Abstract:
:The 5'-cap structures of eukaryotic mRNAs are important for RNA stability, pre-mRNA splicing, mRNA export, and protein translation. Many viruses have evolved mechanisms for generating their own cap structures with methylation at the N7 position of the capped guanine and the ribose 2'-Oposition of the first nucleotide, which help viral RNAs escape recognition by the host innate immune system. The RNA genomes of coronavirus were identified to have 5'-caps in the early 1980s. However, for decades the RNA capping mechanisms of coronaviruses remained unknown. Since 2003, the outbreak of severe acute respiratory syndrome coronavirus has drawn increased attention and stimulated numerous studies on the molecular virology of coronaviruses. Here, we review the current understanding of the mechanisms adopted by coronaviruses to produce the 5'-cap structure and methylation modification of viral genomic RNAs.
journal_name
Virol Sinjournal_title
Virologica Sinicaauthors
Chen Y,Guo Ddoi
10.1007/s12250-016-3726-4subject
Has Abstractpub_date
2016-02-01 00:00:00pages
3-11issue
1eissn
1674-0769issn
1995-820Xpii
10.1007/s12250-016-3726-4journal_volume
31pub_type
杂志文章,评审abstract::Conventional influenza vaccines need to be designed and manufactured yearly. However, they occasionally provide poor protection owing to antigenic mismatch. Hence, there is an urgent need to develop universal vaccines against influenza virus. Using nucleoprotein (NP) and extracellular domain of matrix protein 2 (M2e) ...
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journal_title:Virologica Sinica
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journal_title:Virologica Sinica
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journal_title:Virologica Sinica
pub_type: 杂志文章,meta分析
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pub_type: 杂志文章
doi:10.1007/s12250-010-3137-x
更新日期:2010-10-01 00:00:00
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更新日期:2016-12-01 00:00:00
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journal_title:Virologica Sinica
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doi:10.1007/s12250-016-3872-8
更新日期:2017-02-01 00:00:00
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journal_title:Virologica Sinica
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journal_title:Virologica Sinica
pub_type: 杂志文章,评审
doi:10.1007/s12250-014-3412-3
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doi:10.1007/s12250-020-00322-2
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pub_type: 杂志文章,评审
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journal_title:Virologica Sinica
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