In vitro anti-influenza virus activities of sulfated polysaccharide fractions from Gracilaria lemaneiformis.

abstract：:Hepatitis C virus (HCV) is a global health concern, notably in Southeast Asia, and in Laos the presentation of the HCV-induced liver disease is poorly known. Our objective was thus to describe a comprehensive HCV infection pattern in order to guide national health policies. A study on a group of 1765 patients formerly...

journal_title：Virologica Sinica

authors： Paboriboune P,Vial T,Sitbounlang P,Bertani S,Trépo C,Dény P,Babin FX,Steenkeste N,Pineau P,Deharo E

更新日期：2018-08-01 00:00:00

abstract：:In this study, the coding region of type O FMDV capsid protein VP1 and a series of codon optimized DNA sequences coding for VP1 amino acid residues 141-160 (epitope1), tandem repeat 200-213 (epitope2 (+2)) and the combination of two epitopes (epitope1-2) was genetically cloned into the prokaryotic expression vector pP...

journal_title：Virologica Sinica

authors： Gao SD,Du JZ,Chang HY,Cong GZ,Shao JJ,Lin T,Song S,Xie QG

更新日期：2010-02-01 00:00:00

abstract：:Human cytomegalovirus (HCMV), a herpesvirus, is an important human pathogen that causes asymptomatic infections in healthy or immunocompetent individuals but can lead to severe and potentially life-threatening complications in immune-immature individuals such as neonates or immune-compromised patients such as organ-tr...

journal_title：Virologica Sinica

authors： Liu G,Hai R,Liu F

更新日期：2017-10-01 00:00:00

abstract：:Shiga toxin B-subunit (STxB) from Shigella dysenteriae targets in vivo antigen to cancer cells, dendritic cells (DC) and B cells, which preferentially express the globotriaosylceramide (Gb3) receptor. This pivotal role has encouraged scientists to investigate fusing STxB with other clinical antigens. Due to the challe...

journal_title：Virologica Sinica

authors： Sadraeian M,Ghoshoon MB,Mohkam M,Karimi Z,Rasoul-Amini S,Ghasemi Y

更新日期：2013-02-01 00:00:00

abstract：:In this study, the decay of maternal peste des petits ruminants virus (PPRV) antibodies in kids born to goats vaccinated with Asian lineage IV PPR vaccine and the efficacy of passive immunity against PPRV was assessed to determine the appropriate period for vaccination in kids. Serum samples collected from kids born t...

journal_title：Virologica Sinica

authors： Balamurugan V,Sen A,Venkatesan G,Rajak KK,Bhanuprakash V,Singh RK

更新日期：2012-08-01 00:00:00

abstract：:Lepidopteran heat-tolerant (ht) cell lines have been obtained with sf-9, sf-21 and several Bombyx cells. They have a distinct karyotype, membrane lipid composition, morphology and growth kinetics from the parental cell lines. In this paper, we report the development of ht cell lines from other insect species and exami...

journal_title：Virologica Sinica

authors： Wu YL,Jiang L,Hashimoto Y,Granados RR,Li GX

更新日期：2011-06-01 00:00:00

abstract：:Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in Pakistan, nasal (n = 77...

journal_title：Virologica Sinica

authors： Zohaib A,Saqib M,Athar MA,Chen J,Sial AU,Khan S,Taj Z,Sadia H,Tahir U,Tayyab MH,Qureshi MA,Mansoor MK,Naeem MA,Hu BJ,Khan BA,Ujjan ID,Li B,Zhang W,Luo Y,Zhu Y,Waruhiu C,Khan I,Yang XL,Sajid MS,Corman VM,

更新日期：2018-10-01 00:00:00

abstract：:The papain-like protease (PL(pro)) of Middle-East respiratory syndrome coronavirus (MERS-CoV) has proteolytic, deubiquitinating, and deISGylating activities. The latter two are involved in the suppression of the antiviral innate immune response of the host cell. To contribute to an understanding of this process, we pr...

journal_title：Virologica Sinica

authors： Lei J,Hilgenfeld R

更新日期：2016-08-01 00:00:00

abstract：:Neutralizing antibodies are considered to be an important protective parameter used in HIV-1 vaccine evaluation. However, the exact role that neutralizing antibodies plays in controlling the disease progression of HIV-1 infected peoples is still undetermined. In this paper, we compared the protective function of the n...

journal_title：Virologica Sinica

authors： Wang Z,Li TY,Li JY,Chen LL,Liu YJ,Li HP,Bao ZY,Wang XL,Zhuang DM,Liu SY,Li L

更新日期：2012-06-01 00:00:00

abstract：:The recent emergence and rapid global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pose an unprecedented medical and socioeconomic crisis, and the disease caused by it, Coronavirus disease 2019 (COVID-19), was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. C...

journal_title：Virologica Sinica

authors： Wang S,Trilling M,Sutter K,Dittmer U,Lu M,Zheng X,Yang D,Liu J

更新日期：2020-12-01 00:00:00

abstract：:H9N2 subtype avian influenza virus (AIV) is an influenza A virus that is widely spread throughout Asia, where it jeopardizes the poultry industry and provides genetic material for emerging human pathogens. To better understand the epidemicity and genetics of H9 subtype AIVs, we conducted active surveillance in live po...

journal_title：Virologica Sinica

authors： Hu Z,Peng F,Xiong Z,Zhang W,Li T,Shi Y,Xie J,Jin X,Huang J,Xiao H,Bi D,Song N,Li Z

更新日期：2020-09-14 00:00:00

abstract：:An exogenous avian leukosis virus (ALV) strain SDAU09C1 was isolated in DF-1 cells from one of 240 imported 1-day-old white meat-type grand parent breeder chicks. Inoculation of SDAU09C1 in ALV-free chickens induced antibody reactions specific to subgroup A or B. But gp85 amino acid sequence comparisons indicated that...

journal_title：Virologica Sinica

authors： Zhang QC,Zhao DM,Guo HJ,Cui ZZ

更新日期：2010-04-01 00:00:00

abstract：:Avian infectious bronchitis virus (IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopatho...

journal_title：Virologica Sinica

authors： He Y,Xie Z,Dai J,Cao Y,Hou J,Zheng Y,Wei T,Mo M,Wei P

更新日期：2016-02-01 00:00:00

abstract：:Omsk hemorrhagic fever virus (OHFV) is a tick-borne flavivirus classified as a biosafety level-4 (BSL4) pathogen. Studies of OHFV are restricted to be conducted within BSL4 laboratories. Currently, no commercial vaccines or antiviral drugs are available against OHFV infection. In this study, we recovered a replication...

journal_title：Virologica Sinica

authors： Zhang Q,Li N,Deng C,Zhang Z,Li X,Yoshii K,Ye H,Zhang B

更新日期：2019-08-01 00:00:00

abstract：:Banana bunchy top virus (BBTV), family Nanaviridae, genus Babuvirus, is a single stranded DNA virus (ssDNA) that causes banana bunchy top disease (BBTD) in banana plants. It is the most common and most destructive of all viruses in these plants and is widespread throughout the Asia-Pacific region. In this study we iso...

journal_title：Virologica Sinica

authors： Yu NT,Feng TC,Zhang YL,Wang JH,Liu ZX

更新日期：2011-08-01 00:00:00

abstract：:The virus receptors are key for the viral infection of host cells. Identification of the virus receptors is still challenging at present. Our previous study has shown that human virus receptor proteins have some unique features including high N-glycosylation level, high number of interaction partners and high expressi...

journal_title：Virologica Sinica

authors： Zhang Z,Ye S,Wu A,Jiang T,Peng Y

更新日期：2020-07-28 00:00:00

abstract：:Chikungunya virus (CHIKV) is a mosquito-borne virus that causes epidemics widely in the world especially in the tropical and subtropical regions. Phylogenetic analysis has found that the CHIKV lineages were associated with the spatial and temporal distributions, which were related to the virus adaption to the major mo...

journal_title：Virologica Sinica

authors： Shi J,Su Z,Fan Z,Wang J,Liu S,Zhang B,Wei H,Jehan S,Jamil N,Shen S,Deng F

更新日期：2017-12-01 00:00:00

abstract：:Banana bunchy top virus (BBTV) poses a serious danger to banana crops worldwide. BBTV-encoded protein B4 is a determinant of pathogenicity. However, the relevant molecular mechanisms underlying its effects remain unknown. In this study, we found that a functional peptide could be liberated from protein B4, likely via ...

journal_title：Virologica Sinica

authors： Zhuang J,Lin W,Coates CJ,Shang P,Wei T,Wu Z,Xie L

更新日期：2019-06-01 00:00:00

abstract：:Conventional influenza vaccines need to be designed and manufactured yearly. However, they occasionally provide poor protection owing to antigenic mismatch. Hence, there is an urgent need to develop universal vaccines against influenza virus. Using nucleoprotein (NP) and extracellular domain of matrix protein 2 (M2e) ...

journal_title：Virologica Sinica

authors： Wang W,Huang B,Wang X,Tan W,Ruan L

更新日期：2019-10-01 00:00:00

abstract：:A novel Clade 2.3.2.1c H5N1 reassortant virus caused several outbreaks in wild birds in some regions of China from late 2014 to 2015. Based on the genetic and phylogenetic analyses, the viruses possess a stable gene constellation with a Clade 2.3.2.1c HA, a H9N2-derived PB2 gene and the other six genes of Asian H5N1-o...

journal_title：Virologica Sinica

authors： Bi Y,Chen J,Zhang Z,Li M,Cai T,Sharshov K,Susloparov I,Shestopalov A,Wong G,He Y,Xing Z,Sun J,Liu D,Liu Y,Liu L,Liu W,Lei F,Shi W,Gao GF

更新日期：2016-08-01 00:00:00

abstract：:Severe fever with thrombocytopenia syndrome virus (SFTSV), the causative agent of a febrile human disease, was first identified from central and eastern provinces in China, and later in Japan and South Korea. Hubei Province is one of the major SFTS epidemic areas in the central part of China. This study reported the i...

journal_title：Virologica Sinica

authors： Wu X,Li M,Zhang Y,Liang B,Shi J,Fang Y,Su Z,Li M,Zhang W,Xu L,Wang J,Wu Q,Tang S,Wang H,Zhang T,Peng C,Zheng X,Deng F,Shen S

更新日期：2020-09-22 00:00:00

abstract：:A 62-year-old man had chronic hepatitis B virus (HBV) infection and was diagnosed with liver cirrhosis. At the time of diagnosis the patient's virologic markers were positive for hepatitis B surface antigen (HBsAg), antibody to hepatitis B e antigen (anti-HBe) and antibody to hepatitis B core antigen (anti-HBc), while...

journal_title：Virologica Sinica

authors： Wu C,Shi H,Wang Y,Lu M,Xu Y,Chen X

更新日期：2012-12-01 00:00:00

abstract：:Dengue virus (DENV) and Zika virus (ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery ...

journal_title：Virologica Sinica

authors： Ji Z,Li F,Xia Z,Guo X,Gao M,Sun F,Cheng Y,Wu Y,Li W,Ali SA,Cao Z

更新日期：2018-12-01 00:00:00

abstract：:Similar to Hepatitis C virus (HCV) infection in humans, HCVcc infection can also result in persistent and chronic infection. The core protein is a variable protein and exists in several sizes. Some sizes of core proteins have been reported to be related to chronic HCV infection. To study the possible role of the core ...

journal_title：Virologica Sinica

authors： Liao Q,Tian J,Wu Y,Chen X

更新日期：2013-06-01 00:00:00

abstract：:Porcine respiratory disease complex (PRDC) is a serious health problem that mainly affects growing and finishing pigs. PRDC is caused by a combination of viral and bacterial agents, such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), Mycoplasma hyopneumoniae (Myh), Actinob...

journal_title：Virologica Sinica

authors： Jiménez LF,Ramírez Nieto G,Alfonso VV,Correa JJ

更新日期：2014-08-01 00:00:00

abstract：:The epidemiology of HIV-1 varies in different areas of the world, and it is possible that this complexity may leave unique footprints in the viral genome. Thus, we attempted to find significant patterns in global HIV-1 genome sequences. By applying the rule inference algorithm RIPPER (Repeated Incremental Pruning to P...

journal_title：Virologica Sinica

authors： Wang Y,Rawi R,Hoffmann D,Sun B,Yang R

更新日期：2013-08-01 00:00:00

abstract：:The 5'-cap structures of eukaryotic mRNAs are important for RNA stability, pre-mRNA splicing, mRNA export, and protein translation. Many viruses have evolved mechanisms for generating their own cap structures with methylation at the N7 position of the capped guanine and the ribose 2'-Oposition of the first nucleotide,...

journal_title：Virologica Sinica

authors： Chen Y,Guo D

更新日期：2016-02-01 00:00:00

abstract：:Receptors interaction protein 2 (RIP2) is a specific adaptor molecule in the downstream of NOD2. The role of RIP2 during foot-and-mouth disease virus (FMDV) infection remains unknown. Here, our results showed that RIP2 inhibited FMDV replication and played an important role in the activation of IFN-β and NF-ĸB signal ...

journal_title：Virologica Sinica

authors： Liu H,Xue Q,Zhu Z,Yang F,Cao W,Liu X,Zheng H

更新日期：2021-01-05 00:00:00

abstract：:Respiratory syncytial virus (RSV) is the key underlying cause of acute lower respiratory tract infection in infants; however, no licensed vaccine against RSV infection is currently available. This study was undertaken to assess the preventive effect of vaccine on RSV infection. In this metaanalysis, 1,792 published ra...

journal_title：Virologica Sinica

authors： Zhu T,Zhang C,Yu L,Chen J,Qiu H,Lyu W,Huang S

更新日期：2015-10-01 00:00:00

abstract：:Ebola virus (EBOV) and Marburg virus (MARV) are causative agents of severe hemorrhagic fever with high mortality rates in humans and non-human primates and there is currently no licensed vaccine or therapeutics. To date, there is no specific laboratory diagnostic test in China, while there is a national need to provid...

journal_title：Virologica Sinica

authors： Huang Y,Wei H,Wang Y,Shi Z,Raoul H,Yuan Z

更新日期：2012-10-01 00:00:00