Novel Primate Bocaparvovirus Species 3 Identified in Wild Macaca Mulatta in China.

Abstract:

:Primate bocaparvovirus (BOV) is a possible cause of respiratory disorders and gastroenteritis in humans. However, the diversity and evolution of these viruses remain largely unknown, despite the identification of a growing number of BOVs in non-human primates (NHPs). Here, we report the identification of a novel BOV (provisionally named Macaca mulatta bocaparvovirus [MmBOV]) in the feces of wild Macaca mulatta in China by viral metagenomic analysis. Seven of 400 fecal samples from Macaca mulatta were positive for MmBOV. An almost complete genome sequence of 4,831 nucleotides was obtained, which had genomic organization and protein motifs similar to human bocaviruses (HOBVs), and shared characteristically low G/C content and weak codon usage bias. Sequence analyses of NS1, NP1, and VP1 revealed that MmBOV was most closely related to HBOV4 of Primate bocaparvovirus 2 (approximately 68.4%/70.6%, 73.3%/67.6%, and 70.4%/73.1% nucleotide/amino acid identities, respectively). Additionally, phylogenetic analysis revealed that MmBOV formed an independent peripheral branch, but clustered closely with those of the Primate bocaparvovirus species in the BOV genus (particularly HBOV4). These data strongly suggest that HBOV4 originated from NHP bocaparvoviruses around 200-300 years ago, and that NHPs may act as HBOV reservoirs. Following the International Committee of Taxonomy for Viruses guidelines, we propose MmBOV as a new species (tentatively named Primate bocaparvovirus 3) in the genus Bocaparvovirus, which is the first report of a novel species of primate BOV. Our data facilitate future research on the genetic diversity and evolution of primate bocaparvoviruses and highlight the importance of bocaparvovirus surveys in wild NHPs.

journal_name

Virol Sin

journal_title

Virologica Sinica

authors

Ao Y,Duan Z

doi

10.1007/s12250-019-00163-8

subject

Has Abstract

pub_date

2020-02-01 00:00:00

pages

34-42

issue

1

eissn

1674-0769

issn

1995-820X

pii

10.1007/s12250-019-00163-8

journal_volume

35

pub_type

杂志文章
  • Flu Universal Vaccines: New Tricks on an Old Virus.

    abstract::Conventional influenza vaccines are based on predicting the circulating viruses year by year, conferring limited effectiveness since the antigenicity of vaccine strains does not always match the circulating viruses. This necessitates development of universal influenza vaccines that provide broader and lasting protecti...

    journal_title:Virologica Sinica

    pub_type: 杂志文章,评审

    doi:10.1007/s12250-020-00283-6

    authors: Du R,Cui Q,Rong L

    更新日期:2020-09-01 00:00:00

  • Association of swine influenza H1N1 pandemic virus (SIV-H1N1p) with porcine respiratory disease complex in sows from commercial pig farms in Colombia.

    abstract::Porcine respiratory disease complex (PRDC) is a serious health problem that mainly affects growing and finishing pigs. PRDC is caused by a combination of viral and bacterial agents, such as porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), Mycoplasma hyopneumoniae (Myh), Actinob...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-014-3471-5

    authors: Jiménez LF,Ramírez Nieto G,Alfonso VV,Correa JJ

    更新日期:2014-08-01 00:00:00

  • B cell epitopes within VP1 of type O foot-and-mouth disease virus for detection of viral antibodies.

    abstract::In this study, the coding region of type O FMDV capsid protein VP1 and a series of codon optimized DNA sequences coding for VP1 amino acid residues 141-160 (epitope1), tandem repeat 200-213 (epitope2 (+2)) and the combination of two epitopes (epitope1-2) was genetically cloned into the prokaryotic expression vector pP...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-010-3041-4

    authors: Gao SD,Du JZ,Chang HY,Cong GZ,Shao JJ,Lin T,Song S,Xie QG

    更新日期:2010-02-01 00:00:00

  • An Effective Platform for Exploring Rotavirus Receptors by Bacterial Surface Display System.

    abstract::Rotavirus (RV) is a major foodborne pathogen. For RV prevention and control, it is a key to uncover the interaction mechanism between virus and its receptors. However, it is hard to specially purify the viral receptors, including histo-blood group antigens (HBGAs). Previously, the protruding domain protein (P protein)...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-019-00174-5

    authors: Liu D,Geng H,Zhang Z,Xing Y,Yang D,Liu Z,Wang D

    更新日期:2020-02-01 00:00:00

  • A new strategy for full-length Ebola virus glycoprotein expression in E.coli.

    abstract::Ebola virus (EBOV) causes severe hemorrhagic fever in humans and non-human primates with high rates of fatality. Glycoprotein (GP) is the only envelope protein of EBOV, which may play a critical role in virus attachment and entry as well as stimulating host protective immune responses. However, the lack of expression ...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-016-3845-y

    authors: Zai J,Yi Y,Xia H,Zhang B,Yuan Z

    更新日期:2016-12-01 00:00:00

  • Laboratory detection and diagnosis of filoviruses.

    abstract::Ebola virus (EBOV) and Marburg virus (MARV), belonging to the Filoviridae family, emerged four decades ago and caused severe viral hemorrhagic fever in human and other primates. As high as 50-90% mortality, filoviruses can cause significant threats to public health. However, so far no specific and efficient vaccine ha...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-011-3186-9

    authors: Wang YP,Zhang XE,Wei HP

    更新日期:2011-04-01 00:00:00

  • Molecular mechanisms of coronavirus RNA capping and methylation.

    abstract::The 5'-cap structures of eukaryotic mRNAs are important for RNA stability, pre-mRNA splicing, mRNA export, and protein translation. Many viruses have evolved mechanisms for generating their own cap structures with methylation at the N7 position of the capped guanine and the ribose 2'-Oposition of the first nucleotide,...

    journal_title:Virologica Sinica

    pub_type: 杂志文章,评审

    doi:10.1007/s12250-016-3726-4

    authors: Chen Y,Guo D

    更新日期:2016-02-01 00:00:00

  • Zika virus and Zika fever.

    abstract::An emerging mosquito-borne arbovirus named Zika virus (ZIKV), of the family Flaviviridae and genus Flavivirus, is becoming a global health threat. ZIKV infection was long neglected due to its sporadic nature and mild symptoms. However, recently, with its rapid spread from Asia to the Americas, affecting more than 30 c...

    journal_title:Virologica Sinica

    pub_type: 杂志文章,评审

    doi:10.1007/s12250-016-3780-y

    authors: Wang Z,Wang P,An J

    更新日期:2016-04-01 00:00:00

  • Genetic and Molecular Characterization of H9N2 Avian Influenza Viruses Isolated from Live Poultry Markets in Hubei Province, Central China, 2013-2017.

    abstract::H9N2 subtype avian influenza virus (AIV) is an influenza A virus that is widely spread throughout Asia, where it jeopardizes the poultry industry and provides genetic material for emerging human pathogens. To better understand the epidemicity and genetics of H9 subtype AIVs, we conducted active surveillance in live po...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-020-00260-z

    authors: Hu Z,Peng F,Xiong Z,Zhang W,Li T,Shi Y,Xie J,Jin X,Huang J,Xiao H,Bi D,Song N,Li Z

    更新日期:2020-09-14 00:00:00

  • Different responses of two highly permissive cell lines upon HCV infection.

    abstract::The construction of the first infectious clone JFH-1 speeds up the research on hepatitis C virus (HCV). However, Huh7 cell line was the only highly permissive cell line for HCV infection and only a few clones were fully permissive. In this study, two different fully permissive clones of Huh7 cells, Huh7.5.1 and Huh7-L...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-013-3342-5

    authors: Chen H,Pei R,Chen X

    更新日期:2013-08-01 00:00:00

  • Ion channels as antivirus targets.

    abstract::Ion channels are membrane proteins that are found in a number of viruses and which are of crucial physiological importance in the viral life cycle. They have one common feature in that their action mode involves a change of electrochemical or proton gradient across the bilayer lipid membrane which modulates viral or c...

    journal_title:Virologica Sinica

    pub_type: 杂志文章,评审

    doi:10.1007/s12250-010-3136-y

    authors: Liang X,Li ZY

    更新日期:2010-08-01 00:00:00

  • Countrywide Survey for MERS-Coronavirus Antibodies in Dromedaries and Humans in Pakistan.

    abstract::Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a zoonotic pathogen capable of causing severe respiratory disease in humans. Although dromedary camels are considered as a major reservoir host, the MERS-CoV infection dynamics in camels are not fully understood. Through surveillance in Pakistan, nasal (n = 77...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-018-0051-0

    authors: Zohaib A,Saqib M,Athar MA,Chen J,Sial AU,Khan S,Taj Z,Sadia H,Tahir U,Tayyab MH,Qureshi MA,Mansoor MK,Naeem MA,Hu BJ,Khan BA,Ujjan ID,Li B,Zhang W,Luo Y,Zhu Y,Waruhiu C,Khan I,Yang XL,Sajid MS,Corman VM,

    更新日期:2018-10-01 00:00:00

  • Foot-and-Mouth Disease Virus Inhibits RIP2 Protein Expression to Promote Viral Replication.

    abstract::Receptors interaction protein 2 (RIP2) is a specific adaptor molecule in the downstream of NOD2. The role of RIP2 during foot-and-mouth disease virus (FMDV) infection remains unknown. Here, our results showed that RIP2 inhibited FMDV replication and played an important role in the activation of IFN-β and NF-ĸB signal ...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-020-00322-2

    authors: Liu H,Xue Q,Zhu Z,Yang F,Cao W,Liu X,Zheng H

    更新日期:2021-01-05 00:00:00

  • A Crowned Killer's Résumé: Genome, Structure, Receptors, and Origin of SARS-CoV-2.

    abstract::The recent emergence and rapid global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pose an unprecedented medical and socioeconomic crisis, and the disease caused by it, Coronavirus disease 2019 (COVID-19), was declared a pandemic by the World Health Organization (WHO) on March 11, 2020. C...

    journal_title:Virologica Sinica

    pub_type: 杂志文章,评审

    doi:10.1007/s12250-020-00298-z

    authors: Wang S,Trilling M,Sutter K,Dittmer U,Lu M,Zheng X,Yang D,Liu J

    更新日期:2020-12-01 00:00:00

  • Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks.

    abstract::Avian infectious bronchitis virus (IBV) is a Gammacoronavirus in the family Coronaviridae and causes highly contagious respiratory disease in chickens. Innate immunity plays significant roles in host defense against IBV. Here, we explored the interaction between IBV and the host innate immune system. Severe histopatho...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-015-3696-y

    authors: He Y,Xie Z,Dai J,Cao Y,Hou J,Zheng Y,Wei T,Mo M,Wei P

    更新日期:2016-02-01 00:00:00

  • Comparison of influenza outbreaks in the Republic of Kazakhstan and Russia induced by 2009 yearly new variant of A(H1N1) influenza virus.

    abstract::The aim of the work is the comparison of the epidemiology of influenza and acute respiratory virus infections (ARVI) in the Republic of Kazakhstan with the corresponding influenza epidemic in Russia induced by influenza pandemic virus A/California/07/2009 in 2009. Data on influenza and ARVI from the Republic of Kazakh...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-011-3203-z

    authors: Karpova LS,Popovtseva NM,Stolyarova TP,Stolyarov KA,Mamadaliyev SM,Khairullin BM,Sandybayev NT,Kydyrbayev ZhK,Orynbayev MB,Ospanov KS,Baiserkin BS,Boibosinov EU

    更新日期:2011-10-01 00:00:00

  • Ocular herpes: the pathophysiology, management and treatment of herpetic eye diseases.

    abstract::Herpesviruses are a prominent cause of human viral disease, second only to the cold and influenza viruses. Most herpesvirus infections are mild or asymptomatic. However, when the virus invades the eye, a number of pathologies can develop and its associated sequelae have become a considerable source of ocular morbidity...

    journal_title:Virologica Sinica

    pub_type: 杂志文章,评审

    doi:10.1007/s12250-014-3539-2

    authors: Zhu L,Zhu H

    更新日期:2014-12-01 00:00:00

  • Bovine herpesvirus 1 protein bICP0 represses the transcription of bISG15 in fetal bovine lung cells.

    abstract::The ubiquitin-like modifier bISG15 is an antiviral protein found in fetal bovine lung (FBL) cells. Bovine Herpesvirus 1(BHV-1), which is a viral pathogen of cattle, can infect FBL cells and induce cytopathic effects. Real-time PCR assays showed that BHV-1's infection could repress the basal or inducible transcription ...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-011-3213-x

    authors: Liu C,Kong XH,Qiao WT,Geng YQ

    更新日期:2011-12-01 00:00:00

  • The identification of three sizes of core proteins during the establishment of persistent hepatitis C virus infection in vitro.

    abstract::Similar to Hepatitis C virus (HCV) infection in humans, HCVcc infection can also result in persistent and chronic infection. The core protein is a variable protein and exists in several sizes. Some sizes of core proteins have been reported to be related to chronic HCV infection. To study the possible role of the core ...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-013-3296-7

    authors: Liao Q,Tian J,Wu Y,Chen X

    更新日期:2013-06-01 00:00:00

  • Bioinformatic analysis of BBTV satellite DNA in Hainan.

    abstract::Banana bunchy top virus (BBTV), family Nanaviridae, genus Babuvirus, is a single stranded DNA virus (ssDNA) that causes banana bunchy top disease (BBTD) in banana plants. It is the most common and most destructive of all viruses in these plants and is widespread throughout the Asia-Pacific region. In this study we iso...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-011-3196-7

    authors: Yu NT,Feng TC,Zhang YL,Wang JH,Liu ZX

    更新日期:2011-08-01 00:00:00

  • Transcriptional regulation by HSV-1 induced HTRP via acetylation system.

    abstract::The protein HTRP (human transcription regulator protein) is encoded by the differential gene htrp and induced by Herpes simplex virus type 1 (HSV-1) infection in KMB-17 cells. HTRP was found to interact with SAP30 (mSin3A Association Protein), one of the components of co-repressor complex mSin3A, which is part of the ...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-010-3147-8

    authors: Chen J,Li YM,Li JF,Liu LD,Liao Y,Na RX,Wang JJ,Wang LC,Li QH

    更新日期:2010-12-01 00:00:00

  • Detection of congenital cytomegalovirus in newborns using nucleic acid amplification techniques and its public health implications.

    abstract::Human cytomegalovirus (HCMV), a herpesvirus, is an important human pathogen that causes asymptomatic infections in healthy or immunocompetent individuals but can lead to severe and potentially life-threatening complications in immune-immature individuals such as neonates or immune-compromised patients such as organ-tr...

    journal_title:Virologica Sinica

    pub_type: 杂志文章,评审

    doi:10.1007/s12250-017-4055-y

    authors: Liu G,Hai R,Liu F

    更新日期:2017-10-01 00:00:00

  • The Prevalence, Genetic Characterization, and Evolutionary Analysis of Porcine Pegivirus in Guangdong, China.

    abstract::Porcine pegivirus (PPgV) is a member of the Pegivirus genus in the Flaviviridae family. PPgV is an emerging virus that has been discovered in swine herds in Germany, the United States, China, Poland, Italy, and the United Kingdom, indicating a wide geographical distribution. In this retrospective study, 339 pig serum ...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-020-00240-3

    authors: Xie Y,Wang X,Feng J,Wei L,Li G,Si G,Chen Y,Yan H,He D

    更新日期:2020-07-08 00:00:00

  • Productive HBV infection of well-differentiated, hNTCP-expressing human hepatoma-derived (Huh7) cells.

    abstract::Feasible and effective cell models for hepatitis B virus (HBV) infection are required for investigating the complete lifecycle of this virus, including the early steps of viral entry. Resistance to dimethyl sulfoxide/polyethylene glycol (DMSO/PEG), hNTCP expression, and a differentiated state are the limiting factors ...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-017-3983-x

    authors: Zhou M,Zhao K,Yao Y,Yuan Y,Pei R,Wang Y,Chen J,Hu X,Zhou Y,Chen X,Wu C

    更新日期:2017-12-01 00:00:00

  • Interplay between hepatitis B virus and the innate immune responses: implications for new therapeutic strategies.

    abstract::Hepatitis B virus (HBV) infection is still a worldwide health problem; however, the current antiviral therapies for chronic hepatitis B are limited in efficacy. The outcome of HBV infection is thought to be the result of complex interactions between the HBV and the host immune system. While the role of the adaptive im...

    journal_title:Virologica Sinica

    pub_type: 杂志文章,评审

    doi:10.1007/s12250-014-3412-3

    authors: Chen J,Yuan Z

    更新日期:2014-02-01 00:00:00

  • Prediction of the Receptorome for the Human-Infecting Virome.

    abstract::The virus receptors are key for the viral infection of host cells. Identification of the virus receptors is still challenging at present. Our previous study has shown that human virus receptor proteins have some unique features including high N-glycosylation level, high number of interaction partners and high expressi...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-020-00259-6

    authors: Zhang Z,Ye S,Wu A,Jiang T,Peng Y

    更新日期:2020-07-28 00:00:00

  • Prevalence of HIV Indeterminate Western Blot Tests and Follow-up of HIV Antibody Sero-Conversion in Southeastern China.

    abstract::HIV-indeterminate Western blotting (WB) results are typically obtained in WB confirmatory assays, and the number of indeterminate samples may increase with the detection of HIV infections, which will present considerable challenges for the management of HIV/AIDS. Nucleic acid detection has been used as a laboratory te...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-019-00130-3

    authors: Wu S,Gao M,Zheng J,Yan P,Wang W,Lu X,Qiu Y,Yan Y

    更新日期:2019-08-01 00:00:00

  • Stability of HIV-1 subtype B and C Tat is associated with variation in the carboxyl-terminal region.

    abstract::The multifunctional trans-activator Tat is an essential regulatory protein for HIV-1 replication and is characterized by high sequence diversity. Numerous experimental studies have examined Tat in HIV-1 subtype B, but research on subtype C Tat is lacking, despite the high prevalence of infections caused by subtype C w...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-016-3681-0

    authors: Zhao X,Qian L,Zhou D,Qi D,Liu C,Kong X

    更新日期:2016-06-01 00:00:00

  • A Prognostic Model to Predict Recovery of COVID-19 Patients Based on Longitudinal Laboratory Findings.

    abstract::The temporal change patterns of laboratory data may provide insightful clues into the whole course of COVID-19. This study aimed to evaluate longitudinal change patterns of key laboratory tests in patients with COVID-19, and identify independent prognostic factors by examining the associations between laboratory findi...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-020-00317-z

    authors: Tian S,Zhu X,Sun X,Wang J,Zhou Q,Wang C,Chen L,Li S,Xu J

    更新日期:2020-12-01 00:00:00

  • Chimeric Newcastle Disease Virus-like Particles Containing DC-Binding Peptide-Fused Haemagglutinin Protect Chickens from Virulent Newcastle Disease Virus and H9N2 Avian Influenza Virus Challenge.

    abstract::Newcastle disease virus (NDV) and H9N2 subtype Avian influenza virus (AIV) are two notorious avian respiratory pathogens that cause great losses in the poultry industry. Current inactivated commercial vaccines against NDV and AIV have the disadvantages of inadequate mucosal responses, while an attenuated live vaccine ...

    journal_title:Virologica Sinica

    pub_type: 杂志文章

    doi:10.1007/s12250-020-00199-1

    authors: Xu X,Qian J,Qin L,Li J,Xue C,Ding J,Wang W,Ding W,Yin R,Jin N,Ding Z

    更新日期:2020-08-01 00:00:00