Abstract:
METHODS:The diagnostic performance of transrectal ultrasound (TRUS) gland volume and prostate specific antigen (PSA) results were evaluated in 204 men consecutively scheduled to undergo transurethral prostatic resection (TUR). RESULTS:Nonpalpable prostate cancer was detected by TRUS alone in 18% (29 of 161) and by TUR alone in 9% (14/161), for an overall cancer incidence of 27%. A predicted PSA value (TRUS gland volume x 0.20 ng/ml/g = polyclonal PSA) was used for comparison with serum PSA for each patient. TRUS positive predictive value improved from 52% to 86% when serum PSA exceeded the predicted value. The specificity and positive predictive value of PSA at 2.5 ng/ml were 23% and 37%, respectively, which increased to 88% and 72%, respectively, when serum PSA exceeded the predicted value. CONCLUSIONS:Predicted PSA values produce decision levels near the 95th percentile for each patient and assist individual biopsy decisions better than grouped gland volume ranges. Wider application of TRUS and PSA in any clinical setting or early detection program is now possible.
journal_name
Cancerjournal_title
Cancerauthors
Lee F,Littrup PJ,Loft-Christensen L,Kelly BS Jr,McHugh TA,Siders DB,Mitchell AE,Newby JEdoi
10.1002/1097-0142(19920701)70:1+<211::aid-cncr2820subject
Has Abstractpub_date
1992-07-01 00:00:00pages
211-20issue
1 Suppleissn
0008-543Xissn
1097-0142journal_volume
70pub_type
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