The Saffold Virus-Penang 2B and 3C Proteins, but not the L Protein, Induce Apoptosis in HEp-2 and Vero Cells.

abstract：:During virus infection, RIG-I-like receptors (RLRs) recognize viral RNAs and recruit the adaptor protein VISA to activate downstream signaling, leading to activation of transcription factors NF-κB and IRF3, which collaborate to induce type I interferons (IFNs). IFNs further induce expression of hundreds of IFN-stimula...

journal_title：Virologica Sinica

authors： Wang DP,Zhang HY,Liao BW,Tong Z,Xu ZS,Wang YY,Yang Y

更新日期：2020-08-07 00:00:00

abstract：:Southern rice black-streaked dwarf virus (SRBSDV) is a novel Fijivirus prevalent in rice in southern and central China, and northern Vietnam. Its genome has 10 segments of double-stranded RNA named S1 to S10 according to their size. An isolate of SRBSDV, JNi4, was obtained from naturally infected maize plants from Ji'...

journal_title：Virologica Sinica

authors： Yin X,Xu FF,Zheng FQ,Li XD,Liu BS,Zhang CQ

更新日期：2011-02-01 00:00:00

abstract：:The protein HTRP (human transcription regulator protein) is encoded by the differential gene htrp and induced by Herpes simplex virus type 1 (HSV-1) infection in KMB-17 cells. HTRP was found to interact with SAP30 (mSin3A Association Protein), one of the components of co-repressor complex mSin3A, which is part of the ...

journal_title：Virologica Sinica

authors： Chen J,Li YM,Li JF,Liu LD,Liao Y,Na RX,Wang JJ,Wang LC,Li QH

更新日期：2010-12-01 00:00:00

abstract：:An emerging mosquito-borne arbovirus named Zika virus (ZIKV), of the family Flaviviridae and genus Flavivirus, is becoming a global health threat. ZIKV infection was long neglected due to its sporadic nature and mild symptoms. However, recently, with its rapid spread from Asia to the Americas, affecting more than 30 c...

journal_title：Virologica Sinica

authors： Wang Z,Wang P,An J

更新日期：2016-04-01 00:00:00

abstract：:HIV-indeterminate Western blotting (WB) results are typically obtained in WB confirmatory assays, and the number of indeterminate samples may increase with the detection of HIV infections, which will present considerable challenges for the management of HIV/AIDS. Nucleic acid detection has been used as a laboratory te...

journal_title：Virologica Sinica

authors： Wu S,Gao M,Zheng J,Yan P,Wang W,Lu X,Qiu Y,Yan Y

更新日期：2019-08-01 00:00:00

abstract：:An exogenous avian leukosis virus (ALV) strain SDAU09C1 was isolated in DF-1 cells from one of 240 imported 1-day-old white meat-type grand parent breeder chicks. Inoculation of SDAU09C1 in ALV-free chickens induced antibody reactions specific to subgroup A or B. But gp85 amino acid sequence comparisons indicated that...

journal_title：Virologica Sinica

authors： Zhang QC,Zhao DM,Guo HJ,Cui ZZ

更新日期：2010-04-01 00:00:00

abstract：:Exosomes are cell-derived vesicles that are secreted by many eukaryotic cells. It has recently attracted attention as vehicles of intercellular communication. Virus-infected cells release exosomes, which contain viral proteins, RNA, and pathogenic molecules. However, the role of exosomes in virus infection process rem...

journal_title：Virologica Sinica

authors： Wang J,Wu F,Liu C,Dai W,Teng Y,Su W,Kong W,Gao F,Cai L,Hou A,Jiang C

更新日期：2019-02-01 00:00:00

abstract：:The epidemiology of HIV-1 varies in different areas of the world, and it is possible that this complexity may leave unique footprints in the viral genome. Thus, we attempted to find significant patterns in global HIV-1 genome sequences. By applying the rule inference algorithm RIPPER (Repeated Incremental Pruning to P...

journal_title：Virologica Sinica

authors： Wang Y,Rawi R,Hoffmann D,Sun B,Yang R

更新日期：2013-08-01 00:00:00

abstract：:The 5'-cap structures of eukaryotic mRNAs are important for RNA stability, pre-mRNA splicing, mRNA export, and protein translation. Many viruses have evolved mechanisms for generating their own cap structures with methylation at the N7 position of the capped guanine and the ribose 2'-Oposition of the first nucleotide,...

journal_title：Virologica Sinica

authors： Chen Y,Guo D

更新日期：2016-02-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is causally related to Kaposi's sarcoma (KS), primary effusion lymphoma (PEL) and a proportion of cases of multicentric Castleman's disease (MCD). The ORF73 protein was cloned into pQE80L-orf73 and expressed in E.coli and purified. The expressed recombinant ORF73 was iden...

journal_title：Virologica Sinica

authors： Ouyang XX,Fu BS,Li BL,Zeng Y,Xu FH,Wang LD

更新日期：2010-06-01 00:00:00

abstract：:Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in Pakistan, nasal (n = 77...

journal_title：Virologica Sinica

authors： Zohaib A,Saqib M,Athar MA,Chen J,Sial AU,Khan S,Taj Z,Sadia H,Tahir U,Tayyab MH,Qureshi MA,Mansoor MK,Naeem MA,Hu BJ,Khan BA,Ujjan ID,Li B,Zhang W,Luo Y,Zhu Y,Waruhiu C,Khan I,Yang XL,Sajid MS,Corman VM,

更新日期：2018-10-01 00:00:00

abstract：:Dengue virus (DENV) and Zika virus (ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery ...

journal_title：Virologica Sinica

authors： Ji Z,Li F,Xia Z,Guo X,Gao M,Sun F,Cheng Y,Wu Y,Li W,Ali SA,Cao Z

更新日期：2018-12-01 00:00:00

abstract：:A 62-year-old man had chronic hepatitis B virus (HBV) infection and was diagnosed with liver cirrhosis. At the time of diagnosis the patient's virologic markers were positive for hepatitis B surface antigen (HBsAg), antibody to hepatitis B e antigen (anti-HBe) and antibody to hepatitis B core antigen (anti-HBc), while...

journal_title：Virologica Sinica

authors： Wu C,Shi H,Wang Y,Lu M,Xu Y,Chen X

更新日期：2012-12-01 00:00:00

abstract：:Receptors interaction protein 2 (RIP2) is a specific adaptor molecule in the downstream of NOD2. The role of RIP2 during foot-and-mouth disease virus (FMDV) infection remains unknown. Here, our results showed that RIP2 inhibited FMDV replication and played an important role in the activation of IFN-β and NF-ĸB signal ...

journal_title：Virologica Sinica

authors： Liu H,Xue Q,Zhu Z,Yang F,Cao W,Liu X,Zheng H

更新日期：2021-01-05 00:00:00

abstract：:In this paper, in vitro anti-influenza virus activities of sulfated polysaccharide fractions from Gracilaria lemaneiformis were investigated. Cytotoxicities and antiviral activities of Gracilaria lemaneiformis polysaccharides (PGL), Gracilaria lemaneiformis polysaccharide fraction-1 (GL-1), Gracilaria lemaneiformis po...

journal_title：Virologica Sinica

authors： Chen MZ,Xie HG,Yang LW,Liao ZH,Yu J

更新日期：2010-10-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the key underlying cause of acute lower respiratory tract infection in infants; however, no licensed vaccine against RSV infection is currently available. This study was undertaken to assess the preventive effect of vaccine on RSV infection. In this metaanalysis, 1,792 published ra...

journal_title：Virologica Sinica

authors： Zhu T,Zhang C,Yu L,Chen J,Qiu H,Lyu W,Huang S

更新日期：2015-10-01 00:00:00

abstract：:Hepatitis E virus (HEV) is the prototype of the family Hepeviridae and the causative agent of common acute viral hepatitis. Genetically diverse HEV-related viruses have been detected in a variety of mammals and some of them may have zoonotic potential. In this study, we tested 278 specimens collected from seven wild s...

journal_title：Virologica Sinica

authors： Wang B,Li W,Zhou JH,Li B,Zhang W,Yang WH,Pan H,Wang LX,Bock CT,Shi ZL,Zhang YZ,Yang XL

更新日期：2018-02-01 00:00:00

abstract：:Feasible and effective cell models for hepatitis B virus (HBV) infection are required for investigating the complete lifecycle of this virus, including the early steps of viral entry. Resistance to dimethyl sulfoxide/polyethylene glycol (DMSO/PEG), hNTCP expression, and a differentiated state are the limiting factors ...

journal_title：Virologica Sinica

authors： Zhou M,Zhao K,Yao Y,Yuan Y,Pei R,Wang Y,Chen J,Hu X,Zhou Y,Chen X,Wu C

更新日期：2017-12-01 00:00:00

abstract：:Cancer cell lines have been used widely in cancer biology, and as biological or functional cell systems in many biomedical research fields. These cells are usually defective for many normal activities or functions due to significant genetic and epigenetic changes. Normal primary cell yields and viability from any orig...

journal_title：Virologica Sinica

authors： Liu X,Wu Y,Rong L

更新日期：2020-06-01 00:00:00

abstract：:Primate bocaparvovirus (BOV) is a possible cause of respiratory disorders and gastroenteritis in humans. However, the diversity and evolution of these viruses remain largely unknown, despite the identification of a growing number of BOVs in non-human primates (NHPs). Here, we report the identification of a novel BOV (...

journal_title：Virologica Sinica

authors： Ao Y,Duan Z

更新日期：2020-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV), a herpesvirus, is an important human pathogen that causes asymptomatic infections in healthy or immunocompetent individuals but can lead to severe and potentially life-threatening complications in immune-immature individuals such as neonates or immune-compromised patients such as organ-tr...

journal_title：Virologica Sinica

authors： Liu G,Hai R,Liu F

更新日期：2017-10-01 00:00:00

abstract：:Neutralizing antibodies are considered to be an important protective parameter used in HIV-1 vaccine evaluation. However, the exact role that neutralizing antibodies plays in controlling the disease progression of HIV-1 infected peoples is still undetermined. In this paper, we compared the protective function of the n...

journal_title：Virologica Sinica

authors： Wang Z,Li TY,Li JY,Chen LL,Liu YJ,Li HP,Bao ZY,Wang XL,Zhuang DM,Liu SY,Li L

更新日期：2012-06-01 00:00:00

abstract：:Human endogenous retrovirus W env (HERV-W env) plays a critical role in many neuropsychological diseases such as schizophrenia and multiple sclerosis (MS). These diseases are accompanied by immunological reactions in the central nervous system (CNS). Microglia are important immunocytes in brain inflammation that can p...

journal_title：Virologica Sinica

authors： Xiao R,Li S,Cao Q,Wang X,Yan Q,Tu X,Zhu Y,Zhu F

更新日期：2017-06-01 00:00:00

abstract：:Japanese encephalitis (JE) is a viral encephalitis disease caused by Japanese encephalitis virus (JEV) infection. Uncontrolled inflammatory responses in the central nervous system (CNS) are a hallmark of severe JE. Although the CCR2-CCL2 axis is important for monocytes trafficking during JEV infection, little is known...

journal_title：Virologica Sinica

authors： Zhang F,Qi L,Li T,Li X,Yang D,Cao S,Ye J,Wei B

更新日期：2019-10-01 00:00:00

abstract：:Ion channels are membrane proteins that are found in a number of viruses and which are of crucial physiological importance in the viral life cycle. They have one common feature in that their action mode involves a change of electrochemical or proton gradient across the bilayer lipid membrane which modulates viral or c...

journal_title：Virologica Sinica

authors： Liang X,Li ZY

更新日期：2010-08-01 00:00:00

abstract：:Lepidopteran heat-tolerant (ht) cell lines have been obtained with sf-9, sf-21 and several Bombyx cells. They have a distinct karyotype, membrane lipid composition, morphology and growth kinetics from the parental cell lines. In this paper, we report the development of ht cell lines from other insect species and exami...

journal_title：Virologica Sinica

authors： Wu YL,Jiang L,Hashimoto Y,Granados RR,Li GX

更新日期：2011-06-01 00:00:00

abstract：:Circular RNAs (circRNAs) belong to a class of non-coding RNAs with diverse biological functions. However, little is known about their roles in case of pseudorabies virus (PrV) infection. Here, we analyzed the expression profile of host circRNAs from a virulent PrV type II strain DX (PrV-DX) infected and an attenuated ...

journal_title：Virologica Sinica

authors： Li H,Tang W,Jin Y,Dong W,Yan Y,Zhou J

更新日期：2020-07-02 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors show clinical promise for the treatment of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the effect of HDAC inhibitor treatment on hepatitis C virus (HCV) replication in Huh7 human liver cells and in a mouse model of HCV infection. Viral replica...

journal_title：Virologica Sinica

authors： Zhou Y,Wang Q,Yang Q,Tang J,Xu C,Gai D,Chen X,Chen J

更新日期：2018-10-01 00:00:00

abstract：:Newcastle disease virus (NDV) and H9N2 subtype Avian influenza virus (AIV) are two notorious avian respiratory pathogens that cause great losses in the poultry industry. Current inactivated commercial vaccines against NDV and AIV have the disadvantages of inadequate mucosal responses, while an attenuated live vaccine ...

journal_title：Virologica Sinica

authors： Xu X,Qian J,Qin L,Li J,Xue C,Ding J,Wang W,Ding W,Yin R,Jin N,Ding Z

更新日期：2020-08-01 00:00:00

abstract：:Chikungunya virus (CHIKV) is a mosquito-borne virus that causes epidemics widely in the world especially in the tropical and subtropical regions. Phylogenetic analysis has found that the CHIKV lineages were associated with the spatial and temporal distributions, which were related to the virus adaption to the major mo...

journal_title：Virologica Sinica

authors： Shi J,Su Z,Fan Z,Wang J,Liu S,Zhang B,Wei H,Jehan S,Jamil N,Shen S,Deng F

更新日期：2017-12-01 00:00:00