Abstract:
:Human endogenous retrovirus W env (HERV-W env) plays a critical role in many neuropsychological diseases such as schizophrenia and multiple sclerosis (MS). These diseases are accompanied by immunological reactions in the central nervous system (CNS). Microglia are important immunocytes in brain inflammation that can produce a gasotransmitter-nitric oxide (NO). NO not only plays a role in the function of neuronal cells but also participates in the pathogenesis of various neuropsychological diseases. In this study, we reported increased NO production in CHME-5 microglia cells after they were transfected with HERV-W env. Moreover, HERV-W env increased the expression and function of human inducible nitric oxide synthase (hiNOS) and enhanced the promoter activity of hiNOS. Microglial migration was also enhanced. These data revealed that HERV-W env might contribute to increase NO production and microglial migration ability in neuropsychological disorders by regulating the expression of inducible NOS. Results from this study might lead to the identification of novel targets for the treatment of neuropsychological diseases, including neuroinflammatory diseases, stroke, and neurodegenerative diseases.
journal_name
Virol Sinjournal_title
Virologica Sinicaauthors
Xiao R,Li S,Cao Q,Wang X,Yan Q,Tu X,Zhu Y,Zhu Fdoi
10.1007/s12250-017-3997-4subject
Has Abstractpub_date
2017-06-01 00:00:00pages
216-225issue
3eissn
1674-0769issn
1995-820Xpii
10.1007/s12250-017-3997-4journal_volume
32pub_type
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