Abstract:
:In this study of 454 colorectal carcinoma colectomy specimens, (289 were associated with and 165 were unassociated with schistosomiasis. Schistosome infestation was found to play an etiologic role in bowel malignancy in patients having diffuse involvement of the large intestine and a history of ten years or more of colitic symptoms. Diminutive polyps, pseudopolyps, ectopically proliferating glands, disintegrated muscularis mucosae, denudation, and multicentric carcinoma were frequently encountered in the schistosomiasis-associated (SA) group, whereas papillary and adenomatous polyps were most common in the schistosomiasis nonassociated (SN) group. Pseudopolyposis, ectopically regenerating glands, and multicentricity are thought to be predisposing factors in the development of colorectal cancer. This sequence of events is analogous to the development of carcinoma in ulcerative colitis.
journal_name
Cancerjournal_title
Cancerauthors
Ming-Chai C,Chi-Yuan C,Pei-Yu C,Jen-Chun Hdoi
10.1002/1097-0142(19801001)46:7<1661::aid-cncr2820subject
Has Abstractpub_date
1980-10-01 00:00:00pages
1661-75issue
7eissn
0008-543Xissn
1097-0142journal_volume
46pub_type
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