Small carcinoma of the pancreas. Clinical and pathologic evaluation of 17 patients.

Abstract:

:The clinical and pathologic characteristics of 17 small carcinomas (less than 2 cm in diameter) of the pancreas are reviewed in this article. All the tumors were located in the head of the pancreas, and the clue to the diagnosis was jaundice in ten patients and abdominal pain in seven. Carcinoembryonic antigen (CEA) and CA 19-9 were not reliable markers for detecting small carcinomas of the pancreas. Ultrasonography (US), computerized tomography (CT), percutaneous transhepatic cholangiography (PTC), and endoscopic retrograde cholangiopancreatography (ERCP) were useful diagnostic tools. Lymph node metastases were found in 41% of affected patients, capsular invasion in 24%, retroperitoneal invasion in 24%, and portal system involvement in 29%. In five patients the carcinoma was Stage I; in eight patients, Stage II; in two patients, Stage III, and in two patients, Stage IV. Fifteen patients with Stages I to III and one patient with Stage IV underwent curative pancreaticoduodenectomy or total pancreatectomy, and one patient with liver metastasis and Stage IV underwent noncurative pancreaticoduodenectomy. The cumulative 4-year survival rate was 37%. Although four patients with Stage I disease lived for more than 48 months, the survival period of the 12 patients with Stages II to IV disease was less than 25 months. Thus, small carcinoma of the pancreas is not always curable; however, a small, localized lesion without any extratumoral extension can be resected with a chance of cure.

journal_name

Cancer

journal_title

Cancer

authors

Manabe T,Miyashita T,Ohshio G,Nonaka A,Suzuki T,Endo K,Takahashi M,Tobe T

doi

10.1002/1097-0142(19880701)62:1<135::aid-cncr28206

subject

Has Abstract

pub_date

1988-07-01 00:00:00

pages

135-41

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

62

pub_type

杂志文章

相关文献

CANCER文献大全
  • Does endoscopic follow-up improve the outcome of patients with benign gastric ulcers and gastric cancer?

    abstract::This study investigated whether an endoscopic surveillance program for patients with "benign" gastric ulcers and gastric cancer leads to early detection of neoplasms and improves survival. The clinical course of all patients diagnosed between 1977 and 1986 as having either gastric ulcers or gastric cancer was followed...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920115)69:2<301::aid-cncr28206

    authors: Eckardt VF,Giessler W,Kanzler G,Bernhard G

    更新日期:1992-01-15 00:00:00

  • Medical adrenalectomy in patients with advanced breast cancer.

    abstract::Medical adrenalectomy, consisting of aminoglutethimide plus either dexamethasone or hydrocortisone, was administered to 53 women with advanced breast cancer. Sixteen (30%) patients had an objective response, five patients had stabilization of disease, 26 patients demonstrated progression of disease, two patients did n...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820315)49:6<1145::aid-cncr2820

    authors: Horsley JS 3rd,Newsome HH,Brown PW,Neifeld JP,Terz JJ,Lawrence W Jr

    更新日期:1982-03-15 00:00:00

  • Enzyme pattern and marker antigens in nodular "regenerative" hyperplasia of the liver.

    abstract::Characteristic alterations of marker enzymes and tumor-associated antigens have been detected in the preneoplastic lesions of experimental hepatocarcinogenesis. An identical pattern of enzyme activity (increased gammaglutamyl transferase, loss of glucose-6-phosphatase, and canalicular adenosine triphosphatase) was dem...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810401)47:7<1796::aid-cncr2820

    authors: Thung SN,Gerber MA

    更新日期:1981-04-01 00:00:00

  • Radiotherapy results for nodular sclerosing Hodgkin's disease after clinical staging.

    abstract::Certain features of nodular sclerosing Hodgkin's disease predispose toward achievement of excellent radiotherapeutic results using clinical staging rather than currently advocated surgical staging including laparatomy. These include a distinct pattern of contiguous lymphatic involvement and the infrequent disseminatio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197704)39:4<1439::aid-cncr282039

    authors: Johnson RE,Zimbler H,Berard CW,Herdt J,Brereton HD

    更新日期:1977-04-01 00:00:00

  • Extraskeletal mesenchymal chondrosarcoma of the orbit.

    abstract::Mesenchymal chondrosarcoma, an uncommon lesion of bone and extraskeletal tissue, is rare in the orbit. A case of extraskeletal mesenchymal chondrosarcoma of the orbit in a 28-year-old woman presenting with proptosis and diminution of vision in the left eye is reported. Histologically, the tumor showed areas of undiffe...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19931001)72:7<2224::aid-cncr2820

    authors: Bagchi M,Husain N,Goel MM,Agrawal PK,Bhatt S

    更新日期:1993-10-01 00:00:00

  • Radition therpay control of nine patients with malignant thymoma.

    abstract::Malignant thymoma is a relatively rare condition and a review of the literature reveals approximately 100 reported cases. Only a small percentage of these have been treated with megavoltage radiation therapy; therefore, it is difficult to find the necessary information to establish a proper time-dose relationship for ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197801)41:1<117::aid-cncr2820410

    authors: Marks RD Jr,Wallace KM,Pettit HS

    更新日期:1978-01-01 00:00:00

  • Stage III endometrial carcinoma. A review of 90 cases.

    abstract::The authors present a retrospective review of 90 cases of Stage III endometrial carcinoma seen over a 10-year period at the Princess Margaret Hospital, Toronto. Overall 5-year survival was 45.5% and disease-free survival was 36.0%. Prognostic factors identified within Stage III were tumor grade, geographic distributio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851115)56:10<2519::aid-cncr282

    authors: Mackillop WJ,Pringle JF

    更新日期:1985-11-15 00:00:00

  • Radioimmunoassay for plasma glutathione S-transferase-pi and its clinical application in gastrointestinal cancer.

    abstract:BACKGROUND:Plasma acidic glutathione S-transferase (GST-pi) concentrations in 135 patients with gastrointestinal cancer were measured by an improved radioimmunoassay (RIA). METHODS:Blood was collected into a silicified glass tube containing a specific anticoagulant. The plasma, which was separated rapidly by centrifug...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19951015)76:8<1363::aid-cncr2820

    authors: Fan KC,Huang YC,Li CH

    更新日期:1995-10-15 00:00:00

  • Positron emission tomography of patients with head and neck carcinoma before and after high dose irradiation.

    abstract:BACKGROUND:Positron emission tomography (PET) with labeled fluorodeoxyglucose (FDG) demonstrates increased tracer uptake in many neoplasms. This study was undertaken to define the patterns of FDG uptake in head and neck neoplasms before and after high dose irradiation. METHODS:Twenty-five patients were evaluated prosp...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940815)74:4<1355::aid-cncr2820

    authors: Greven KM,Williams DW 3rd,Keyes JW Jr,McGuirt WF,Watson NE Jr,Randall ME,Raben M,Geisinger KR,Cappellari JO

    更新日期:1994-08-15 00:00:00

  • Gender differences in the effect of grief reactions and burnout on emotional distress among clinical oncologists.

    abstract:BACKGROUND:The current study was conducted to examine gender differences in the effect of grief reactions and burnout on emotional distress among clinical oncologists. METHODS:The participants included a convenience sample of 178 oncologists from Israel (52 of whom were women) and Canada (48 of whom were women). Oncol...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30236

    authors: Granek L,Krzyzanowska MK,Nakash O,Cohen M,Ariad S,Barbera L,Levy R,Ben-David M

    更新日期:2016-12-01 00:00:00

  • p53CM1 expression is not associated with prognosis in uterine cervical carcinoma.

    abstract:BACKGROUND AND METHODS:Specimens obtained from 192 patients with Stage III squamous cell carcinoma of the cervix treated by radiation therapy alone were investigated with an immunohistochemical method for the expression of p53CM1, a monoclonal antibody that recognizes wild and mutant type p53 gene products in histologi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930701)72:1<160::aid-cncr28207

    authors: Oka K,Nakano T,Arai T

    更新日期:1993-07-01 00:00:00

  • Methyl CCNU and adriamycin for patients with metastatic sarcomas: a Southwest Oncology Group study.

    abstract::This protocol study (SWOG-7431) combining adriamycin and methyl CCNU (MAD) for metastatic sarcomas was initially used on patients who were refractory to cytoxan, vincristine, and/or actinomycin-D. After the initial good results, the study was expanded to include any untreated patients with metastatic sarcoma. The init...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800801)46:3<446::aid-cncr28204

    authors: Rivkin SE,Gottlieb JA,Thigpen T,El Mawla NG,Saiki J,Dixon DO

    更新日期:1980-08-01 00:00:00

  • Radiographic evaluation of metastatic melanoma.

    abstract::Malignant melanoma can potentially involve any organ system in the body once it metastasizes beyond the regional lymph nodes. A survey of the radiographic and associated clinical manifestations of metastatic melanoma is presented. The findings from 74 autopsies of patients who died of metastatic melanoma are included....

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197807)42:1<127::aid-cncr2820420

    authors: Meyer JE

    更新日期:1978-07-01 00:00:00

  • Patterns and predictors of cancer-related fatigue in ovarian and endometrial cancers: 1-year longitudinal study.

    abstract:BACKGROUND:Fatigue is a common and distressing symptom for patients with gynecologic cancers. Few studies have empirically examined whether it spontaneously resolves. This study was aimed at identifying longitudinal patterns of fatigue and predictors of clinically significant fatigue 1 year after treatment completion. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32927

    authors: Poort H,de Rooij BH,Uno H,Weng S,Ezendam NPM,van de Poll-Franse L,Wright AA

    更新日期:2020-08-01 00:00:00

  • The United States experience with oral controlled-release morphine (MS Contin tablets). Parts I and II. Review of nine dose titration studies and clinical pharmacology of 15-mg, 30-mg, 60-mg, and 100-mg tablet strengths in normal subjects.

    abstract::The results of nine US multicenter, sequential crossover, dose titration studies of controlled-release oral morphine (MS Contin 30 mg tablets [MSC], Purdue Frederick, Norwalk, CT) are reviewed in Part I. The studies demonstrated the prolonged analgesic efficacy of the preparation in the treatment of patients with mode...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890601)63:11<2348::aid-cncr282

    authors: Kaiko RF,Grandy RP,Oshlack B,Pav J,Horodniak J,Thomas G,Ingber E,Goldenheim PD

    更新日期:1989-06-01 00:00:00

  • Evaluation of chromosome aneuploidy in tissue sections of preinvasive breast carcinomas using interphase cytogenetics.

    abstract:BACKGROUND:Little is known about cellular level genetic alterations in preinvasive breast lesions, particularly lobular carcinoma in situ. METHODS:We employed fluorescence in situ hybridization (FISH) using pericentromeric (alpha satellite) probes to assess numerical alterations of chromosomes 1, 7, 8, 16, 17, and X i...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960115)77:2<315::AID-CNC

    authors: Visscher DW,Wallis TL,Crissman JD

    更新日期:1996-01-15 00:00:00

  • Improved survival in women with BRCA-associated ovarian carcinoma.

    abstract:BACKGROUND:The objective of this study was to determine the clinical characteristics, treatment response, and frequency of p53 overexpression in Ashkenazi Jewish women with hereditary ovarian carcinoma. METHODS:Seventy-one Jewish women with epithelial ovarian carcinoma (EOC) were tested for the three BRCA founder muta...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11310

    authors: Cass I,Baldwin RL,Varkey T,Moslehi R,Narod SA,Karlan BY

    更新日期:2003-05-01 00:00:00

  • Favorable prognosis after late relapse of Hodgkin's disease.

    abstract:BACKGROUND:Most relapses of Hodgkin's disease (HD) occur within the first 2 years after diagnosis, but they may develop after a longer observation period. The aim of this study was to define the incidence, clinical course, and prognostic factors for late relapse (LR) of Hodgkin's disease. For this purpose, the authors ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Garcia-Carbonero R,Paz-Ares L,Arcediano A,Lahuerta J,Bartolome A,Cortes-Funes H

    更新日期:1998-08-01 00:00:00

  • Nonaspirin nonsteroidal anti-inflammatory drugs and gastric cancer risk after Helicobacter pylori eradication: A territory-wide study.

    abstract:BACKGROUND:Despite Helicobacter pylori (HP) eradication, individuals can still develop gastric cancer (GC). Prior studies have demonstrated that nonaspirin nonsteroidal anti-inflammatory drugs (NA-NSAIDs) reduce the risk of GC, but this may be caused by immortal time bias and failure to adjust for HP status. The object...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.33412

    authors: Li B,Cheung KS,Wong IY,Leung WK,Law S

    更新日期:2021-01-20 00:00:00

  • Checkpoint inhibitors in patients with metastatic renal cell carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium.

    abstract:BACKGROUND:To the authors' knowledge, outcomes and prognostic tools have yet to be clearly defined in patients with metastatic renal cell carcinoma (mRCC) who are treated with immuno-oncology (IO) checkpoint inhibitors (programmed death-ligand 1 [PD-L1] inhibitors). In the current study, the authors aimed to establish ...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.31595

    authors: Yip SM,Wells C,Moreira R,Wong A,Srinivas S,Beuselinck B,Porta C,Sim HW,Ernst DS,Rini BI,Yuasa T,Basappa NS,Kanesvaran R,Wood LA,Canil C,Kapoor A,Fu SYF,Choueiri TK,Heng DYC

    更新日期:2018-09-15 00:00:00

  • Alternating noncross-resistant combination chemotherapy and active nonspecific immunotherapy with BCG or MER-BCG for advanced breast carcinoma.

    abstract::One hundred fifty-six evaluable patients with metastatic breast cancer were treated with vincristine, Adriamycin and cyclophosphamide alternating at fixed intervals with 5-FU and methotrexate. Immunotherapy with BCG or MER-BCG was administered to all patients in two consecutive treatment programs. Overall objective re...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19800215)45:4<742::aid-cncr28204

    authors: Blumenschein GR,Hortobagyi GN,Richman SP,Gutterman JU,Tashima CK,Buzdar AU,Burgess MA,Livingston RB,Hersh EM

    更新日期:1980-02-15 00:00:00

  • Cisplatin, vindesine and bleomycin (CVB) combination chemotherapy of advanced non-small cell lung cancer.

    abstract::Fifty-four patients with advanced squamous, large-cell or adeno-carcinoma of the lung were treated with a three drug regimen of high-dose cisplatin, vindesine and a four-day bleomycin infusion (CVB). All patients had measurable disease; none had previously received chemotherapy. Of 52 patients evaluable for response, ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830315)51:6<1050::aid-cncr2820

    authors: Itri LM,Gralla RJ,Kelsen DP,Chapman RA,Casper ES,Braun DW Jr,Howard JE,Golbey R,Heelan RT

    更新日期:1983-03-15 00:00:00

  • Preoperative or postoperative irradiation as adjunctive treatment with radical mastectomy in breast cancer.

    abstract::Results from the standpoint of survival rates and locoregional failures are compared in three series of patients having had a radical mastectomy for breast cancer: (1) radical mastectomy alone for the patients who had essentially outer quadrant lesions and a negative axilla; (2) postoperative irradiation when the axil...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19830415)51:8<1388::aid-cncr2820

    authors: Rodger A,Montague ED,Fletcher G

    更新日期:1983-04-15 00:00:00

  • Nurses provide valuable proxy assessment of the health-related quality of life of children with Hodgkin disease.

    abstract:BACKGROUND:We prospectively compared the proxy reporting of health-related quality of life (HRQL) by parents and nurses of children with Hodgkin disease to see how well they correlated with the children's report. METHODS:Children with all stages of Hodgkin disease, their parents, and the clinic nurse were all asked to...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24888

    authors: Klaassen RJ,Barr RD,Hughes J,Rogers P,Anderson R,Grundy P,Ali SK,Yanofsky R,Abla O,Silva M,Carret AS,Cappelli M

    更新日期:2010-03-15 00:00:00

  • Multiple early gastric carcinomas. Clinicopathologic features and histogenesis.

    abstract:BACKGROUND:Multiple early gastric carcinomas were found in 5-15% of patients with early gastric carcinoma. The goals of this study were to clarify the clinicopathologic features of multiple early gastric carcinomas and to investigate their histogenesis. METHODS:Of 724 patients with early gastric carcinoma, there were ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Isozaki H,Okajima K,Hu X,Fujii K,Sako S

    更新日期:1996-11-15 00:00:00

  • Gastric carcinoids. An immunohistochemical and clinicopathologic study of 104 patients.

    abstract:BACKGROUND:Gastric carcinoids are uncommon, and are unlike carcinoids at other gastrointestinal sites, clinically and pathologically. METHODS:The authors studied specimens from 104 patients with gastric carcinoid, with study emphasis being placed on pathologic features, immunohistochemistry, clinical associations, and...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940415)73:8<2053::aid-cncr2820

    authors: Thomas RM,Baybick JH,Elsayed AM,Sobin LH

    更新日期:1994-04-15 00:00:00

  • The prevalence of polyps of the large intestine in Oslo: an autopsy study.

    abstract::The colon and rectum were removed from 445 consecutive autopsies and examined for the presence of polypoid lesions under an illuminating magnifying lens. There were seven clinically undiagnosed carcinomas, 329 adenomas, 174 hyperplastic polyps, 59 mucosal tags, 34 other polypoid lesions, and 54 polyps in which no hist...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820215)49:4<819::aid-cncr28204

    authors: Vatn MH,Stalsberg H

    更新日期:1982-02-15 00:00:00

  • Pathomorphologic evaluation of pulmonary radiofrequency ablation: proof of cell death is characterized by DNA fragmentation and apoptotic bodies.

    abstract:BACKGROUND:Radiofrequency (RF) ablation is an increasingly applied technique. Promising results of hepatic RF ablation raised expectations of its capabilities for treatment of primary and secondary lung tumors. Because of different thermal and electrical properties of lung tissue, compared with liver tissue, a simple a...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.23882

    authors: Clasen S,Krober SM,Kosan B,Aebert H,Fend F,Bomches A,Claussen CD,Pereira PL

    更新日期:2008-12-01 00:00:00

  • Medullary carcinoma of the breast. An unusual cytologic finding in cyst fluid aspirates.

    abstract::Cystic medullary carcinoma of the breast is unusual. This report describes five patients with medullary carcinoma who presented clinically with a breast cyst. Fine-needle aspiration biopsy (NAB) was performed as part of the initial physical examination and the retrieved cyst fluid was examined cytologically. Four of t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900115)65:2<277::aid-cncr28206

    authors: Howell LP,Kline TS

    更新日期:1990-01-15 00:00:00

  • The natural five-year course in bronchial carcinoma. Epidemiologic results.

    abstract::A series of 273 unselected patients with bronchial carcinoma, comprising a total prospective 5-year study from a Swedish county with an observed 5-year survival of 7.0%, is presented. The autopsy rate in deceased patients was 94%. All diagnoses were histologically or cytologically verified. The 5-year survival rates f...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840515)53:10<2211::aid-cncr282

    authors: Nõu E

    更新日期:1984-05-15 00:00:00