Clear cell sarcoma of tendons and aponeuroses in pediatric patients: a report from the Italian and German Soft Tissue Sarcoma Cooperative Group.

Abstract:

BACKGROUND:Clear cell sarcoma (CCS) of tendons and aponeuroses is extremely rare in childhood and little information is available on its clinical management. Originally believed to be a type of melanoma of soft tissue origin, CCS is now considered a distinct clinicopathologic entity that behaves like a high-grade soft tissue sarcoma. We report on a series of 28 pediatric patients treated from 1980 to 2000 by the Soft Tissue Sarcoma Italian Cooperative Group and the German Cooperative Group. METHODS:Patients were treated with a multimodality therapeutic approach. Surgical resection was complete in 17 patients (mutilating in 3), radiotherapy was administered to 8 patients, and 20 patients received chemotherapy. RESULTS:After a median follow-up of 102 months (range, 19-238 months), the 5-year and event-free survival rates were 66.4% and 63.3%, respectively. Seventeen patients were alive in first remission, two were alive in second remission, and nine had died of disease. The response to chemotherapy in the 7 evaluable patients included one partial remission, one minor response, and five no responses. Radiotherapy contributed to achieving local control in four of six Intergroup Rhabdomyosarcoma Study (IRS) Group II patients. Statistically significant differences in outcome were evident according to IRS group, tumor size, and site. CONCLUSIONS:Our study confirms the aggressive behavior of CCS. Complete surgical resection represents the mainstay of treatment, and even the only treatment for patients with small tumors. Radiotherapy may control microscopic residual disease after surgery. Chemotherapy is ineffective and the prognosis is unfavorable for patients with unresectable and large tumors.

journal_name

Cancer

journal_title

Cancer

authors

Ferrari A,Casanova M,Bisogno G,Mattke A,Meazza C,Gandola L,Sotti G,Cecchetto G,Harms D,Koscielniak E,Treuner J,Carli M

doi

10.1002/cncr.10597

subject

Has Abstract

pub_date

2002-06-15 00:00:00

pages

3269-76

issue

12

eissn

0008-543X

issn

1097-0142

journal_volume

94

pub_type

杂志文章

相关文献

CANCER文献大全
  • Bone scan as a stratification variable in advanced prostate cancer.

    abstract::The serial technetium 99 (99Tc) bone scans of 76 patients with Stage D-2 prostate cancers were reviewed. Sites of metastases in skeletal areas in decreasing order were vertebrae, ribs, pelvis, long bones, and skull. Patients with one or two involved skeletal areas had a significantly longer progression-free interval a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910715)68:2<316::aid-cncr28206

    authors: Knudson G,Grinis G,Lopez-Majano V,Sansi P,Targonski P,Rubenstein M,Sharifi R,Guinan P

    更新日期:1991-07-15 00:00:00

  • A tool for predicting breast carcinoma mortality in women who do not receive adjuvant therapy.

    abstract:BACKGROUND:Among the several proposed risk classification schemes for predicting survival in women with breast carcinoma, one of the most commonly used is the Nottingham Prognostic Index (NPI). The goal of the current study was to use a continuous prognostic model (similar to those that have already been demonstrated t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20635

    authors: Kattan MW,Giri D,Panageas KS,Hummer A,Cranor M,Van Zee KJ,Hudis CA,Norton L,Borgen PI,Tan LK

    更新日期:2004-12-01 00:00:00

  • Effect of oral prophylactic broad spectrum nonabsorbable antibiotics on the gastrointestinal absorption of nutrients and methotrexate in small cell bronchogenic carcinoma patients.

    abstract::Patients with small cell bronchogenic carcinoma, in a study utilizing laminar-air-flow-protected environments, oral prophylactic broad spectrum non-absorbable antibiotics (PNAA), and intensive combination chemotherapy, were examined to determine the effects of PNAA on serum biochemical values and on gastrointestinal a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197610)38:4<1556::aid-cncr282038

    authors: Cohen MH,Creaven PJ,Fossieck BE,Johnston AV,Williams CL

    更新日期:1976-10-01 00:00:00

  • Small cell carcinomas of the parotid gland. A clinicopathologic study of three cases.

    abstract::Clinical, histological and ultrastructural features of three small cell carcinomas arising in the parotid gland are presented. The light microscopic appearance of two of the neoplasms suggested neuroendocrine cell derivation, confirmed by electron microscopy in both instances. The fine structure of the third neoplasm ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831201)52:11<2115::aid-cncr282

    authors: Kraemer BB,Mackay B,Batsakis JG

    更新日期:1983-12-01 00:00:00

  • Prevalence and predictors of emotional and behavioural functioning of children where a parent has cancer: a multinational study.

    abstract:BACKGROUND:This study aimed to evaluate prevalence and risk factors for emotional and behavioral problems in dependent children of cancer patients using a multinational research design. METHODS:The sample comprised 350 ill parents, 250 healthy partners, and 352 children. Parents assessed the child's psychological func...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.24449

    authors: Thastum M,Watson M,Kienbacher C,Piha J,Steck B,Zachariae R,Baldus C,Romer G

    更新日期:2009-09-01 00:00:00

  • Magnetic resonance imaging as a biomarker in renal cell carcinoma.

    abstract::The ability to noninvasively discriminate the most common types of renal cell carcinoma (RCC) based on their magnetic resonance imaging (MRI) appearances or their magnetic resonance phenotypes is achievable. Intracellular lipids, a histologic characteristic of the clear cell RCC, can be identified on chemical shift MR...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.24237

    authors: Pedrosa I,Alsop DC,Rofsky NM

    更新日期:2009-05-15 00:00:00

  • Cytologic features of renal medullary carcinoma.

    abstract:BACKGROUND:Renal medullary carcinoma is a rare tumor that is most common in young black men with sickle cell disease or trait. Patients often present with advanced disease at the time of diagnosis, and their prognosis is poor, even with aggressive therapy. The clinical and pathologic features of renal medullary carcino...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20764

    authors: Assad L,Resetkova E,Oliveira VL,Sun W,Stewart JM,Katz RL,Caraway NP

    更新日期:2005-02-25 00:00:00

  • Cytogenetics and comorbidity predict outcomes in older myelodysplastic syndrome patients after allogeneic stem cell transplantation using reduced intensity conditioning.

    abstract:BACKGROUND:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only treatment with a curative potential for myelodysplastic syndrome (MDS) patients. Allo-HSCT has substantial risks, particularly in the elderly, and its role for older MDS patients has yet to be defined. METHODS:We analyzed 88 MDS pati...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30632

    authors: Yucel OK,Saliba RM,Rondon G,Ahmed S,Alousi A,Bashir Q,Ciurea SO,Popat U,Khouri I,Marin D,Rezvani K,Kebriaei P,Shpall EJ,Champlin RE,Oran B

    更新日期:2017-07-15 00:00:00

  • Management and results of endometrial carcinoma treated at Instituto Português de Oncologia de Francisco Gentil.

    abstract::The experience of 260 patients with endometrial carcinoma was reviewed. The influence of factors such as age, stage of disease, grade and degree of myometrial penetration on the survival was presented, showing that survival decreases in elderly patients, in patients with advanced stage of disease, when the tumor is un...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197702)39:2<675::aid-cncr2820390

    authors: Tavares MA,Patricio MB,Vilhena M,Da Silva JN

    更新日期:1977-02-01 00:00:00

  • Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines.

    abstract:BACKGROUND:: Survival rates for gastrointestinal (GI) and bronchopulmonary (BP) neuroendocrine tumors (NETs) have not altered significantly (5-year survival rate: GI NETs, 64.1%; BP NETs, 87%-89%) in 30 years (from 1973 to 2004). No effective or specific antineoplastic agents are available to date, although somatostati...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24533

    authors: Drozdov I,Kidd M,Gustafsson BI,Svejda B,Joseph R,Pfragner R,Modlin IM

    更新日期:2009-11-01 00:00:00

  • A familial occurrence of natural killer cell--T-lymphocyte proliferation disease in two children.

    abstract::Several reports describe the association of hyperlymphocytosis with neutropenia. This syndrome, named lymphoproliferative disease, is characterized by a chronic indolent clinical course, bone marrow lymphocyte infiltration, and granulopenia of central origin. The proliferating lymphocytes share large granular lymphocy...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910515)67:10<2610::aid-cncr282

    authors: Le Deist F,de Saint Basile G,Coulombel L,Breton-Gorius J,Maier-Redelsperger M,Beljorde K,Bremard C,Griscelli C

    更新日期:1991-05-15 00:00:00

  • Prognostic variables in patients with hepatic metastases from colorectal cancer. Importance of medical assessment of liver involvement.

    abstract::Variation in response rates to chemotherapy and survival in patients with hepatic metastases from colorectal carcinoma may be due to patient selection factors. The prognostic importance of 13 factors were analyzed in 112 patients with only hepatic metastases, who were eligible for hepatic artery infusional chemotherap...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890215)63:4<742::aid-cncr28206

    authors: Kemeny N,Niedzwiecki D,Shurgot B,Oderman P

    更新日期:1989-02-15 00:00:00

  • The treatment of ejaculation disorders after retroperitoneal lymph node dissection.

    abstract::In 14 patients by bilateral retroperitoneal lymph node dissection for nonseminoma tumors of the testes, several sexual functions before and after node dissection were compared. All patients had normal sexual function before the operation. After the operation, antegrade ejaculation was found to have disappeared complet...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821215)50:12<2967::aid-cncr282

    authors: Nijman JM,Jager S,Boer PW,Kremer J,Oldhoff J,Koops HS

    更新日期:1982-12-15 00:00:00

  • NV-128, a novel isoflavone derivative, induces caspase-independent cell death through the Akt/mammalian target of rapamycin pathway.

    abstract:BACKGROUND:Resistance to apoptosis is 1 of the key events that confer chemoresistance and is mediated by the overexpression of antiapoptotic proteins, which inhibit caspase activation. The objective of this study was to evaluate whether the activation of an alternative, caspase-independent cell death pathway could prom...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24397

    authors: Alvero AB,Montagna MK,Chen R,Kim KH,Kyungjin K,Visintin I,Fu HH,Brown D,Mor G

    更新日期:2009-07-15 00:00:00

  • Cytologic factors associated with prognosis in patients with peripheral adenocarcinoma of the lung measuring 3 cm or less in greatest dimension.

    abstract:BACKGROUND:Recently, peripheral lung adenocarcinomas (PLA) measuring < or = 3 cm in greatest dimension often have been diagnosed using diagnostic radiology. The objective of the current study was to determine which cytologic factors are associated with a favorable outcome and an unfavorable outcome in patients with PLA...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20686

    authors: Kobayashi Y,Yokose T,Kawamura K,Iwasaki S,Murata Y,Onuma S,Hasebe T,Nagai K,Sasaki S,Ochiai A

    更新日期:2005-02-25 00:00:00

  • ThinPrep Pap Test: performance and biopsy follow-up in a university hospital.

    abstract:BACKGROUND:The ThinPrep Pap Test (TP), a liquid-based cervical cytology preparation, was approved for use in the U.S. in 1996. The purpose of this study was to compare TP performance and biopsy follow-up studies with a similar population of high risk patients sampled by conventional Papanicolaou (Pap) smear (CS). METH...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19990625)87:3<105::aid-cnc

    authors: Carpenter AB,Davey DD

    更新日期:1999-06-25 00:00:00

  • Suicide risk among cancer survivors: Head and neck versus other cancers.

    abstract:BACKGROUND:Cancer survivors face psychosocial issues that increase their risk of suicide. This study examined the risk of suicide across cancer sites, with a focus on survivors of head and neck cancer (HNC). METHODS:The Surveillance, Epidemiology, and End Results 18-registry database (from 2000 to 2014) was queried fo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31675

    authors: Osazuwa-Peters N,Simpson MC,Zhao L,Boakye EA,Olomukoro SI,Deshields T,Loux TM,Varvares MA,Schootman M

    更新日期:2018-10-15 00:00:00

  • Hormonal treatment for metastatic breast cancer. An Eastern Cooperative Oncology Group Phase III trial comparing aminoglutethimide to tamoxifen.

    abstract:BACKGROUND:Tamoxifen and aminoglutethimide are two hormone therapies reported to be effective palliative approaches for patients with metastatic breast cancer. The current trial was designed to evaluate their relative therapeutic effectiveness. METHODS:Two hundred forty-nine postmenopausal women with advanced breast c...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/1097-0142(19940115)73:2<354::aid-cncr28207

    authors: Gale KE,Andersen JW,Tormey DC,Mansour EG,Davis TE,Horton J,Wolter JM,Smith TJ,Cummings FJ

    更新日期:1994-01-15 00:00:00

  • Racial disparities and survival for nonsmall-cell lung cancer in a large cohort of black and white elderly patients.

    abstract:BACKGROUND:This study aimed to examine disparities in survival and associated factors for patients with nonsmall-cell lung cancer (NSCLC) and to determine whether racial disparities varied over time (1991-1995, 1996-1999, and 2000-2002). METHODS:The authors studied 70,901 patients aged>or=65 years with stage I-IV NSCL...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24521

    authors: Hardy D,Xia R,Liu CC,Cormier JN,Nurgalieva Z,Du XL

    更新日期:2009-10-15 00:00:00

  • The growing teratoma syndrome.

    abstract::Six patients with metastatic mixed germ-cell tumors who had been treated successfully with chemotherapy had recurring solitary enlarging masses. Four had enlarging pulmonary masses and two patients had enlarging abdominal masses. Each had the presumed chemotherapy refractory mass surgically resected and was found to h...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821015)50:8<1629::aid-cncr2820

    authors: Logothetis CJ,Samuels ML,Trindade A,Johnson DE

    更新日期:1982-10-15 00:00:00

  • Fine-needle aspiration biopsy of granulocytic sarcoma: a clinicopathologic study of 27 cases.

    abstract:BACKGROUND:Because of morphologic similarities, the differential diagnosis of granulocytic sarcoma (GS) in fine-needle aspiration (FNA) specimens includes non-Hodgkin or Hodgkin lymphoma, extramedullary hematopoiesis, poorly differentiated carcinoma, and infection. METHODS:Twenty-six FNAs and 1 pleural effusion fluid ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Suh YK,Shin HJ

    更新日期:2000-12-25 00:00:00

  • Relationship between cytokine gene single nucleotide polymorphisms and symptom burden and quality of life in lung cancer survivors.

    abstract:BACKGROUND:Previous research has demonstrated that many lung cancer survivors report difficulties with symptom control and experience a poor quality of life (QOL). Although recent studies have suggested a relationship of single nucleotide polymorphisms (SNPs) in several cytokine genes with cancer susceptibility and pro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25255

    authors: Rausch SM,Clark MM,Patten C,Liu H,Felten S,Li Y,Sloan J,Yang P

    更新日期:2010-09-01 00:00:00

  • A clinical and pathological staging system for soft tissue sarcomas.

    abstract::A system for staging the clinical status of patients with soft tissue sarcomas is presented, based on the clinical characteristics of the primary tumor (size, extension), the involvement of lymph nodes, the presence of metastases, and the grade of the tumor. This represents the TNM system with grade of tumor (G) added...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197710)40:4<1562::aid-cncr282040

    authors: Russell WO,Cohen J,Enzinger F,Hajdu SI,Heise H,Martin RG,Meissner W,Miller WT,Schmitz RL,Suit HD

    更新日期:1977-10-01 00:00:00

  • Intrapulmonary presentation of extraskeletal myxoid chondrosarcoma of the extremity. Report of two cases.

    abstract::Two cases of extraskeletal myxoid chondrosarcoma are reported. The patients presented with metastasis to the lung, 10 years and 2 years, respectively, prior to discovery of the primary neoplasms in the soft tissues of the lower extremities. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860901)58:5<1144::aid-cncr2820

    authors: D'Ambrosio FG,Shiu MH,Brennan MF

    更新日期:1986-09-01 00:00:00

  • Malignant histiocytosis with rearrangement of the heavy chain gene and evidence of monocyte-macrophage lineage.

    abstract::A unique case of malignant histiocytosis (MH) is reported. Its origin from the monocyte-macrophage system was indicated by expression of highly specific myeloid cell markers (My4, MCS2, and cytoplasmic lysozyme), diffuse activity of acid phosphatase and NaF-sensitive alpha-naphthyl acetate esterase, lack of immunologi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881001)62:7<1306::aid-cncr2820

    authors: Kamesaki H,Koya M,Miwa H,Kita K,Doi S,Tatsumi E,Hatanaka M,Uchino H

    更新日期:1988-10-01 00:00:00

  • Sequential therapy with sorafenib and sunitinib in renal cell carcinoma.

    abstract:BACKGROUND:Sunitinib and sorafenib are small-molecule tyrosine kinase inhibitors (TKI) with antitumor activity in advanced renal cell carcinoma. A retrospective study was conducted to assess the response of renal cell carcinoma to sequential treatment with these two agents. METHODS:Tumor response was evaluated by usin...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24009

    authors: Dudek AZ,Zolnierek J,Dham A,Lindgren BR,Szczylik C

    更新日期:2009-01-01 00:00:00

  • Interferon activity and its characterization in the sera of patients with head and neck cancer.

    abstract::The interferon (IFN) assay of the sera from the 40 patients with head and neck cancer was performed by the plaque-reduction assay with vesicular stomatitis virus in FL cells derived from human amniotic membrane. The patients mainly had Stage III or IV lesion without distant metastasis, and previously had not received ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841001)54:7<1239::aid-cncr2820

    authors: Sato M,Yoshida H,Yanagawa T,Yura Y,Urata M,Atsumi M,Furumoto N,Hayashi Y,Takegawa Y

    更新日期:1984-10-01 00:00:00

  • Malignant metastatic disease of the eye: management of an uncommon complication.

    abstract::Twenty-four patients with metastatic cancer of the choroid were seen in the Department of Therapeutic Radiology, Rush-Presbyterian--St. Luke's Medical Center, Chicago, between 1964 and 1975. One fourth of the patients had involvement in both eyes, for a total of 30 eyes involved with metastatic cancer. The most common...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Reddy S,Saxena VS,Hendrickson F,Deutsch W

    更新日期:1981-02-15 00:00:00

  • The frequency of founder mutations in the BRCA1, BRCA2, and APC genes in Australian Ashkenazi Jews: implications for the generality of U.S. population data.

    abstract:BACKGROUND:Several studies have shown that Ashkenazi Jews in the United States and Israel have a high prevalence of the founder mutations BRCA1 185delAG, BRCA1 5382insC, BRCA2 6174delT, and APC I1307K at frequencies of 1.0--1.1%, 0.2--0.3%, 0.6--1.4%, and 6.1--7.0%, respectively. The objective of this study was to comp...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010715)92:2<440::aid-cncr1340>

    authors: Bahar AY,Taylor PJ,Andrews L,Proos A,Burnett L,Tucker K,Friedlander M,Buckley MF

    更新日期:2001-07-15 00:00:00

  • Can immunohistochemical markers and mitotic rate improve prognostic precision in patients with primary melanoma?

    abstract:BACKGROUND:In addition to tumor thickness, several other prognostic parameters have been identified in primary human melanomas. Some are available readily (localization, gender, age, and ulceration). Others must be evaluated with a moderate or even substantial amount of work (mitoses and immunohistochemical markers). T...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19990601)85:11<2391::aid-c

    authors: Ostmeier H,Fuchs B,Otto F,Mawick R,Lippold A,Krieg V,Suter L

    更新日期:1999-06-01 00:00:00