Predicted prostate specific antigen results using transrectal ultrasound gland volume. Differentiation of benign prostatic hyperplasia and prostate cancer.

Abstract:

METHODS:The diagnostic performance of transrectal ultrasound (TRUS) gland volume and prostate specific antigen (PSA) results were evaluated in 204 men consecutively scheduled to undergo transurethral prostatic resection (TUR). RESULTS:Nonpalpable prostate cancer was detected by TRUS alone in 18% (29 of 161) and by TUR alone in 9% (14/161), for an overall cancer incidence of 27%. A predicted PSA value (TRUS gland volume x 0.20 ng/ml/g = polyclonal PSA) was used for comparison with serum PSA for each patient. TRUS positive predictive value improved from 52% to 86% when serum PSA exceeded the predicted value. The specificity and positive predictive value of PSA at 2.5 ng/ml were 23% and 37%, respectively, which increased to 88% and 72%, respectively, when serum PSA exceeded the predicted value. CONCLUSIONS:Predicted PSA values produce decision levels near the 95th percentile for each patient and assist individual biopsy decisions better than grouped gland volume ranges. Wider application of TRUS and PSA in any clinical setting or early detection program is now possible.

journal_name

Cancer

journal_title

Cancer

authors

Lee F,Littrup PJ,Loft-Christensen L,Kelly BS Jr,McHugh TA,Siders DB,Mitchell AE,Newby JE

doi

10.1002/1097-0142(19920701)70:1+<211::aid-cncr2820

subject

Has Abstract

pub_date

1992-07-01 00:00:00

pages

211-20

issue

1 Suppl

eissn

0008-543X

issn

1097-0142

journal_volume

70

pub_type

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