Abstract:
:The emergence of circulating vaccine-derived polioviruses through evolution of the oral polio vaccine (OPV) poses a significant obstacle to polio eradication. Understanding the early genetic changes that occur as OPV evolves and transmits is important for preventing future outbreaks. Here, we use deep sequencing to define the evolutionary trajectories of type 2 OPV in a vaccine trial. By sequencing 497 longitudinal stool samples from 271 OPV2 recipients and household contacts, we were able to examine the extent of convergent evolution in vaccinated individuals and the amount of viral diversity that is transmitted. In addition to rapid reversion of key attenuating mutations, we identify strong selection at 19 sites across the genome. We find that a tight transmission bottleneck limits the onward transmission of these early adaptive mutations. Our results highlight the distinct evolutionary dynamics of live attenuated virus vaccines and have important implications for the success of next-generation OPV.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Valesano AL,Taniuchi M,Fitzsimmons WJ,Islam MO,Ahmed T,Zaman K,Haque R,Wong W,Famulare M,Lauring ASdoi
10.1016/j.chom.2020.10.011subject
Has Abstractpub_date
2021-01-13 00:00:00pages
32-43.e4issue
1eissn
1931-3128issn
1934-6069pii
S1931-3128(20)30574-6journal_volume
29pub_type
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