Lobular carcinoma arising in fibroadenoma of the breast.

abstract：BACKGROUND:Cyclooxygenase 2 (COX-2)-dependent signaling represents a potential mechanism of resistance to therapy with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. This is mediated in part through an EGFR-independent activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regul...

journal_title：Cancer

authors： Reckamp KL,Koczywas M,Cristea MC,Dowell JE,Wang HJ,Gardner BK,Milne GL,Figlin RA,Fishbein MC,Elashoff RM,Dubinett SM

更新日期：2015-09-15 00:00:00

abstract：:In recent years, an increased understanding of T-cell-regulatory mechanisms has led to the development of a novel class of immune-checkpoint inhibitors that have robust clinical activity against a broad array of malignancies-even those that historically were not believed to be sensitive to immune therapy. With this, t...

journal_title：Cancer

authors： Salama AK,Postow MA,Salama JK

更新日期：2016-06-01 00:00:00

abstract：:Twelve cases of thymic carcinoid were studied by electron microscopy and immunohistochemistry. Clinically, all of them presented either as asymptomatic, radiographically detected mediastinal masses or as neoplasms producing symptoms of thoracic structural displacement or Cushing's syndrome. By light microscopic examin...

journal_title：Cancer

authors： Wick MR,Scheithauer BW

更新日期：1984-02-01 00:00:00

abstract：BACKGROUND:The effect on prognosis of adding imatinib mesylate to the treatment of patients with Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML) has not been explored fully. The objective of the current study was to evaluate the benefit of adding imatinib to the treatment sequence of patients w...

journal_title：Cancer

authors： Kantarjian H,O'Brien S,Cortes J,Shan J,Giles F,Garcia-Manero G,Verstovsek S,Faderl S,Rios MB,Talpaz M

更新日期：2003-10-01 00:00:00

abstract：:A strong activity of the tartrate-resistant acid phosphatase, isoenzyme 5b, was observed in mouse spleen. The enzyme of the mouse spleen had similar electrophoretic mobility and related antigenicity to that of the reticulum cells of leukemic reticuloendotheliosis. Enzyme histochemical studies showed many non-phagocyti...

journal_title：Cancer

authors： Kuehler D,Lam KW,Yam LT

更新日期：1981-02-15 00:00:00

abstract：:Based on laboratory studies showing enhanced cytotoxicity of floxuridine (FUDR) when used with high doses of leucovorin (LV), a pilot study of FUDR and LV through an implantable pump was initiated for the treatment of hepatic metastases from colorectal cancer. The highest dose of LV that could be administered, taking ...

journal_title：Cancer

authors： Kemeny N,Cohen A,Bertino JR,Sigurdson ER,Botet J,Oderman P

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:The Fuhrman grading system is an established predictor of survival in patients with renal cell carcinoma (RCC). The predictive accuracy of various Fuhrman grading schemes was tested with the intent of improving the prediction of RCC-specific survival (RCC-SS). METHODS:The analyses targeted 5453 patients fro...

journal_title：Cancer

authors： Rioux-Leclercq N,Karakiewicz PI,Trinh QD,Ficarra V,Cindolo L,de la Taille A,Tostain J,Zigeuner R,Mejean A,Patard JJ

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Cancer patients with single tumors live longer today due to earlier detection and improved treatment methods. For this reason, the authors see more patients who develop a second primary tumor. The etiology of the second tumor can be the same as the first, whether treatment-induced or unknown. The prognoses o...

journal_title：Cancer

authors： Robinson E,Segal R,Struminger L,Faraggi D,El'ad-Yarum R,Mekori T

更新日期：1999-05-01 00:00:00

abstract：:Since 1975, the Department of Radiation Therapy, University of Maryland Hospital initiated a policy of supplementing the dose to the affected parametrium by using radium needles implants in conjunction with a protruding tandem preferably, or Manchester ovoid in the case of absence of the lower segment of the uterus. T...

journal_title：Cancer

authors： Prempree T

更新日期：1983-08-15 00:00:00

abstract：BACKGROUND:False-positive cancer screening results may affect a patient's willingness to obtain future screening. METHODS:The authors conducted logistic regression analysis of 450,484 person-years of electronic medical records (2006-2015) in 92,405 individuals aged 50 to 75 years. Exposures were false-positive breast,...

journal_title：Cancer

authors： Taksler GB,Keating NL,Rothberg MB

更新日期：2018-06-01 00:00:00

abstract：:The unique case of a 60-year-old patient with a non-Hodgkin's B-cell lymphoma of the lymphoplasmacytic type and three associated monoclonal proteins, is described. The patient also exhibited various autoimmune phenomena that were consistent with the diagnoses of Sjögren's syndrome and autoimmune thyroiditis. The evolu...

journal_title：Cancer

authors： Berg AR,Weisenburger DD,Linder J,Armitage JO

更新日期：1986-05-01 00:00:00

abstract：:There are three principal disturbances in bone remodelling that occur in neoplasia affecting the skeleton. The first is an increase in bone turnover that in solid tumors may be confined to sites of metastases or be a generalized phenomenon, most likely related to the secretion of parathyroid hormone-related protein. I...

journal_title：Cancer

authors： Kanis JA,McCloskey EV

更新日期：1997-10-15 00:00:00

abstract：BACKGROUND:It is unclear whether palliative endourologic or percutaneous urinary diversion in the treatment of advanced cancer provides significant improvement in quality or duration of life. The purpose of this study was to evaluate survival and performance status after endourologic palliative urinary diversion in pat...

journal_title：Cancer

authors： Shekarriz B,Shekarriz H,Upadhyay J,Banerjee M,Becker H,Pontes JE,Wood DP Jr

更新日期：1999-02-15 00:00:00

abstract：BACKGROUND:Nilotinib is a potent, second-generation inhibitor of BCR-ABL1 tyrosine kinase and has been approved as frontline and salvage therapy for patients with chronic-phase chronic myeloid leukemia (CP-CML). METHODS:In this single-institution, phase 2 study, 122 patients with newly diagnosed CP-CML received niloti...

journal_title：Cancer

authors： Masarova L,Cortes JE,Patel KP,O'Brien S,Nogueras-Gonzalez GM,Konopleva M,Verstovsek S,Garcia-Manero G,Ferrajoli A,Kadia TM,Ravandi-Kashani F,Borthakur G,DellaSala S,Estrov Z,Jabbour EJ,Kantarjian HM

更新日期：2020-04-01 00:00:00

abstract：:We counted the number of toluidine blue positive mast cells within and around the tumor in 44 patients with soft tissue sarcomas (STS). Irrespective of their histologic types, these cases were broadly divided into the following two groups: (1) low count (less than 20 mast cells/10 high-power fields [HPF]) and (2) high...

journal_title：Cancer

authors： Ueda T,Aozasa K,Tsujimoto M,Yoshikawa H,Kato T,Ono K,Matsumoto K

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Multiple cell-signaling ligands and receptors-including vascular endothelial growth factor (VEGF), insulin-like growth factor (IGF), endothelial growth factor (EGF), v-akt murine thymoma viral oncogene homolog (AKT), platelet-derived growth factor (PDGF), mitogen-activated protein kinase (MAPK), and 70-kilod...

journal_title：Cancer

authors： Abdeen A,Chou AJ,Healey JH,Khanna C,Osborne TS,Hewitt SM,Kim M,Wang D,Moody K,Gorlick R

更新日期：2009-11-15 00:00:00

abstract：BACKGROUND:The use of docetaxel prolongs survival for patients with castrate-resistant prostate cancer (CRPC). Inhibition of vascular endothelial growth factor (VEGF) with bevacizumab may further enhance the antitumor effect of docetaxel and estramustine in patients with CRPC. METHODS:This cooperative group trial enro...

journal_title：Cancer

authors： Picus J,Halabi S,Kelly WK,Vogelzang NJ,Whang YE,Kaplan EB,Stadler WM,Small EJ,Cancer and Leukemia Group B.

更新日期：2011-02-01 00:00:00

abstract：:The ultrastructure of a chondroid syringoma is described. The tumor nests are formed by clumps, solid cords and tubular structures distributed diffusely throughout a stroma of varying density. Two different types of cells form this tumor: dark cells forming the inner layer of the tubuloalveolar and ductal structures a...

journal_title：Cancer

authors： Varela-Durán J,Díaz-Flores L,Varela-Núnez R

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:Human epidermal growth factor receptor 2 (HER2) is a therapeutic target in patients with esophageal adenocarcinoma (EAC), with gene amplification used as a selection criterion for treatment, although to the authors' knowledge the concordance between amplification and HER2 protein expression remains undefined...

journal_title：Cancer

authors： Yoon HH,Sukov WR,Shi Q,Sattler CA,Wiktor AE,Diasio RB,Wu TT,Jenkins RB,Sinicrope FA

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The diagnosis of melanomas at an early stage is associated with improved survival, so the recognition of changes in pigmented skin lesions over time is important. We have developed a computer imaging system with the aim of assisting clinicians in differentiating early melanomas from benign pigmented skin les...

journal_title：Cancer

authors： Aitken JF,Pfitzner J,Battistutta D,O'Rourke PK,Green AC,Martin NG

更新日期：1996-07-15 00:00:00

abstract：:Fifty-four patients with advanced squamous, large-cell or adeno-carcinoma of the lung were treated with a three drug regimen of high-dose cisplatin, vindesine and a four-day bleomycin infusion (CVB). All patients had measurable disease; none had previously received chemotherapy. Of 52 patients evaluable for response, ...

journal_title：Cancer

authors： Itri LM,Gralla RJ,Kelsen DP,Chapman RA,Casper ES,Braun DW Jr,Howard JE,Golbey R,Heelan RT

更新日期：1983-03-15 00:00:00

abstract：:A bolus intravenous dose of 5-fluorouracil of 600 mg/M2 was added exactly 1 hour after methotrexate administration in an established combination program including bleomycin and cisplatin for advanced squamous cell cancer of the head and neck. Results were no better than those observed previously with the three drugs, ...

journal_title：Cancer

authors： Vogl SE,Komisar A,Kaplan BH,Engstrom PF,Kasule OH,Stolbach L,Lerner H,Muggia F

更新日期：1986-02-15 00:00:00

abstract：:To investigate histologic prognostic factors in soft tissue sarcomas (STS), multivariate analysis was performed on 236 patients with complete clinical information. These included 141 males and 95 females with an age range from 1 to 85 years (median, 47.6 years). Histologically, malignant fibrous histiocytoma (33.5%) w...

journal_title：Cancer

authors： Tsujimoto M,Aozasa K,Ueda T,Morimura Y,Komatsubara Y,Doi T

更新日期：1988-09-01 00:00:00

abstract：BACKGROUND:Increased soluble human epidermal growth factor receptor 2 (sHER2) is an indicator of a poor prognosis in HER2-positive metastatic breast cancer. In this study, the authors evaluated levels of sHER2 during treatment and at the time of disease recurrence in the adjuvant North Central Cancer Treatment Group N9...

journal_title：Cancer

authors： Moreno-Aspitia A,Hillman DW,Dyar SH,Tenner KS,Gralow J,Kaufman PA,Davidson NE,Lafky JM,Reinholz MM,Lingle WL,Kutteh LA,Carney WP,Dueck AC,Perez EA

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND:This study aimed to examine disparities in survival and associated factors for patients with nonsmall-cell lung cancer (NSCLC) and to determine whether racial disparities varied over time (1991-1995, 1996-1999, and 2000-2002). METHODS:The authors studied 70,901 patients aged>or=65 years with stage I-IV NSCL...

journal_title：Cancer

authors： Hardy D,Xia R,Liu CC,Cormier JN,Nurgalieva Z,Du XL

更新日期：2009-10-15 00:00:00

abstract：BACKGROUND:Metastases to the breast from extramammary primary tumors are uncommon. Malignant melanoma is one of the most common neoplasms to secondarily involve the mammary parenchyma. METHODS:Seven cases of malignant melanoma metastatic to the breast diagnosed by fine-needle aspiration biopsy are presented. RESULTS:...

journal_title：Cancer

authors： Cangiarella J,Symmans WF,Cohen JM,Goldenberg A,Shapiro RL,Waisman J

更新日期：1998-06-25 00:00:00

abstract：BACKGROUND:The effectiveness of adjuvant chemotherapy in soft tissue sarcomas remains a matter of controversy. The authors reviewed their experience with 14 patients with localized disease treated with intensive doxorubicin-cisplatin-ifosfamide-based chemotherapy. METHODS:Fourteen patients with newly diagnosed nonmeta...

journal_title：Cancer

authors： Kampe CE,Rosen G,Eilber F,Eckardt J,Lowenbraun S,Foster J,Forscher C,Selch M

更新日期：1993-10-01 00:00:00

abstract：BACKGROUND:Full-scale implementation of lung cancer screening in the United States will increase detection of early stages. This study was aimed at assessing the capacity required for treating those cancers. METHODS:A well-established microsimulation model was extended with treatment data from the National Cancer Data...

journal_title：Cancer

authors： Blom EF,Ten Haaf K,Arenberg DA,de Koning HJ

更新日期：2019-06-15 00:00:00

abstract：BACKGROUND:Bioimpedance spectroscopy (BIS) has enabled the early identification of breast cancer-related lymphedema. In this study, differences in health service metrics and in the incidence of breast cancer-related lymphedema are evaluated in an early surveillance model of care compared with a traditional referral mod...

journal_title：Cancer

authors： Koelmeyer LA,Borotkanics RJ,Alcorso J,Prah P,Winch CJ,Nakhel K,Dean CM,Boyages J

更新日期：2019-03-15 00:00:00

abstract：:Systemic fungal infections are recognized at increasing frequency during the course of intensive therapy for acute leukemias and require parenteral antifungal treatment mostly by amphotericin B (ampho B) alone or in combination with 5-Fluorocytosine (5-FC). Because of the potential myelosuppressive side effects of 5-F...

journal_title：Cancer

authors： Hiddemann W,Essink ME,Fegeler W,Zühlsdorf M,Sauerland C,Büchner T

更新日期：1991-07-01 00:00:00