The HIV-1 Tat team gets bigger.

Abstract:

:Productive transcription of the HIV-1 genome involves RNA polymerase II working in concert with the viral protein Tat and its team of cofactors in a highly orchestrated process. Now, Pagans and colleagues report that the lysine methyltransferase Set7/9-KMT7 associates with Tat to stimulate RNA polymerase II elongation of the integrated provirus. Set7/9-KMT7 also methylates Tat, and this enhances Tat function.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Rice AP

doi

10.1016/j.chom.2010.03.001

subject

Has Abstract

pub_date

2010-03-18 00:00:00

pages

179-81

issue

3

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(10)00074-0

journal_volume

7

pub_type

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