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Networking at the level of host immunity: immune cell interactions during persistent viral infections.

Abstract：

:Persistent viral infections are the result of a series of connected events that culminate in diminished immunity and the inability to eliminate infection. By building our understanding of how distinct components of the immune system function both individually and collectively in productive versus abortive responses, new potential therapeutic targets can be developed to overcome immune dysfunction and thus fight persistent infections. Using lymphocytic choriomeningitis virus (LCMV) as a model of a persistent virus infection and drawing parallels to persistent human viral infections such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV), we describe the cellular relationships and interactions that determine the outcome of initial infection and highlight immune targets for therapeutic intervention to prevent or treat persistent infections. Ultimately, these findings will further our understanding of the immunologic basis of persistent viral infection and likely lead to strategies to treat human viral infections.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Ng CT,Snell LM,Brooks DG,Oldstone MB

doi

10.1016/j.chom.2013.05.014

subject

Has Abstract

pub_date

2013-06-12 00:00:00

pages

652-64

issue

6

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(13)00197-2

journal_volume

13

pub_type

杂志文章,评审

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