Abstract:
BACKGROUND:The purpose was to compare the differential expression of Survivin in normal bladder tissue, bladder transitional cell carcinoma (TCC) of different stages, and to determine whether expression of Survivin is associated with TCC clinical outcomes. METHODS:Immunohistochemical staining for Survivin was carried out on archival bladder specimens from 9 normal controls and 222 consecutive patients who underwent radical cystectomy and bilateral lymphadenectomy. Lymph node tissue involved with TCC from 50 of the 222 cystectomy patients was also evaluated. RESULTS:Survivin was expressed in none of the normal bladder specimens, 64% of the cystectomy specimens, and 94% of the malignant lymph nodes. Multivariable analyses performed in the cystectomy patients revealed that Survivin expression was associated with disease recurrence (P = .040), disease-specific mortality (P = .037), and all-cause mortality (P = .044). CONCLUSIONS:The findings of the study provide a rationale for further evaluation of Survivin and its downstream signaling pathways in bladder cancer and raise the potential for Survivin-targeted therapy for bladder cancer.
journal_name
Cancerjournal_title
Cancerauthors
Shariat SF,Ashfaq R,Karakiewicz PI,Saeedi O,Sagalowsky AI,Lotan Ydoi
10.1002/cncr.22521subject
Has Abstractpub_date
2007-03-15 00:00:00pages
1106-13issue
6eissn
0008-543Xissn
1097-0142journal_volume
109pub_type
杂志文章相关文献
CANCER文献大全abstract::Patients who are diagnosed with osteosarcoma (OS) today receive the same therapy that patients have received over the last 4 decades. Extensive efforts to identify more effective or less toxic regimens have proved disappointing. As we enter a postgenomic era in which we now recognize OS not as a cancer of mutations bu...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.32351
更新日期:2019-10-15 00:00:00
abstract::Proficiency testing in cytopathology and in other disciplines should be based on firm statistical and scientific foundations, because test theory in general is a heavily statistical subject. Statistical considerations have demonstrated that the design of "short" proficiency tests in cytopathology, including the curren...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23154
更新日期:2007-12-25 00:00:00
abstract:BACKGROUND:The role of adjuvant therapy in the management of patients with malignant mixed Müllerian tumors (MMMT) of the uterus has not been defined. The outcome of planned multimodality therapy for patients with apparent early stage disease was assessed. METHODS:A pilot study was performed on 38 patients with clinic...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:2001-04-15 00:00:00
abstract:BACKGROUND:Recent evidence has identified pre-existing type 2 diabetes mellitus (T2DM) as a risk factor for the development of PAC, but relatively little is known about its effects on survival. Our aim was to determine the effect of varying durations of pre-existing T2DM on survival in patients with PAC. METHODS:We co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27731
更新日期:2013-01-15 00:00:00
abstract:BACKGROUND:In a previous phase 2 trial, axitinib was active and well tolerated in patients with advanced thyroid cancer. In this second phase 2 trial, the efficacy and safety of axitinib were evaluated further in this population, and pharmacokinetic/pharmacodynamic relationships and patient-reported outcomes were asses...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.28766
更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Systematic symptom assessment is not routinely performed in pediatric oncology. The objectives of the current study were to characterize the symptoms of pediatric oncology outpatients and evaluate agreement between patient and proxy reports and the association between children's ratings and oncologists' trea...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29597
更新日期:2015-11-15 00:00:00
abstract::An autopsy case of prostaglandin E-producing hepatocellular carcinoma with hypercalcemia is presented in this article. A 72-year-old man showed high serum calcium levels (14.2 to 17.3 mg/100 ml) and hypophosphatemia. The plasma level of immunoreactive parathyroid hormone was below the normal range. Administration of o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880501)61:9<1813::aid-cncr2820
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays an important role in the process of lymphocyte-mediated cytotoxicity against malignant cells. Osteoprotegerin (OPG) is a soluble decoy receptor for TRAIL, and circulating OPG has been implicated in the protection of cells from TRAIL-mediat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20550
更新日期:2004-10-15 00:00:00
abstract:BACKGROUND:Well differentiated (WD) and dedifferentiated (DD) retroperitoneal liposarcoma (RPLS) have distinct biologic behaviors. Consequently, the therapeutic approaches for these tumors differ and mandate an accurate preoperative diagnosis. The authors of this report evaluated whether computed tomography (CT) can be...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.24045
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Bone morphogenetic proteins (BMP) induce ectopic bone formation in vivo and may play a role in normal bone development. In addition, bone morphogenetic activity, as measured in a bone-forming assay in immunodeficient, athymic nu/nu mice, is present in a proportion of osteosarcomas; this activity, which may b...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940101)73:1<85::aid-cncr282073
更新日期:1994-01-01 00:00:00
abstract::Renal cell carcinoma (RCC) has remained refractory to substantive change of its natural history despite intervention with a number of therapeutic modalities. Alpha interferons leukocyte interferon alpha [HuIFN-alpha (Le)] and lymphoblastoid interferon alpha [HuIFN-alpha (Ly)] initially were shown to produce regression...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860415)57:8+<1696::aid-cncr282
更新日期:1986-04-15 00:00:00
abstract:BACKGROUND:Cytogenetics and multicolor flow cytometry (MFC) are useful tools for monitoring outcome of treatment in acute myeloid leukemia (AML). However, no data are available regarding the meaning of results when the 2 tests do not agree. METHODS:The authors of this report analyzed 1464 pairs of concurrent cytogenet...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26539
更新日期:2012-05-01 00:00:00
abstract:BACKGROUND:Since endoscopic treatment was first evaluated and established as a treatment for patients with early stage gastric carcinoma, metachronous disease recurrence at other sites in the stomach after endoscopic treatment has become a major problem. METHODS:A retrospective case-control study was conducted on 10 p...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2001-01-15 00:00:00
abstract::Since 1972 plasma CEA levels of 25 cancer patients have been assayed to evaluate the reliability of CEA as an early indicator of recurrent gastrointestinal cancer. Identification of significant elevations in CEA levels required definition of exactly what a given value meant. Intraassay and interassay accuracy was dete...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197702)39:2<440::aid-cncr2820390
更新日期:1977-02-01 00:00:00
abstract:BACKGROUND:Multiple intraesophageal primary cancer and upper aerodigestive tract (UADT) cancer associated with esophageal cancer are common diseases, especially in heavy drinkers. They are often explained by the concept of field cancerization, which suggests a similar etiology. However, little is known about the nature...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960515)77:10<1986::AID-C
更新日期:1996-05-15 00:00:00
abstract::Using a silver staining technique, nucleolar organizer region-associated proteins (Ag-NOR) were studied in paraffin sections of five specimens of normal bronchial epithelium, eight of atypical squamous metaplasia, five of carcinoma in situ, and seven of microinvasive squamous cell carcinoma. The mean number of Ag-NOR ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910115)67:2<472::aid-cncr28206
更新日期:1991-01-15 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the results of thyroid fine-needle aspiration (FNA) and to determine the reasons for the discrepancies between the cytologic and histologic diagnoses. METHODS:The authors evaluated the cytologic and histologic results of 133 FNAs obtained from 92 patients who underw...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970825)81:4<253::aid-cnc
更新日期:1997-08-25 00:00:00
abstract::The immunologic and clinicopathologic features of common acute lymphoblastic leukemia antigen (CALLA)-positive and CALLA-negative T-acute lymphoblastic leukemia (ALL) and of CALLA-positive non-T, non-B ALL (common ALL) of childhood were compared. Twenty-seven percent of children with T-ALL had blasts that expressed CA...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870615)59:12<2020::aid-cncr282
更新日期:1987-06-15 00:00:00
abstract:BACKGROUND:Patient safety is a critical concern in clinical oncology, but the ability to measure adverse events (AEs) across cancer care is limited by a narrow focus on treatment-related toxicities. The objective of this study was to assess the nature and extent of AEs among cancer patients across inpatient and outpati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30916
更新日期:2017-12-01 00:00:00
abstract::A classification for childhood brain tumors based upon revision of nomenclature of all brain tumors published by the World Health Organization (WHO) in 1979 is proposed. Applicability of the WHO classification scheme was tested in a combined study of the clinical and pathologic features of approximately 3300 brain tum...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851001)56:7+<1869::aid-cncr282
更新日期:1985-10-01 00:00:00
abstract::The 136 patients who underwent total laryngectomy as the primary treatment for squamous cell carcinoma of the glottis at the Mayo Clinic in 1970 through 1981 were followed by retrospective record review for at least 4 years or until death, local recurrence, neck recurrence, or delayed neck metastasis. Cancer recurred ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890701)64:1<143::aid-cncr28206
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:The chromophobe variant of renal cell carcinoma is a recently described and frequently unrecognized tumor. Because the prognosis of the chromophobe variant appears to be intermediate between that of oncocytoma and the clear cell variant of renal cell carcinoma, accurate diagnosis may be important for appropr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970425)81:2<122::aid-cnc
更新日期:1997-04-25 00:00:00
abstract::We report a case of inadvertent administration of over twice the usual dose of methyl-CCNU. The patient exhibited an early onset of bone marrow suppression. Profound pancytopenia, including lymphopenia, persisted for over seven weeks, Although early recovery started at about five weeks. Permanent marrow damage was ind...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821101)50:9<1728::aid-cncr2820
更新日期:1982-11-01 00:00:00
abstract:BACKGROUND:The expression of a distinct alpha-3/4-monofucosylated polylactosaminoglycan epitope, which is detected by monoclonal antibody FW6, was investigated by comparative immunohistochemical analysis of colorectal tissue specimens exhibiting different grades of premalignant and malignant transformation. The presenc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950915)76:6<954::aid-cncr28207
更新日期:1995-09-15 00:00:00
abstract::To assess the importance of radiation dose fraction size in the treatment of malignant melanomas, the records of 48 patients (83 sites) treated at Tufts-New England Medical Center from 1971 to 1979 have been retrospectively reviewed. During this period, the dose fractionation schemes evolved from standard fraction siz...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810315)47:6<1262::aid-cncr2820
更新日期:1981-03-15 00:00:00
abstract::Seventy patients with poor prognosis, metastatic breast cancer were treated with FUVAC induction chemotherapy (5-fluorouracil, vinblastine, Adriamycin [doxorubicin] and cyclophosphamide). Consolidation therapy was given to 30 of 48 responders (63%), of whom 23 received sequential hemibody irradiation (HBI) at 8 cGy, c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870401)59:7<1249::aid-cncr2820
更新日期:1987-04-01 00:00:00
abstract::Seventeen cases of intranasal epithelial tumors are reviewed. Thirteen were epithelial papillomas and four were squamous cell carcinomas associated with epithelial papillomas. In two cases followed over a 10 year period, transformation from an initial papilloma into a carcinoma was demonstrated. The histopathologic ca...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197612)38:6<2503::aid-cncr282038
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:Radiation recall is a recurrence of acute toxicity within a previously quiescent radiation field that occurs with subsequent administration of chemotherapy. METHODS:A patient with acquired immune deficiency syndrome (AIDS)-related Kaposi sarcoma (KS) who had radiation recall is reported. The patient was par...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19930215)71:4<1322::aid-cncr2820
更新日期:1993-02-15 00:00:00
abstract::Of 209 Hodgkin's disease patients treated at least 6 months with a five-drug combination of induction chemotherapy and having a complete remission, four patients developed acute myelogenous leukemia (AML) as a second malignant neoplasm. The overall relative risk for development of AML is 185.0 (P less than 0.05) and t...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19831215)52:12<2209::aid-cncr282
更新日期:1983-12-15 00:00:00
abstract:BACKGROUND:The clinical relevance of DNA image cytometry (ICM) and flow cytometry (FCM) remains under investigation in breast carcinoma. The objective of the current work was to study the prognostic value of DNA ICM and FCM in a series of patients randomized in a control trial. A multivariate analysis has been performe...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/1097-0142(20001015)89:8<1748::aid-cncr15>3
更新日期:2000-10-15 00:00:00