fenestrated endothelial cells. The endothelium was generally surrounded by lamell...


    pub_type: 杂志文章


    authors: Kubota T,Hirano A,Sato K,Yamamoto S

    更新日期:1985-02-15 00:00:00

  • Mammographically detected recurrent nonpalpable carcinoma developing in a transverse rectus abdominus myocutaneous flap. A case report.

    abstract:BACKGROUND:Breast reconstruction is performed with increasing frequency and has become important in the treatment of mastectomy patients. METHODS:The development of recurrent carcinoma after a mastectomy and transverse rectus abdominus myocutaneous (TRAM) flap procedure is described. RESULTS:The lesion was nonpalpabl...


    pub_type: 杂志文章


    authors: Mund DF,Wolfson P,Gorczyca DP,Fu YS,Love SM,Bassett LW

    更新日期:1994-11-15 00:00:00

  • Alternating non-cross-resistant combination chemotherapy for small cell anaplastic carcinoma of the lung.

    abstract::The development of drug resistance limits the survival or patients with small cell anaplastic carcinoma of the lung (SCLC). The present study was undertaken to overcome this problem by administering two alternating noncross resistant combination chemotherapy regimens. One-hundred-one patients were entered on study, an...


    pub_type: 杂志文章


    authors: Aroney RS,Bell DR,Chan WK,Dalley DN,Levi JA

    更新日期:1982-06-15 00:00:00

  • Linked claims and medical records for cancer case management : evaluation of mammography abnormalities.

    abstract:BACKGROUND:Failure to obtain the requisite follow-up of patients with abnormal mammograms may delay cancer diagnosis and impact outcome. Up to 20% of women do not receive timely recommended follow-up. The current study tested the accuracy of the linkage of payer claims and clinical data to identify the appropriate trea...


    pub_type: 杂志文章


    authors: Eberl MM,Watroba N,Reinhardt M,Pomerantz J,Serghany J,Broffman G,Fox CH,Mahoney MC,Edge SB

    更新日期:2007-08-01 00:00:00

  • Cancer prevention through health promotion. Defining the role of physicians in public health.

    abstract::In recent years a major focus in the delivery of cancer prevention services has been on the actions of physicians in ambulatory care practice. Whereas delivery of these services has increased markedly, it is likely that physician actions overall are not producing expected measurable benefits to whole populations. The ...


    pub_type: 杂志文章,评审


    authors: Love RR

    更新日期:1994-08-15 00:00:00

  • Treatment of acute leukemia in adults.

    abstract::Improvement in the management of acute leukemia in adults has not progressed nearly so rapidly as has the treatment of childhood leukemia. One important difference is that most adults have myeloblastic or related forms of the disease (AML), whereas the majority of children have lymphoblastic leukemia (ALL). However, e...


    pub_type: 杂志文章


    authors: Clarkson BD,Dowling MD,Gee TS,Cunningham IB,Burchenal JH

    更新日期:1975-08-01 00:00:00

  • Fine-needle aspiration of chromophobe renal cell carcinoma. Analysis of six cases.

    abstract:BACKGROUND:The chromophobe variant of renal cell carcinoma is a recently described and frequently unrecognized tumor. Because the prognosis of the chromophobe variant appears to be intermediate between that of oncocytoma and the clear cell variant of renal cell carcinoma, accurate diagnosis may be important for appropr...


    pub_type: 杂志文章


    authors: Granter SR,Renshaw AA

    更新日期:1997-04-25 00:00:00

  • Severe 5-fluorouracil toxicity secondary to dihydropyrimidine dehydrogenase deficiency. A potentially more common pharmacogenetic syndrome.

    abstract::This study describes the inheritance of a defect in pyrimidine catabolism and its association with drug-induced toxicity in a patient receiving 5-fluorouracil (FUra) as adjuvant chemotherapy for breast carcinoma. The study population included the affected patient (proband), nine of her blood relatives, and seven healt...


    pub_type: 杂志文章


    authors: Harris BE,Carpenter JT,Diasio RB

    更新日期:1991-08-01 00:00:00

  • Wilms' tumor in adolescence.

    abstract::Two cases of Wilms' tumor in adolescent males are presented. The clinical and radiographic findings were unusual and both presented atypical gross and microscopic features that could be correlated with the radiographic findings. Histologic examination of both tumors showed evidence of tubular and glomerular maturation...


    pub_type: 杂志文章


    authors: Merten DF,Yang SS,Bernstein J

    更新日期:1976-03-01 00:00:00

  • Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field.

    abstract:BACKGROUND:Single-walled carbon nanotubes (SWNTs) have remarkable physicochemical properties that may have several medical applications. The authors have discovered a novel property of SWNTs-heat release in a radiofrequency (RF) field-that they hypothesized may be used to produce thermal cytotoxicity in malignant cells...


    pub_type: 杂志文章


    authors: Gannon CJ,Cherukuri P,Yakobson BI,Cognet L,Kanzius JS,Kittrell C,Weisman RB,Pasquali M,Schmidt HK,Smalley RE,Curley SA

    更新日期:2007-12-15 00:00:00

  • A comparative study of a BCNU containing 4-drug program versus MOPP versus 3-drug combinations in advanced Hodgkin's disease: a cooperative study by the Cancer and Leukemia Group B.

    abstract::A prospective randomized trial by CALGB examined the relative value of four chemotherapy regimens in 537 patients with stage III B and IV Hodgkin's disease. A new combination BOPP, derived by substitution of BCNU for nitrogen mustard in the MOPP regimen, was compared to MOPP and to two 3-drug regimens, derived by remo...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nissen NI,Pajak TF,Glidewell O,Pedersen-Bjergaard J,Stutzman L,Falkson G,Cuttner J,Blom J,Leone L,Sawitsky A,Coleman M,Haurani F,Spurr CL,Harley JB,Seligman B,Cornell C Jr,Henry P,Senn HJ,Brunner K,Martz G,Maurice

    更新日期:1979-01-01 00:00:00

  • Familial adult T-cell leukemia.

    abstract::Two siblings who developed adult T-cell leukemia (ATL) are presented. The patient and 7 of 26 healthy family members examined had the serum antibodies against ATL-associated antigens (ATLA). This family study shows that two main routes of transmission of human T-cell leukemia virus (HTLV) may be involved: one is the r...


    pub_type: 杂志文章


    authors: Miyamoto Y,Yamaguchi K,Nishimura H,Takatsuki K,Motoori T,Morimatsu M,Yasaka T,Ohya I,Koga T

    更新日期:1985-01-01 00:00:00