Abstract:
BACKGROUND:For the current report, the authors examined the characteristic features of morphology and molecular biology of phosphatase and tensin homolog (PTEN), beta-catenin, and p53 immunocytochemistry in endometrial carcinoma by using thin-layer cytologic preparations. METHODS:During a 6-month period, 120 endometrial samples were collected directly by using the Uterobrush, and thin-layer specimens were prepared. Immunocytochemical expression levels of PTEN, beta-catenin, and p53 were investigated by using 40 specimens of endometrial carcinoma (EC), and 30 specimens each of proliferative endometrium, secretory endometrium, and atrophic endometrium. RESULTS:For PTEN immunoreactivity, the a cutoff value of 50% PTEN expression appeared to be useful for the correct diagnosis of EC in endometrial cytology. For beta-catenin immunoreactivity, an increase in cytoplasmic and nuclear beta-catenin expression and a loss of beta-catenin expression appeared to be useful for the correct diagnosis of EC in endometrial cytology and may aid in the stratification of EC into low grade and high grade EC. For p53 immunoreactivity, the application of a cutoff score >or=4 for nuclear p53 expression appeared to be useful for the diagnosis of high-grade EC in endometrial cytology. CONCLUSIONS:Immunocytochemical findings from a combination of PTEN, beta-catenin, and p53, in addition to cytomorphologic features, appeared to be useful for the more accurate diagnosis of EC in endometrial cytology.
journal_name
Cancerjournal_title
Cancerauthors
Norimatsu Y,Miyamoto M,Kobayashi TK,Moriya T,Shimizu K,Yanoh K,Tsukayama C,Miyake Y,Ohno Edoi
10.1002/cncr.23495subject
Has Abstractpub_date
2008-06-25 00:00:00pages
155-64issue
3eissn
0008-543Xissn
1097-0142journal_volume
114pub_type
杂志文章相关文献
CANCER文献大全abstract::Deguelin is a rotenoid compound that exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants. An analysis of evidence from both in vitro and in vivo studies suggests that deguelin displays potent anticancer activity against multiple cancer types and exhibits chemopreventive pot...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.32069
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Human papillomaviruses (HPV) have been implicated strongly in the pathogenesis of human squamous cell carcinomas, especially of anogenital carcinomas. Some pathologic changes of the esophagus may be one of the candidates for HPV etiology, but the role of HPV infections in the carcinogenesis of the esophagus ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921101)70:9<2234::aid-cncr2820
更新日期:1992-11-01 00:00:00
abstract::Light microscopic, immunocytochemical and ultrastructural studies were performed on chondrosarcomas which contained a second, noncartilagenous mesenchymal component. Attention was focused on the nonchondroid portion of each tumor in an attempt to elucidate the histogenesis of this mixed variant of chondrosarcoma. The ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860715)58:2<287::aid-cncr28205
更新日期:1986-07-15 00:00:00
abstract:BACKGROUND:The objective of this study was to evaluate changes in clinical and pathologic characteristics of prostate cancer in patients who underwent surgery at a large tertiary care center in the context of increased use of active surveillance (AS) and minimally invasive surgery (MIS). METHODS:The authors retrospect...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26132
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Assessment of the responses of osteosarcoma patients to preoperative chemotherapy is of clinical importance. The purpose of this study was to estimate the accuracy of angiography and thallium-201 scintigraphy, compared with histology, in assessing the responses of patients with osteosarcoma to preoperative c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990915)86:6<949::aid-cnc
更新日期:1999-09-15 00:00:00
abstract::Twenty-three adult patients (ages greater than 15 years) and 75 children with acute lymphoblastic leukemia were treated with similar intensive, sequential cytotoxic protocols (L-2). The adult patients have lower remission rate (78%) than the children (98%). The duration of remission and the length of survival are also...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197603)37:3<1256::aid-cncr282037
更新日期:1976-03-01 00:00:00
abstract::The cytologic, histologic and ultrastructural features of a malignant carcinomatous mesothelioma of the tunica vaginalis testis in a 30-year old patient are described. This is the first such case with preoperative diagnosis by cytologic examination of hydrocele fluid and the second with documented history of exposure ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820101)49:1<119::aid-cncr28204
更新日期:1982-01-01 00:00:00
abstract::The molecular genetic alterations in colorectal carcinoma are among the best understood of any common human cancer. Identified abnormalities include both dominant-acting oncogenes (ras, myc, src) and suppressor genes which undergo inactivation or deletion (deleted in colorectal carcinoma gene [DCC], p53, adenomatous p...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19920315)69:6+<1589::aid-cncr282
更新日期:1992-03-15 00:00:00
abstract::One hundred fifteen patients underwent surgical treatment of renal cell carcinoma. Survival time was analyzed by statistical regression methods in order to determine the joint significance of stage, using both the Robson and TNM classifications, histologic grade, cell type, and demographic features of the patient samp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830901)52:5<899::aid-cncr28205
更新日期:1983-09-01 00:00:00
abstract:BACKGROUND:Patients aged >10 years with rhabdomyosarcoma have an inferior outcome compared with patients ages 1 to 9 years, which may be explained by toxicities (adverse events [AEs]) that result in chemotherapy dose reductions. METHODS:AEs observed during 1 of 3 randomized chemotherapy regimens (vincristine, dactinom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26358
更新日期:2012-02-15 00:00:00
abstract::To assess the importance of radiation dose fraction size in the treatment of malignant melanomas, the records of 48 patients (83 sites) treated at Tufts-New England Medical Center from 1971 to 1979 have been retrospectively reviewed. During this period, the dose fractionation schemes evolved from standard fraction siz...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810315)47:6<1262::aid-cncr2820
更新日期:1981-03-15 00:00:00
abstract:BACKGROUND:The goal of this study was to compare health-related quality of life (HRQL) from diagnosis to 10 years postdiagnosis among breast cancer survivors (BCS) and women without cancer over the same period and to identify BCS subgroups exhibiting different HRQL trajectories. METHODS:Our analysis included 141 BCS a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32757
更新日期:2020-05-15 00:00:00
abstract::The results of nine US multicenter, sequential crossover, dose titration studies of controlled-release oral morphine (MS Contin 30 mg tablets [MSC], Purdue Frederick, Norwalk, CT) are reviewed in Part I. The studies demonstrated the prolonged analgesic efficacy of the preparation in the treatment of patients with mode...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890601)63:11<2348::aid-cncr282
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND:The mortality of patients with colorectal carcinoma depends mainly upon subsequent liver metastasis even after curative operation. However, it is very difficult to predict the incidence of liver metastasis by analyzing conventional tumor markers or pathologic findings. In the current study, the authors exami...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960415)77:8<1729::AID-CN
更新日期:1996-04-15 00:00:00
abstract::The value of the serum level of carcinoembryonic antigen (CEA) as an indicator of recurrent colorectal carcinoma has been accepted, and the use of serial CEA levels to monitor postoperative chemotherapy has been suggested, However, elevated CEA levels may be associated with nonneoplastic conditions, of which the most ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810201)47:3<481::aid-cncr28204
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:Immunophenotypic analysis is an established tool in the diagnosis and classification of many hematolymphoid disorders; however, the role of flow cytometry (FC) in detecting bone marrow involvement during the staging of non-Hodgkin lymphoma (NHL) has yet to be defined. METHODS:The authors retrospectively ana...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-02-15 00:00:00
abstract:BACKGROUND:The p53 tumor suppressor gene encodes a nuclear phosphoprotein that is thought to be important to cell cycle regulation and DNA repair and that also may regulate induction of apoptosis by ionizing radiation. Somatic p53 gene mutations occur in 30-50% of breast carcinomas and are associated with poor prognosi...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::Twenty-four women with ovarian carcinoma that had metastasized to the liver were treated with intrahepatic infusional therapy. No consistent drug regimen was used. There were no complete responders; however, 33% had a partial response. All responses were noticed after the first course of therapy. The median length of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870601)59:11<1866::aid-cncr282
更新日期:1987-06-01 00:00:00
abstract:BACKGROUND:There is controversy regarding the effect of age on breast carcinoma, and previous analyses have often excluded the most elderly patients as well as those with advanced cancers. This study assessed treatment variations and outcome in relation to age for a complete series of patients who presented with breast...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000115)88:2<369::aid-cnc
更新日期:2000-01-15 00:00:00
abstract:BACKGROUND:The diagnostic accuracy of technetium-99m methoxyisobutylisonitrile (Tc-MIBI) single photon emission computed tomography (SPECT) and computed tomography (CT) of the head and neck for differentiating recurrent or residual nasopharyngeal carcinomas (NPC) from benign lesions after radiotherapy was compared with...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/cncr.10400
更新日期:2002-04-01 00:00:00
abstract:BACKGROUND:Nodal status is one of the most important prognostic factors for distal bile duct cancer. The pattern of lymphatic spread of distal bile duct cancer was analyzed by determining the frequency of involvement of various lymph nodes. MATERIALS AND METHODS:From 1973 to 1991, 29 patients with distal bile duct can...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931001)72:7<2112::aid-cncr2820
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Cirrhosis of viral etiology due to hepatitis B virus (HBV) or hepatitis C virus (HCV) infection is a risk factor for hepatocellular carcinoma (HCC). The current study evaluated the rate of incidence of HCC in patients with compensated cirrhosis of viral etiology. METHODS:Two hundred fifty-nine cirrhotic pat...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-05-15 00:00:00
abstract:BACKGROUND:Although cutaneous desmoplastic malignant melanoma (DMM) has been well characterized, those arising from the oral mucosa have been less well defined. METHODS:We evaluated the clinical and pathologic features of three patients with biopsy-proven DMM examined at the North Carolina Baptist Hospital. Routine he...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960801)78:3<383::AID-CNC
更新日期:1996-08-01 00:00:00
abstract::Because Forssman antigen, one of the most well-known heteroantigens, has been noted in certain cancerous tissues, it would seem that the serum levels of the Forssman antibody of patients with these cancers would be low, owing to the absorption of the naturally occurring antibody by the Forssman antigen-containing canc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890415)63:8<1528::aid-cncr2820
更新日期:1989-04-15 00:00:00
abstract:BACKGROUND:The prognostic significance and optimal care of children with differentiated thyroid cancer and pulmonary metastases are not well established. METHODS:Of 209 patients younger than 25 years of age who were treated at University of Texas M. D. Anderson Cancer Center between 1960 and 1990 and for whom there wa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930215)71:4<1348::aid-cncr2820
更新日期:1993-02-15 00:00:00
abstract:BACKGROUND:Fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) tests are commonly used to assess human epidermal growth factor 2 (HER2) status of tumors in patients with breast cancer. This analysis evaluates the likely cost-effectiveness of expanded retesting to assess HER2 tumor status in women w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28196
更新日期:2013-09-01 00:00:00
abstract::A 22-micron glass microsphere called TheraSphere (Theragenics Corp., Atlanta, GA) has been developed in which yttrium 89 oxide is incorporated into the glass matrix and is activated by neutron bombardment to form the beta-emitting isotope yttrium 90 (Y 90) before using the spheres as radiotherapeutic vehicles. The inj...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880401)61:7<1336::aid-cncr2820
更新日期:1988-04-01 00:00:00
abstract:BACKGROUND:The long-term impact of breast carcinoma and its treatment was assessed in 153 breast carcinoma survivors previously treated on a Phase III randomized trial (Cancer and Leukemia Group B [CALGB 7581]) a median of 20 years after entry to CALGB 7581. METHODS:Survivors were interviewed by telephone using the fo...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/cncr.11531
更新日期:2003-08-15 00:00:00
abstract::The clinical presentation of the disease and the results of treatment in 42 patients with malignant peripheral neuroectodermal tumors (MPNT) entered into the Cooperative Ewing's, soft tissue, and neuroblastoma trials of the German Society of Pediatric Oncology were retrospectively analyzed. Within the Ewing's sarcoma ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880115)61:2<349::aid-cncr28206
更新日期:1988-01-15 00:00:00
abstract:BACKGROUND:The diagnosis of melanomas at an early stage is associated with improved survival, so the recognition of changes in pigmented skin lesions over time is important. We have developed a computer imaging system with the aim of assisting clinicians in differentiating early melanomas from benign pigmented skin les...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960715)78:2<252::AID-CNC
更新日期:1996-07-15 00:00:00