当前位置： SCI文献检索 > Cell Host & Microbe期刊下所有文献 > HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design.

HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design.

Abstract：

:Eliciting HIV-1-specific broadly neutralizing antibodies (bNAbs) remains a challenge for vaccine development, and the potential of passively delivered bNAbs for prophylaxis and therapeutics is being explored. We used neutralization data from four large virus panels to comprehensively map viral signatures associated with bNAb sensitivity, including amino acids, hypervariable region characteristics, and clade effects across four different classes of bNAbs. The bNAb signatures defined for the variable loop 2 (V2) epitope region of HIV-1 Env were then employed to inform immunogen design in a proof-of-concept exploration of signature-based epitope targeted (SET) vaccines. V2 bNAb signature-guided mutations were introduced into Env 459C to create a trivalent vaccine, and immunization of guinea pigs with V2-SET vaccines resulted in increased breadth of NAb responses compared with Env 459C alone. These data demonstrate that bNAb signatures can be utilized to engineer HIV-1 Env vaccine immunogens capable of eliciting antibody responses with greater neutralization breadth.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Bricault CA,Yusim K,Seaman MS,Yoon H,Theiler J,Giorgi EE,Wagh K,Theiler M,Hraber P,Macke JP,Kreider EF,Learn GH,Hahn BH,Scheid JF,Kovacs JM,Shields JL,Lavine CL,Ghantous F,Rist M,Bayne MG,Neubauer GH,McMahan K,

doi

10.1016/j.chom.2018.12.001

subject

Has Abstract

pub_date

2019-01-09 00:00:00

pages

59-72.e8

issue

1

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(18)30599-7

journal_volume

25

pub_type

杂志文章

相关文献

Cell Host & Microbe文献大全
  • Increased expression of LDL receptor-related protein 1 during human cytomegalovirus infection reduces virion cholesterol and infectivity.

    abstract：:In response to virus infection, cells can alter protein expression to modify cellular functions and limit viral replication. To examine host protein expression during infection with human cytomegalovirus (HCMV), an enveloped DNA virus, we performed a semiquantitative, temporal analysis of the cell surface proteome in ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.05.012

    authors： Gudleski-O'Regan N,Greco TM,Cristea IM,Shenk T

    更新日期：2012-07-19 00:00:00

  • Protectors of the Neonatal Gut: Clostridia Send Pathogens Packing.

    abstract：:Commensal bacteria are known to provide colonization resistance in the gut. But exactly which ones provide this function? In a recent paper in Science, Kim et al. (2017) revealed that Clostridia added to mouse infant gut microbiota are sufficient to limit colonization of pathogenic Enterobacteriaceae. ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2017.06.002

    authors： Behnsen J

    更新日期：2017-06-14 00:00:00

  • The cancer microbiome atlas: a pan-cancer comparative analysis to distinguish tissue-resident microbiota from contaminants.

    abstract：:Studying the microbial composition of internal organs and their associations with disease remains challenging due to the difficulty of acquiring clinical biopsies. We designed a statistical model to analyze the prevalence of species across sample types from The Cancer Genome Atlas (TCGA), revealing that species equipr...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.12.001

    authors： Dohlman AB,Arguijo Mendoza D,Ding S,Gao M,Dressman H,Iliev ID,Lipkin SM,Shen X

    更新日期：2020-12-21 00:00:00

  • HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

    abstract：:HIV-1 Nef, which is required for the efficient onset of AIDS, enhances viral replication and infectivity by exerting multiple effects on infected cells. Nef downregulates cell-surface MHC-I molecules by an uncharacterized PI3K pathway requiring the actions of two Nef motifs-EEEE(65) and PXXP(75). We report that the Ne...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2007.03.004

    authors： Hung CH,Thomas L,Ruby CE,Atkins KM,Morris NP,Knight ZA,Scholz I,Barklis E,Weinberg AD,Shokat KM,Thomas G

    更新日期：2007-04-19 00:00:00

  • Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health.

    abstract：:Dietary supplementation with fermentable fiber suppresses adiposity and the associated parameters of metabolic syndrome. Microbiota-generated fiber-derived short-chain fatty acids (SCFAs) and free fatty acid receptors including GPR43 are thought to mediate these effects. We find that while fermentable (inulin), but no...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2017.11.003

    authors： Zou J,Chassaing B,Singh V,Pellizzon M,Ricci M,Fythe MD,Kumar MV,Gewirtz AT

    更新日期：2018-01-10 00:00:00

  • Inducible Germline IgMs Bridge Trypanosome Lytic Factor Assembly and Parasite Recognition.

    abstract：:Trypanosomiasis is a devastating neglected tropical disease affecting livestock and humans. Humans are susceptible to two Trypanosoma brucei subspecies but protected from other trypanosomes by circulating high-density lipoprotein (HDL) complexes called trypanosome lytic factors (TLFs) 1 and 2. TLFs contain apolipoprot...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.04.012

    authors： Verdi J,Zipkin R,Hillman E,Gertsch RA,Pangburn SJ,Thomson R,Papavasiliou N,Sternberg J,Raper J

    更新日期：2020-07-08 00:00:00

  • Infection-Induced Peroxisome Biogenesis Is a Metabolic Strategy for Herpesvirus Replication.

    abstract：:Viral proteins have evolved to target cellular organelles and usurp their functions for virus replication. Despite the knowledge of these critical functions for several organelles, little is known about peroxisomes during infection. Peroxisomes are primarily metabolic organelles with important functions in lipid metab...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.09.002

    authors： Jean Beltran PM,Cook KC,Hashimoto Y,Galitzine C,Murray LA,Vitek O,Cristea IM

    更新日期：2018-10-10 00:00:00

  • Tousled-like kinases modulate reactivation of gammaherpesviruses from latency.

    abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV) is linked to human malignancies. The majority of tumor cells harbor latent virus, and a small percentage undergo spontaneous lytic replication. Both latency and lytic replication are important for viral pathogenesis and spread, but the cellular players involved in the swi...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.12.005

    authors： Dillon PJ,Gregory SM,Tamburro K,Sanders MK,Johnson GL,Raab-Traub N,Dittmer DP,Damania B

    更新日期：2013-02-13 00:00:00

  • Shigella phagocytic vacuolar membrane remnants participate in the cellular response to pathogen invasion and are regulated by autophagy.

    abstract：:Intracellular pathogens like Shigella flexneri enter host cells by phagocytosis. Once inside, the pathogen breaks the vacuolar membrane for cytosolic access. The fate and function of the vacuolar membrane remnants are not clear. Examining Shigella-infected nonmyeloid cells, we observed that proteins associated with va...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2009.07.005

    authors： Dupont N,Lacas-Gervais S,Bertout J,Paz I,Freche B,Van Nhieu GT,van der Goot FG,Sansonetti PJ,Lafont F

    更新日期：2009-08-20 00:00:00

  • Sweet Talk: Regulating Glucose Metabolism in Toxoplasma.

    abstract：:Toxoplasma gondii, the causative agent of toxoplasmosis, is an intracellular parasite that demonstrates a remarkable ability to adapt to nutrient availability. In this issue of Cell Host & Microbe, Blume et al. (2015) describe the unique role of a gluconeogenic enzyme in regulation of glucose catabolism in T. gondii. ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2015.07.012

    authors： Guggisberg AM,Odom AR

    更新日期：2015-08-12 00:00:00

  • Bacterial Autophagy: How to Take a Complement.

    abstract：:Complement, a complex system of serum proteins, contributes to host defense through multiple mechanisms. In this issue of Cell Host & Microbe, Sorbara et al. (2018) discovered that cytosolic pathogens opsonized by complement are restricted by autophagy. This unexpected role for complement is important for cell-autonom...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2018.04.010

    authors： Sancho-Shimizu V,Mostowy S

    更新日期：2018-05-09 00:00:00

  • RIG-I goes beyond naked recognition.

    abstract：:It is currently unclear at which point during viral replication that RNA genomes are first recognized as nonself by the immune system. In this issue of Cell Host & Microbe, Weber et al. show that incoming nucleocapsid-bound genomes are sufficient to bind and activate innate immune sensors. ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2013.02.012

    authors： Bowzard JB,Ranjan P,Sambhara S

    更新日期：2013-03-13 00:00:00

  • Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection.

    abstract：:Type I interferons (IFNs-I) fulfil multiple protective functions during pathogenic infections, but they can also cause detrimental effects and enhance immunopathology. Here, we report that IFNs-I promote the dysregulation of iron homeostasis in macrophages during systemic infections with the intracellular pathogen Can...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2020.01.023

    authors： Riedelberger M,Penninger P,Tscherner M,Seifert M,Jenull S,Brunnhofer C,Scheidl B,Tsymala I,Bourgeois C,Petryshyn A,Glaser W,Limbeck A,Strobl B,Weiss G,Kuchler K

    更新日期：2020-03-11 00:00:00

  • How Good Roommates Can Protect against Microbial Sepsis.

    abstract：:In this issue of Cell Host & Microbe, Wilmore et al. (2018) co-housed isogenic mouse populations, uncovering commensal bacteria-induced serum IgA and IgA-producing bone marrow plasma cells as critical components of resistance against sepsis. They further identified gut microbial taxa that may account for the induction...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2018.02.007

    authors： Beyaert R,Libert C

    更新日期：2018-03-14 00:00:00

  • Defining a core set of actin cytoskeletal proteins critical for actin-based motility of Rickettsia.

    abstract：:Many Rickettsia species are intracellular bacterial pathogens that use actin-based motility for spread during infection. However, while other bacteria assemble actin tails consisting of branched networks, Rickettsia assemble long parallel actin bundles, suggesting the use of a distinct mechanism for exploiting actin. ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2010.04.008

    authors： Serio AW,Jeng RL,Haglund CM,Reed SC,Welch MD

    更新日期：2010-05-20 00:00:00

  • Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression.

    abstract：:After invading host cells, Toxoplasma gondii multiplies within a parasitophorous vacuole (PV) that is maintained by parasite proteins secreted from organelles called dense granules. Most dense granule proteins remain within the PV, and few are known to access the host cell cytosol. We identify GRA16 as a dense granule...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2013.03.002

    authors： Bougdour A,Durandau E,Brenier-Pinchart MP,Ortet P,Barakat M,Kieffer S,Curt-Varesano A,Curt-Bertini RL,Bastien O,Coute Y,Pelloux H,Hakimi MA

    更新日期：2013-04-17 00:00:00

  • Anthrax toxin delivers a one-two punch.

    abstract：:Although anthrax toxin was identified as a major Bacillus anthracis virulence factor over 50 years ago, defining the physiologically relevant targets has been challenging. Liu et al. demonstrate that intoxication of myeloid-derived cells contributes to establishing infection but is not required for mortality resulting...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2010.10.011

    authors： Bradley KA,LeVine SM

    更新日期：2010-11-18 00:00:00

  • A neuron-specific role for autophagy in antiviral defense against herpes simplex virus.

    abstract：:Type I interferons (IFNs) are considered to be the universal mechanism by which viral infections are controlled. However, many IFN-stimulated genes (ISGs) rely on antiviral pathways that are toxic to host cells, which may be detrimental in nonrenewable cell types, such as neurons. We show that dorsal root ganglionic (...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.07.013

    authors： Yordy B,Iijima N,Huttner A,Leib D,Iwasaki A

    更新日期：2012-09-13 00:00:00

  • H. pylori's BabA Embraces Change.

    abstract：:Long before the cause was discovered, peptic ulcers were known to occur preferentially in individuals of certain blood groups. In this issue of Cell Host & Microbe, Moonens et al. (2016) perform structural analyses of the Helicobacter pylori adhesin BabA to determine how the bacteria discriminately bind different bloo...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2015.12.013

    authors： Sweeney EG,Guillemin K

    更新日期：2016-01-13 00:00:00

  • Spacer Acquisition Rates Determine the Immunological Diversity of the Type II CRISPR-Cas Immune Response.

    abstract：:CRISPR-Cas systems provide acquired immunity in prokaryotes. Upon infection, short sequences from the phage genome, known as spacers, are inserted between the CRISPR repeats. Spacers are transcribed into small RNA molecules that guide nucleases to their targets. The forces that shape the distribution of newly acquired...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.12.016

    authors： Heler R,Wright AV,Vucelja M,Doudna JA,Marraffini LA

    更新日期：2019-02-13 00:00:00

  • A2B adenosine receptor induces protective antihelminth type 2 immune responses.

    abstract：:The type 2 immune response evoked by intestinal nematode parasites contributes to worm expulsion and tolerance to associated tissue damage. We investigated whether this host response is affected by blocking signaling by the putative endogenous danger signal adenosine, which can be released during inflammation and host...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.02.001

    authors： Patel N,Wu W,Mishra PK,Chen F,Millman A,Csóka B,Koscsó B,Eltzschig HK,Haskó G,Gause WC

    更新日期：2014-03-12 00:00:00

  • Copper in microbial pathogenesis: meddling with the metal.

    abstract：:Transition metals such as iron, zinc, copper, and manganese are essential for the growth and development of organisms ranging from bacteria to mammals. Numerous studies have focused on the impact of iron availability during bacterial and fungal infections, and increasing evidence suggests that copper is also involved ...

    journal_title：Cell host & microbe

    pub_type： 杂志文章,评审

    doi：10.1016/j.chom.2012.01.009

    authors： Samanovic MI,Ding C,Thiele DJ,Darwin KH

    更新日期：2012-02-16 00:00:00

  • Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes.

    abstract：:Salmonella Typhimurium causes diarrhea by infecting the epithelium and lamina propria of the intestinal mucosa and by secreting various effector proteins through type III secretion systems (TTSSs). However, the mechanisms by which Salmonella transverses the epithelium and is subsequently released into the lamina propr...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2011.11.013

    authors： Müller AJ,Kaiser P,Dittmar KE,Weber TC,Haueter S,Endt K,Songhet P,Zellweger C,Kremer M,Fehling HJ,Hardt WD

    更新日期：2012-01-19 00:00:00

  • The Trypanosoma cruzi flagellum is discarded via asymmetric cell division following invasion and provides early targets for protective CD8⁺ T cells.

    abstract：:During invasion of host cells by Trypanosoma cruzi, the parasite that causes Chagas disease, the elongated, flagellated trypomastigotes remodel into oval amastigotes with no external flagellum. The underlying mechanism of this remodeling and the fate of the flagellum are obscure. We discovered that T. cruzi trypomasti...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2014.09.003

    authors： Kurup SP,Tarleton RL

    更新日期：2014-10-08 00:00:00

  • Epithelium, tear down this wall!

    abstract：:The presence of bacteria within epithelial-lined compartments, such as the lung, elicits rapid recruitment of innate immune cells. In this issue of Cell Host & Microbe, Chun and Prince (2009) report that epithelial cells facilitate this process by reorganizing their intercellular junctions to enhance immune cell trans...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2008.12.008

    authors： Nalle SC,Turner JR

    更新日期：2009-01-22 00:00:00

  • Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?

    abstract：:Dietary factors, microbial composition, and metabolism are intimately intertwined into a complex network whose activities influence important intestinal functions. In a recent issue of Cell, Belcheva et al. (2014) show that microbial-derived butyrate promotes proliferation of cancer-initiated intestinal epithelial cel...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2014.07.011

    authors： Bultman SJ,Jobin C

    更新日期：2014-08-13 00:00:00

  • Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin.

    abstract：:Regulatory T cells (Tregs) are required to establish immune tolerance to commensal microbes. Tregs accumulate abruptly in the skin during a defined window of postnatal tissue development. However, the mechanisms mediating Treg migration to neonatal skin are unknown. Here we show that hair follicle (HF) development fac...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2017.03.001

    authors： Scharschmidt TC,Vasquez KS,Pauli ML,Leitner EG,Chu K,Truong HA,Lowe MM,Sanchez Rodriguez R,Ali N,Laszik ZG,Sonnenburg JL,Millar SE,Rosenblum MD

    更新日期：2017-04-12 00:00:00

  • Malaria pulls a FASt one.

    abstract：:Cure of rodent malaria with the biocide triclosan highlighted the enzyme FabI as an antimalarial drug target. In this issue of Cell Host & Microbe, Yu et al. (2008) show that FabI is not the principle target of triclosan yet plays an important role specifically in malaria liver stage development. ...

    journal_title：Cell host & microbe

    pub_type： 评论,杂志文章

    doi：10.1016/j.chom.2008.11.006

    authors： Spalding MD,Prigge ST

    更新日期：2008-12-11 00:00:00

  • Uncovering common principles in protein export of malaria parasites.

    abstract：:For proliferation, the malaria parasite Plasmodium falciparum needs to modify the infected host cell extensively. To achieve this, the parasite exports proteins containing a Plasmodium export element (PEXEL) into the host cell. Phosphatidylinositol-3-phosphate binding and cleavage of the PEXEL are thought to mediate p...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2012.09.010

    authors： Grüring C,Heiber A,Kruse F,Flemming S,Franci G,Colombo SF,Fasana E,Schoeler H,Borgese N,Stunnenberg HG,Przyborski JM,Gilberger TW,Spielmann T

    更新日期：2012-11-15 00:00:00

  • HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.

    abstract：:Hepatitis C virus (HCV) vaccine efforts are hampered by the extensive genetic diversity of HCV envelope glycoproteins E1 and E2. Structures of broadly neutralizing antibodies (bNAbs) (e.g., HEPC3, HEPC74) isolated from individuals who spontaneously cleared HCV infection facilitate immunogen design to elicit antibodies...

    journal_title：Cell host & microbe

    pub_type： 杂志文章

    doi：10.1016/j.chom.2018.10.009

    authors： Flyak AI,Ruiz S,Colbert MD,Luong T,Crowe JE Jr,Bailey JR,Bjorkman PJ

    更新日期：2018-11-14 00:00:00