Humoral hypercalcemia in patients with colorectal carcinoma: report of two cases and review of the literature.

Abstract:

BACKGROUND:Humoral hypercalcemia rarely is associated with colorectal carcinoma; to the authors' knowledge only nine cases have been reported to date. METHODS:Two cases of advanced colorectal carcinoma with humoral hypercalcemia of malignancy (HHM) are presented. RESULTS:The two patients had severe hypercalcemia without bone metastases. The diagnosis of HHM was based on findings of hypercalcemia, hypophosphoremia, elevated serum parathyroid hormone-related peptide (PTHrP), and positive tumor immunoreactivity to monoclonal PTHrP antiserum. One patient had a colonic adenocarcinoma with a neuroendocrine component and the other patient had rectal adenocarcinoma. Immunoreactive PTHrP was found in both tumor components. Bisphosphonate treatment normalized the hypercalcemia within a few days but it recurred in the patients 2 weeks and 3 weeks later, respectively. The prognosis was extremely poor. CONCLUSIONS:To the authors' knowledge the two cases presented in the current study are the first to be reported with HHM-associated colorectal carcinoma with positive tumor immunoreactivity to PTHrP monoclonal antiserum.

journal_name

Cancer

journal_title

Cancer

authors

Lortholary AH,Cadeau SD,Bertrand GM,Guerin-Meyer VI,Gamelin EC,Audran MJ

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

2217-21

issue

11

eissn

0008-543X

issn

1097-0142

pii

10.1002/(SICI)1097-0142(19991201)86:11<2217::AID-C

journal_volume

86

pub_type

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