Abstract：
:The clinically silent Plasmodium liver stage is an obligatory step in the establishment of malaria infection and disease. We report here that expression of heme oxygenase-1 (HO-1, encoded by Hmox1) is upregulated in the liver following infection by Plasmodium berghei and Plasmodium yoelii sporozoites. HO-1 overexpression in the liver leads to a proportional increase in parasite liver load, and treatment of mice with carbon monoxide and with biliverdin, each an enzymatic product of HO-1, also increases parasite liver load. Conversely, mice lacking Hmox1 completely resolve the infection. In the absence of HO-1, the levels of inflammatory cytokines involved in the control of liver infection are increased. These findings suggest that, while stimulating inflammation, the liver stage of Plasmodium also induces HO-1 expression, which modulates the host inflammatory response, protecting the infected hepatocytes and promoting the liver stage of infection.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Epiphanio S,Mikolajczak SA,Gonçalves LA,Pamplona A,Portugal S,Albuquerque S,Goldberg M,Rebelo S,Anderson DG,Akinc A,Vornlocher HP,Kappe SH,Soares MP,Mota MMdoi
10.1016/j.chom.2008.04.003subject
Has Abstractpub_date
2008-05-15 00:00:00pages
331-8issue
5eissn
1931-3128issn
1934-6069pii
S1931-3128(08)00121-2journal_volume
3pub_type
杂志文章abstract：:Pioneering plant research has shown that many Nod-like receptors (NLRs) detect pathogens indirectly via recognizing modifications of other host proteins. In this issue, two groups show that the RPM1 NLR is activated by phosphorylation of the host protein RIN4, probably resulting from activation of a host kinase by pat...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 杂志文章,评审
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 杂志文章
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
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doi：10.1016/j.chom.2011.04.009
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2016.11.011
更新日期：2016-12-14 00:00:00
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journal_title：Cell host & microbe
pub_type： 杂志文章,评审
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2009.01.003
更新日期：2009-02-19 00:00:00
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2009.08.009
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 杂志文章
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2013.12.002
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2012.02.002
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abstract：:Vaccines are the most effective means available for preventing infectious diseases. However, vaccine-induced immune responses are highly variable between individuals and between populations in different regions of the world. Understanding the basis of this variation is, thus, of fundamental importance to human health....
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
pub_type： 杂志文章
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abstract：:(+)strand RNA viruses have to overcome various points of restriction in the host to establish successful infection. In plants, this includes RNA silencing. To uncover additional bottlenecks to RNA virus infection, we genetically attenuated the impact of RNA silencing on transgenically expressed Potato virus X (PVX), a...
journal_title：Cell host & microbe
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