Successful therapy of an ACTH-producing gastric carcinoid APUD tumor: report of a case and review of the literature.

Abstract:

:A case of a patient with a metastatic ACTH (adrenocorticotrophic hormone)-producing gastric carcinoid APUD (amine precursor uptake and decarboxylation) tumor is presented. The patient presented with Cushing's syndrome and very high levels of ACTH. The Cushing's syndrome was controlled medically, and when the patient deteriorated clinically she received treatment with a combination of BCNU, adriamycin, and ftorafur. She responded dramatically with marked clinical improvement and normalization of plasma ACTH levels. The current status of the APUD cell concept is discussed, with its overall implications for treatment of this group of malignancies.

journal_name

Cancer

journal_title

Cancer

authors

Marcus FS,Friedman MA,Callen PW,Churg A,Harbour J

doi

10.1002/1097-0142(19800901)46:5<1263::aid-cncr2820

subject

Has Abstract

pub_date

1980-09-01 00:00:00

pages

1263-9

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

46

pub_type

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