当前位置： SCI文献检索 > Cell Host & Microbe期刊下所有文献 > Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.

Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.

Abstract：

:Surface-associated TRAP (thrombospondin-related anonymous protein) family proteins are conserved across the phylum of apicomplexan parasites. TRAP proteins are thought to play an integral role in parasite motility and cell invasion by linking the extracellular environment with the parasite submembrane actomyosin motor. Blood stage forms of the malaria parasite Plasmodium express a TRAP family protein called merozoite-TRAP (MTRAP) that has been implicated in erythrocyte invasion. Using MTRAP-deficient mutants of the rodent-infecting P. berghei and human-infecting P. falciparum parasites, we show that MTRAP is dispensable for erythrocyte invasion. Instead, MTRAP is essential for gamete egress from erythrocytes, where it is necessary for the disruption of the gamete-containing parasitophorous vacuole membrane, and thus for parasite transmission to mosquitoes. This indicates that motor-binding TRAP family members function not just in parasite motility and cell invasion but also in membrane disruption and cell egress.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Bargieri DY,Thiberge S,Tay CL,Carey AF,Rantz A,Hischen F,Lorthiois A,Straschil U,Singh P,Singh S,Triglia T,Tsuboi T,Cowman A,Chitnis C,Alano P,Baum J,Pradel G,Lavazec C,Ménard R

doi

10.1016/j.chom.2016.10.015

subject

Has Abstract

pub_date

2016-11-09 00:00:00

pages

618-630

issue

5

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(16)30441-3

journal_volume

20

pub_type

杂志文章

相关文献

Cell Host & Microbe文献大全
  • Making It Stick: A Compelling Case for Precision Microbiome Reconstitution.

    abstract：:Modification of the intestinal microbiome is an emerging target to improve health and prevent or treat a number of diseases. In this issue of Cell Host & Microbe, Maldonado-Gómez et al. (2016) uncover the basic principles that govern the successful establishment and persistence of an exogenously introduced gut bacteri...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2016.09.012

    authors： Berry D

    更新日期：2016-10-12 00:00:00

  • Co-option of Membrane Wounding Enables Virus Penetration into Cells.

    abstract：:During cell entry, non-enveloped viruses undergo partial uncoating to expose membrane lytic proteins for gaining access to the cytoplasm. We report that adenovirus uses membrane piercing to induce and hijack cellular wound removal processes that facilitate further membrane disruption and infection. Incoming adenovirus...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2015.06.006

    authors： Luisoni S,Suomalainen M,Boucke K,Tanner LB,Wenk MR,Guan XL,Grzybek M,Coskun Ü,Greber UF

    更新日期：2015-07-08 00:00:00

  • Phosphorylation-Regulated Activation of the Arabidopsis RRS1-R/RPS4 Immune Receptor Complex Reveals Two Distinct Effector Recognition Mechanisms.

    abstract：:The Arabidopsis immune receptors RPS4 and RRS1 interact to co-confer responsiveness to bacterial effectors. The RRS1-R allele, with RPS4, responds to AvrRps4 and PopP2, whereas RRS1-S responds only to AvrRps4. Here, we show that the C terminus of RRS1-R but not RRS1-S is phosphorylated. Phosphorylation at Thr1214 in t...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.03.008

    authors： Guo H,Ahn HK,Sklenar J,Huang J,Ma Y,Ding P,Menke FLH,Jones JDG

    更新日期：2020-05-13 00:00:00

  • Heme oxygenase-1 is an anti-inflammatory host factor that promotes murine plasmodium liver infection.

    abstract：:The clinically silent Plasmodium liver stage is an obligatory step in the establishment of malaria infection and disease. We report here that expression of heme oxygenase-1 (HO-1, encoded by Hmox1) is upregulated in the liver following infection by Plasmodium berghei and Plasmodium yoelii sporozoites. HO-1 overexpress...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2008.04.003

    authors： Epiphanio S,Mikolajczak SA,Gonçalves LA,Pamplona A,Portugal S,Albuquerque S,Goldberg M,Rebelo S,Anderson DG,Akinc A,Vornlocher HP,Kappe SH,Soares MP,Mota MM

    更新日期：2008-05-15 00:00:00

  • A critical role for SOCS3 in innate resistance to Toxoplasma gondii.

    abstract：:The innate and adaptive immune responses that confer resistance to the intracellular pathogen Toxoplasma gondii critically depend on IL-12 production, which drives interferon-γ (IFN-γ) expression. Certain cytokines can activate STAT3 and limit IL-12 production to prevent infection-associated immune pathology, but T. g...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2011.07.009

    authors： Whitmarsh RJ,Gray CM,Gregg B,Christian DA,May MJ,Murray PJ,Hunter CA

    更新日期：2011-09-15 00:00:00

  • Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner.

    abstract：:The prototypic arenavirus lymphocytic choriomeningitis virus (LCMV), which naturally persists in rodents, represents a model for HIV, HBV, and HCV. Cleavage of the viral glycoprotein precursor by membrane-bound transcription factor peptidase, site 1 (Mbtps1 or site-1 protease), is crucial for the life cycle of arenavi...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2011.02.006

    authors： Popkin DL,Teijaro JR,Sullivan BM,Urata S,Rutschmann S,de la Torre JC,Kunz S,Beutler B,Oldstone M

    更新日期：2011-03-17 00:00:00

  • KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses.

    abstract：:Human type A Enteroviruses (EV-As) cause diseases ranging from hand-foot-and-mouth disease to poliomyelitis-like disease. Although cellular receptors are identified for some EV-As, they remain elusive for the majority of EV-As. We identify the cell surface molecule KREMEN1 as an entry receptor for coxsackievirus A10 (...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.03.019

    authors： Staring J,van den Hengel LG,Raaben M,Blomen VA,Carette JE,Brummelkamp TR

    更新日期：2018-05-09 00:00:00

  • Measles virus takes a two-pronged attack on PP1.

    abstract：:During viral infection, RIG-I-like receptors (RLRs) are activated upon dephosphorylation by the phosphatase PP1, resulting in type I interferon production. In this issue, Davis et al. (2014) and Mesman et al. (2014) show that measles virus inhibits this antiviral response by targeting PP1 and thus preventing RLR depho...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2014.06.013

    authors： Seya T

    更新日期：2014-07-09 00:00:00

  • Host metabolism regulates intracellular growth of Trypanosoma cruzi.

    abstract：:Metabolic coupling of intracellular pathogens with host cells is essential for successful colonization of the host. Establishment of intracellular infection by the protozoan Trypanosoma cruzi leads to the development of human Chagas' disease, yet the functional contributions of the host cell toward the infection proce...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.11.011

    authors： Caradonna KL,Engel JC,Jacobi D,Lee CH,Burleigh BA

    更新日期：2013-01-16 00:00:00

  • Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication.

    abstract：:Herpes simplex virus 1 (HSV-1) establishes infections in humans and mice, but some non-human primates exhibit resistance via unknown mechanisms. Innate immune recognition pathways are highly conserved but are pivotal in determining susceptibility to DNA virus infections. We report that variation of a single amino acid...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.07.004

    authors： Zhang J,Zhao J,Xu S,Li J,He S,Zeng Y,Xie L,Xie N,Liu T,Lee K,Seo GJ,Chen L,Stabell AC,Xia Z,Sawyer SL,Jung J,Huang C,Feng P

    更新日期：2018-08-08 00:00:00

  • Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals.

    abstract：:In 2014, an outbreak of avian A/H10N7 influenza virus occurred among seals along North-European coastal waters, significantly impacting seal populations. Here, we examine the cross-species transmission and mammalian adaptation of this influenza A virus, revealing changes in the hemagglutinin surface protein that incre...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.08.011

    authors： Herfst S,Zhang J,Richard M,McBride R,Lexmond P,Bestebroer TM,Spronken MIJ,de Meulder D,van den Brand JM,Rosu ME,Martin SR,Gamblin SJ,Xiong X,Peng W,Bodewes R,van der Vries E,Osterhaus ADME,Paulson JC,Skehel JJ,Fouch

    更新日期：2020-10-07 00:00:00

  • Cofactors required for TLR7- and TLR9-dependent innate immune responses.

    abstract：:Pathogens commonly utilize endocytic pathways to gain cellular access. The endosomal pattern recognition receptors TLR7 and TLR9 detect pathogen-encoded nucleic acids to initiate MyD88-dependent proinflammatory responses to microbial infection. Using genome-wide RNAi screening and integrative systems-based analysis, w...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.02.002

    authors： Chiang CY,Engel A,Opaluch AM,Ramos I,Maestre AM,Secundino I,De Jesus PD,Nguyen QT,Welch G,Bonamy GM,Miraglia LJ,Orth AP,Nizet V,Fernandez-Sesma A,Zhou Y,Barton GM,Chanda SK

    更新日期：2012-03-15 00:00:00

  • Caging and COM-Bating Antibiotic Resistance.

    abstract：:Horizontal gene transfer (HGT) facilitates spead of antibiotic resistance elements. In this issue of Cell Host & Microbe, Domenech et al. discover that compounds disrupting proton motive force block natural competence (COM) and interrupt intraspecies HGT and exchange of antibiotic resistance. Such strategies might min...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2020.03.013

    authors： Rosch JW,Tuomanen EI

    更新日期：2020-04-08 00:00:00

  • Keeping viruses in Chk: DNA damage signaling puts the brakes on transformation.

    abstract：:Oncogenic viruses infect many cells but rarely lead to tumorigenesis. In this issue of Cell Host & Microbe, Nikitin et al. describe how a protective DNA damage response acts to suppress transformation in the majority of cells latently infected with Epstein-Barr virus (EBV). ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2010.11.010

    authors： Lilley CE,Weitzman MD

    更新日期：2010-12-16 00:00:00

  • Carving a Niche for Antibacterial α-Defensins when Craving.

    abstract：:In this issue of Cell Host & Microbe, Liang et al. (2019) show that α-defensins in the gastrointestinal tract sustain defenses to enteric pathogens during starvation. mTOR-dependent sensing of nutrient loss promotes production of an α-defensin regulator, which sustains α-defensin levels, loss of which increases lethal...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2019.04.009

    authors： Foerster EG,Girardin SE

    更新日期：2019-05-08 00:00:00

  • Regional Diversity of the Gastrointestinal Microbiome.

    abstract：:The role of gut microbes in health and disease has often been surmised from stool, which is easily sampled and rich in microbial diversity, density, and abundance. Microbial analyses of stool have been accepted as measures to determine the relationship of gut microbiomes with host health and disease, based on the beli...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2019.08.011

    authors： Martinez-Guryn K,Leone V,Chang EB

    更新日期：2019-09-11 00:00:00

  • A neuron-specific role for autophagy in antiviral defense against herpes simplex virus.

    abstract：:Type I interferons (IFNs) are considered to be the universal mechanism by which viral infections are controlled. However, many IFN-stimulated genes (ISGs) rely on antiviral pathways that are toxic to host cells, which may be detrimental in nonrenewable cell types, such as neurons. We show that dorsal root ganglionic (...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.07.013

    authors： Yordy B,Iijima N,Huttner A,Leib D,Iwasaki A

    更新日期：2012-09-13 00:00:00

  • Virus budding and the ESCRT pathway.

    abstract：:Enveloped viruses escape infected cells by budding through limiting membranes. In the decade since the discovery that HIV recruits cellular ESCRT (endosomal sorting complexes required for transport) machinery to facilitate viral budding, this pathway has emerged as the major escape route for enveloped viruses. In cell...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2013.08.012

    authors： Votteler J,Sundquist WI

    更新日期：2013-09-11 00:00:00

  • The host nonsense-mediated mRNA decay pathway restricts Mammalian RNA virus replication.

    abstract：:In addition to classically defined immune mechanisms, cell-intrinsic processes can restrict virus infection and have shaped virus evolution. The details of this virus-host interaction are still emerging. Following a genome-wide siRNA screen for host factors affecting replication of Semliki Forest virus (SFV), a positi...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.08.007

    authors： Balistreri G,Horvath P,Schweingruber C,Zünd D,McInerney G,Merits A,Mühlemann O,Azzalin C,Helenius A

    更新日期：2014-09-10 00:00:00

  • A Blueprint for HIV Vaccine Discovery.

    abstract：:Despite numerous attempts over many years to develop an HIV vaccine based on classical strategies, none has convincingly succeeded to date. A number of approaches are being pursued in the field, including building upon possible efficacy indicated by the recent RV144 clinical trial, which combined two HIV vaccines. Her...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2012.09.008

    authors： Burton DR,Ahmed R,Barouch DH,Butera ST,Crotty S,Godzik A,Kaufmann DE,McElrath MJ,Nussenzweig MC,Pulendran B,Scanlan CN,Schief WR,Silvestri G,Streeck H,Walker BD,Walker LM,Ward AB,Wilson IA,Wyatt R

    更新日期：2012-10-18 00:00:00

  • A Single Legionella Effector Catalyzes a Multistep Ubiquitination Pathway to Rearrange Tubular Endoplasmic Reticulum for Replication.

    abstract：:Intracellular pathogens manipulate host organelles to support replication within cells. For Legionella pneumophila, the bacterium translocates proteins that establish an endoplasmic reticulum (ER)-associated replication compartment. We show here that the bacterial Sde proteins target host reticulon 4 (Rtn4) to control...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2016.12.007

    authors： Kotewicz KM,Ramabhadran V,Sjoblom N,Vogel JP,Haenssler E,Zhang M,Behringer J,Scheck RA,Isberg RR

    更新日期：2017-02-08 00:00:00

  • A Microbial Drugstore for Motility.

    abstract：:While there is growing appreciation that the microbiome regulates gut-brain signaling, the underlying mechanisms remain elusive. In this issue of Cell Host & Microbe, Bhattarai et al. (2018) identify bacteria-derived tryptamine as a ligand for the gut-epithelium-expressed GPCR 5-HT4 receptor, thereby functioning as a ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2018.05.020

    authors： Cryan JF,Clarke G,Dinan TG,Schellekens H

    更新日期：2018-06-13 00:00:00

  • Multiple targets of nitric oxide in the tricarboxylic acid cycle of Salmonella enterica serovar typhimurium.

    abstract：:Host nitric oxide (NO⋅) production is important for controlling intracellular bacterial pathogens, including Salmonella enterica serovar Typhimurium, but the underlying mechanisms are incompletely understood. S. Typhmurium 14028s is prototrophic for all amino acids but cannot synthesize methionine (M) or lysine (K) du...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2011.06.004

    authors： Richardson AR,Payne EC,Younger N,Karlinsey JE,Thomas VC,Becker LA,Navarre WW,Castor ME,Libby SJ,Fang FC

    更新日期：2011-07-21 00:00:00

  • Microbial pathogen-induced necrotic cell death mediated by the inflammasome components CIAS1/cryopyrin/NLRP3 and ASC.

    abstract：:Cryopyrin (CIAS1, NLRP3) and ASC are components of the inflammasome, a multiprotein complex required for caspase-1 activation and cytokine IL-1beta production. CIAS1 mutations underlie autoinflammation characterized by excessive IL-1beta secretion. Disease-associated cryopyrin also causes a program of necrosis-like ce...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2007.07.009

    authors： Willingham SB,Bergstralh DT,O'Connor W,Morrison AC,Taxman DJ,Duncan JA,Barnoy S,Venkatesan MM,Flavell RA,Deshmukh M,Hoffman HM,Ting JP

    更新日期：2007-09-13 00:00:00

  • The cancer microbiome atlas: a pan-cancer comparative analysis to distinguish tissue-resident microbiota from contaminants.

    abstract：:Studying the microbial composition of internal organs and their associations with disease remains challenging due to the difficulty of acquiring clinical biopsies. We designed a statistical model to analyze the prevalence of species across sample types from The Cancer Genome Atlas (TCGA), revealing that species equipr...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.12.001

    authors： Dohlman AB,Arguijo Mendoza D,Ding S,Gao M,Dressman H,Iliev ID,Lipkin SM,Shen X

    更新日期：2020-12-21 00:00:00

  • Finding Leishmania: a deadly game of hide-and-seek.

    abstract：:Leishmaniasis is a chronic infection in which intracellular parasites avoid destruction by the immune system. Using intravital imaging, Filipe-Santos et al. (2009) demonstrate that some parasitized dendritic cells receive much less attention than others during their choreographed dance with T cells, suggesting that th...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章,评审

    doi：10.1016/j.chom.2009.07.002

    authors： Scott P

    更新日期：2009-07-23 00:00:00

  • Both Neutralizing and Non-Neutralizing Human H7N9 Influenza Vaccine-Induced Monoclonal Antibodies Confer Protection.

    abstract：:Pathogenic H7N9 avian influenza viruses continue to represent a public health concern, and several candidate vaccines are currently being developed. It is vital to assess if protective antibodies are induced following vaccination and to characterize the diversity of epitopes targeted. Here we characterized the binding...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2016.05.014

    authors： Henry Dunand CJ,Leon PE,Huang M,Choi A,Chromikova V,Ho IY,Tan GS,Cruz J,Hirsh A,Zheng NY,Mullarkey CE,Ennis FA,Terajima M,Treanor JJ,Topham DJ,Subbarao K,Palese P,Krammer F,Wilson PC

    更新日期：2016-06-08 00:00:00

  • Mammalian PGRPs also mind the fort.

    abstract：:Peptidoglycan recognition proteins (PGRPs or Pglyrps) regulate antibacterial responses in Drosophila, yet their functions in humans remain unclear. In this issue of Cell Host & Microbe, Saha and colleagues report that mammalian PGRPs can prevent aberrant interferon-gamma--induced inflammatory damage in vivo by modulat...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2010.07.010

    authors： Rubino S,Lee J,Girardin SE

    更新日期：2010-08-19 00:00:00

  • Automated Prediction and Annotation of Small Open Reading Frames in Microbial Genomes.

    abstract：:Small open reading frames (smORFs) and their encoded microproteins play central roles in microbes. However, there is a vast unexplored space of smORFs within human-associated microbes. A recent bioinformatic analysis used evolutionary conservation signals to enhance prediction of small protein families. To facilitate ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.11.002

    authors： Durrant MG,Bhatt AS

    更新日期：2021-01-13 00:00:00

  • Homeostasis in infected epithelia: stem cells take the lead.

    abstract：:To maintain tissue homeostasis and avoid disease, epithelial cells damaged by pathogens need to be readily replenished, and this is mainly achieved by the activation of stem cells. In this Short Review, we discuss recent developments in the exciting field of host epithelia-pathogen interaction in Drosophila as well as...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2009.10.001

    authors： Pitsouli C,Apidianakis Y,Perrimon N

    更新日期：2009-10-22 00:00:00