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Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice.

Abstract：

:Bone marrow transplantation (BMT) offers curative potential for patients with high-risk hematologic malignancies, but the post-transplantation period is characterized by profound immunodeficiency. Recent studies indicate that the intestinal microbiota not only regulates mucosal immunity, but can also contribute to systemic immunity and hematopoiesis. Using antibiotic-mediated microbiota depletion in a syngeneic BMT mouse model, here we describe a role for the intestinal flora in hematopoietic recovery after BMT. Depletion of the intestinal microbiota resulted in impaired recovery of lymphocyte and neutrophil counts, while recovery of the hematopoietic stem and progenitor compartments and the erythroid lineage were largely unaffected. Depletion of the intestinal microbiota also reduced dietary energy uptake and visceral fat stores. Caloric supplementation through sucrose in the drinking water improved post-BMT hematopoietic recovery in mice with a depleted intestinal flora. Taken together, we show that the intestinal microbiota contribute to post-BMT hematopoietic reconstitution in mice through improved dietary energy uptake.

journal_name

Cell Host Microbe

journal_title

Cell host & microbe

authors

Staffas A,Burgos da Silva M,Slingerland AE,Lazrak A,Bare CJ,Holman CD,Docampo MD,Shono Y,Durham B,Pickard AJ,Cross JR,Stein-Thoeringer C,Velardi E,Tsai JJ,Jahn L,Jay H,Lieberman S,Smith OM,Pamer EG,Peled JU,Cohen

doi

10.1016/j.chom.2018.03.002

subject

Has Abstract

pub_date

2018-04-11 00:00:00

pages

447-457.e4

issue

4

eissn

1931-3128

issn

1934-6069

pii

S1931-3128(18)30099-4

journal_volume

23

pub_type

杂志文章

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