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Uncovering common principles in protein export of malaria parasites.

Abstract：

:For proliferation, the malaria parasite Plasmodium falciparum needs to modify the infected host cell extensively. To achieve this, the parasite exports proteins containing a Plasmodium export element (PEXEL) into the host cell. Phosphatidylinositol-3-phosphate binding and cleavage of the PEXEL are thought to mediate protein export. We show that these requirements can be bypassed, exposing a second level of export control in the N terminus generated after PEXEL cleavage that is sufficient to distinguish exported from nonexported proteins. Furthermore, this region also corresponds to the export domain of a second group of exported proteins lacking PEXELs (PNEPs), indicating shared export properties among different exported parasite proteins. Concordantly, export of both PNEPs and PEXEL proteins depends on unfolding, revealing translocation as a common step in export. However, translocation of transmembrane proteins occurs at the parasite plasma membrane, one step before translocation of soluble proteins, indicating unexpectedly complex translocation events at the parasite periphery.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Grüring C,Heiber A,Kruse F,Flemming S,Franci G,Colombo SF,Fasana E,Schoeler H,Borgese N,Stunnenberg HG,Przyborski JM,Gilberger TW,Spielmann T

doi

10.1016/j.chom.2012.09.010

subject

Has Abstract

pub_date

2012-11-15 00:00:00

pages

717-29

issue

5

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(12)00349-6

journal_volume

12

pub_type

杂志文章

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