Abstract：
:Histone deacetylase (HDAC) inhibitors show clinical promise for the treatment of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the effect of HDAC inhibitor treatment on hepatitis C virus (HCV) replication in Huh7 human liver cells and in a mouse model of HCV infection. Viral replication was markedly suppressed by the HDAC3 inhibitor at concentrations below 1 mmol/L, with no cellular toxicity. This was accompanied by upregulation of liver-expressed antimicrobial peptide 1(LEAP-1) and downregulation of apolipoprotein-A1 (Apo-A1), as determined by microarray and quantitative RT-PCR analyses. Moreover, HDAC3 was found to modulate the binding of CCAAT-enhancer-binding protein α (C/EBPα), hypoxia-inducible factor 1α (HIF1α), and signal transducer and activator of transcription 3 (STAT3) to the LEAP-1 promoter. HDAC3 inhibitor treatment also blocked HCV replication in a mouse model of HCV infection. These results indicate that epigenetic therapy with HDAC3 inhibitor may be a potential treatment for diseases associated with HCV infection such as HCC.
journal_name
Virol Sinjournal_title
Virologica Sinicaauthors
Zhou Y,Wang Q,Yang Q,Tang J,Xu C,Gai D,Chen X,Chen Jdoi
10.1007/s12250-018-0057-7subject
Has Abstractpub_date
2018-10-01 00:00:00pages
418-428issue
5eissn
1674-0769issn
1995-820Xpii
10.1007/s12250-018-0057-7journal_volume
33pub_type
杂志文章abstract：:Receptors interaction protein 2 (RIP2) is a specific adaptor molecule in the downstream of NOD2. The role of RIP2 during foot-and-mouth disease virus (FMDV) infection remains unknown. Here, our results showed that RIP2 inhibited FMDV replication and played an important role in the activation of IFN-β and NF-ĸB signal ...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-020-00322-2
更新日期：2021-01-05 00:00:00
abstract：:An emerging mosquito-borne arbovirus named Zika virus (ZIKV), of the family Flaviviridae and genus Flavivirus, is becoming a global health threat. ZIKV infection was long neglected due to its sporadic nature and mild symptoms. However, recently, with its rapid spread from Asia to the Americas, affecting more than 30 c...
journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-016-3780-y
更新日期：2016-04-01 00:00:00
abstract：:During transcription initiation, RNA polymerase binds tightly to the promoter DNA defining the start of transcription, transcribes comparatively slowly, and frequently releases short transcripts (3-8 nucleotides) in a process called abortive cycling. Transitioning to elongation, the second phase of transcription, the ...
journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-013-3397-3
更新日期：2013-12-01 00:00:00
abstract：:During virus infection, RIG-I-like receptors (RLRs) recognize viral RNAs and recruit the adaptor protein VISA to activate downstream signaling, leading to activation of transcription factors NF-κB and IRF3, which collaborate to induce type I interferons (IFNs). IFNs further induce expression of hundreds of IFN-stimula...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-020-00267-6
更新日期：2020-08-07 00:00:00
abstract：:The recent emergence and rapid global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pose an unprecedented medical and socioeconomic crisis, and the disease caused by it, Coronavirus disease 2019 (COVID-19), was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. C...
journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-020-00298-z
更新日期：2020-12-01 00:00:00
abstract：:Banana bunchy top virus (BBTV), family Nanaviridae, genus Babuvirus, is a single stranded DNA virus (ssDNA) that causes banana bunchy top disease (BBTD) in banana plants. It is the most common and most destructive of all viruses in these plants and is widespread throughout the Asia-Pacific region. In this study we iso...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-011-3196-7
更新日期：2011-08-01 00:00:00
abstract：:Bat SARS-like coronavirus (SL-CoV) has a genome organization almost identical to that of SARS-CoV, but the N-terminus of the Spike (S) proteins, which interacts with host receptor and is a major target of neutralizing antibodies against CoVs, of the two viruses has only 63-64% sequence identity. Although there have be...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-013-3292-y
更新日期：2013-04-01 00:00:00
abstract：:Circular RNAs (circRNAs) belong to a class of non-coding RNAs with diverse biological functions. However, little is known about their roles in case of pseudorabies virus (PrV) infection. Here, we analyzed the expression profile of host circRNAs from a virulent PrV type II strain DX (PrV-DX) infected and an attenuated ...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-020-00255-w
更新日期：2020-07-02 00:00:00
abstract：:Dengue virus (DENV) and Zika virus (ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery ...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-018-0068-4
更新日期：2018-12-01 00:00:00
abstract：:Effective oral infection is set off by interaction of a group of conserved per os infectivity factors (PIFs) with larval midgut columnar epithelial cells. We constructed pseudotyped viruses by substituting pif1, pif2 or pif3 genes of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) with their homologs from Mamestra...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-018-0014-5
更新日期：2018-04-01 00:00:00
abstract：:Shiga toxin B-subunit (STxB) from Shigella dysenteriae targets in vivo antigen to cancer cells, dendritic cells (DC) and B cells, which preferentially express the globotriaosylceramide (Gb3) receptor. This pivotal role has encouraged scientists to investigate fusing STxB with other clinical antigens. Due to the challe...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-013-3286-9
更新日期：2013-02-01 00:00:00
abstract：:Japanese encephalitis (JE) is a viral encephalitis disease caused by Japanese encephalitis virus (JEV) infection. Uncontrolled inflammatory responses in the central nervous system (CNS) are a hallmark of severe JE. Although the CCR2-CCL2 axis is important for monocytes trafficking during JEV infection, little is known...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-019-00134-z
更新日期：2019-10-01 00:00:00
abstract：:Oncolytic alphavirus M1 has been shown to selectively target and kill cancer cells, but cytopathic morphologies induced by M1 virus and the life cycle of the M1 strain in cancer cells remain unclear. Here, we study the key stages of M1 virus infection and replication in the M1 virus-sensitive HepG2 liver cancer cell l...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-020-00339-7
更新日期：2021-01-22 00:00:00
abstract：:Cancer cell lines have been used widely in cancer biology, and as biological or functional cell systems in many biomedical research fields. These cells are usually defective for many normal activities or functions due to significant genetic and epigenetic changes. Normal primary cell yields and viability from any orig...
journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-020-00244-z
更新日期：2020-06-01 00:00:00
abstract：:Neutralizing antibodies are considered to be an important protective parameter used in HIV-1 vaccine evaluation. However, the exact role that neutralizing antibodies plays in controlling the disease progression of HIV-1 infected peoples is still undetermined. In this paper, we compared the protective function of the n...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-012-3239-8
更新日期：2012-06-01 00:00:00
abstract：:Avian infectious bronchitis virus (IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopatho...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-015-3696-y
更新日期：2016-02-01 00:00:00
abstract：:Conventional influenza vaccines need to be designed and manufactured yearly. However, they occasionally provide poor protection owing to antigenic mismatch. Hence, there is an urgent need to develop universal vaccines against influenza virus. Using nucleoprotein (NP) and extracellular domain of matrix protein 2 (M2e) ...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-019-00138-9
更新日期：2019-10-01 00:00:00
abstract：:In this study, the coding region of type O FMDV capsid protein VP1 and a series of codon optimized DNA sequences coding for VP1 amino acid residues 141-160 (epitope1), tandem repeat 200-213 (epitope2 (+2)) and the combination of two epitopes (epitope1-2) was genetically cloned into the prokaryotic expression vector pP...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-010-3041-4
更新日期：2010-02-01 00:00:00
abstract：:Recreational waters contaminated with human fecal pollution are a public health concern, and ensuring the safety of recreational waters for public use is a priority of both the Environmental Protection Agency (EPA) and the Centers for Disease Control and Prevention (CDC). Current recreational water standards rely on f...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-015-3644-x
更新日期：2015-10-01 00:00:00
abstract：:Hepatitis E virus (HEV) is the prototype of the family Hepeviridae and the causative agent of common acute viral hepatitis. Genetically diverse HEV-related viruses have been detected in a variety of mammals and some of them may have zoonotic potential. In this study, we tested 278 specimens collected from seven wild s...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-018-0011-8
更新日期：2018-02-01 00:00:00
abstract：:Our previous work has shown that Saffold virus (SAFV) induced several rodent and primate cell lines to undergo apoptosis (Xu et al. in Emerg Microb Infect 3:1-8, 2014), but the essential viral proteins of SAFV involved in apoptotic activity lack study. In this study, we individually transfected the viral proteins of S...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-019-00116-1
更新日期：2019-06-01 00:00:00
abstract：:Chikungunya virus (CHIKV) is a mosquito-borne virus that causes epidemics widely in the world especially in the tropical and subtropical regions. Phylogenetic analysis has found that the CHIKV lineages were associated with the spatial and temporal distributions, which were related to the virus adaption to the major mo...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-017-4077-5
更新日期：2017-12-01 00:00:00
abstract：:The temporal change patterns of laboratory data may provide insightful clues into the whole course of COVID-19. This study aimed to evaluate longitudinal change patterns of key laboratory tests in patients with COVID-19, and identify independent prognostic factors by examining the associations between laboratory findi...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-020-00317-z
更新日期：2020-12-01 00:00:00
abstract：:Porcine respiratory disease complex (PRDC) is a serious health problem that mainly affects growing and finishing pigs. PRDC is caused by a combination of viral and bacterial agents, such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), Mycoplasma hyopneumoniae (Myh), Actinob...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-014-3471-5
更新日期：2014-08-01 00:00:00
abstract：:Ebola virus (EBOV) and Marburg virus (MARV), belonging to the Filoviridae family, emerged four decades ago and caused severe viral hemorrhagic fever in human and other primates. As high as 50-90% mortality, filoviruses can cause significant threats to public health. However, so far no specific and efficient vaccine ha...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-011-3186-9
更新日期：2011-04-01 00:00:00
abstract：:The protein HTRP (human transcription regulator protein) is encoded by the differential gene htrp and induced by Herpes simplex virus type 1 (HSV-1) infection in KMB-17 cells. HTRP was found to interact with SAP30 (mSin3A Association Protein), one of the components of co-repressor complex mSin3A, which is part of the ...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-010-3147-8
更新日期：2010-12-01 00:00:00
abstract：:Hepatitis B virus (HBV) infection is still a worldwide health problem; however, the current antiviral therapies for chronic hepatitis B are limited in efficacy. The outcome of HBV infection is thought to be the result of complex interactions between the HBV and the host immune system. While the role of the adaptive im...
journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-014-3412-3
更新日期：2014-02-01 00:00:00
abstract：:A 62-year-old man had chronic hepatitis B virus (HBV) infection and was diagnosed with liver cirrhosis. At the time of diagnosis the patient's virologic markers were positive for hepatitis B surface antigen (HBsAg), antibody to hepatitis B e antigen (anti-HBe) and antibody to hepatitis B core antigen (anti-HBc), while...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-012-3284-3
更新日期：2012-12-01 00:00:00
abstract：:Primate bocaparvovirus (BOV) is a possible cause of respiratory disorders and gastroenteritis in humans. However, the diversity and evolution of these viruses remain largely unknown, despite the identification of a growing number of BOVs in non-human primates (NHPs). Here, we report the identification of a novel BOV (...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-019-00163-8
更新日期：2020-02-01 00:00:00
abstract：:Similar to Hepatitis C virus (HCV) infection in humans, HCVcc infection can also result in persistent and chronic infection. The core protein is a variable protein and exists in several sizes. Some sizes of core proteins have been reported to be related to chronic HCV infection. To study the possible role of the core ...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-013-3296-7
更新日期：2013-06-01 00:00:00
