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Multi-Donor Longitudinal Antibody Repertoire Sequencing Reveals the Existence of Public Antibody Clonotypes in HIV-1 Infection.

Abstract：

:Characterization of single antibody lineages within infected individuals has provided insights into the development of Env-specific antibodies. However, a systems-level understanding of the humoral response against HIV-1 is limited. Here, we interrogated the antibody repertoires of multiple HIV-infected donors from an infection-naive state through acute and chronic infection using next-generation sequencing. This analysis revealed the existence of "public" antibody clonotypes that were shared among multiple HIV-infected individuals. The HIV-1 reactivity for representative antibodies from an identified public clonotype shared by three donors was confirmed. Furthermore, a meta-analysis of publicly available antibody repertoire sequencing datasets revealed antibodies with high sequence identity to known HIV-reactive antibodies, even in repertoires that were reported to be HIV naive. The discovery of public antibody clonotypes in HIV-infected individuals represents an avenue of significant potential for better understanding antibody responses to HIV-1 infection, as well as for clonotype-specific vaccine development.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Setliff I,McDonnell WJ,Raju N,Bombardi RG,Murji AA,Scheepers C,Ziki R,Mynhardt C,Shepherd BE,Mamchak AA,Garrett N,Karim SA,Mallal SA,Crowe JE Jr,Morris L,Georgiev IS

doi

10.1016/j.chom.2018.05.001

subject

Has Abstract

pub_date

2018-06-13 00:00:00

pages

845-854.e6

issue

6

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(18)30228-2

journal_volume

23

pub_type

杂志文章

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