Abstract:
:The virus receptors are key for the viral infection of host cells. Identification of the virus receptors is still challenging at present. Our previous study has shown that human virus receptor proteins have some unique features including high N-glycosylation level, high number of interaction partners and high expression level. Here, a random-forest model was built to identify human virus receptorome from human cell membrane proteins with an accepted accuracy based on the combination of the unique features of human virus receptors and protein sequences. A total of 1424 human cell membrane proteins were predicted to constitute the receptorome of the human-infecting virome. In addition, the combination of the random-forest model with protein-protein interactions between human and viruses predicted in previous studies enabled further prediction of the receptors for 693 human-infecting viruses, such as the enterovirus, norovirus and West Nile virus. Finally, the candidate alternative receptors of the SARS-CoV-2 were also predicted in this study. As far as we know, this study is the first attempt to predict the receptorome for the human-infecting virome and would greatly facilitate the identification of the receptors for viruses.
journal_name
Virol Sinjournal_title
Virologica Sinicaauthors
Zhang Z,Ye S,Wu A,Jiang T,Peng Ydoi
10.1007/s12250-020-00259-6subject
Has Abstractpub_date
2020-07-28 00:00:00eissn
1674-0769issn
1995-820Xpii
10.1007/s12250-020-00259-6pub_type
杂志文章abstract::Porcine respiratory disease complex (PRDC) is a serious health problem that mainly affects growing and finishing pigs. PRDC is caused by a combination of viral and bacterial agents, such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), Mycoplasma hyopneumoniae (Myh), Actinob...
journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-014-3471-5
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abstract::Herpesviruses are a prominent cause of human viral disease, second only to the cold and influenza viruses. Most herpesvirus infections are mild or asymptomatic. However, when the virus invades the eye, a number of pathologies can develop and its associated sequelae have become a considerable source of ocular morbidity...
journal_title:Virologica Sinica
pub_type: 杂志文章,评审
doi:10.1007/s12250-014-3539-2
更新日期:2014-12-01 00:00:00
abstract::In this study, the decay of maternal peste des petits ruminants virus (PPRV) antibodies in kids born to goats vaccinated with Asian lineage IV PPR vaccine and the efficacy of passive immunity against PPRV was assessed to determine the appropriate period for vaccination in kids. Serum samples collected from kids born t...
journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-012-3249-6
更新日期:2012-08-01 00:00:00
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journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-015-3644-x
更新日期:2015-10-01 00:00:00
abstract::Laos is the only landlocked country in Southeast Asia and borders Thailand, Myanmar and Cambodia, the three countries in this region that have been hardest hit by human immunodeficiency virus (HIV). Laos has been regarded as a low-HIV-prevalence country for decades. To understand the status of HIV in Laos in recent ye...
journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-020-00215-4
更新日期:2020-10-01 00:00:00
abstract::Hepatitis C virus (HCV) is a global health concern, notably in Southeast Asia, and in Laos the presentation of the HCV-induced liver disease is poorly known. Our objective was thus to describe a comprehensive HCV infection pattern in order to guide national health policies. A study on a group of 1765 patients formerly...
journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-018-0039-9
更新日期:2018-08-01 00:00:00
abstract::Dengue virus (DENV) and Zika virus (ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery ...
journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-018-0068-4
更新日期:2018-12-01 00:00:00
abstract::Omsk hemorrhagic fever virus (OHFV) is a tick-borne flavivirus classified as a biosafety level-4 (BSL4) pathogen. Studies of OHFV are restricted to be conducted within BSL4 laboratories. Currently, no commercial vaccines or antiviral drugs are available against OHFV infection. In this study, we recovered a replication...
journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-019-00109-0
更新日期:2019-08-01 00:00:00
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journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-020-00322-2
更新日期:2021-01-05 00:00:00
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journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-020-00339-7
更新日期:2021-01-22 00:00:00
abstract::Isolates of Newcastle disease virus (NDV) from deceased wild and domestic pigeons in Kazakhstan were obtained from the Almaty region during 2005 and were genotypically analyzed by using reverse transcription polymerase chain reaction (RT-PCR) with primers specific to the viral fusion (F) protein gene. Part of the ampl...
journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-012-3234-0
更新日期:2012-04-01 00:00:00
abstract::Conventional influenza vaccines are based on predicting the circulating viruses year by year, conferring limited effectiveness since the antigenicity of vaccine strains does not always match the circulating viruses. This necessitates development of universal influenza vaccines that provide broader and lasting protecti...
journal_title:Virologica Sinica
pub_type: 杂志文章,评审
doi:10.1007/s12250-020-00283-6
更新日期:2020-09-01 00:00:00
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journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-020-00267-6
更新日期:2020-08-07 00:00:00
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journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-019-00134-z
更新日期:2019-10-01 00:00:00
abstract::Feasible and effective cell models for hepatitis B virus (HBV) infection are required for investigating the complete lifecycle of this virus, including the early steps of viral entry. Resistance to dimethyl sulfoxide/polyethylene glycol (DMSO/PEG), hNTCP expression, and a differentiated state are the limiting factors ...
journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-017-3983-x
更新日期:2017-12-01 00:00:00
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journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-019-00174-5
更新日期:2020-02-01 00:00:00
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journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-020-00317-z
更新日期:2020-12-01 00:00:00
abstract::Ebola virus (EBOV) and Marburg virus (MARV) are causative agents of severe hemorrhagic fever with high mortality rates in humans and non-human primates and there is currently no licensed vaccine or therapeutics. To date, there is no specific laboratory diagnostic test in China, while there is a national need to provid...
journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-012-3252-y
更新日期:2012-10-01 00:00:00
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journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-017-3997-4
更新日期:2017-06-01 00:00:00
abstract::Ebola virus (EBOV) causes severe hemorrhagic fever in humans and non-human primates with high rates of fatality. Glycoprotein (GP) is the only envelope protein of EBOV, which may play a critical role in virus attachment and entry as well as stimulating host protective immune responses. However, the lack of expression ...
journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-016-3845-y
更新日期:2016-12-01 00:00:00
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journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-010-3137-x
更新日期:2010-10-01 00:00:00
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journal_title:Virologica Sinica
pub_type: 杂志文章,评审
doi:10.1007/s12250-017-4055-y
更新日期:2017-10-01 00:00:00
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journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-019-00116-1
更新日期:2019-06-01 00:00:00
abstract::An emerging mosquito-borne arbovirus named Zika virus (ZIKV), of the family Flaviviridae and genus Flavivirus, is becoming a global health threat. ZIKV infection was long neglected due to its sporadic nature and mild symptoms. However, recently, with its rapid spread from Asia to the Americas, affecting more than 30 c...
journal_title:Virologica Sinica
pub_type: 杂志文章,评审
doi:10.1007/s12250-016-3780-y
更新日期:2016-04-01 00:00:00
abstract::Cancer cell lines have been used widely in cancer biology, and as biological or functional cell systems in many biomedical research fields. These cells are usually defective for many normal activities or functions due to significant genetic and epigenetic changes. Normal primary cell yields and viability from any orig...
journal_title:Virologica Sinica
pub_type: 杂志文章,评审
doi:10.1007/s12250-020-00244-z
更新日期:2020-06-01 00:00:00
abstract::The multifunctional trans-activator Tat is an essential regulatory protein for HIV-1 replication and is characterized by high sequence diversity. Numerous experimental studies have examined Tat in HIV-1 subtype B, but research on subtype C Tat is lacking, despite the high prevalence of infections caused by subtype C w...
journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-016-3681-0
更新日期:2016-06-01 00:00:00
abstract::Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in Pakistan, nasal (n = 77...
journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-018-0051-0
更新日期:2018-10-01 00:00:00
abstract::Lepidopteran heat-tolerant (ht) cell lines have been obtained with sf-9, sf-21 and several Bombyx cells. They have a distinct karyotype, membrane lipid composition, morphology and growth kinetics from the parental cell lines. In this paper, we report the development of ht cell lines from other insect species and exami...
journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-011-3177-x
更新日期:2011-06-01 00:00:00
abstract::Newcastle disease virus (NDV) and H9N2 subtype Avian influenza virus (AIV) are two notorious avian respiratory pathogens that cause great losses in the poultry industry. Current inactivated commercial vaccines against NDV and AIV have the disadvantages of inadequate mucosal responses, while an attenuated live vaccine ...
journal_title:Virologica Sinica
pub_type: 杂志文章
doi:10.1007/s12250-020-00199-1
更新日期:2020-08-01 00:00:00
abstract::Ion channels are membrane proteins that are found in a number of viruses and which are of crucial physiological importance in the viral life cycle. They have one common feature in that their action mode involves a change of electrochemical or proton gradient across the bilayer lipid membrane which modulates viral or c...
journal_title:Virologica Sinica
pub_type: 杂志文章,评审
doi:10.1007/s12250-010-3136-y
更新日期:2010-08-01 00:00:00