Abstract：
:Severe fever with thrombocytopenia syndrome virus (SFTSV), the causative agent of a febrile human disease, was first identified from central and eastern provinces in China, and later in Japan and South Korea. Hubei Province is one of the major SFTS epidemic areas in the central part of China. This study reported the isolation of 11 new SFTSV strains from patients in Hubei Province collected in 2017. Extensive phylogenetic analyses were conducted based on the complete coding sequences of SFTSV segments including the new strains. It was suggested that five different SFTSV genotypes were circulating in Hubei, and 15 reassortment patterns and migration pathways correlated with each genotype were identified, which was more than previously recognized. Hubei Province was more involved in the evolutionary events of SFTSV than that previously thought in which the evolutionary events of SFTSV were reported to be independent from those in other epidemic regions. Further divergence of SFTSV strains was suggested by pairwise comparison of SFTSV sequences from each genotype and sequence identity normalized to representative strain in genotype C1. Subsequently, amino acid variations specific for genotype(s), strain(s), or cluster(s) were inspected, which may be related to differential biological activity of SFTSV strains/genotypes. In conclusion, we analyzed the current status of SFTSV phylogeny in Hubei Province and discussed the possible events correlated to SFTSV evolution. It provided an in-depth insight into SFTSV evolution, raising concerns for the use of proper SFTSV strains in future studies.
journal_name
Virol Sinjournal_title
Virologica Sinicaauthors
Wu X,Li M,Zhang Y,Liang B,Shi J,Fang Y,Su Z,Li M,Zhang W,Xu L,Wang J,Wu Q,Tang S,Wang H,Zhang T,Peng C,Zheng X,Deng F,Shen Sdoi
10.1007/s12250-020-00289-0subject
Has Abstractpub_date
2020-09-22 00:00:00eissn
1674-0769issn
1995-820Xpii
10.1007/s12250-020-00289-0pub_type
杂志文章abstract：:Hepatitis C virus (HCV) is a global health concern, notably in Southeast Asia, and in Laos the presentation of the HCV-induced liver disease is poorly known. Our objective was thus to describe a comprehensive HCV infection pattern in order to guide national health policies. A study on a group of 1765 patients formerly...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-018-0039-9
更新日期：2018-08-01 00:00:00
abstract：:Ion channels are membrane proteins that are found in a number of viruses and which are of crucial physiological importance in the viral life cycle. They have one common feature in that their action mode involves a change of electrochemical or proton gradient across the bilayer lipid membrane which modulates viral or c...
journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-010-3136-y
更新日期：2010-08-01 00:00:00
abstract：:The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics o...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-016-3872-8
更新日期：2017-02-01 00:00:00
abstract：:The papain-like protease (PL(pro)) of Middle-East respiratory syndrome coronavirus (MERS-CoV) has proteolytic, deubiquitinating, and deISGylating activities. The latter two are involved in the suppression of the antiviral innate immune response of the host cell. To contribute to an understanding of this process, we pr...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-016-3742-4
更新日期：2016-08-01 00:00:00
abstract：:Southern rice black-streaked dwarf virus (SRBSDV) is a novel Fijivirus prevalent in rice in southern and central China, and northern Vietnam. Its genome has 10 segments of double-stranded RNA named S1 to S10 according to their size. An isolate of SRBSDV, JNi4, was obtained from naturally infected maize plants from Ji'...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-011-3170-9
更新日期：2011-02-01 00:00:00
abstract：:The 5'-cap structures of eukaryotic mRNAs are important for RNA stability, pre-mRNA splicing, mRNA export, and protein translation. Many viruses have evolved mechanisms for generating their own cap structures with methylation at the N7 position of the capped guanine and the ribose 2'-Oposition of the first nucleotide,...
journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-016-3726-4
更新日期：2016-02-01 00:00:00
abstract：:Ebola virus (EBOV) and Marburg virus (MARV) are causative agents of severe hemorrhagic fever with high mortality rates in humans and non-human primates and there is currently no licensed vaccine or therapeutics. To date, there is no specific laboratory diagnostic test in China, while there is a national need to provid...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-012-3252-y
更新日期：2012-10-01 00:00:00
abstract：:A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-o...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-016-3750-4
更新日期：2016-08-01 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-020-00240-3
更新日期：2020-07-08 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-020-00244-z
更新日期：2020-06-01 00:00:00
abstract：:Hepatitis E virus (HEV) is the prototype of the family Hepeviridae and the causative agent of common acute viral hepatitis. Genetically diverse HEV-related viruses have been detected in a variety of mammals and some of them may have zoonotic potential. In this study, we tested 278 specimens collected from seven wild s...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-018-0011-8
更新日期：2018-02-01 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-019-00094-4
更新日期：2019-06-01 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-019-00130-3
更新日期：2019-08-01 00:00:00
abstract：:Human cytomegalovirus (HCMV), a herpesvirus, is an important human pathogen that causes asymptomatic infections in healthy or immunocompetent individuals but can lead to severe and potentially life-threatening complications in immune-immature individuals such as neonates or immune-compromised patients such as organ-tr...
journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-017-4055-y
更新日期：2017-10-01 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-012-3239-8
更新日期：2012-06-01 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-013-3296-7
更新日期：2013-06-01 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-011-3213-x
更新日期：2011-12-01 00:00:00
abstract：:A 62-year-old man had chronic hepatitis B virus (HBV) infection and was diagnosed with liver cirrhosis. At the time of diagnosis the patient's virologic markers were positive for hepatitis B surface antigen (HBsAg), antibody to hepatitis B e antigen (anti-HBe) and antibody to hepatitis B core antigen (anti-HBc), while...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-012-3284-3
更新日期：2012-12-01 00:00:00
abstract：:The recent emergence and rapid global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pose an unprecedented medical and socioeconomic crisis, and the disease caused by it, Coronavirus disease 2019 (COVID-19), was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. C...
journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-020-00298-z
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journal_title：Virologica Sinica
pub_type： 杂志文章,评审
doi：10.1007/s12250-013-3397-3
更新日期：2013-12-01 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章,meta分析
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更新日期：2015-10-01 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-020-00259-6
更新日期：2020-07-28 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-015-3696-y
更新日期：2016-02-01 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-013-3286-9
更新日期：2013-02-01 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-015-3644-x
更新日期：2015-10-01 00:00:00
abstract：:The epidemiology of HIV-1 varies in different areas of the world, and it is possible that this complexity may leave unique footprints in the viral genome. Thus, we attempted to find significant patterns in global HIV-1 genome sequences. By applying the rule inference algorithm RIPPER (Repeated Incremental Pruning to P...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-013-3348-z
更新日期：2013-08-01 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-019-00134-z
更新日期：2019-10-01 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-010-3106-4
更新日期：2010-06-01 00:00:00
abstract：:Banana bunchy top virus (BBTV), family Nanaviridae, genus Babuvirus, is a single stranded DNA virus (ssDNA) that causes banana bunchy top disease (BBTD) in banana plants. It is the most common and most destructive of all viruses in these plants and is widespread throughout the Asia-Pacific region. In this study we iso...
journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-011-3196-7
更新日期：2011-08-01 00:00:00
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journal_title：Virologica Sinica
pub_type： 杂志文章
doi：10.1007/s12250-020-00322-2
更新日期：2021-01-05 00:00:00
