Abstract:
:Bat SARS-like coronavirus (SL-CoV) has a genome organization almost identical to that of SARS-CoV, but the N-terminus of the Spike (S) proteins, which interacts with host receptor and is a major target of neutralizing antibodies against CoVs, of the two viruses has only 63-64% sequence identity. Although there have been reports studying the overall immunogenicity of SSL, knowledge on the precise location of immunodominant determinants for SSL is still lacking. In this study, using a series of truncated expressed SSL fragments and SSL specific mouse sera, we identified two immunogenic determinants for SSL. Importantly, one of the two regions seems to be located in a region not shared by known immunogenic determinants of the SSARS. This finding will be of potential use in future monitoring of SL-CoV infection in bats and spillover animals and in development of more effective vaccine to cover broad protection against this new group of coronaviruses.
journal_name
Virol Sinjournal_title
Virologica Sinicaauthors
Zhou P,Han Z,Wang LF,Shi Zdoi
10.1007/s12250-013-3292-ysubject
Has Abstractpub_date
2013-04-01 00:00:00pages
92-6issue
2eissn
1674-0769issn
1995-820Xjournal_volume
28pub_type
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