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A Blueprint for HIV Vaccine Discovery.

Abstract：

:Despite numerous attempts over many years to develop an HIV vaccine based on classical strategies, none has convincingly succeeded to date. A number of approaches are being pursued in the field, including building upon possible efficacy indicated by the recent RV144 clinical trial, which combined two HIV vaccines. Here, we argue for an approach based, in part, on understanding the HIV envelope spike and its interaction with broadly neutralizing antibodies (bnAbs) at the molecular level and using this understanding to design immunogens as possible vaccines. BnAbs can protect against virus challenge in animal models, and many such antibodies have been isolated recently. We further propose that studies focused on how best to provide T cell help to B cells that produce bnAbs are crucial for optimal immunization strategies. The synthesis of rational immunogen design and immunization strategies, together with iterative improvements, offers great promise for advancing toward an HIV vaccine.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Burton DR,Ahmed R,Barouch DH,Butera ST,Crotty S,Godzik A,Kaufmann DE,McElrath MJ,Nussenzweig MC,Pulendran B,Scanlan CN,Schief WR,Silvestri G,Streeck H,Walker BD,Walker LM,Ward AB,Wilson IA,Wyatt R

doi

10.1016/j.chom.2012.09.008

subject

Has Abstract

pub_date

2012-10-18 00:00:00

pages

396-407

issue

4

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(12)00315-0

journal_volume

12

pub_type

杂志文章,评审

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