Cleavage of the Babuvirus Movement Protein B4 into Functional Peptides Capable of Host Factor Conjugation is Required for Virulence.

abstract：:Conventional influenza vaccines are based on predicting the circulating viruses year by year, conferring limited effectiveness since the antigenicity of vaccine strains does not always match the circulating viruses. This necessitates development of universal influenza vaccines that provide broader and lasting protecti...

journal_title：Virologica Sinica

authors： Du R,Cui Q,Rong L

更新日期：2020-09-01 00:00:00

abstract：:Feasible and effective cell models for hepatitis B virus (HBV) infection are required for investigating the complete lifecycle of this virus, including the early steps of viral entry. Resistance to dimethyl sulfoxide/polyethylene glycol (DMSO/PEG), hNTCP expression, and a differentiated state are the limiting factors ...

journal_title：Virologica Sinica

authors： Zhou M,Zhao K,Yao Y,Yuan Y,Pei R,Wang Y,Chen J,Hu X,Zhou Y,Chen X,Wu C

更新日期：2017-12-01 00:00:00

abstract：:Ion channels are membrane proteins that are found in a number of viruses and which are of crucial physiological importance in the viral life cycle. They have one common feature in that their action mode involves a change of electrochemical or proton gradient across the bilayer lipid membrane which modulates viral or c...

journal_title：Virologica Sinica

authors： Liang X,Li ZY

更新日期：2010-08-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a global health concern, notably in Southeast Asia, and in Laos the presentation of the HCV-induced liver disease is poorly known. Our objective was thus to describe a comprehensive HCV infection pattern in order to guide national health policies. A study on a group of 1765 patients formerly...

journal_title：Virologica Sinica

authors： Paboriboune P,Vial T,Sitbounlang P,Bertani S,Trépo C,Dény P,Babin FX,Steenkeste N,Pineau P,Deharo E

更新日期：2018-08-01 00:00:00

abstract：:Porcine respiratory disease complex (PRDC) is a serious health problem that mainly affects growing and finishing pigs. PRDC is caused by a combination of viral and bacterial agents, such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), Mycoplasma hyopneumoniae (Myh), Actinob...

journal_title：Virologica Sinica

authors： Jiménez LF,Ramírez Nieto G,Alfonso VV,Correa JJ

更新日期：2014-08-01 00:00:00

abstract：:Lepidopteran heat-tolerant (ht) cell lines have been obtained with sf-9, sf-21 and several Bombyx cells. They have a distinct karyotype, membrane lipid composition, morphology and growth kinetics from the parental cell lines. In this paper, we report the development of ht cell lines from other insect species and exami...

journal_title：Virologica Sinica

authors： Wu YL,Jiang L,Hashimoto Y,Granados RR,Li GX

更新日期：2011-06-01 00:00:00

abstract：:Primate bocaparvovirus (BOV) is a possible cause of respiratory disorders and gastroenteritis in humans. However, the diversity and evolution of these viruses remain largely unknown, despite the identification of a growing number of BOVs in non-human primates (NHPs). Here, we report the identification of a novel BOV (...

journal_title：Virologica Sinica

authors： Ao Y,Duan Z

更新日期：2020-02-01 00:00:00

abstract：:During virus infection, RIG-I-like receptors (RLRs) recognize viral RNAs and recruit the adaptor protein VISA to activate downstream signaling, leading to activation of transcription factors NF-κB and IRF3, which collaborate to induce type I interferons (IFNs). IFNs further induce expression of hundreds of IFN-stimula...

journal_title：Virologica Sinica

authors： Wang DP,Zhang HY,Liao BW,Tong Z,Xu ZS,Wang YY,Yang Y

更新日期：2020-08-07 00:00:00

abstract：:Laos is the only landlocked country in Southeast Asia and borders Thailand, Myanmar and Cambodia, the three countries in this region that have been hardest hit by human immunodeficiency virus (HIV). Laos has been regarded as a low-HIV-prevalence country for decades. To understand the status of HIV in Laos in recent ye...

journal_title：Virologica Sinica

authors： Chen X,Ye M,Wang Y,Zhang C,Zheng YT

更新日期：2020-10-01 00:00:00

abstract：:The recent emergence and rapid global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pose an unprecedented medical and socioeconomic crisis, and the disease caused by it, Coronavirus disease 2019 (COVID-19), was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. C...

journal_title：Virologica Sinica

authors： Wang S,Trilling M,Sutter K,Dittmer U,Lu M,Zheng X,Yang D,Liu J

更新日期：2020-12-01 00:00:00

abstract：:Omsk hemorrhagic fever virus (OHFV) is a tick-borne flavivirus classified as a biosafety level-4 (BSL4) pathogen. Studies of OHFV are restricted to be conducted within BSL4 laboratories. Currently, no commercial vaccines or antiviral drugs are available against OHFV infection. In this study, we recovered a replication...

journal_title：Virologica Sinica

authors： Zhang Q,Li N,Deng C,Zhang Z,Li X,Yoshii K,Ye H,Zhang B

更新日期：2019-08-01 00:00:00

abstract：:The temporal change patterns of laboratory data may provide insightful clues into the whole course of COVID-19. This study aimed to evaluate longitudinal change patterns of key laboratory tests in patients with COVID-19, and identify independent prognostic factors by examining the associations between laboratory findi...

journal_title：Virologica Sinica

authors： Tian S,Zhu X,Sun X,Wang J,Zhou Q,Wang C,Chen L,Li S,Xu J

更新日期：2020-12-01 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors show clinical promise for the treatment of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the effect of HDAC inhibitor treatment on hepatitis C virus (HCV) replication in Huh7 human liver cells and in a mouse model of HCV infection. Viral replica...

journal_title：Virologica Sinica

authors： Zhou Y,Wang Q,Yang Q,Tang J,Xu C,Gai D,Chen X,Chen J

更新日期：2018-10-01 00:00:00

abstract：:Newcastle disease virus (NDV) and H9N2 subtype Avian influenza virus (AIV) are two notorious avian respiratory pathogens that cause great losses in the poultry industry. Current inactivated commercial vaccines against NDV and AIV have the disadvantages of inadequate mucosal responses, while an attenuated live vaccine ...

journal_title：Virologica Sinica

authors： Xu X,Qian J,Qin L,Li J,Xue C,Ding J,Wang W,Ding W,Yin R,Jin N,Ding Z

更新日期：2020-08-01 00:00:00

abstract：:The virus receptors are key for the viral infection of host cells. Identification of the virus receptors is still challenging at present. Our previous study has shown that human virus receptor proteins have some unique features including high N-glycosylation level, high number of interaction partners and high expressi...

journal_title：Virologica Sinica

authors： Zhang Z,Ye S,Wu A,Jiang T,Peng Y

更新日期：2020-07-28 00:00:00

abstract：:An exogenous avian leukosis virus (ALV) strain SDAU09C1 was isolated in DF-1 cells from one of 240 imported 1-day-old white meat-type grand parent breeder chicks. Inoculation of SDAU09C1 in ALV-free chickens induced antibody reactions specific to subgroup A or B. But gp85 amino acid sequence comparisons indicated that...

journal_title：Virologica Sinica

authors： Zhang QC,Zhao DM,Guo HJ,Cui ZZ

更新日期：2010-04-01 00:00:00

abstract：:Similar to Hepatitis C virus (HCV) infection in humans, HCVcc infection can also result in persistent and chronic infection. The core protein is a variable protein and exists in several sizes. Some sizes of core proteins have been reported to be related to chronic HCV infection. To study the possible role of the core ...

journal_title：Virologica Sinica

authors： Liao Q,Tian J,Wu Y,Chen X

更新日期：2013-06-01 00:00:00

abstract：:HIV-indeterminate Western blotting (WB) results are typically obtained in WB confirmatory assays, and the number of indeterminate samples may increase with the detection of HIV infections, which will present considerable challenges for the management of HIV/AIDS. Nucleic acid detection has been used as a laboratory te...

journal_title：Virologica Sinica

authors： Wu S,Gao M,Zheng J,Yan P,Wang W,Lu X,Qiu Y,Yan Y

更新日期：2019-08-01 00:00:00

abstract：:The epidemiology of HIV-1 varies in different areas of the world, and it is possible that this complexity may leave unique footprints in the viral genome. Thus, we attempted to find significant patterns in global HIV-1 genome sequences. By applying the rule inference algorithm RIPPER (Repeated Incremental Pruning to P...

journal_title：Virologica Sinica

authors： Wang Y,Rawi R,Hoffmann D,Sun B,Yang R

更新日期：2013-08-01 00:00:00

abstract：:Japanese encephalitis (JE) is a viral encephalitis disease caused by Japanese encephalitis virus (JEV) infection. Uncontrolled inflammatory responses in the central nervous system (CNS) are a hallmark of severe JE. Although the CCR2-CCL2 axis is important for monocytes trafficking during JEV infection, little is known...

journal_title：Virologica Sinica

authors： Zhang F,Qi L,Li T,Li X,Yang D,Cao S,Ye J,Wei B

更新日期：2019-10-01 00:00:00

abstract：:An emerging mosquito-borne arbovirus named Zika virus (ZIKV), of the family Flaviviridae and genus Flavivirus, is becoming a global health threat. ZIKV infection was long neglected due to its sporadic nature and mild symptoms. However, recently, with its rapid spread from Asia to the Americas, affecting more than 30 c...

journal_title：Virologica Sinica

authors： Wang Z,Wang P,An J

更新日期：2016-04-01 00:00:00

abstract：:Effective oral infection is set off by interaction of a group of conserved per os infectivity factors (PIFs) with larval midgut columnar epithelial cells. We constructed pseudotyped viruses by substituting pif1, pif2 or pif3 genes of Helicoverpa armigera nucleopolyhedrovirus (HearNPV) with their homologs from Mamestra...

journal_title：Virologica Sinica

authors： Makalliwa GA,Wang X,Zhang H,Zhang N,Chen C,Li J,Deng F,Wang H,Wang M,Hu Z

更新日期：2018-04-01 00:00:00

abstract：:Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in Pakistan, nasal (n = 77...

journal_title：Virologica Sinica

authors： Zohaib A,Saqib M,Athar MA,Chen J,Sial AU,Khan S,Taj Z,Sadia H,Tahir U,Tayyab MH,Qureshi MA,Mansoor MK,Naeem MA,Hu BJ,Khan BA,Ujjan ID,Li B,Zhang W,Luo Y,Zhu Y,Waruhiu C,Khan I,Yang XL,Sajid MS,Corman VM,

更新日期：2018-10-01 00:00:00

abstract：:Hepatitis E virus (HEV) is the prototype of the family Hepeviridae and the causative agent of common acute viral hepatitis. Genetically diverse HEV-related viruses have been detected in a variety of mammals and some of them may have zoonotic potential. In this study, we tested 278 specimens collected from seven wild s...

journal_title：Virologica Sinica

authors： Wang B,Li W,Zhou JH,Li B,Zhang W,Yang WH,Pan H,Wang LX,Bock CT,Shi ZL,Zhang YZ,Yang XL

更新日期：2018-02-01 00:00:00

abstract：:The protein HTRP (human transcription regulator protein) is encoded by the differential gene htrp and induced by Herpes simplex virus type 1 (HSV-1) infection in KMB-17 cells. HTRP was found to interact with SAP30 (mSin3A Association Protein), one of the components of co-repressor complex mSin3A, which is part of the ...

journal_title：Virologica Sinica

authors： Chen J,Li YM,Li JF,Liu LD,Liao Y,Na RX,Wang JJ,Wang LC,Li QH

更新日期：2010-12-01 00:00:00

abstract：:H9N2 subtype avian influenza virus (AIV) is an influenza A virus that is widely spread throughout Asia, where it jeopardizes the poultry industry and provides genetic material for emerging human pathogens. To better understand the epidemicity and genetics of H9 subtype AIVs, we conducted active surveillance in live po...

journal_title：Virologica Sinica

authors： Hu Z,Peng F,Xiong Z,Zhang W,Li T,Shi Y,Xie J,Jin X,Huang J,Xiao H,Bi D,Song N,Li Z

更新日期：2020-09-14 00:00:00

abstract：:In this study, the decay of maternal peste des petits ruminants virus (PPRV) antibodies in kids born to goats vaccinated with Asian lineage IV PPR vaccine and the efficacy of passive immunity against PPRV was assessed to determine the appropriate period for vaccination in kids. Serum samples collected from kids born t...

journal_title：Virologica Sinica

authors： Balamurugan V,Sen A,Venkatesan G,Rajak KK,Bhanuprakash V,Singh RK

更新日期：2012-08-01 00:00:00

abstract：:Our previous work has shown that Saffold virus (SAFV) induced several rodent and primate cell lines to undergo apoptosis (Xu et al. in Emerg Microb Infect 3:1-8, 2014), but the essential viral proteins of SAFV involved in apoptotic activity lack study. In this study, we individually transfected the viral proteins of S...

journal_title：Virologica Sinica

authors： Xu Y,Victorio CBL,Meng T,Jia Q,Tan YJ,Chua KB

更新日期：2019-06-01 00:00:00

abstract：:Human cytomegalovirus (HCMV), a herpesvirus, is an important human pathogen that causes asymptomatic infections in healthy or immunocompetent individuals but can lead to severe and potentially life-threatening complications in immune-immature individuals such as neonates or immune-compromised patients such as organ-tr...

journal_title：Virologica Sinica

authors： Liu G,Hai R,Liu F

更新日期：2017-10-01 00:00:00

abstract：:Herpesviruses are a prominent cause of human viral disease, second only to the cold and influenza viruses. Most herpesvirus infections are mild or asymptomatic. However, when the virus invades the eye, a number of pathologies can develop and its associated sequelae have become a considerable source of ocular morbidity...

journal_title：Virologica Sinica

authors： Zhu L,Zhu H

更新日期：2014-12-01 00:00:00