Abstract：
:In this study, the decay of maternal peste des petits ruminants virus (PPRV) antibodies in kids born to goats vaccinated with Asian lineage IV PPR vaccine and the efficacy of passive immunity against PPRV was assessed to determine the appropriate period for vaccination in kids. Serum samples collected from kids born to vaccinated, unvaccinated and infected goats at different time intervals were tested by PPR competitive ELISA and serum neutralization test (SNT). Maternal antibodies in kids were detectable up to 6 months with a decline trend from the third month onwards and receded below the protective level by the fourth month. The kid with an SN titre of 1:8 at the time of immunization showed significant PPRV specific antibody response (percentage inhibition of 76; SN titers >1:16), when tested on 21 day post-vaccination and was completely protected from infection upon virulent PPRV challenge. Similarly, the kid with 1:8 SN titers was completely protected from PPR infection on active challenge. Therefore, PPR vaccination is recommended in kids, aged 4 months and born to immunized or exposed goats. This could be a suitable period to avoid window of susceptibility in kids to PPRV and the effort to eliminate PPR infection from susceptible populations.
journal_name
Virol Sinjournal_title
Virologica Sinicaauthors
Balamurugan V,Sen A,Venkatesan G,Rajak KK,Bhanuprakash V,Singh RKdoi
10.1007/s12250-012-3249-6subject
Has Abstractpub_date
2012-08-01 00:00:00pages
228-33issue
4eissn
1674-0769issn
1995-820Xjournal_volume
27pub_type
杂志文章abstract：:Our previous work has shown that Saffold virus (SAFV) induced several rodent and primate cell lines to undergo apoptosis (Xu et al. in Emerg Microb Infect 3:1-8, 2014), but the essential viral proteins of SAFV involved in apoptotic activity lack study. In this study, we individually transfected the viral proteins of S...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-019-00116-1
更新日期：2019-06-01 00:00:00
abstract：:Porcine respiratory disease complex (PRDC) is a serious health problem that mainly affects growing and finishing pigs. PRDC is caused by a combination of viral and bacterial agents, such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), Mycoplasma hyopneumoniae (Myh), Actinob...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-014-3471-5
更新日期：2014-08-01 00:00:00
abstract：:Conventional influenza vaccines need to be designed and manufactured yearly. However, they occasionally provide poor protection owing to antigenic mismatch. Hence, there is an urgent need to develop universal vaccines against influenza virus. Using nucleoprotein (NP) and extracellular domain of matrix protein 2 (M2e) ...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-019-00138-9
更新日期：2019-10-01 00:00:00
abstract：:Shiga toxin B-subunit (STxB) from Shigella dysenteriae targets in vivo antigen to cancer cells, dendritic cells (DC) and B cells, which preferentially express the globotriaosylceramide (Gb3) receptor. This pivotal role has encouraged scientists to investigate fusing STxB with other clinical antigens. Due to the challe...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-013-3286-9
更新日期：2013-02-01 00:00:00
abstract：:The papain-like protease (PL(pro)) of Middle-East respiratory syndrome coronavirus (MERS-CoV) has proteolytic, deubiquitinating, and deISGylating activities. The latter two are involved in the suppression of the antiviral innate immune response of the host cell. To contribute to an understanding of this process, we pr...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-016-3742-4
更新日期：2016-08-01 00:00:00
abstract：:Similar to Hepatitis C virus (HCV) infection in humans, HCVcc infection can also result in persistent and chronic infection. The core protein is a variable protein and exists in several sizes. Some sizes of core proteins have been reported to be related to chronic HCV infection. To study the possible role of the core ...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-013-3296-7
更新日期：2013-06-01 00:00:00
abstract：:Recreational waters contaminated with human fecal pollution are a public health concern, and ensuring the safety of recreational waters for public use is a priority of both the Environmental Protection Agency (EPA) and the Centers for Disease Control and Prevention (CDC). Current recreational water standards rely on f...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-015-3644-x
更新日期：2015-10-01 00:00:00
abstract：:During transcription initiation, RNA polymerase binds tightly to the promoter DNA defining the start of transcription, transcribes comparatively slowly, and frequently releases short transcripts (3-8 nucleotides) in a process called abortive cycling. Transitioning to elongation, the second phase of transcription, the ...
journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-013-3397-3
更新日期：2013-12-01 00:00:00
abstract：:Hepatitis E virus (HEV) is the prototype of the family Hepeviridae and the causative agent of common acute viral hepatitis. Genetically diverse HEV-related viruses have been detected in a variety of mammals and some of them may have zoonotic potential. In this study, we tested 278 specimens collected from seven wild s...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-018-0011-8
更新日期：2018-02-01 00:00:00
abstract：:The temporal change patterns of laboratory data may provide insightful clues into the whole course of COVID-19. This study aimed to evaluate longitudinal change patterns of key laboratory tests in patients with COVID-19, and identify independent prognostic factors by examining the associations between laboratory findi...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-020-00317-z
更新日期：2020-12-01 00:00:00
abstract：:Rotavirus (RV) is a major foodborne pathogen. For RV prevention and control, it is a key to uncover the interaction mechanism between virus and its receptors. However, it is hard to specially purify the viral receptors, including histo-blood group antigens (HBGAs). Previously, the protruding domain protein (P protein)...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-019-00174-5
更新日期：2020-02-01 00:00:00
abstract：:In this paper, in vitro anti-influenza virus activities of sulfated polysaccharide fractions from Gracilaria lemaneiformis were investigated. Cytotoxicities and antiviral activities of Gracilaria lemaneiformis polysaccharides (PGL), Gracilaria lemaneiformis polysaccharide fraction-1 (GL-1), Gracilaria lemaneiformis po...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-010-3137-x
更新日期：2010-10-01 00:00:00
abstract：:Bat SARS-like coronavirus (SL-CoV) has a genome organization almost identical to that of SARS-CoV, but the N-terminus of the Spike (S) proteins, which interacts with host receptor and is a major target of neutralizing antibodies against CoVs, of the two viruses has only 63-64% sequence identity. Although there have be...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-013-3292-y
更新日期：2013-04-01 00:00:00
abstract：:Receptors interaction protein 2 (RIP2) is a specific adaptor molecule in the downstream of NOD2. The role of RIP2 during foot-and-mouth disease virus (FMDV) infection remains unknown. Here, our results showed that RIP2 inhibited FMDV replication and played an important role in the activation of IFN-β and NF-ĸB signal ...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-020-00322-2
更新日期：2021-01-05 00:00:00
abstract：:Cancer cell lines have been used widely in cancer biology, and as biological or functional cell systems in many biomedical research fields. These cells are usually defective for many normal activities or functions due to significant genetic and epigenetic changes. Normal primary cell yields and viability from any orig...
journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-020-00244-z
更新日期：2020-06-01 00:00:00
abstract：:The construction of the first infectious clone JFH-1 speeds up the research on hepatitis C virus (HCV). However, Huh7 cell line was the only highly permissive cell line for HCV infection and only a few clones were fully permissive. In this study, two different fully permissive clones of Huh7 cells, Huh7.5.1 and Huh7-L...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-013-3342-5
更新日期：2013-08-01 00:00:00
abstract：:Chikungunya virus (CHIKV) is a mosquito-borne virus that causes epidemics widely in the world especially in the tropical and subtropical regions. Phylogenetic analysis has found that the CHIKV lineages were associated with the spatial and temporal distributions, which were related to the virus adaption to the major mo...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-017-4077-5
更新日期：2017-12-01 00:00:00
abstract：:The 5'-cap structures of eukaryotic mRNAs are important for RNA stability, pre-mRNA splicing, mRNA export, and protein translation. Many viruses have evolved mechanisms for generating their own cap structures with methylation at the N7 position of the capped guanine and the ribose 2'-Oposition of the first nucleotide,...
journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-016-3726-4
更新日期：2016-02-01 00:00:00
abstract：:The recent emergence and rapid global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pose an unprecedented medical and socioeconomic crisis, and the disease caused by it, Coronavirus disease 2019 (COVID-19), was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. C...
journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-020-00298-z
更新日期：2020-12-01 00:00:00
abstract：:Porcine pegivirus (PPgV) is a member of the Pegivirus genus in the Flaviviridae family. PPgV is an emerging virus that has been discovered in swine herds in Germany, the United States, China, Poland, Italy, and the United Kingdom, indicating a wide geographical distribution. In this retrospective study, 339 pig serum ...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-020-00240-3
更新日期：2020-07-08 00:00:00
abstract：:The aim of the work is the comparison of the epidemiology of influenza and acute respiratory virus infections (ARVI) in the Republic of Kazakhstan with the corresponding influenza epidemic in Russia induced by influenza pandemic virus A/California/07/2009 in 2009. Data on influenza and ARVI from the Republic of Kazakh...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-011-3203-z
更新日期：2011-10-01 00:00:00
abstract：:The epidemiology of HIV-1 varies in different areas of the world, and it is possible that this complexity may leave unique footprints in the viral genome. Thus, we attempted to find significant patterns in global HIV-1 genome sequences. By applying the rule inference algorithm RIPPER (Repeated Incremental Pruning to P...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-013-3348-z
更新日期：2013-08-01 00:00:00
abstract：:The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics o...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-016-3872-8
更新日期：2017-02-01 00:00:00
abstract：:Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in Pakistan, nasal (n = 77...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-018-0051-0
更新日期：2018-10-01 00:00:00
abstract：:Lepidopteran heat-tolerant (ht) cell lines have been obtained with sf-9, sf-21 and several Bombyx cells. They have a distinct karyotype, membrane lipid composition, morphology and growth kinetics from the parental cell lines. In this paper, we report the development of ht cell lines from other insect species and exami...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-011-3177-x
更新日期：2011-06-01 00:00:00
abstract：:Histone deacetylase (HDAC) inhibitors show clinical promise for the treatment of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the effect of HDAC inhibitor treatment on hepatitis C virus (HCV) replication in Huh7 human liver cells and in a mouse model of HCV infection. Viral replica...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-018-0057-7
更新日期：2018-10-01 00:00:00
abstract：:H9N2 subtype avian influenza virus (AIV) is an influenza A virus that is widely spread throughout Asia, where it jeopardizes the poultry industry and provides genetic material for emerging human pathogens. To better understand the epidemicity and genetics of H9 subtype AIVs, we conducted active surveillance in live po...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-020-00260-z
更新日期：2020-09-14 00:00:00
abstract：:The multifunctional trans-activator Tat is an essential regulatory protein for HIV-1 replication and is characterized by high sequence diversity. Numerous experimental studies have examined Tat in HIV-1 subtype B, but research on subtype C Tat is lacking, despite the high prevalence of infections caused by subtype C w...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-016-3681-0
更新日期：2016-06-01 00:00:00
abstract：:During virus infection, RIG-I-like receptors (RLRs) recognize viral RNAs and recruit the adaptor protein VISA to activate downstream signaling, leading to activation of transcription factors NF-κB and IRF3, which collaborate to induce type I interferons (IFNs). IFNs further induce expression of hundreds of IFN-stimula...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-020-00267-6
更新日期：2020-08-07 00:00:00
abstract：:Hepatitis B virus (HBV) infection is still a worldwide health problem; however, the current antiviral therapies for chronic hepatitis B are limited in efficacy. The outcome of HBV infection is thought to be the result of complex interactions between the HBV and the host immune system. While the role of the adaptive im...
journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-014-3412-3
更新日期：2014-02-01 00:00:00
