Ocular herpes: the pathophysiology, management and treatment of herpetic eye diseases.

abstract：:Isolates of Newcastle disease virus (NDV) from deceased wild and domestic pigeons in Kazakhstan were obtained from the Almaty region during 2005 and were genotypically analyzed by using reverse transcription polymerase chain reaction (RT-PCR) with primers specific to the viral fusion (F) protein gene. Part of the ampl...

journal_title：Virologica Sinica

authors： Bogoyavlenskiy A,Berezin V,Prilipov A,Usachev E,Korotetskiy I,Zaitceva I,Kydyrmanov A,Sayatov M

更新日期：2012-04-01 00:00:00

abstract：:Human cytomegalovirus (HCMV), a herpesvirus, is an important human pathogen that causes asymptomatic infections in healthy or immunocompetent individuals but can lead to severe and potentially life-threatening complications in immune-immature individuals such as neonates or immune-compromised patients such as organ-tr...

journal_title：Virologica Sinica

authors： Liu G,Hai R,Liu F

更新日期：2017-10-01 00:00:00

abstract：:Feasible and effective cell models for hepatitis B virus (HBV) infection are required for investigating the complete lifecycle of this virus, including the early steps of viral entry. Resistance to dimethyl sulfoxide/polyethylene glycol (DMSO/PEG), hNTCP expression, and a differentiated state are the limiting factors ...

journal_title：Virologica Sinica

authors： Zhou M,Zhao K,Yao Y,Yuan Y,Pei R,Wang Y,Chen J,Hu X,Zhou Y,Chen X,Wu C

更新日期：2017-12-01 00:00:00

abstract：:During transcription initiation, RNA polymerase binds tightly to the promoter DNA defining the start of transcription, transcribes comparatively slowly, and frequently releases short transcripts (3-8 nucleotides) in a process called abortive cycling. Transitioning to elongation, the second phase of transcription, the ...

journal_title：Virologica Sinica

authors： Theis K

更新日期：2013-12-01 00:00:00

abstract：:H9N2 subtype avian influenza virus (AIV) is an influenza A virus that is widely spread throughout Asia, where it jeopardizes the poultry industry and provides genetic material for emerging human pathogens. To better understand the epidemicity and genetics of H9 subtype AIVs, we conducted active surveillance in live po...

journal_title：Virologica Sinica

authors： Hu Z,Peng F,Xiong Z,Zhang W,Li T,Shi Y,Xie J,Jin X,Huang J,Xiao H,Bi D,Song N,Li Z

更新日期：2020-09-14 00:00:00

abstract：:Similar to Hepatitis C virus (HCV) infection in humans, HCVcc infection can also result in persistent and chronic infection. The core protein is a variable protein and exists in several sizes. Some sizes of core proteins have been reported to be related to chronic HCV infection. To study the possible role of the core ...

journal_title：Virologica Sinica

authors： Liao Q,Tian J,Wu Y,Chen X

更新日期：2013-06-01 00:00:00

abstract：:The temporal change patterns of laboratory data may provide insightful clues into the whole course of COVID-19. This study aimed to evaluate longitudinal change patterns of key laboratory tests in patients with COVID-19, and identify independent prognostic factors by examining the associations between laboratory findi...

journal_title：Virologica Sinica

authors： Tian S,Zhu X,Sun X,Wang J,Zhou Q,Wang C,Chen L,Li S,Xu J

更新日期：2020-12-01 00:00:00

abstract：:During virus infection, RIG-I-like receptors (RLRs) recognize viral RNAs and recruit the adaptor protein VISA to activate downstream signaling, leading to activation of transcription factors NF-κB and IRF3, which collaborate to induce type I interferons (IFNs). IFNs further induce expression of hundreds of IFN-stimula...

journal_title：Virologica Sinica

authors： Wang DP,Zhang HY,Liao BW,Tong Z,Xu ZS,Wang YY,Yang Y

更新日期：2020-08-07 00:00:00

abstract：:Japanese encephalitis (JE) is a viral encephalitis disease caused by Japanese encephalitis virus (JEV) infection. Uncontrolled inflammatory responses in the central nervous system (CNS) are a hallmark of severe JE. Although the CCR2-CCL2 axis is important for monocytes trafficking during JEV infection, little is known...

journal_title：Virologica Sinica

authors： Zhang F,Qi L,Li T,Li X,Yang D,Cao S,Ye J,Wei B

更新日期：2019-10-01 00:00:00

abstract：:Human endogenous retrovirus W env (HERV-W env) plays a critical role in many neuropsychological diseases such as schizophrenia and multiple sclerosis (MS). These diseases are accompanied by immunological reactions in the central nervous system (CNS). Microglia are important immunocytes in brain inflammation that can p...

journal_title：Virologica Sinica

authors： Xiao R,Li S,Cao Q,Wang X,Yan Q,Tu X,Zhu Y,Zhu F

更新日期：2017-06-01 00:00:00

abstract：:In this study, the coding region of type O FMDV capsid protein VP1 and a series of codon optimized DNA sequences coding for VP1 amino acid residues 141-160 (epitope1), tandem repeat 200-213 (epitope2 (+2)) and the combination of two epitopes (epitope1-2) was genetically cloned into the prokaryotic expression vector pP...

journal_title：Virologica Sinica

authors： Gao SD,Du JZ,Chang HY,Cong GZ,Shao JJ,Lin T,Song S,Xie QG

更新日期：2010-02-01 00:00:00

abstract：:Ebola virus (EBOV) and Marburg virus (MARV), belonging to the Filoviridae family, emerged four decades ago and caused severe viral hemorrhagic fever in human and other primates. As high as 50-90% mortality, filoviruses can cause significant threats to public health. However, so far no specific and efficient vaccine ha...

journal_title：Virologica Sinica

authors： Wang YP,Zhang XE,Wei HP

更新日期：2011-04-01 00:00:00

abstract：:Bat SARS-like coronavirus (SL-CoV) has a genome organization almost identical to that of SARS-CoV, but the N-terminus of the Spike (S) proteins, which interacts with host receptor and is a major target of neutralizing antibodies against CoVs, of the two viruses has only 63-64% sequence identity. Although there have be...

journal_title：Virologica Sinica

authors： Zhou P,Han Z,Wang LF,Shi Z

更新日期：2013-04-01 00:00:00

abstract：:Neutralizing antibodies are considered to be an important protective parameter used in HIV-1 vaccine evaluation. However, the exact role that neutralizing antibodies plays in controlling the disease progression of HIV-1 infected peoples is still undetermined. In this paper, we compared the protective function of the n...

journal_title：Virologica Sinica

authors： Wang Z,Li TY,Li JY,Chen LL,Liu YJ,Li HP,Bao ZY,Wang XL,Zhuang DM,Liu SY,Li L

更新日期：2012-06-01 00:00:00

abstract：:Exosomes are cell-derived vesicles that are secreted by many eukaryotic cells. It has recently attracted attention as vehicles of intercellular communication. Virus-infected cells release exosomes, which contain viral proteins, RNA, and pathogenic molecules. However, the role of exosomes in virus infection process rem...

journal_title：Virologica Sinica

authors： Wang J,Wu F,Liu C,Dai W,Teng Y,Su W,Kong W,Gao F,Cai L,Hou A,Jiang C

更新日期：2019-02-01 00:00:00

abstract：:The multifunctional trans-activator Tat is an essential regulatory protein for HIV-1 replication and is characterized by high sequence diversity. Numerous experimental studies have examined Tat in HIV-1 subtype B, but research on subtype C Tat is lacking, despite the high prevalence of infections caused by subtype C w...

journal_title：Virologica Sinica

authors： Zhao X,Qian L,Zhou D,Qi D,Liu C,Kong X

更新日期：2016-06-01 00:00:00

abstract：:Dengue virus (DENV) and Zika virus (ZIKV) have spread throughout many countries in the developing world and infect millions of people every year, causing severe harm to human health and the economy. Unfortunately, there are few effective vaccines and therapies available against these viruses. Therefore, the discovery ...

journal_title：Virologica Sinica

authors： Ji Z,Li F,Xia Z,Guo X,Gao M,Sun F,Cheng Y,Wu Y,Li W,Ali SA,Cao Z

更新日期：2018-12-01 00:00:00

abstract：:The construction of the first infectious clone JFH-1 speeds up the research on hepatitis C virus (HCV). However, Huh7 cell line was the only highly permissive cell line for HCV infection and only a few clones were fully permissive. In this study, two different fully permissive clones of Huh7 cells, Huh7.5.1 and Huh7-L...

journal_title：Virologica Sinica

authors： Chen H,Pei R,Chen X

更新日期：2013-08-01 00:00:00

abstract：:Banana bunchy top virus (BBTV) poses a serious danger to banana crops worldwide. BBTV-encoded protein B4 is a determinant of pathogenicity. However, the relevant molecular mechanisms underlying its effects remain unknown. In this study, we found that a functional peptide could be liberated from protein B4, likely via ...

journal_title：Virologica Sinica

authors： Zhuang J,Lin W,Coates CJ,Shang P,Wei T,Wu Z,Xie L

更新日期：2019-06-01 00:00:00

abstract：:Laos is the only landlocked country in Southeast Asia and borders Thailand, Myanmar and Cambodia, the three countries in this region that have been hardest hit by human immunodeficiency virus (HIV). Laos has been regarded as a low-HIV-prevalence country for decades. To understand the status of HIV in Laos in recent ye...

journal_title：Virologica Sinica

authors： Chen X,Ye M,Wang Y,Zhang C,Zheng YT

更新日期：2020-10-01 00:00:00

abstract：:In this study, the decay of maternal peste des petits ruminants virus (PPRV) antibodies in kids born to goats vaccinated with Asian lineage IV PPR vaccine and the efficacy of passive immunity against PPRV was assessed to determine the appropriate period for vaccination in kids. Serum samples collected from kids born t...

journal_title：Virologica Sinica

authors： Balamurugan V,Sen A,Venkatesan G,Rajak KK,Bhanuprakash V,Singh RK

更新日期：2012-08-01 00:00:00

abstract：:Conventional influenza vaccines are based on predicting the circulating viruses year by year, conferring limited effectiveness since the antigenicity of vaccine strains does not always match the circulating viruses. This necessitates development of universal influenza vaccines that provide broader and lasting protecti...

journal_title：Virologica Sinica

authors： Du R,Cui Q,Rong L

更新日期：2020-09-01 00:00:00

abstract：:Ion channels are membrane proteins that are found in a number of viruses and which are of crucial physiological importance in the viral life cycle. They have one common feature in that their action mode involves a change of electrochemical or proton gradient across the bilayer lipid membrane which modulates viral or c...

journal_title：Virologica Sinica

authors： Liang X,Li ZY

更新日期：2010-08-01 00:00:00

abstract：:The epidemiology of HIV-1 varies in different areas of the world, and it is possible that this complexity may leave unique footprints in the viral genome. Thus, we attempted to find significant patterns in global HIV-1 genome sequences. By applying the rule inference algorithm RIPPER (Repeated Incremental Pruning to P...

journal_title：Virologica Sinica

authors： Wang Y,Rawi R,Hoffmann D,Sun B,Yang R

更新日期：2013-08-01 00:00:00

abstract：:Avian infectious bronchitis virus (IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopatho...

journal_title：Virologica Sinica

authors： He Y,Xie Z,Dai J,Cao Y,Hou J,Zheng Y,Wei T,Mo M,Wei P

更新日期：2016-02-01 00:00:00

abstract：:The protein HTRP (human transcription regulator protein) is encoded by the differential gene htrp and induced by Herpes simplex virus type 1 (HSV-1) infection in KMB-17 cells. HTRP was found to interact with SAP30 (mSin3A Association Protein), one of the components of co-repressor complex mSin3A, which is part of the ...

journal_title：Virologica Sinica

authors： Chen J,Li YM,Li JF,Liu LD,Liao Y,Na RX,Wang JJ,Wang LC,Li QH

更新日期：2010-12-01 00:00:00

abstract：:The dengue virus (DENV) is a vital global public health issue. The 2014 dengue epidemic in Guangzhou, China, caused approximately 40,000 cases of infection and five deaths. We carried out a comprehensive investigation aimed at identifying the transmission sources in this dengue epidemic. To analyze the phylogenetics o...

journal_title：Virologica Sinica

authors： Li G,Pan P,He Q,Kong X,Wu K,Zhang W,Liu Y,Huang H,Liu J,Zhang Z,Wu,Lai X,Liu X,Wu J

更新日期：2017-02-01 00:00:00

abstract：:Newcastle disease virus (NDV) and H9N2 subtype Avian influenza virus (AIV) are two notorious avian respiratory pathogens that cause great losses in the poultry industry. Current inactivated commercial vaccines against NDV and AIV have the disadvantages of inadequate mucosal responses, while an attenuated live vaccine ...

journal_title：Virologica Sinica

authors： Xu X,Qian J,Qin L,Li J,Xue C,Ding J,Wang W,Ding W,Yin R,Jin N,Ding Z

更新日期：2020-08-01 00:00:00

abstract：:Histone deacetylase (HDAC) inhibitors show clinical promise for the treatment of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the effect of HDAC inhibitor treatment on hepatitis C virus (HCV) replication in Huh7 human liver cells and in a mouse model of HCV infection. Viral replica...

journal_title：Virologica Sinica

authors： Zhou Y,Wang Q,Yang Q,Tang J,Xu C,Gai D,Chen X,Chen J

更新日期：2018-10-01 00:00:00

abstract：:Primate bocaparvovirus (BOV) is a possible cause of respiratory disorders and gastroenteritis in humans. However, the diversity and evolution of these viruses remain largely unknown, despite the identification of a growing number of BOVs in non-human primates (NHPs). Here, we report the identification of a novel BOV (...

journal_title：Virologica Sinica

authors： Ao Y,Duan Z

更新日期：2020-02-01 00:00:00