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Host metabolism regulates intracellular growth of Trypanosoma cruzi.

Abstract：

:Metabolic coupling of intracellular pathogens with host cells is essential for successful colonization of the host. Establishment of intracellular infection by the protozoan Trypanosoma cruzi leads to the development of human Chagas' disease, yet the functional contributions of the host cell toward the infection process remain poorly characterized. Here, a genome-scale functional screen identified interconnected metabolic networks centered around host energy production, nucleotide metabolism, pteridine biosynthesis, and fatty acid oxidation as key processes that fuel intracellular T. cruzi growth. Additionally, the host kinase Akt, which plays essential roles in various cellular processes, was critical for parasite replication. Targeted perturbations in these host metabolic pathways or Akt-dependent signaling pathways modulated the parasite's replicative capacity, highlighting the adaptability of this intracellular pathogen to changing conditions in the host. These findings identify key cellular process regulating intracellular T. cruzi growth and illuminate the potential to leverage host pathways to limit T. cruzi infection.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Caradonna KL,Engel JC,Jacobi D,Lee CH,Burleigh BA

doi

10.1016/j.chom.2012.11.011

subject

Has Abstract

pub_date

2013-01-16 00:00:00

pages

108-17

issue

1

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(12)00426-X

journal_volume

13

pub_type

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