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A PfRH5-based vaccine is efficacious against heterologous strain blood-stage Plasmodium falciparum infection in aotus monkeys.

Abstract：

:Antigenic diversity has posed a critical barrier to vaccine development against the pathogenic blood-stage infection of the human malaria parasite Plasmodium falciparum. To date, only strain-specific protection has been reported by trials of such vaccines in nonhuman primates. We recently showed that P. falciparum reticulocyte binding protein homolog 5 (PfRH5), a merozoite adhesin required for erythrocyte invasion, is highly susceptible to vaccine-inducible strain-transcending parasite-neutralizing antibody. In vivo efficacy of PfRH5-based vaccines has not previously been evaluated. Here, we demonstrate that PfRH5-based vaccines can protect Aotus monkeys against a virulent vaccine-heterologous P. falciparum challenge and show that such protection can be achieved by a human-compatible vaccine formulation. Protection was associated with anti-PfRH5 antibody concentration and in vitro parasite-neutralizing activity, supporting the use of this in vitro assay to predict the in vivo efficacy of future vaccine candidates. These data suggest that PfRH5-based vaccines have potential to achieve strain-transcending efficacy in humans.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Douglas AD,Baldeviano GC,Lucas CM,Lugo-Roman LA,Crosnier C,Bartholdson SJ,Diouf A,Miura K,Lambert LE,Ventocilla JA,Leiva KP,Milne KH,Illingworth JJ,Spencer AJ,Hjerrild KA,Alanine DG,Turner AV,Moorhead JT,Edgel KA,Wu

doi

10.1016/j.chom.2014.11.017

subject

Has Abstract

pub_date

2015-01-14 00:00:00

pages

130-9

issue

1

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(14)00455-7

journal_volume

17

pub_type

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