Abstract:
:Respiratory syncytial virus (RSV) is the key underlying cause of acute lower respiratory tract infection in infants; however, no licensed vaccine against RSV infection is currently available. This study was undertaken to assess the preventive effect of vaccine on RSV infection. In this metaanalysis, 1,792 published randomized clinical trials of RSV vaccines from Jan 1973 to Sep 2015 were examined. Among thirteen studies that met the inclusion criteria, eleven studies estimated the impact of RSV vaccines and four studies estimated the effect of adjuvants. The odds ratios (ORs) were 0.31 (95% CI, 0.15-0.67) and 0.62 (95% CI, 0.29-1.34), respectively. We found that RSV subunit vaccines can significantly reduce the incidence of RSV infection and that whether vaccination with adjuvant therapy was an effective strategy still remained to be studied. This analysis of the preventive effect of vaccines on RSV infection has direct applications for the prevention of RSV infections.
journal_name
Virol Sinjournal_title
Virologica Sinicaauthors
Zhu T,Zhang C,Yu L,Chen J,Qiu H,Lyu W,Huang Sdoi
10.1007/s12250-015-3630-3subject
Has Abstractpub_date
2015-10-01 00:00:00pages
371-8issue
5eissn
1674-0769issn
1995-820Xpii
10.1007/s12250-015-3630-3journal_volume
30pub_type
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