Foot-and-Mouth Disease Virus Inhibits RIP2 Protein Expression to Promote Viral Replication.

Abstract:

:Receptors interaction protein 2 (RIP2) is a specific adaptor molecule in the downstream of NOD2. The role of RIP2 during foot-and-mouth disease virus (FMDV) infection remains unknown. Here, our results showed that RIP2 inhibited FMDV replication and played an important role in the activation of IFN-β and NF-ĸB signal pathways during FMDV infection. FMDV infection triggered RIP2 transcription, while it reduced the expression of RIP2 protein. Detailed analysis showed that FMDV 2B, 2C, 3Cpro, and Lpro proteins were responsible for inducing the reduction of RIP2 protein. 3Cpro and Lpro are viral proteinases that can induce the cleavage or reduction of many host proteins and block host protein synthesis. The carboxyl terminal 105-114 and 135-144 regions of 2B were essential for reduction of RIP2. Our results also showed that the N terminal 1-61 region of 2C were essential for the reduction of RIP2. The 2C-induced reduction of RIP2 was dependent on inducing the reduction of poly(A)-binding protein 1 (PABPC1). The interaction between RIP2 and 2C was observed in the context of viral infection, and the residues 1-61 were required for the interaction. These data clarify novel mechanisms of reduction of RIP2 mediated by FMDV.

journal_name

Virol Sin

journal_title

Virologica Sinica

authors

Liu H,Xue Q,Zhu Z,Yang F,Cao W,Liu X,Zheng H

doi

10.1007/s12250-020-00322-2

subject

Has Abstract

pub_date

2021-01-05 00:00:00

eissn

1674-0769

issn

1995-820X

pii

10.1007/s12250-020-00322-2

pub_type

杂志文章
  • Characterization of pigeon paramyxoviruses (Newcastle disease virus) isolated in Kazakhstan in 2005.

    abstract::Isolates of Newcastle disease virus (NDV) from deceased wild and domestic pigeons in Kazakhstan were obtained from the Almaty region during 2005 and were genotypically analyzed by using reverse transcription polymerase chain reaction (RT-PCR) with primers specific to the viral fusion (F) protein gene. Part of the ampl...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-012-3234-0

    authors: Bogoyavlenskiy A,Berezin V,Prilipov A,Usachev E,Korotetskiy I,Zaitceva I,Kydyrmanov A,Sayatov M

    更新日期:2012-04-01 00:00:00

  • A case of hepatitis B reactivation due to the hepatitis B virus escape mutant in a patient undergoing chemotherapy.

    abstract::A 62-year-old man had chronic hepatitis B virus (HBV) infection and was diagnosed with liver cirrhosis. At the time of diagnosis the patient's virologic markers were positive for hepatitis B surface antigen (HBsAg), antibody to hepatitis B e antigen (anti-HBe) and antibody to hepatitis B core antigen (anti-HBc), while...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-012-3284-3

    authors: Wu C,Shi H,Wang Y,Lu M,Xu Y,Chen X

    更新日期:2012-12-01 00:00:00

  • Chimeric Newcastle Disease Virus-like Particles Containing DC-Binding Peptide-Fused Haemagglutinin Protect Chickens from Virulent Newcastle Disease Virus and H9N2 Avian Influenza Virus Challenge.

    abstract::Newcastle disease virus (NDV) and H9N2 subtype Avian influenza virus (AIV) are two notorious avian respiratory pathogens that cause great losses in the poultry industry. Current inactivated commercial vaccines against NDV and AIV have the disadvantages of inadequate mucosal responses, while an attenuated live vaccine ...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-020-00199-1

    authors: Xu X,Qian J,Qin L,Li J,Xue C,Ding J,Wang W,Ding W,Yin R,Jin N,Ding Z

    更新日期:2020-08-01 00:00:00

  • Molecular mechanisms of coronavirus RNA capping and methylation.

    abstract::The 5'-cap structures of eukaryotic mRNAs are important for RNA stability, pre-mRNA splicing, mRNA export, and protein translation. Many viruses have evolved mechanisms for generating their own cap structures with methylation at the N7 position of the capped guanine and the ribose 2'-Oposition of the first nucleotide,...

    journal_title:Virologica Sinica

    pub_type: 杂志文章,评审

    doi:10.1007/s12250-016-3726-4

    authors: Chen Y,Guo D

    更新日期:2016-02-01 00:00:00

  • A new strategy for full-length Ebola virus glycoprotein expression in E.coli.

    abstract::Ebola virus (EBOV) causes severe hemorrhagic fever in humans and non-human primates with high rates of fatality. Glycoprotein (GP) is the only envelope protein of EBOV, which may play a critical role in virus attachment and entry as well as stimulating host protective immune responses. However, the lack of expression ...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-016-3845-y

    authors: Zai J,Yi Y,Xia H,Zhang B,Yuan Z

    更新日期:2016-12-01 00:00:00

  • Novel SFTSV Phylogeny Reveals New Reassortment Events and Migration Routes.

    abstract::Severe fever with thrombocytopenia syndrome virus (SFTSV), the causative agent of a febrile human disease, was first identified from central and eastern provinces in China, and later in Japan and South Korea. Hubei Province is one of the major SFTS epidemic areas in the central part of China. This study reported the i...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-020-00289-0

    authors: Wu X,Li M,Zhang Y,Liang B,Shi J,Fang Y,Su Z,Li M,Zhang W,Xu L,Wang J,Wu Q,Tang S,Wang H,Zhang T,Peng C,Zheng X,Deng F,Shen S

    更新日期:2020-09-22 00:00:00

  • Improving Cross-Protection against Influenza Virus Using Recombinant Vaccinia Vaccine Expressing NP and M2 Ectodomain Tandem Repeats.

    abstract::Conventional influenza vaccines need to be designed and manufactured yearly. However, they occasionally provide poor protection owing to antigenic mismatch. Hence, there is an urgent need to develop universal vaccines against influenza virus. Using nucleoprotein (NP) and extracellular domain of matrix protein 2 (M2e) ...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-019-00138-9

    authors: Wang W,Huang B,Wang X,Tan W,Ruan L

    更新日期:2019-10-01 00:00:00

  • Differential CircRNA Expression Profiles in PK-15 Cells Infected with Pseudorabies Virus Type II.

    abstract::Circular RNAs (circRNAs) belong to a class of non-coding RNAs with diverse biological functions. However, little is known about their roles in case of pseudorabies virus (PrV) infection. Here, we analyzed the expression profile of host circRNAs from a virulent PrV type II strain DX (PrV-DX) infected and an attenuated ...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-020-00255-w

    authors: Li H,Tang W,Jin Y,Dong W,Yan Y,Zhou J

    更新日期:2020-07-02 00:00:00

  • Extensive evolution analysis of the global chikungunya virus strains revealed the origination of CHIKV epidemics in Pakistan in 2016.

    abstract::Chikungunya virus (CHIKV) is a mosquito-borne virus that causes epidemics widely in the world especially in the tropical and subtropical regions. Phylogenetic analysis has found that the CHIKV lineages were associated with the spatial and temporal distributions, which were related to the virus adaption to the major mo...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-017-4077-5

    authors: Shi J,Su Z,Fan Z,Wang J,Liu S,Zhang B,Wei H,Jehan S,Jamil N,Shen S,Deng F

    更新日期:2017-12-01 00:00:00

  • Similar neutralizing activity in the HIV-1 infected long term non-progressors(LTNPs) and typical progressors(TPs).

    abstract::Neutralizing antibodies are considered to be an important protective parameter used in HIV-1 vaccine evaluation. However, the exact role that neutralizing antibodies plays in controlling the disease progression of HIV-1 infected peoples is still undetermined. In this paper, we compared the protective function of the n...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-012-3239-8

    authors: Wang Z,Li TY,Li JY,Chen LL,Liu YJ,Li HP,Bao ZY,Wang XL,Zhuang DM,Liu SY,Li L

    更新日期:2012-06-01 00:00:00

  • The Saffold Virus-Penang 2B and 3C Proteins, but not the L Protein, Induce Apoptosis in HEp-2 and Vero Cells.

    abstract::Our previous work has shown that Saffold virus (SAFV) induced several rodent and primate cell lines to undergo apoptosis (Xu et al. in Emerg Microb Infect 3:1-8, 2014), but the essential viral proteins of SAFV involved in apoptotic activity lack study. In this study, we individually transfected the viral proteins of S...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-019-00116-1

    authors: Xu Y,Victorio CBL,Meng T,Jia Q,Tan YJ,Chua KB

    更新日期:2019-06-01 00:00:00

  • Ion channels as antivirus targets.

    abstract::Ion channels are membrane proteins that are found in a number of viruses and which are of crucial physiological importance in the viral life cycle. They have one common feature in that their action mode involves a change of electrochemical or proton gradient across the bilayer lipid membrane which modulates viral or c...

    journal_title:Virologica Sinica

    pub_type: 杂志文章,评审

    doi:10.1007/s12250-010-3136-y

    authors: Liang X,Li ZY

    更新日期:2010-08-01 00:00:00

  • Flu Universal Vaccines: New Tricks on an Old Virus.

    abstract::Conventional influenza vaccines are based on predicting the circulating viruses year by year, conferring limited effectiveness since the antigenicity of vaccine strains does not always match the circulating viruses. This necessitates development of universal influenza vaccines that provide broader and lasting protecti...

    journal_title:Virologica Sinica

    pub_type: 杂志文章,评审

    doi:10.1007/s12250-020-00283-6

    authors: Du R,Cui Q,Rong L

    更新日期:2020-09-01 00:00:00

  • The preventive effect of vaccine prophylaxis on severe respiratory syncytial virus infection: A meta-analysis.

    abstract::Respiratory syncytial virus (RSV) is the key underlying cause of acute lower respiratory tract infection in infants; however, no licensed vaccine against RSV infection is currently available. This study was undertaken to assess the preventive effect of vaccine on RSV infection. In this metaanalysis, 1,792 published ra...

    journal_title:Virologica Sinica

    pub_type: 杂志文章,meta分析

    doi:10.1007/s12250-015-3630-3

    authors: Zhu T,Zhang C,Yu L,Chen J,Qiu H,Lyu W,Huang S

    更新日期:2015-10-01 00:00:00

  • Association of swine influenza H1N1 pandemic virus (SIV-H1N1p) with porcine respiratory disease complex in sows from commercial pig farms in Colombia.

    abstract::Porcine respiratory disease complex (PRDC) is a serious health problem that mainly affects growing and finishing pigs. PRDC is caused by a combination of viral and bacterial agents, such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), Mycoplasma hyopneumoniae (Myh), Actinob...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-014-3471-5

    authors: Jiménez LF,Ramírez Nieto G,Alfonso VV,Correa JJ

    更新日期:2014-08-01 00:00:00

  • Countrywide Survey for MERS-Coronavirus Antibodies in Dromedaries and Humans in Pakistan.

    abstract::Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in Pakistan, nasal (n = 77...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-018-0051-0

    authors: Zohaib A,Saqib M,Athar MA,Chen J,Sial AU,Khan S,Taj Z,Sadia H,Tahir U,Tayyab MH,Qureshi MA,Mansoor MK,Naeem MA,Hu BJ,Khan BA,Ujjan ID,Li B,Zhang W,Luo Y,Zhu Y,Waruhiu C,Khan I,Yang XL,Sajid MS,Corman VM,

    更新日期:2018-10-01 00:00:00

  • Establishment, growth kinetics, and susceptibility to AcMNPV of heat tolerant lepidopteran cell lines.

    abstract::Lepidopteran heat-tolerant (ht) cell lines have been obtained with sf-9, sf-21 and several Bombyx cells. They have a distinct karyotype, membrane lipid composition, morphology and growth kinetics from the parental cell lines. In this paper, we report the development of ht cell lines from other insect species and exami...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-011-3177-x

    authors: Wu YL,Jiang L,Hashimoto Y,Granados RR,Li GX

    更新日期:2011-06-01 00:00:00

  • Stability of HIV-1 subtype B and C Tat is associated with variation in the carboxyl-terminal region.

    abstract::The multifunctional trans-activator Tat is an essential regulatory protein for HIV-1 replication and is characterized by high sequence diversity. Numerous experimental studies have examined Tat in HIV-1 subtype B, but research on subtype C Tat is lacking, despite the high prevalence of infections caused by subtype C w...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-016-3681-0

    authors: Zhao X,Qian L,Zhou D,Qi D,Liu C,Kong X

    更新日期:2016-06-01 00:00:00

  • Chevrier's Field Mouse (Apodemus chevrieri) and Père David's Vole (Eothenomys melanogaster) in China Carry Orthohepeviruses that form Two Putative Novel Genotypes Within the Species Orthohepevirus C.

    abstract::Hepatitis E virus (HEV) is the prototype of the family Hepeviridae and the causative agent of common acute viral hepatitis. Genetically diverse HEV-related viruses have been detected in a variety of mammals and some of them may have zoonotic potential. In this study, we tested 278 specimens collected from seven wild s...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-018-0011-8

    authors: Wang B,Li W,Zhou JH,Li B,Zhang W,Yang WH,Pan H,Wang LX,Bock CT,Shi ZL,Zhang YZ,Yang XL

    更新日期:2018-02-01 00:00:00

  • Laboratory detection and diagnosis of filoviruses.

    abstract::Ebola virus (EBOV) and Marburg virus (MARV), belonging to the Filoviridae family, emerged four decades ago and caused severe viral hemorrhagic fever in human and other primates. As high as 50-90% mortality, filoviruses can cause significant threats to public health. However, so far no specific and efficient vaccine ha...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-011-3186-9

    authors: Wang YP,Zhang XE,Wei HP

    更新日期:2011-04-01 00:00:00

  • Productive HBV infection of well-differentiated, hNTCP-expressing human hepatoma-derived (Huh7) cells.

    abstract::Feasible and effective cell models for hepatitis B virus (HBV) infection are required for investigating the complete lifecycle of this virus, including the early steps of viral entry. Resistance to dimethyl sulfoxide/polyethylene glycol (DMSO/PEG), hNTCP expression, and a differentiated state are the limiting factors ...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-017-3983-x

    authors: Zhou M,Zhao K,Yao Y,Yuan Y,Pei R,Wang Y,Chen J,Hu X,Zhou Y,Chen X,Wu C

    更新日期:2017-12-01 00:00:00

  • Human endogenous retrovirus W env increases nitric oxide production and enhances the migration ability of microglia by regulating the expression of inducible nitric oxide synthase.

    abstract::Human endogenous retrovirus W env (HERV-W env) plays a critical role in many neuropsychological diseases such as schizophrenia and multiple sclerosis (MS). These diseases are accompanied by immunological reactions in the central nervous system (CNS). Microglia are important immunocytes in brain inflammation that can p...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-017-3997-4

    authors: Xiao R,Li S,Cao Q,Wang X,Yan Q,Tu X,Zhu Y,Zhu F

    更新日期:2017-06-01 00:00:00

  • Novel Primate Bocaparvovirus Species 3 Identified in Wild Macaca Mulatta in China.

    abstract::Primate bocaparvovirus (BOV) is a possible cause of respiratory disorders and gastroenteritis in humans. However, the diversity and evolution of these viruses remain largely unknown, despite the identification of a growing number of BOVs in non-human primates (NHPs). Here, we report the identification of a novel BOV (...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-019-00163-8

    authors: Ao Y,Duan Z

    更新日期:2020-02-01 00:00:00

  • Isolation and identification of a subgroup A avian leukosis virus from imported meat-type grand-parent chickens.

    abstract::An exogenous avian leukosis virus (ALV) strain SDAU09C1 was isolated in DF-1 cells from one of 240 imported 1-day-old white meat-type grand parent breeder chicks. Inoculation of SDAU09C1 in ALV-free chickens induced antibody reactions specific to subgroup A or B. But gp85 amino acid sequence comparisons indicated that...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-010-3095-3

    authors: Zhang QC,Zhao DM,Guo HJ,Cui ZZ

    更新日期:2010-04-01 00:00:00

  • Different responses of two highly permissive cell lines upon HCV infection.

    abstract::The construction of the first infectious clone JFH-1 speeds up the research on hepatitis C virus (HCV). However, Huh7 cell line was the only highly permissive cell line for HCV infection and only a few clones were fully permissive. In this study, two different fully permissive clones of Huh7 cells, Huh7.5.1 and Huh7-L...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-013-3342-5

    authors: Chen H,Pei R,Chen X

    更新日期:2013-08-01 00:00:00

  • Bioinformatic analysis of BBTV satellite DNA in Hainan.

    abstract::Banana bunchy top virus (BBTV), family Nanaviridae, genus Babuvirus, is a single stranded DNA virus (ssDNA) that causes banana bunchy top disease (BBTD) in banana plants. It is the most common and most destructive of all viruses in these plants and is widespread throughout the Asia-Pacific region. In this study we iso...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-011-3196-7

    authors: Yu NT,Feng TC,Zhang YL,Wang JH,Liu ZX

    更新日期:2011-08-01 00:00:00

  • Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks.

    abstract::Avian infectious bronchitis virus (IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopatho...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-015-3696-y

    authors: He Y,Xie Z,Dai J,Cao Y,Hou J,Zheng Y,Wei T,Mo M,Wei P

    更新日期:2016-02-01 00:00:00

  • Rapid detection of filoviruses by real-time TaqMan polymerase chain reaction assays.

    abstract::Ebola virus (EBOV) and Marburg virus (MARV) are causative agents of severe hemorrhagic fever with high mortality rates in humans and non-human primates and there is currently no licensed vaccine or therapeutics. To date, there is no specific laboratory diagnostic test in China, while there is a national need to provid...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-012-3252-y

    authors: Huang Y,Wei H,Wang Y,Shi Z,Raoul H,Yuan Z

    更新日期:2012-10-01 00:00:00

  • Interplay between hepatitis B virus and the innate immune responses: implications for new therapeutic strategies.

    abstract::Hepatitis B virus (HBV) infection is still a worldwide health problem; however, the current antiviral therapies for chronic hepatitis B are limited in efficacy. The outcome of HBV infection is thought to be the result of complex interactions between the HBV and the host immune system. While the role of the adaptive im...

    journal_title:Virologica Sinica

    pub_type: 杂志文章,评审

    doi:10.1007/s12250-014-3412-3

    authors: Chen J,Yuan Z

    更新日期:2014-02-01 00:00:00

  • Snapshots of a viral RNA polymerase switching gears from transcription initiation to elongation.

    abstract::During transcription initiation, RNA polymerase binds tightly to the promoter DNA defining the start of transcription, transcribes comparatively slowly, and frequently releases short transcripts (3-8 nucleotides) in a process called abortive cycling. Transitioning to elongation, the second phase of transcription, the ...

    journal_title:Virologica Sinica

    pub_type: 杂志文章,评审

    doi:10.1007/s12250-013-3397-3

    authors: Theis K

    更新日期:2013-12-01 00:00:00