Genetic variants of the p53 and p73 genes jointly increase risk of second primary malignancies in patients after index squamous cell carcinoma of the head and neck.

abstract：:Prostatic intra-epithelial neoplasia (PIN, or intraductal dysplasia) is considered a precursor of invasive carcinoma, characterized by proliferation and anaplasia of cells lining prostatic ducts and acini. The highest grade of PIN, Grade 3, is thought to represent carcinoma in situ. To quantitate the degree of disrupt...

journal_title：Cancer

authors： Bostwick DG,Brawer MK

更新日期：1987-02-15 00:00:00

abstract：BACKGROUND:There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population-based analysis of long-term survivors was conducted to investigate the roles of sociodemographic factors and upfront stem cell transplantation (SCT). METHODS:The National Cancer ...

journal_title：Cancer

authors： Hsieh RW,Go RS,Abeykoon JP,Kapoor P,Kumar SK,Gertz MA,Buadi FK,Leung N,Gonsalves WI,Kourelis TV,Warsame RM,Dispenzieri A,Lacy MQ,Kyle RA,Rajkumar SV,Paludo J

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Constitutional or somatic mosaic epimutations are increasingly recognized as a mechanism of gene dysregulation resulting in cancer susceptibility. Beckwith-Wiedemann syndrome is the cancer predisposition syndrome most commonly associated with epimutation and is extremely variable in its phenotypic presentati...

journal_title：Cancer

authors： Fiala EM,Ortiz MV,Kennedy JA,Glodzik D,Fleischut MH,Duffy KA,Hathaway ER,Heaton T,Gerstle JT,Steinherz P,Shukla N,McNeer N,Tkachuk K,Bouvier N,Cadoo K,Carlo MI,Latham A,Dubard Gault M,Joseph V,Kemel Y,Kentsis A,

更新日期：2020-07-01 00:00:00

abstract：:The radionuclide, gallium-67, accumulates in a wide variety of neoplastic and inflammatory lesions. Diffuse bilateral lung localization of 67Ga occurred in two cases of interstitial pneumonitis associated with bleomycin therapy. Clinical symptoms and laboratory evaluation of pulmonary status correlated with scintigrap...

journal_title：Cancer

authors： Richman SD,Levenson SM,Bunn PA,Flinn GS,Johnston GS,DeVita VT

更新日期：1975-12-01 00:00:00

abstract：BACKGROUND:Prior studies raise concern about gender bias in cancer research, including insufficient inclusion of women or men, or studying women and men differently. The 1993 National Institutes of Health Revitalization Act aimed to eliminate gender bias in medicine. To examine changes in medical and psychological lite...

journal_title：Cancer

authors： Hoyt MA,Rubin LR

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) tests are commonly used to assess human epidermal growth factor 2 (HER2) status of tumors in patients with breast cancer. This analysis evaluates the likely cost-effectiveness of expanded retesting to assess HER2 tumor status in women w...

journal_title：Cancer

authors： Garrison LP Jr,Lalla D,Brammer M,Babigumira JB,Wang B,Perez EA

更新日期：2013-09-01 00:00:00

abstract：:Endoscopic neodymium yttrium aluminium garnet (Nd YAG) laser therapy, is a new and simple method for the palliative treatment of inoperable colorectal cancer. To date the authors have treated 70 patients and the value of this method was assessed prospectively in 14 patients. Quality of life was measured before, during...

journal_title：Cancer

authors： McGowan I,Barr H,Krasner N

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND:Strumal carcinoids (SC) are ovarian tumors containing thyroid parenchyma admixed with carcinoid elements. Microscopically, the carcinoid component of SC usually presents a ribbon or trabecular pattern similar to the pattern exhibited by hindgut carcinoids. The authors designed an immunohistochemical study to...

journal_title：Cancer

authors： Sidhu J,Sánchez RL

更新日期：1993-09-01 00:00:00

abstract：:Disulfiram (tetraethylthiuram disulfide, Antabuse) and sodium diethyldithiocarbamate, when added to the diet, inhibit 1,2-dimethylhydrazine (DMH)-induced neoplasia of the large bowel in female CF1 mice. Ethylene bis(dithiocarbamato)manganese (Maneb) and bis(ethylxanthogen), two pesticides with structural similarities ...

journal_title：Cancer

authors： Wattenberg LW,Lam LK,Fladmoe AV,Borchert P

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:To clarify the differences in angiogenesis between benign and malignant ovarian tumors, the authors examined the immunohistochemical characteristics and the density of tumor vessels in both tumor groups. Intratumoral vascularization was observed preoperatively by transvaginal color Doppler ultrasound. METHO...

journal_title：Cancer

authors： Emoto M,Iwasaki H,Mimura K,Kawarabayashi T,Kikuchi M

更新日期：1997-09-01 00:00:00

abstract：:Fifty-one patients with metastatic breast cancer were randomly allocated to receive either a four drug combination consisting of cyclophosphamide, methotrexate, 5-fluorouracil, and prednisone (CMFP), or a combination of vincristine, Adriamycin, and cyclophosphamide (VAC) with cross-over on relapse. Objective responses...

journal_title：Cancer

authors： Carmo-Pereira J,Costa FO,Henriques E

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:Previous Phase II trials evaluating paclitaxel as a single agent have produced objective response rates of 38-40%. However, in these studies patients had recurrent disease and had received previous treatment with chemotherapy, radiation, surgery, or some combination of the same. To the authors' knowledge, th...

journal_title：Cancer

authors： Grecula JC,Smith RE,Rhoades CA,Sharma P,Agrawal A,Zhang H,Allen J,Goldman FP,Young D,Schuller DE

更新日期：2000-12-15 00:00:00

abstract：BACKGROUND:Both genetic and epigenetic changes in nonsmall cell lung cancer (NSCLC) are known to be a common event. METHODS:Mutations in the epidermal growth factor receptor gene (EGFR), HER-2, and KRAS and the methylation profile of 9 genes for NSCLC were analyzed and correlated with clinical and histologic data. RE...

journal_title：Cancer

authors： Suzuki M,Shigematsu H,Iizasa T,Hiroshima K,Nakatani Y,Minna JD,Gazdar AF,Fujisawa T

更新日期：2006-05-15 00:00:00

abstract：:Levamisole, used in vitro at therapeutic concentrations, was found able to restore the defective Fc-receptor activity of cancer patient neutrophils. In addition, the drug prevented the inhibition of normal neutrophils Fc-receptor function by cancer patient sera. The neutrophil Fc-receptor function was also restored in...

journal_title：Cancer

authors： Patrone F,Dallegri F,Pistoia V,Ghio R,Sacchetti C

更新日期：1985-04-15 00:00:00

abstract：BACKGROUND:This study was performed to develop a sensitive method for the detection of circulating hepatocellular carcinoma (HCC) cells in peripheral blood, in advance of the diagnosis of distant metastasis of HCC by conventional means. METHODS:Peripheral blood (5 ml) samples were obtained from 64 patients with HCC an...

journal_title：Cancer

authors： Komeda T,Fukuda Y,Sando T,Kita R,Furukawa M,Nishida N,Amenomori M,Nakao K

更新日期：1995-05-01 00:00:00

abstract：:An 11-year-old female with a large embryonal carcinoma of the left ovary was treated by unilateral salpingo-oophorectomy combined with a systemic chemotherapy of a total dose of 1.9 mg of dactinomycin. The preoperative serum alpha-fetoprotein (AFP) level of 70,350 ng/ml decreased to 270 ng/ml 5 weeks after the operati...

journal_title：Cancer

authors： Nakakuma K,Tashiro S,Uemura K,Takayama K

更新日期：1983-10-15 00:00:00

abstract：:This paper reports the prognosis results of a retrospective study of over 2000 cases of uterine cervix carcinoma totally treated at Institut Gustave-Roussy from 1950 to 1963. From the study of their long-term survival, an overall cure rate was estimated at 49% seven years after the start of primary treatment. A study ...

journal_title：Cancer

authors： Pejovic MH,Wolff JP,Kramar A,Goldfarb E

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:BRAF inhibitors are effective in melanoma and other cancers with BRAF mutations; however, patients ultimately develop therapeutic resistance through the activation of alternative signaling pathways such as RAF/RAS or MET. The authors hypothesized that combining the BRAF inhibitor vemurafenib with either the ...

journal_title：Cancer

authors： Janku F,Sakamuri D,Kato S,Huang HJ,Call SG,Naing A,Holley VR,Patel SP,Amaria RN,Falchook GS,Piha-Paul SA,Zinner RG,Tsimberidou AM,Hong DS,Meric-Bernstam F

更新日期：2021-02-01 00:00:00

abstract：:Radiation-induced small bowel injury is a limiting factor to postoperative tumoricidal pelvic doses exceeding 4500 to 5000 cGy. Data from a review of the literature showed the inadequacy of medical measures and the bad reproducibility of radiation therapeutic attempts to decrease small intestine damage. Recent studies...

journal_title：Cancer

authors： Rodier JF,Janser JC,Rodier D,Dauplat J,Kauffmann P,Le Bouedec G,Giraud B,Lorimier G

更新日期：1991-12-15 00:00:00

abstract：BACKGROUND:Disseminated intravascular coagulation (DIC) and primary fibrinolysis have both been reported in association with prostate carcinoma. The correct diagnosis of the coagulopathy can be difficult and the appropriate management controversial. METHODS:A case is presented of a man in whom DIC and soft tissue hemo...

journal_title：Cancer

authors： Cooper DL,Sandler AB,Wilson LD,Duffy TP

更新日期：1992-08-01 00:00:00

abstract：BACKGROUND:Endometrial carcinoma is one of the most frequent malignancies in the female genital tract, and its incidence has been increasing in Japan. Histologic grade is an important factor for organizing treatment strategies, including hormone therapy, and for predicting the prognosis of the patient. The objective of...

journal_title：Cancer

authors： Nishimura Y,Watanabe J,Jobo T,Hattori M,Arai T,Kuramoto H

更新日期：2005-02-25 00:00:00

abstract：:The case of a 71-year-old woman who developed generalized weakness, lymphadenopathy, and a skin rash during methyldopa therapy is described. The prompt disappearance of symptoms following the discontinuation of the drug implicates it in the initial triggering of the abnormal lymphoid proliferation. Shortly thereafter,...

journal_title：Cancer

authors： Weisenburger DD

更新日期：1978-11-01 00:00:00

abstract：BACKGROUND:The care of patients with a brain metastasis from unknown primary site is controversial. The authors reviewed the results of stereotactic radiosurgery in this group of patients to better define clinical expectations. METHODS:During an 11-year interval, radiosurgery was performed in 421 patients with brain m...

journal_title：Cancer

authors： Maesawa S,Kondziolka D,Thompson TP,Flickinger JC,Dade L

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Gastric mucosal blood flow, secretion of mucin, and renewal of the gastric mucosal cells are considered to be defensive factors against gastric mucosal injuries. These factors are regulated by the nervous system and neuropeptides. Gastrectomy may affect this regulation and induce gastric mucosal changes, suc...

journal_title：Cancer

authors： Kaminishi M,Shimizu N,Shiomoyama S,Yamaguchi H,Ogawa T,Sakai S,Kuramoto S,Oohara T

更新日期：1995-03-15 00:00:00

abstract：:The clinical, patient-oriented focus of medicine and psychology is contrasted with the epidemiologic (public health) approach in assessing the role of life-style factors and health promotion in cancer research. The unifying host-agent-environment epidemiologic paradigm is applied to contemporary cancer prevention issu...

journal_title：Cancer

authors： Celentano DD

更新日期：1991-02-01 00:00:00

abstract：:Doxorubicin has been reported to cause ventricular arrhythmias and sudden death in the first 24 hours after administration. The authors placed continuous electrocardiographic recording devices on 30 patients 24 hours before, during, and 24 hours after doxorubicin administration. Nine patients experienced arrhythmias b...

journal_title：Cancer

authors： Friess GG,Boyd JF,Geer MR,Garcia JC

更新日期：1985-12-15 00:00:00

abstract：BACKGROUND:A high cure rate may be attained for locally advanced, undifferentiated nasopharyngeal carcinoma (NPC) in children, provided that a combined modality of treatment is employed. Both local and systemic therapies are necessary. Results at a single pediatric institution were analyzed. METHODS:From November 1988...

journal_title：Cancer

authors： Zubizarreta PA,D'Antonio G,Raslawski E,Gallo G,Preciado MV,Casak SJ,Scopinaro M,Morales G,Sackmann-Muriel F

更新日期：2000-08-01 00:00:00

abstract：:A clinicopathologic study of 51 patients with endoscopically removed large bowel polyps showing histologic evidence of malignancy, either focally, to a massive extent, or comprising the entire polyp, revealed only one absolute finding capable of predicting residual disease, namely, the presence of cancer at the resect...

journal_title：Cancer

authors： Lipper S,Kahn LB,Ackerman LV

更新日期：1983-11-01 00:00:00

abstract：BACKGROUND:Extragonadal germ cell tumors (EGGCT) are uncommon, occur primarily in the mediastinum and retroperitoneum, and have been noted to have variable response rates to cisplatin-based chemotherapy regimens. METHODS:The Southwest Oncology Group (SWOG) has completed a prospective trial of combination chemotherapy ...

journal_title：Cancer

authors： Bukowski RM,Wolf M,Kulander BG,Montie J,Crawford ED,Blumenstein B

更新日期：1993-04-15 00:00:00

abstract：:Peripheral blood lymphocytes of patients with multiple myeloma, macroglobulinemia, and monoclonal gammopathy of uncertain significance were analyzed for B cells, and cells bearing kappa light chains and lambda light chains on their surfaces. Compared with controls, the number of B cells were decreased in all three gro...

journal_title：Cancer

authors： Dillman RO,Royston I,Meserve BL,Griffiths JC

更新日期：1981-11-15 00:00:00