Abstract：
:Intracellular pathogens like Shigella flexneri enter host cells by phagocytosis. Once inside, the pathogen breaks the vacuolar membrane for cytosolic access. The fate and function of the vacuolar membrane remnants are not clear. Examining Shigella-infected nonmyeloid cells, we observed that proteins associated with vacuolar membrane remnants are polyubiquinated, recruit the autophagy marker LC3 and adaptor p62, and are targeted to autophagic degradation. Further, inflammasome components and caspase-1 were localized to these membranes and correlated with dampened inflammatory response and necrotic cell death. In Atg4B mutant cells in which autophagosome maturation is blocked, polyubiquitinated proteins and P62 accumulated on membrane remnants, and as in autophagy-deficient Atg5(-/-) cells, the early inflammatory and cytokine response was exacerbated. Our results suggest that host membranes, after rupture by an invading cytoplasm-targeted bacterium, contribute to the cellular responses to infection by acting as a signaling node, with autophagy playing a central role in regulating these responses.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Dupont N,Lacas-Gervais S,Bertout J,Paz I,Freche B,Van Nhieu GT,van der Goot FG,Sansonetti PJ,Lafont Fdoi
10.1016/j.chom.2009.07.005subject
Has Abstractpub_date
2009-08-20 00:00:00pages
137-49issue
2eissn
1931-3128issn
1934-6069pii
S1931-3128(09)00250-9journal_volume
6pub_type
杂志文章abstract：:Duffy antigen receptor for chemokines (DARC) expressed on red blood cells (RBCs) influences plasma levels of HIV-1-suppressive and proinflammatory chemokines such as CCL5/RANTES. DARC is also the RBC receptor for Plasmodium vivax. Africans with DARC -46C/C genotype, which confers a DARC-negative phenotype, are resista...
journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 杂志文章,评审
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2020.08.011
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2019.02.005
更新日期：2019-04-10 00:00:00
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2010.03.001
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2014.06.004
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2016.10.011
更新日期：2016-12-14 00:00:00
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journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2008.07.009
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
pub_type： 杂志文章
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
pub_type： 杂志文章
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journal_title：Cell host & microbe
pub_type： 杂志文章
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更新日期：2018-11-14 00:00:00
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2012.07.013
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abstract：:Typhoidal and non-typhoidal Salmonelleae (NTS) cause typhoid fever and gastroenteritis, respectively, in humans. Salmonella typhoid toxin contributes to typhoid disease progression and chronic infection, but little is known about the role of its NTS ortholog. We found that typhoid toxin and its NTS ortholog induce dif...
journal_title：Cell host & microbe
pub_type： 杂志文章
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