Abstract:
BACKGROUND:Humoral hypercalcemia rarely is associated with colorectal carcinoma; to the authors' knowledge only nine cases have been reported to date. METHODS:Two cases of advanced colorectal carcinoma with humoral hypercalcemia of malignancy (HHM) are presented. RESULTS:The two patients had severe hypercalcemia without bone metastases. The diagnosis of HHM was based on findings of hypercalcemia, hypophosphoremia, elevated serum parathyroid hormone-related peptide (PTHrP), and positive tumor immunoreactivity to monoclonal PTHrP antiserum. One patient had a colonic adenocarcinoma with a neuroendocrine component and the other patient had rectal adenocarcinoma. Immunoreactive PTHrP was found in both tumor components. Bisphosphonate treatment normalized the hypercalcemia within a few days but it recurred in the patients 2 weeks and 3 weeks later, respectively. The prognosis was extremely poor. CONCLUSIONS:To the authors' knowledge the two cases presented in the current study are the first to be reported with HHM-associated colorectal carcinoma with positive tumor immunoreactivity to PTHrP monoclonal antiserum.
journal_name
Cancerjournal_title
Cancerauthors
Lortholary AH,Cadeau SD,Bertrand GM,Guerin-Meyer VI,Gamelin EC,Audran MJsubject
Has Abstractpub_date
1999-12-01 00:00:00pages
2217-21issue
11eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19991201)86:11<2217::AID-Cjournal_volume
86pub_type
杂志文章,评审相关文献
CANCER文献大全abstract:BACKGROUND:Preclinical and clinical studies suggest synergistic activity between somatostatin analogues and mammalian target of rapamycin inhibitors. The activity and safety of everolimus was assessed in combination with octreotide long-acting repeatable (LAR) in patients with neuroendocrine tumors (NETs) of gastroente...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.28726
更新日期:2014-08-15 00:00:00
abstract::With increasing numbers of survivors from cancer at a young age, the issue of fertility preservation has assumed greater importance. This review describes normal ovarian and testicular function and summarizes what is known about the effect of chemotherapy and radiotherapy on the gonads and uterus. All young patients w...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.26045
更新日期:2011-05-15 00:00:00
abstract:BACKGROUND:Desmoid tumors are mesenchymal nonmetastasizing neoplasms. Although rare in the general population, they are a common extracolonic manifestation of familial adenomatous polyposis (FAP). Because of high tumor recurrence rates, surgery has been less than satisfactory in the treatment of desmoid tumors. In the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11937
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:The authors evaluated the effects of taxol, a microtubular inhibitor, as a possible radiation sensitizer on the human leukemic cell line (HL-60). Taxol acts as a mitotic inhibitor, blocking cells in the G2M-phase of the cell cycle. The differential radiation sensitivity of cells in various phases of the cell...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930601)71:11<3774::aid-cncr282
更新日期:1993-06-01 00:00:00
abstract::A 12-year-old boy with primary reticulum cell sarcoma of the testis who is alive and free of tumor 32 months after orchiectomy, radiation therapy to inguinal, iliac and retroperitoneal lymph nodes and chemotherapy is reported. Seven previously documented cases of childhood primary testicular lymphoma are reviewed. The...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197602)37:2<935::aid-cncr2820370
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND:Nineteen patients with Ewing sarcoma of bone, each younger than 3 years of age at the time of initial presentation, are reported. These children represent an unusually young age group for documented Ewing sarcoma and represent 2.6% of all patients registered in the Intergroup Ewing's Sarcoma Study (IESS). M...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930315)71:6<2109::aid-cncr2820
更新日期:1993-03-15 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the feasibility, toxicity, and efficacy of the combination of paclitaxel, carboplatin, and long-term continuous infusion 5-fluorouracil (5-FU) in the treatment of advanced squamous carcinomas of various primary sites. METHODS:Patients were eligible for this trial if...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20010801)92:3<642::aid-cncr1365>
更新日期:2001-08-01 00:00:00
abstract::The two cancers specific to women for which substantial research on their relationship to exogenous estrogens has been reported are endometrial cancer and breast cancer. With the former, the link to estrogen use is well established. The estrogen use patterns associated with increased risk of endometrial cancer are cha...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19901015)60:8+<1960::aid-cncr282
更新日期:1987-10-15 00:00:00
abstract:BACKGROUND:The purpose of the current study was to describe a population of young patients with breast carcinoma, their characteristics at the time of diagnosis, and the association of these characteristics with disease recurrence and survival. METHODS:Four hundred fifty-two women age < or = 35 years with breast carci...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21070
更新日期:2005-06-15 00:00:00
abstract::Breast cancer is the most common malignant tumor among women in the world. In 2005, there were approximately 272,000 new cases diagnosed and more than 70,000 deaths from breast cancer in China. Of the patients who are newly diagnosed with breast cancer each year, approximately 3% to 10% have distant metastases at the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32832
更新日期:2020-08-15 00:00:00
abstract:BACKGROUND:The activation of the clotting-fibrinolytic system in cancer patients is common and represents an unfavorable clinical sign. D-dimer (DD) is a sensitive marker of fibrinolysis. METHODS:The current study comprised 826 new lung carcinoma patients seen consecutively in a single institution over a 10-year perio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11432
更新日期:2003-06-15 00:00:00
abstract::The concentrations of sex hormone binding globulin (SHBG) were measured in the plasma of 56 men, who were 47 to 85 years of age, by time-resolved immunofluorometric assay with a monoclonal antibody. Twenty-five of the men had untreated carcinoma of the prostate and 17 had untreated prostatic hyperplasia. There were 14...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900715)66:2<354::aid-cncr28206
更新日期:1990-07-15 00:00:00
abstract:BACKGROUND:Stereotactic radiation therapy is highly effective in the treatment of small brain metastases, regardless of the histology. This suggests that small extracranial malignancies may be curable with similar radiation therapy. The authors developed a novel treatment unit for administering such therapy. METHODS:T...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980315)82:6<1062::aid-cn
更新日期:1998-03-15 00:00:00
abstract:BACKGROUND:A new clinical type of pancreatic tumor, the mucin-producing tumor, has been recognized recently. However, it is not always easy to distinguish benign from malignant tumors preoperatively. In this study, three different methods of differentiating mucin-producing tumors of the pancreas were compared. METHODS...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940801)74:3<826::aid-cncr28207
更新日期:1994-08-01 00:00:00
abstract::Various dose-time treatment plans have been used to obtain long duration pain relief in patients with metastatic bone disease. Very little has appeared in the literature evaluating the relationship of dose and fractionation to initial, delayed and permanent bone pain relief. At the Swedish Hospital Tumor Institute, 15...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197602)37:2<984::aid-cncr2820370
更新日期:1976-02-01 00:00:00
abstract::The records of 1,497 patients with histologically proven adenocarcinoma of the stomach were reviewed from Charity Hospital over the 25-year period, 1948 to 1973. The operability rate was 82% and the resectability rate was 48%. In this series gastric carcinoma predominated in males and Negroes. Necropsy studies indicat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197803)41:3<941::aid-cncr2820410
更新日期:1978-03-01 00:00:00
abstract:BACKGROUND:In the current study, the authors propose the quantitative Gleason score (qGS), a modification of the current Gleason grading system for prostate cancer, based on the weighted average of Gleason patterns present in the pathology specimen. They hypothesize that the qGS can improve prostate cancer risk stratif...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27670
更新日期:2012-12-15 00:00:00
abstract::Five hundred forty three adult patients with acute leukemia were entered on the study designed to: (1) test efficacy of vincristine and prednisone used as primary drug therapy in patients with good prognosis as judged by a circulating blast cell count less than 30,000 cm2; (2) investigate the use of either simultaneou...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830915)52:6<958::aid-cncr28205
更新日期:1983-09-15 00:00:00
abstract:BACKGROUND:Preoperative chemoradiation improves survival in esophageal and gastroesophageal junction (GEJ) cancer. We evaluated irinotecan and cisplatin as induction chemotherapy followed by concurrent chemoradiation in esophageal cancer. METHODS:Patients with uT1N1M0 or uT2-4NanyM0 resectable squamous cancer or adeno...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26591
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Onycholysis has been reported in association with the use of several noncytotoxic drugs and with chemotherapy in 135 patients. Onycholysis may be precipitated by exposure to ultraviolet radiation. METHODS:The authors studied 91 patients who received paclitaxel and 187 patients who received doxorubicin. RES...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(20000515)88:10<2367::aid-c
更新日期:2000-05-15 00:00:00
abstract:BACKGROUND:Proliferating cell nuclear antigen (PCNA) is an intranuclear protein that is linked closely to the cell cycle. An immunohistochemical study was performed on the expression of PCNA in various sized hepatocellular carcinomas (HCCs) to determine the relation between the proliferative activity of cancer cells an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950801)76:3<399::aid-cncr28207
更新日期:1995-08-01 00:00:00
abstract::A routine admission chest radiograph (CXR) in pediatric patients with cancer who are admitted to the hospital for fever and neutropenia has been advised because the signs and symptoms of pneumonia may be absent. The authors studied 131 consecutive patient admissions for fever and neutropenia to evaluate the diagnostic...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19910901)68:5<940::aid-cncr28206
更新日期:1991-09-01 00:00:00
abstract::Cancer is the second most common cause of death among those aged > or =65 years, and is a major cause of morbidity. There is some evidence that screening, by detecting precancerous lesions in asymptomatic patients, is effective in reducing cancer-related morbidity and mortality among older men and women. The objective...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.23938
更新日期:2008-12-15 00:00:00
abstract:BACKGROUND:Patients with prostate cancer receiving androgen deprivation therapy (ADT) are at risk of sleep disturbance; however, to the authors' knowledge, the mechanisms by which ADT may affect sleep are not well understood. The current study compared objective and subjective sleep disturbance in ADT recipients and co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31024
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Wild-type p53 protein activates the WAF1/CIP-1 (p21) gene, leading to G1 arrest after DNA damage. The authors investigated the relation of p21 and p53 expression in pancreatic adenocarcinomas to disease stage, overall patient survival, and survival when chemotherapy or radiation therapy was given. METHODS:P...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970801)80:3<372::aid-cnc
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:A novel pancreatic carcinoma cell line, FAMPAC, was identified from investigation of poorly differentiated pancreatic adenocarcinoma cells found in a patient with a familial predisposition to pancreatic carcinoma. A gene responsible for familial pancreatic carcinoma has not been identified to date. METHODS:...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20193
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:The causal relation between high-risk human papillomavirus (HPV) and cervical cancer and its precursor lesions has led to the use of sensitive HPV molecular tests for screening. This study examined the impact of the baseline HPV status on the future risk of cervical intraepithelial neoplasia grade 2 or worse...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31788
更新日期:2019-01-15 00:00:00
abstract::A 58-year-old patient with metastatic prostatic carcinoma had two well-documented episodes of disseminated intravascular coagulation (DIC) occurring 1 year apart and resolving without heparin therapy. This case illustrates that DIC need not have a poor prognosis and may resolve spontaneously despite progressive cancer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197602)37:2<928::aid-cncr2820370
更新日期:1976-02-01 00:00:00
abstract:BACKGROUND:This qualitative study investigated the medical decision-making preferences of adolescent oncology patients and the parental and clinician behaviors that adolescents report to be supportive of their preferred level of decision-making involvement. METHODS:Interviews were conducted with 40 adolescents between...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29663
更新日期:2015-12-15 00:00:00
abstract::If women examine their breasts thoroughly and regularly they may promptly recognize abnormal tissue changes. The level of skill and motivation required for effective breast self-examination (BSE), however, is very high. In a prospective study of 304 patients with newly diagnosed breast cancer, 165 (54%) claimed to pra...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860815)58:4<973::aid-cncr28205
更新日期:1986-08-15 00:00:00