Abstract：
:(+)strand RNA viruses have to overcome various points of restriction in the host to establish successful infection. In plants, this includes RNA silencing. To uncover additional bottlenecks to RNA virus infection, we genetically attenuated the impact of RNA silencing on transgenically expressed Potato virus X (PVX), a (+)strand RNA virus that replicates in Arabidopsis. A genetic screen in this sensitized background uncovered how nonsense-mediated decay (NMD), a host RNA quality control mechanism, recognizes and eliminates PVX RNAs with internal termination codons and long 3' UTRs. NMD also operates in natural infection contexts, and while some viruses have evolved genome expression strategies to overcome this process altogether, the virulence of NMD-activating viruses entails their ability to directly suppress NMD or to promote an NMD-unfavorable cellular state. These principles of induction, evasion, and suppression define NMD as a general viral restriction mechanism in plants that also likely operates in animals.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Garcia D,Garcia S,Voinnet Odoi
10.1016/j.chom.2014.08.001subject
Has Abstractpub_date
2014-09-10 00:00:00pages
391-402issue
3eissn
1931-3128issn
1934-6069pii
S1931-3128(14)00270-4journal_volume
16pub_type
杂志文章abstract：:Viral proteins have evolved to target cellular organelles and usurp their functions for virus replication. Despite the knowledge of these critical functions for several organelles, little is known about peroxisomes during infection. Peroxisomes are primarily metabolic organelles with important functions in lipid metab...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2018.09.002
更新日期：2018-10-10 00:00:00
abstract：:Virulence of emerging community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and other highly pathogenic S. aureus strains depends on their production of phenol-soluble modulin (PSM) peptide toxins, which combine the capacities to attract and lyse neutrophils. The molecular basis of PSM-stimulated ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2010.05.012
更新日期：2010-06-25 00:00:00
abstract：:Neutralizing antibodies (NAbs) are traditionally thought to inhibit virus infection by preventing virion entry into target cells. In addition, antibodies can engage Fc receptors (FcRs) on immune cells to activate antiviral responses. We describe a mechanism by which NAbs inhibit chikungunya virus (CHIKV), the most com...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2018.07.018
更新日期：2018-09-12 00:00:00
abstract：:Oncogenic viruses infect many cells but rarely lead to tumorigenesis. In this issue of Cell Host & Microbe, Nikitin et al. describe how a protective DNA damage response acts to suppress transformation in the majority of cells latently infected with Epstein-Barr virus (EBV). ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2010.11.010
更新日期：2010-12-16 00:00:00
abstract：:Eliciting HIV-1-specific broadly neutralizing antibodies (bNAbs) remains a challenge for vaccine development, and the potential of passively delivered bNAbs for prophylaxis and therapeutics is being explored. We used neutralization data from four large virus panels to comprehensively map viral signatures associated wi...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2018.12.001
更新日期：2019-01-09 00:00:00
abstract：:Although anthrax toxin was identified as a major Bacillus anthracis virulence factor over 50 years ago, defining the physiologically relevant targets has been challenging. Liu et al. demonstrate that intoxication of myeloid-derived cells contributes to establishing infection but is not required for mortality resulting...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2010.10.011
更新日期：2010-11-18 00:00:00
abstract：:Duffy antigen receptor for chemokines (DARC) expressed on red blood cells (RBCs) influences plasma levels of HIV-1-suppressive and proinflammatory chemokines such as CCL5/RANTES. DARC is also the RBC receptor for Plasmodium vivax. Africans with DARC -46C/C genotype, which confers a DARC-negative phenotype, are resista...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2008.06.002
更新日期：2008-07-17 00:00:00
abstract：:After invading host cells, Toxoplasma gondii multiplies within a parasitophorous vacuole (PV) that is maintained by parasite proteins secreted from organelles called dense granules. Most dense granule proteins remain within the PV, and few are known to access the host cell cytosol. We identify GRA16 as a dense granule...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2013.03.002
更新日期：2013-04-17 00:00:00
abstract：:Vaccines are needed to combat the global rise in fungal diseases. In this issue of Cell Host & Microbe, Wüthrich et al. (2015) identify calnexin as a target of antigen-specific CD4 T cell responses against multiple fungal pathogens. This study illustrates that a conserved epitope triggers convergent cell-mediated immu...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2015.03.012
更新日期：2015-04-08 00:00:00
abstract：:Polysaccharide A (PSA), the archetypical immunomodulatory molecule of the gut commensal Bacteroides fragilis, induces regulatory T cells to secrete the anti-inflammatory cytokine interleukin-10 (IL-10). The cellular mediators of PSA's immunomodulatory properties are incompletely understood. In a mouse model of colitis...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2014.03.006
更新日期：2014-04-09 00:00:00
abstract：:Control of virus infection relies on the stimulation of interferon-stimulated genes (ISGs) that inhibit viral replication. In a recent Nature paper, Gizzi et al. (2018) discovered that the ISG viperin inhibits virus replication by generating the ribonucleotide ddhCTP, which interferes with RNA synthesis, thus offering...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2018.07.014
更新日期：2018-08-08 00:00:00
abstract：:Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever, a life-threatening human disease. The lack of animal models due to S. Typhi's strict human host specificity has hindered its study and vaccine development. We find that immunodeficient Rag2(-/-) γc(-/-) mice engrafted with human fetal liver hematopoiet...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2010.09.003
更新日期：2010-10-21 00:00:00
abstract：:In an era of increasing antibiotic resistance, growing clinical need for new drugs, and few lead molecules, new research is helping to identify new targets and the mechanism of action of lead molecules. ...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2009.08.009
更新日期：2009-09-17 00:00:00
abstract：:Characterization of single antibody lineages within infected individuals has provided insights into the development of Env-specific antibodies. However, a systems-level understanding of the humoral response against HIV-1 is limited. Here, we interrogated the antibody repertoires of multiple HIV-infected donors from an...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2018.05.001
更新日期：2018-06-13 00:00:00
abstract：:Recent studies have revealed remarkable species specificity of the Toll-like receptors (TLRs) TLR11 and TLR12 and the immunity-related GTPase (IRG) proteins that are essential elements for detection and immune control of Toxoplasma gondii in mice, but not in humans. The biological and evolutionary implications of thes...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2014.01.004
更新日期：2014-02-12 00:00:00
abstract：:Apicomplexa are unicellular eukaryotic pathogens that carry a vestigial algal endosymbiont, the apicoplast. The physiological function of the apicoplast and its integration into parasite metabolism remain poorly understood and at times controversial. We establish that the Toxoplasma apicoplast membrane-localized phosp...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2009.12.002
更新日期：2010-01-21 00:00:00
abstract：:During viral infection, RIG-I-like receptors (RLRs) are activated upon dephosphorylation by the phosphatase PP1, resulting in type I interferon production. In this issue, Davis et al. (2014) and Mesman et al. (2014) show that measles virus inhibits this antiviral response by targeting PP1 and thus preventing RLR depho...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2014.06.013
更新日期：2014-07-09 00:00:00
abstract：:Local infection in the Drosophila larval intestine elicits a systemic immune reaction in fat bodies. In this issue, Wu and colleagues (2012) show that this is a reactive oxygen species-dependent communication. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2012.04.003
更新日期：2012-04-19 00:00:00
abstract：:The type 2 immune response evoked by intestinal nematode parasites contributes to worm expulsion and tolerance to associated tissue damage. We investigated whether this host response is affected by blocking signaling by the putative endogenous danger signal adenosine, which can be released during inflammation and host...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2014.02.001
更新日期：2014-03-12 00:00:00
abstract：:Rabies virus (RABV), the etiological agent for the lethal disease of rabies, is a deadly zoonotic pathogen. The RABV glycoprotein (RABV-G) is a key factor mediating virus entry and the major target of neutralizing antibodies. Here, we report the crystal structures of RABV-G solved in the free form at ∼pH-8.0 and in th...
journal_title：Cell host & microbe
pub_type： 杂志文章
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2009.12.006
更新日期：2010-01-21 00:00:00
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2016.01.015
更新日期：2016-02-10 00:00:00
abstract：:Transition metals such as iron, zinc, copper, and manganese are essential for the growth and development of organisms ranging from bacteria to mammals. Numerous studies have focused on the impact of iron availability during bacterial and fungal infections, and increasing evidence suggests that copper is also involved ...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2012.01.009
更新日期：2012-02-16 00:00:00
abstract：:Cure of rodent malaria with the biocide triclosan highlighted the enzyme FabI as an antimalarial drug target. In this issue of Cell Host & Microbe, Yu et al. (2008) show that FabI is not the principle target of triclosan yet plays an important role specifically in malaria liver stage development. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2008.11.006
更新日期：2008-12-11 00:00:00
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2018.03.002
更新日期：2018-04-11 00:00:00
abstract：:Hepatitis C virus (HCV) is a single-stranded RNA virus encoding a single polyprotein whose translation is driven by an internal ribosome entry site (IRES). HCV infection strongly induces antiviral interferon-stimulated gene (ISG) expression in the liver, yet it persists, suggesting that HCV can block ISG effector func...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2009.11.004
更新日期：2009-12-17 00:00:00
abstract：:In nonmyeloid cells, Shigella hijacks the mitochondrial checkpoint of cell death, thereby inducing a regulated form of necrosis depending on Bnip3 and cyclophilin D. Carneiro et al. (2009) describe the interplay between this program and a prosurvival response transmitted via the Nod1/Rip2/NF-kappaB/Bcl-2 axis, which d...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章,评审
doi：10.1016/j.chom.2009.01.002
更新日期：2009-02-19 00:00:00
abstract：:The ability of the gut epithelium to defend against pathogens while tolerating harmless commensal organisms remains an important puzzle. In this issue of Cell Host & Microbe, Lee et al. (2015) reveal how pathogen-secreted uracil acts at two steps to induce ROS via the Hedgehog pathway. ...
journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2015.01.010
更新日期：2015-02-11 00:00:00
abstract：:Influenza viruses are important pathogens which pose an ongoing threat to public health due to their ability to mutate and evade immunity elicited by prior infection or vaccination. Their evolutionary diversity is facilitated by the plasticity of the antigenically variable head domain of the major surface glycoprotein...
journal_title：Cell host & microbe
pub_type： 杂志文章,评审
doi：10.1016/j.chom.2018.06.016
更新日期：2018-07-11 00:00:00
abstract：:Interactions between the host and its microbiota are of mutual benefit and promote health. Complex molecular pathways underlie this dialog, but the identity of microbe-derived molecules that mediate the mutualistic state remains elusive. Helicobacter hepaticus is a member of the mouse intestinal microbiota that is tol...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2017.11.002
更新日期：2017-12-13 00:00:00
