Disparities in participation in cancer clinical trials in the United States : a symptom of a healthcare system in crisis.

abstract：:A new human lymphoblastic lymphoma cell line was established (designated HT-1) from the pleural fluid lymphoma cells of a patient with lymphoblastic lymphoma of T-cell type. The HT-1 cells expressed CD1, CD2, CD3, CD4, CD5, CD7, CD8, CD57, and terminal deoxynucleotidyl transferase (TdT) but lacked B-cell-associated an...

journal_title：Cancer

authors： Abe M,Tasaki K,Nozawa Y,Tominaga K,Fukuhara S,Ohsato T,Wakasa H

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:The p53 tumor suppressor gene encodes a nuclear phosphoprotein that is thought to be important to cell cycle regulation and DNA repair and that also may regulate induction of apoptosis by ionizing radiation. Somatic p53 gene mutations occur in 30-50% of breast carcinomas and are associated with poor prognosi...

journal_title：Cancer

authors： Turner BC,Gumbs AA,Carbone CJ,Carter D,Glazer PM,Haffty BG

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Testicular cancer survivors (TCS) have an increased risk of treatment-related cardiovascular disease (CVD), which may limit their overall survival. We evaluated the effects of high-intensity aerobic interval training (HIIT) on traditional and novel CVD risk factors and surrogate markers of mortality in a pop...

journal_title：Cancer

authors： Adams SC,DeLorey DS,Davenport MH,Stickland MK,Fairey AS,North S,Szczotka A,Courneya KS

更新日期：2017-10-15 00:00:00

abstract：:Meaning and purpose in life are associated with the mental and physical health of patients with cancer and survivors and also constitute highly valued outcomes in themselves. Because meaning and purpose are often threatened by a cancer diagnosis and treatment, interventions have been developed to promote meaning and p...

journal_title：Cancer

authors： Park CL,Pustejovsky JE,Trevino K,Sherman AC,Esposito C,Berendsen M,Salsman JM

更新日期：2019-07-15 00:00:00

abstract：:The following case report describes a 22-year-old healthy man, non-smoker, non-drinker, who developed a squamous cell carcinoma of the buccal mucosa. The appearance of this unusual tumor in an unexpected clinical setting was unexplained until it was discovered that the patient had a lifetime habit of chewing plastic m...

journal_title：Cancer

authors： Casterline CL,Casterline PF,Jaques DA

更新日期：1977-04-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori infection is a risk factor for gastric carcinogenesis. High dietary vitamin C intake appears to protect against gastric carcinoma. It has been suggested that vitamin C exerts the protective effect by scavenging free radicals that may be enhanced by H. pylori. However, vitamin C has not be...

journal_title：Cancer

authors： Zhang HM,Wakisaka N,Maeda O,Yamamoto T

更新日期：1997-11-15 00:00:00

abstract：BACKGROUND:It has been postulated that different biologic characteristics of a tumor might account for at least a portion of the disparity in breast cancer survival for patients across racial and ethnic groups. The hormone receptor status of breast tumors is one characteristic with prognostic significance. Results of s...

journal_title：Cancer

authors： Gapstur SM,Dupuis J,Gann P,Collila S,Winchester DP

更新日期：1996-04-15 00:00:00

abstract：:Peanut agglutinin (PNA) receptors were studied in 37 cases of reactive follicular hyperplasia and 66 follicular lymphomas, using the unlabeled peroxidase-antiperoxidase (PAP) method on paraffin embedded material. Based on the binding sites of the lectin, positively stained cells were easily recognized as either cytopl...

journal_title：Cancer

authors： Ree HJ,Hsu SM

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) signaling is a target for antiangiogenic cancer therapy. The authors have previously observed that up to 40% of vessels in colorectal carcinoma (CRC) tumors are negative for VEGF receptor 2 (VEGFR2) expression. Differential activity of transforming growth factor beta...

journal_title：Cancer

authors： Kuczynski EA,Viloria-Petit AM,Coomber BL

更新日期：2011-12-15 00:00:00

abstract：:Platelet kinetics were studied in 70 patients with testicular cancer to elicit the agent responsible for chemotherapy-induced transient early-onset thrombocytopenia; 204 treatment courses were analyzed using three different therapy protocols, which contained vinblastine and bleomycin either alone or in combination wit...

journal_title：Cancer

authors： Steurer G,Kuzmits R,Pavelka M,Sinzinger H,Fritz E,Ludwig H

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:Hemangiopericytomas and malignant solitary fibrous tumors (HPC/SFT) are rare, closely related sarcomas with unpredictable behavior that respond infrequently to chemotherapy. An optimal systemic treatment strategy for advanced HPC/SFT has not yet been identified. METHODS:We retrospectively analyzed the recor...

journal_title：Cancer

authors： Park MS,Patel SR,Ludwig JA,Trent JC,Conrad CA,Lazar AJ,Wang WL,Boonsirikamchai P,Choi H,Wang X,Benjamin RS,Araujo DM

更新日期：2011-11-01 00:00:00

abstract：:In three cases of oligodendrogliomas, atypical cells rich in eosinophilic cytoplasm, resembling plump astroyctic or astroblastic cells, were studied under the electron microscopy. These cells showed finely granular cytoplasm with routine hematoxylin-eosin preparation; ultrastructurally, they exhibited abundant, round ...

journal_title：Cancer

authors： Takei Y,Mirra SS,Miles ML

更新日期：1976-11-01 00:00:00

abstract：:We have used immunohistology and radioimmunoassay procedures to study Chromogranin A (CgA) in human neuroendocrine tumor cell lines, especially small cell lung cancers (SCLC). By immunohistology, CgA could be detected in 11 of 18 classical SCLC cell lines, in a medullary thyroid carcinoma (MTC) cell line, and in only ...

journal_title：Cancer

authors： Deftos LJ,Linnoila RI,Carney DN,Burton DW,Leong SS,O'Connor DT,Murray SS,Gazdar AF

更新日期：1988-07-01 00:00:00

abstract：:Two hundred seventy-nine consecutive patients with Stage II osteogenic sarcoma of the appendicular skeleton treated between 1976 and 1986 were studied to identify predictors of long-term survival. Survival was 77% and 73% at 5 and 10 years, respectively, with continuously disease-free survival being 70% and 69%. On un...

journal_title：Cancer

authors： Glasser DB,Lane JM,Huvos AG,Marcove RC,Rosen G

更新日期：1992-02-01 00:00:00

abstract：BACKGROUND:Desmoid tumors are mesenchymal nonmetastasizing neoplasms. Although rare in the general population, they are a common extracolonic manifestation of familial adenomatous polyposis (FAP). Because of high tumor recurrence rates, surgery has been less than satisfactory in the treatment of desmoid tumors. In the ...

journal_title：Cancer

authors： Hansmann A,Adolph C,Vogel T,Unger A,Moeslein G

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND:The aim of this retrospective study was to determine those prognostic factors associated with response to a second-line chemotherapy in patients with metastatic breast carcinoma (MBC) that was previously responsive to a first-line chemotherapy. METHODS:The 70 MBC patients studied had previously responded to...

journal_title：Cancer

authors： Brun B,Benchalal M,Lebas C,Piedbois P,Lin M,Lebourgeois JP

更新日期：1997-06-01 00:00:00

abstract：BACKGROUND:The Tecumseh Community Health Study (TCHS), initiated in 1959 at the University of Michigan School of Public Health, has provided a resource for long term prospective studies of the incidence of cancer in the setting of a midwestern rural farming community. METHODS:A survey of total and site specific cancer...

journal_title：Cancer

authors： Waterhouse D,Carman WJ,Schottenfeld D,Gridley G,McLean S

更新日期：1996-02-15 00:00:00

abstract：:Twelve cases of thymic carcinoid were studied by electron microscopy and immunohistochemistry. Clinically, all of them presented either as asymptomatic, radiographically detected mediastinal masses or as neoplasms producing symptoms of thoracic structural displacement or Cushing's syndrome. By light microscopic examin...

journal_title：Cancer

authors： Wick MR,Scheithauer BW

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND:Diencephalic syndrome (DS) is a complex of signs and symptoms related to hypothalamic dysfunction; its main features are emaciation, despite a normal or slightly diminished caloric intake, and an alert appearance. DS has been almost exclusively described in association with space-occupying lesions of the hyp...

journal_title：Cancer

authors： Perilongo G,Carollo C,Salviati L,Murgia A,Pillon M,Basso G,Gardiman M,Laverda A

更新日期：1997-07-01 00:00:00

abstract：:There are few cases of catecholamine-secreting paragangliomas of the neck reported in the literature, most of these being of the carotid body and glomus-jugulare type. This report cites the second case of a functioning vagal body tumor secreting norepinephrine predominantly and producing labile hypertension and sympto...

journal_title：Cancer

authors： Tannir NM,Cortas N,Allam C

更新日期：1983-09-01 00:00:00

abstract：:Prostate cancer is the most common male malignancy and the second or third leading cause of cancer death among men in the West. The descriptive epidemiology of prostate cancer suggests that it is a preventable disease. Prevention has the theoretical advantage of not only saving lives, but also reduce the morbidity of ...

journal_title：Cancer

authors： Fleshner N,Zlotta AR

更新日期：2007-11-01 00:00:00

abstract：:Peritoneal mesothelioma in a 61-year-old man, occurred 26 years after abdominal radiotherapy for a testicular seminoma. The patient had no history of asbestos exposure. After asbestos, radiation is the second most frequent defined cause of mesothelioma in North America, but the number of well-documented cases is small...

journal_title：Cancer

authors： Gilks B,Hegedus C,Freeman H,Fratkin L,Churg A

更新日期：1988-05-15 00:00:00

abstract：BACKGROUND:Achieving a pathologic complete response (pCR) with neoadjuvant chemotherapy (NAC) in patients with muscle-invasive bladder cancer (MIBC) has been associated with improved overall survival (OS). This study was aimed at evaluating the impact of pathologic downstaging (pDS; ie, a pT stage at least 1 stage lowe...

journal_title：Cancer

authors： Martini A,Jia R,Ferket BS,Waingankar N,Plimack ER,Crabb SJ,Harshman LC,Yu EY,Powles T,Rosenberg JE,Pal SK,Vaishampayan UN,Necchi A,Wiklund NP,Mehrazin R,Mazumdar M,Sfakianos JP,Galsky MD

更新日期：2019-09-15 00:00:00

abstract：BACKGROUND:In the AFFIRM trial, enzalutamide significantly increased overall survival (OS) for men with metastatic castration-resistant prostate cancer (mCRPC) after chemotherapy versus placebo and significantly decreased prostate-specific antigen (PSA) levels. The goal of this post hoc analysis was to associate levels...

journal_title：Cancer

authors： Armstrong AJ,Saad F,Phung,Dmuchowski C,Shore ND,Fizazi K,Hirmand M,Forer D,Scher HI,Bono J

更新日期：2017-06-15 00:00:00

abstract：:The authors describe two cases of Fournier's gangrene complicating aggressive therapy for hematologic malignancies. Fournier's gangrene is a fulminant necrotizing fasciitis of the scrotum and penis, often with an infectious etiology. Only one prior case has been reported in a patient receiving aggressive chemotherapy ...

journal_title：Cancer

authors： Berg A,Armitage JO,Burns CP

更新日期：1986-06-15 00:00:00

abstract：:A tumor that affects the central nervous system can have a dramatic impact on the individual affected, as well as his or her family and friends. The tumor, regardless of extent or location, may affect the physical, social, vocational, and emotional capabilities of the individual. Basic aspects of rehabilitation for pa...

journal_title：Cancer

authors： Kirshblum S,O'Dell MW,Ho C,Barr K

更新日期：2001-08-15 00:00:00

abstract：:Carcinoembryonic antigen is only a tumor assoicated antigen and is less clinically useful than the original report suggested. However, the CEA assays in clinical use utilize reagents operationally defined by old criteria. There is now abundant evidence that "CEA" consists of a heterogenous family of related glycoprote...

journal_title：Cancer

authors： Alpert E

更新日期：1978-09-01 00:00:00

abstract：:One hundred thirty-five hepatocellular carcinomas were examined for the presence of antigenic tumor markers by the avidin-biotin-peroxidase complex method. Ninety-seven were from the US and 38 came from Argentina. The following markers were tested: alpha-fetoprotein (AFP), alpha-1-antitrypsin (AAT), hepatitis B surfac...

journal_title：Cancer

authors： Chedid A,Chejfec G,Eichorst M,Villamil F,Terg R,Telenta M,Hojman R

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Cell kinetics studies performed with immunohistochemical techniques to estimate the S-phase fraction have elucidated the proliferative potential of individual brain tumors. METHODS:The authors developed a new double-labeling method that enables other cell kinetics variables, including the duration of the S-...

journal_title：Cancer

authors： Shibuya M,Ito S,Davis RL,Wilson CB,Hoshino T

更新日期：1993-05-15 00:00:00

abstract：:Oxygen remains one of the most potent sensitizers of mammalian cells yet studied and, most important, it is maximumly sensitizing at physiologic concentrations. There is very good evidence that solid tumors of both experimental animals and man contain hypoxic and viable cells. In experimental animals hyperbaric oxygen...

journal_title：Cancer

authors： Suit HD

更新日期：1968-10-01 00:00:00