Bovine herpesvirus 1 protein bICP0 represses the transcription of bISG15 in fetal bovine lung cells.

abstract：:Ebola virus (EBOV) and Marburg virus (MARV) are causative agents of severe hemorrhagic fever with high mortality rates in humans and non-human primates and there is currently no licensed vaccine or therapeutics. To date, there is no specific laboratory diagnostic test in China, while there is a national need to provid...

journal_title：Virologica Sinica

authors： Huang Y,Wei H,Wang Y,Shi Z,Raoul H,Yuan Z

更新日期：2012-10-01 00:00:00

abstract：:Severe fever with thrombocytopenia syndrome virus (SFTSV), the causative agent of a febrile human disease, was first identified from central and eastern provinces in China, and later in Japan and South Korea. Hubei Province is one of the major SFTS epidemic areas in the central part of China. This study reported the i...

journal_title：Virologica Sinica

authors： Wu X,Li M,Zhang Y,Liang B,Shi J,Fang Y,Su Z,Li M,Zhang W,Xu L,Wang J,Wu Q,Tang S,Wang H,Zhang T,Peng C,Zheng X,Deng F,Shen S

更新日期：2020-09-22 00:00:00

abstract：:In this study, the decay of maternal peste des petits ruminants virus (PPRV) antibodies in kids born to goats vaccinated with Asian lineage IV PPR vaccine and the efficacy of passive immunity against PPRV was assessed to determine the appropriate period for vaccination in kids. Serum samples collected from kids born t...

journal_title：Virologica Sinica

authors： Balamurugan V,Sen A,Venkatesan G,Rajak KK,Bhanuprakash V,Singh RK

更新日期：2012-08-01 00:00:00

abstract：:A 62-year-old man had chronic hepatitis B virus (HBV) infection and was diagnosed with liver cirrhosis. At the time of diagnosis the patient's virologic markers were positive for hepatitis B surface antigen (HBsAg), antibody to hepatitis B e antigen (anti-HBe) and antibody to hepatitis B core antigen (anti-HBc), while...

journal_title：Virologica Sinica

authors： Wu C,Shi H,Wang Y,Lu M,Xu Y,Chen X

更新日期：2012-12-01 00:00:00

abstract：:Ebola virus (EBOV) causes severe hemorrhagic fever in humans and non-human primates with high rates of fatality. Glycoprotein (GP) is the only envelope protein of EBOV, which may play a critical role in virus attachment and entry as well as stimulating host protective immune responses. However, the lack of expression ...

journal_title：Virologica Sinica

authors： Zai J,Yi Y,Xia H,Zhang B,Yuan Z

更新日期：2016-12-01 00:00:00

abstract：:Cancer cell lines have been used widely in cancer biology, and as biological or functional cell systems in many biomedical research fields. These cells are usually defective for many normal activities or functions due to significant genetic and epigenetic changes. Normal primary cell yields and viability from any orig...

journal_title：Virologica Sinica

authors： Liu X,Wu Y,Rong L

更新日期：2020-06-01 00:00:00

abstract：:In this paper, in vitro anti-influenza virus activities of sulfated polysaccharide fractions from Gracilaria lemaneiformis were investigated. Cytotoxicities and antiviral activities of Gracilaria lemaneiformis polysaccharides (PGL), Gracilaria lemaneiformis polysaccharide fraction-1 (GL-1), Gracilaria lemaneiformis po...

journal_title：Virologica Sinica

authors： Chen MZ,Xie HG,Yang LW,Liao ZH,Yu J

更新日期：2010-10-01 00:00:00

abstract：:Neutralizing antibodies are considered to be an important protective parameter used in HIV-1 vaccine evaluation. However, the exact role that neutralizing antibodies plays in controlling the disease progression of HIV-1 infected peoples is still undetermined. In this paper, we compared the protective function of the n...

journal_title：Virologica Sinica

authors： Wang Z,Li TY,Li JY,Chen LL,Liu YJ,Li HP,Bao ZY,Wang XL,Zhuang DM,Liu SY,Li L

更新日期：2012-06-01 00:00:00

abstract：:Avian infectious bronchitis virus (IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopatho...

journal_title：Virologica Sinica

authors： He Y,Xie Z,Dai J,Cao Y,Hou J,Zheng Y,Wei T,Mo M,Wei P

更新日期：2016-02-01 00:00:00

abstract：:Exosomes are cell-derived vesicles that are secreted by many eukaryotic cells. It has recently attracted attention as vehicles of intercellular communication. Virus-infected cells release exosomes, which contain viral proteins, RNA, and pathogenic molecules. However, the role of exosomes in virus infection process rem...

journal_title：Virologica Sinica

authors： Wang J,Wu F,Liu C,Dai W,Teng Y,Su W,Kong W,Gao F,Cai L,Hou A,Jiang C

更新日期：2019-02-01 00:00:00

abstract：:The papain-like protease (PL(pro)) of Middle-East respiratory syndrome coronavirus (MERS-CoV) has proteolytic, deubiquitinating, and deISGylating activities. The latter two are involved in the suppression of the antiviral innate immune response of the host cell. To contribute to an understanding of this process, we pr...

journal_title：Virologica Sinica

authors： Lei J,Hilgenfeld R

更新日期：2016-08-01 00:00:00

abstract：:Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in Pakistan, nasal (n = 77...

journal_title：Virologica Sinica

authors： Zohaib A,Saqib M,Athar MA,Chen J,Sial AU,Khan S,Taj Z,Sadia H,Tahir U,Tayyab MH,Qureshi MA,Mansoor MK,Naeem MA,Hu BJ,Khan BA,Ujjan ID,Li B,Zhang W,Luo Y,Zhu Y,Waruhiu C,Khan I,Yang XL,Sajid MS,Corman VM,

更新日期：2018-10-01 00:00:00

abstract：:Human endogenous retrovirus W env (HERV-W env) plays a critical role in many neuropsychological diseases such as schizophrenia and multiple sclerosis (MS). These diseases are accompanied by immunological reactions in the central nervous system (CNS). Microglia are important immunocytes in brain inflammation that can p...

journal_title：Virologica Sinica

authors： Xiao R,Li S,Cao Q,Wang X,Yan Q,Tu X,Zhu Y,Zhu F

更新日期：2017-06-01 00:00:00

abstract：:An exogenous avian leukosis virus (ALV) strain SDAU09C1 was isolated in DF-1 cells from one of 240 imported 1-day-old white meat-type grand parent breeder chicks. Inoculation of SDAU09C1 in ALV-free chickens induced antibody reactions specific to subgroup A or B. But gp85 amino acid sequence comparisons indicated that...

journal_title：Virologica Sinica

authors： Zhang QC,Zhao DM,Guo HJ,Cui ZZ

更新日期：2010-04-01 00:00:00

abstract：:The aim of the work is the comparison of the epidemiology of influenza and acute respiratory virus infections (ARVI) in the Republic of Kazakhstan with the corresponding influenza epidemic in Russia induced by influenza pandemic virus A/California/07/2009 in 2009. Data on influenza and ARVI from the Republic of Kazakh...

journal_title：Virologica Sinica

authors： Karpova LS,Popovtseva NM,Stolyarova TP,Stolyarov KA,Mamadaliyev SM,Khairullin BM,Sandybayev NT,Kydyrbayev ZhK,Orynbayev MB,Ospanov KS,Baiserkin BS,Boibosinov EU

更新日期：2011-10-01 00:00:00

abstract：:The 5'-cap structures of eukaryotic mRNAs are important for RNA stability, pre-mRNA splicing, mRNA export, and protein translation. Many viruses have evolved mechanisms for generating their own cap structures with methylation at the N7 position of the capped guanine and the ribose 2'-Oposition of the first nucleotide,...

journal_title：Virologica Sinica

authors： Chen Y,Guo D

更新日期：2016-02-01 00:00:00

abstract：:The temporal change patterns of laboratory data may provide insightful clues into the whole course of COVID-19. This study aimed to evaluate longitudinal change patterns of key laboratory tests in patients with COVID-19, and identify independent prognostic factors by examining the associations between laboratory findi...

journal_title：Virologica Sinica

authors： Tian S,Zhu X,Sun X,Wang J,Zhou Q,Wang C,Chen L,Li S,Xu J

更新日期：2020-12-01 00:00:00

abstract：:Banana bunchy top virus (BBTV), family Nanaviridae, genus Babuvirus, is a single stranded DNA virus (ssDNA) that causes banana bunchy top disease (BBTD) in banana plants. It is the most common and most destructive of all viruses in these plants and is widespread throughout the Asia-Pacific region. In this study we iso...

journal_title：Virologica Sinica

authors： Yu NT,Feng TC,Zhang YL,Wang JH,Liu ZX

更新日期：2011-08-01 00:00:00

abstract：:The virus receptors are key for the viral infection of host cells. Identification of the virus receptors is still challenging at present. Our previous study has shown that human virus receptor proteins have some unique features including high N-glycosylation level, high number of interaction partners and high expressi...

journal_title：Virologica Sinica

authors： Zhang Z,Ye S,Wu A,Jiang T,Peng Y

更新日期：2020-07-28 00:00:00

abstract：:H9N2 subtype avian influenza virus (AIV) is an influenza A virus that is widely spread throughout Asia, where it jeopardizes the poultry industry and provides genetic material for emerging human pathogens. To better understand the epidemicity and genetics of H9 subtype AIVs, we conducted active surveillance in live po...

journal_title：Virologica Sinica

authors： Hu Z,Peng F,Xiong Z,Zhang W,Li T,Shi Y,Xie J,Jin X,Huang J,Xiao H,Bi D,Song N,Li Z

更新日期：2020-09-14 00:00:00

abstract：:Newcastle disease virus (NDV) and H9N2 subtype Avian influenza virus (AIV) are two notorious avian respiratory pathogens that cause great losses in the poultry industry. Current inactivated commercial vaccines against NDV and AIV have the disadvantages of inadequate mucosal responses, while an attenuated live vaccine ...

journal_title：Virologica Sinica

authors： Xu X,Qian J,Qin L,Li J,Xue C,Ding J,Wang W,Ding W,Yin R,Jin N,Ding Z

更新日期：2020-08-01 00:00:00

abstract：:Isolates of Newcastle disease virus (NDV) from deceased wild and domestic pigeons in Kazakhstan were obtained from the Almaty region during 2005 and were genotypically analyzed by using reverse transcription polymerase chain reaction (RT-PCR) with primers specific to the viral fusion (F) protein gene. Part of the ampl...

journal_title：Virologica Sinica

authors： Bogoyavlenskiy A,Berezin V,Prilipov A,Usachev E,Korotetskiy I,Zaitceva I,Kydyrmanov A,Sayatov M

更新日期：2012-04-01 00:00:00

abstract：:Circular RNAs (circRNAs) belong to a class of non-coding RNAs with diverse biological functions. However, little is known about their roles in case of pseudorabies virus (PrV) infection. Here, we analyzed the expression profile of host circRNAs from a virulent PrV type II strain DX (PrV-DX) infected and an attenuated ...

journal_title：Virologica Sinica

authors： Li H,Tang W,Jin Y,Dong W,Yan Y,Zhou J

更新日期：2020-07-02 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is causally related to Kaposi's sarcoma (KS), primary effusion lymphoma (PEL) and a proportion of cases of multicentric Castleman's disease (MCD). The ORF73 protein was cloned into pQE80L-orf73 and expressed in E.coli and purified. The expressed recombinant ORF73 was iden...

journal_title：Virologica Sinica

authors： Ouyang XX,Fu BS,Li BL,Zeng Y,Xu FH,Wang LD

更新日期：2010-06-01 00:00:00

abstract：:Conventional influenza vaccines need to be designed and manufactured yearly. However, they occasionally provide poor protection owing to antigenic mismatch. Hence, there is an urgent need to develop universal vaccines against influenza virus. Using nucleoprotein (NP) and extracellular domain of matrix protein 2 (M2e) ...

journal_title：Virologica Sinica

authors： Wang W,Huang B,Wang X,Tan W,Ruan L

更新日期：2019-10-01 00:00:00

abstract：:Ebola virus (EBOV) and Marburg virus (MARV), belonging to the Filoviridae family, emerged four decades ago and caused severe viral hemorrhagic fever in human and other primates. As high as 50-90% mortality, filoviruses can cause significant threats to public health. However, so far no specific and efficient vaccine ha...

journal_title：Virologica Sinica

authors： Wang YP,Zhang XE,Wei HP

更新日期：2011-04-01 00:00:00

abstract：:Laos is the only landlocked country in Southeast Asia and borders Thailand, Myanmar and Cambodia, the three countries in this region that have been hardest hit by human immunodeficiency virus (HIV). Laos has been regarded as a low-HIV-prevalence country for decades. To understand the status of HIV in Laos in recent ye...

journal_title：Virologica Sinica

authors： Chen X,Ye M,Wang Y,Zhang C,Zheng YT

更新日期：2020-10-01 00:00:00

abstract：:Effective oral infection is set off by interaction of a group of conserved per os infectivity factors (PIFs) with larval midgut columnar epithelial cells. We constructed pseudotyped viruses by substituting pif1, pif2 or pif3 genes of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) with their homologs from Mamestra...

journal_title：Virologica Sinica

authors： Makalliwa GA,Wang X,Zhang H,Zhang N,Chen C,Li J,Deng F,Wang H,Wang M,Hu Z

更新日期：2018-04-01 00:00:00

abstract：:Conventional influenza vaccines are based on predicting the circulating viruses year by year, conferring limited effectiveness since the antigenicity of vaccine strains does not always match the circulating viruses. This necessitates development of universal influenza vaccines that provide broader and lasting protecti...

journal_title：Virologica Sinica

authors： Du R,Cui Q,Rong L

更新日期：2020-09-01 00:00:00

abstract：:HIV-indeterminate Western blotting (WB) results are typically obtained in WB confirmatory assays, and the number of indeterminate samples may increase with the detection of HIV infections, which will present considerable challenges for the management of HIV/AIDS. Nucleic acid detection has been used as a laboratory te...

journal_title：Virologica Sinica

authors： Wu S,Gao M,Zheng J,Yan P,Wang W,Lu X,Qiu Y,Yan Y

更新日期：2019-08-01 00:00:00