Overexpression of p53 and prognosis in breast cancer.

abstract：BACKGROUND:The purpose of this study was to identify genome-wide single nucleotide variants and mutations in African American patients with colorectal cancer (CRC). There is a need of such studies in African Americans, because they display a higher incidence of aggressive CRC tumors. METHODS:We performed whole exome s...

journal_title：Cancer

authors： Ashktorab H,Daremipouran M,Devaney J,Varma S,Rahi H,Lee E,Shokrani B,Schwartz R,Nickerson ML,Brim H

更新日期：2015-01-01 00:00:00

abstract：:The serum lactase dehydrogenase (LDH) of 56 patients with Ewing's sarcoma was examined to determine the use of LDH as a tumor marker. The initial LDH level was used to determine its ability to predict survival. The follow-up LDH level also was examined, as an indicator of recurrent disease. The initial LDH level was f...

journal_title：Cancer

authors： Farley FA,Healey JH,Caparros-Sison B,Godbold J,Lane JM,Glasser DB

更新日期：1987-04-01 00:00:00

abstract：:The authors have performed a clinical and statistical analysis of the presenting features of adult acute leukemia classified according to the French-American-British (FAB) hematopathologic criteria. Observations were made on 70 variables of history, physical examination, and laboratory examination recorded for 195 pat...

journal_title：Cancer

authors： Burns CP,Armitage JO,Frey AL,Dick FR,Jordan JE,Woolson RF

更新日期：1981-05-15 00:00:00

abstract：BACKGROUND:The aim of this study was to determine and compare the added prognostic value of screening tools, geriatric assessment (GA) components, and GA summaries to clinical information for overall survival (OS) in older patients with cancer. METHODS:A screening and a 10-item GA were systematically performed in pati...

journal_title：Cancer

authors： Kenis C,Baitar A,Decoster L,De Grève J,Lobelle JP,Flamaing J,Milisen K,Wildiers H

更新日期：2018-09-15 00:00:00

abstract：:Identification of BCR-ABL as the defining leukemogenic event in chronic myelogenous leukemia (CML) revolutionized the treatment of the disease. Imatinib, a potent BCR-ABL inhibitor, is the standard of care for the first-line treatment of patients with chronic-phase CML because of its high long-term response rates and ...

journal_title：Cancer

authors： Kantarjian HM,Cortes J,La Rosée P,Hochhaus A

更新日期：2010-03-15 00:00:00

abstract：BACKGROUND:Laryngeal cancer is the primary cause of death among patients with head and neck cancer in Argentina. Different prognostic factors have been incidentally dealt with in a number of articles, but there are few studies of prognostic variables, such as age, tobacco, and alcohol, using multifactorial analysis. M...

journal_title：Cancer

authors： Pradier R,González A,Matos E,Loria D,Adan R,Saco P,Califano L

更新日期：1993-04-15 00:00:00

abstract：BACKGROUND:The mortality of patients with colorectal carcinoma depends mainly upon subsequent liver metastasis even after curative operation. However, it is very difficult to predict the incidence of liver metastasis by analyzing conventional tumor markers or pathologic findings. In the current study, the authors exami...

journal_title：Cancer

authors： Kato M,Ito Y,Kobayashi S,Isono K

更新日期：1996-04-15 00:00:00

abstract：BACKGROUND:Because the addition of nimotuzumab to chemoradiation in patients with locally advanced head and neck cancer improved outcomes in a phase 2 study, the authors conducted a phase 3 study to confirm these findings. METHODS:This open-label, investigator-initiated, phase 3, randomized trial was conducted from 20...

journal_title：Cancer

authors： Patil VM,Noronha V,Joshi A,Agarwal J,Ghosh-Laskar S,Budrukkar A,Murthy V,Gupta T,Mahimkar M,Juvekar S,Arya S,Mahajan A,Agarwal A,Purandare N,Rangarajan V,Balaji A,Chaudhari SV,Banavali S,Kannan S,Bhattacharjee A,D

更新日期：2019-09-15 00:00:00

abstract：BACKGROUND:This study was performed to evaluate the use of the 1992 International Union Against Cancer (UICC)/American Joint Committee on Cancer (AJCC) T categories for localized prostate cancer treated with radiation therapy and to compare the prognostic power of this system with the Whitmore-Jewett scheme. METHODS:T...

journal_title：Cancer

authors： Zagars GK,Geara FB,Pollack A,von Eschenbach AC

更新日期：1994-04-01 00:00:00

abstract：:Evaluation and radiotherapy implications of chest relapse patterns in small cell lung carcinoma treated with chemotherapy and radiotherapy to the chest and brain. Emphasis was placed on analysis of patterns of chest disease relapse, chest complications, and sites of initial chest disease relapse in relation to volume ...

journal_title：Cancer

authors： Mira JG,Livingston RB

更新日期：1980-12-15 00:00:00

abstract：:Findings from 1665 women with primary breast cancer, treated at 34 NSABP institutions in Canada and the United States, have failed to demonstrate that patients with medial-central tumors had a greater probability of developing distant metastases or dying than did those with lateral tumors despite the greater incidence...

journal_title：Cancer

authors： Fisher B,Wolmark N,Redmond C,Deutsch M,Fisher ER

更新日期：1981-10-15 00:00:00

abstract：:The results of trials testing combined surgery and chemotherapy in lung cancer are reviewed. Fifteen adjuvant trials using various chemotherapeutic agents were analyzed to determine reasons for their lack of success. Current trials with adjuvant therapy in lung cancer are briefly outlined. In addition, analysis of the...

journal_title：Cancer

authors： Legha SS,Muggia FM,Carter SK

更新日期：1977-04-01 00:00:00

abstract：:Five hundred forty three adult patients with acute leukemia were entered on the study designed to: (1) test efficacy of vincristine and prednisone used as primary drug therapy in patients with good prognosis as judged by a circulating blast cell count less than 30,000 cm2; (2) investigate the use of either simultaneou...

journal_title：Cancer

authors： McCredie KB,Gehan EA,Freireich EJ,Hewlett JS,Coltman CA Jr,Hussein KK,Balcerzak SP,Chen TT

更新日期：1983-09-15 00:00:00

abstract：:The prognostic value of nuclear DNA content was studied retrospectively using flow cytometry in 203 cases of resected hepatocellular carcinoma. The occurrence of DNA aneuploidy, which was detected in 50% of patients, correlated significantly with tumor size and the presence of vascular invasion or intrahepatic metasta...

journal_title：Cancer

authors： Fujimoto J,Okamoto E,Yamanaka N,Toyosaka A,Mitsunobu M

更新日期：1991-02-15 00:00:00

abstract：BACKGROUND:A multicenter trial was conducted to determine the efficacy and toxicity of escalating dosages of liposomal tretinoin (all-trans-retinoic acid) administered once or three times weekly in patients with acquired immunodeficiency syndrome (AIDS)-associated Kaposi sarcoma. METHODS:Seventy-six patients with acqu...

journal_title：Cancer

authors： Bernstein ZP,Chanan-Khan A,Miller KC,Northfelt DW,Lopez-Berestein G,Gill PS

更新日期：2002-12-15 00:00:00

abstract：BACKGROUND:PC-SPES is an herbal supplement whose mechanisms of action are poorly understood, but may be estrogenic. The objective of the current report is to describe the effects of discontinuing PC-SPES treatment in four patients with androgen-independent prostate carcinoma. METHODS:Patient charts were retrospectivel...

journal_title：Cancer

authors： Oh WK,George DJ,Kantoff PW

更新日期：2002-02-01 00:00:00

abstract：:From November 1985 to August 1988, the National Study Group for Oesophageal Cancer collected and centralized data on 1926 new cases of oesophageal cancer in South Africa. A standard data sheet was used to record the age, sex, and condition of the patients, the site, length, and circumferential extent of the tumor, the...

journal_title：Cancer

authors： Mannell A,Murray W

更新日期：1989-12-15 00:00:00

abstract：BACKGROUND:Immunohistological markers specific for a single type of epithelium are rare. Recently, urothelium tissue-specific genes were cloned. The genes encoded a family of transmembrane proteins, uroplakins, that are expressed only in urothelial mucosa. Using uroplakin antibodies on paraffin-embedded tissue, a previ...

journal_title：Cancer

authors： Xu X,Sun TT,Gupta PK,Zhang P,Nasuti JF

更新日期：2001-06-25 00:00:00

abstract：BACKGROUND:Despite the widespread use of Papanicolaou (Pap) smear screening, substantial morbidity and mortality from cervical carcinoma continue in the U.S. Although access to screening is a major barrier to use of the Pap smear, invasive cervical carcinoma (ICC) still is observed in health plan members who have compr...

journal_title：Cancer

authors： Sung HY,Kearney KA,Miller M,Kinney W,Sawaya GF,Hiatt RA

更新日期：2000-05-15 00:00:00

abstract：BACKGROUND:In this report, the authors present the results from a study of patients with unresectable oropharyngeal squamous cell carcinomas who were treated on a protocol of hyperfractionated radiation and high-dose intraarterial cisplatin (HYPERRADPLAT) at the University of Kentucky. METHODS:The study was designed a...

journal_title：Cancer

authors： Spring PM,Valentino J,Arnold SM,Sloan D,Kenady D,Kudrimoti M,Haydon RC 3rd,Lee C,Given C,Mohiuddin M,Regine WF

更新日期：2005-10-15 00:00:00

abstract：BACKGROUND:Uterine leiomyosarcoma (ULMS) is identified in 0.1% to 0.2% of hysterectomy specimens of presumed leiomyoma. To date, there is no preoperative technique that reliably differentiates ULMS from uterine leiomyoma. Increasing use of minimally invasive approaches for the management of leiomyomas may result in ina...

journal_title：Cancer

authors： George S,Barysauskas C,Serrano C,Oduyebo T,Rauh-Hain JA,Del Carmen MG,Demetri GD,Muto MG

更新日期：2014-10-15 00:00:00

abstract：BACKGROUND:Inactivation of the tumor suppressor gene PTEN/MMAC1/TEP1, located on chromosome 10q23, is a common event in advanced stages of diverse human malignancies. However, the prognostic role of PTEN expression in patients with hepatocellular carcinoma (HCC) has not been characterized. METHODS:One hundred five res...

journal_title：Cancer

authors： Hu TH,Huang CC,Lin PR,Chang HW,Ger LP,Lin YW,Changchien CS,Lee CM,Tai MH

更新日期：2003-04-15 00:00:00

abstract：:The morphologic features, phenotype, and functions of OKM1+ leukemic T-cells were studied. The leukemic T-cells in two patients with chronic lymphocytic leukemia (CLL) had specific features of large granular lymphocytes (LGL), and those in two patients with acute lymphocytic leukemia (ALL) had L2 morphologic character...

journal_title：Cancer

authors： Tagawa S,Taniguchi N,Tokumine Y,Tamaki T,Konishi I,Kanayama Y,Inoue R,Machii T,Kitani T

更新日期：1986-04-15 00:00:00

abstract：BACKGROUND:Screening for and the aggressive treatment of prostate carcinoma are controversial, but they are nevertheless being practiced in the U.S. Current clinical studies of the effectiveness of screening will take years to complete. Meanwhile, screening for prostate carcinoma is already having an effect on society....

journal_title：Cancer

authors： Brawley OW

更新日期：1997-11-01 00:00:00

abstract：:Sixty-four adult patients with refractory acute lymphocytic leukemia (ALL) received salvage therapy with the vincristine, doxorubicin (Adriamycin, Adria Laboratories, Columbus, OH), and dexamethasone (VAD) regimen consisting of induction chemotherapy with the three agents followed by multiple-agent maintenance therapy...

journal_title：Cancer

authors： Kantarjian HM,Walters RS,Keating MJ,Barlogie B,McCredie KB,Freireich EJ

更新日期：1989-07-01 00:00:00

abstract：BACKGROUND:Patient navigation may reduce cancer disparities associated with socioeconomic status (SES) and household factors. This study examined whether these factors were associated with delays in diagnostic resolution among patients with cancer screening abnormalities and whether patient navigation ameliorated these...

journal_title：Cancer

authors： Rodday AM,Parsons SK,Snyder F,Simon MA,Llanos AA,Warren-Mears V,Dudley D,Lee JH,Patierno SR,Markossian TW,Sanders M,Whitley EM,Freund KM

更新日期：2015-11-15 00:00:00

abstract：:Ten consecutive diffuse histiocytic lymphoma (DHL) cell lines established in our laboratory were studied for the presence of Epstein-Barr virus (EBV) genomes, lysozyme, nonspecific esterase and other cytochemical reactions, phagocytic activity, cytoplasmic immunoglobulin light and heavy chains, and surface receptors t...

journal_title：Cancer

authors： Epstein AL,Levy R,Kim H,Henle W,Henle G,Kaplan HS

更新日期：1978-11-01 00:00:00

abstract：:Seventeen patients were given DTIC, 200 mg/m2/day in five-day courses every four to six weeks. In four patients (stage II) treated on an adjuvant basis, tumor recurrence has been verified in three. Four of the palliatively treated patients were also given DTIC by regional intra-arterial infusion with minimal positive ...

journal_title：Cancer

authors： Jönsson PE,Agrup G,Arnbjörnsson E,Hafström L,Rorsman H

更新日期：1980-01-15 00:00:00

abstract：:Two groups of children with refractory acute lymphoblastic leukemia were treated with a regimen of methotrexate (MTX) and asparaginase (Asn'ase) based on studies of the effect of MTX in vitro on human lymphoblasts exposed to Asn'ase. Induction therapy in 12 children produced 4 complete remissions, 3 partial remissions...

journal_title：Cancer

authors： Lobel JS,O'Brien RT,McIntosh S,Aspnes GT,Capizzi RL

更新日期：1979-03-01 00:00:00

abstract：:Age-specific incidence curves, cumulative rates, and relative risks were estimated for selected malignancies among male veterans utilizing the Veterans Administration (VA) medical system during 1970 to 1982. Relative risks for malignant tumors of the lung, bronchus, larynx, oral cavity, and esophagus in males using VA...

journal_title：Cancer

authors： Harris RE,Hebert JR,Wynder EL

更新日期：1989-09-01 00:00:00