Abstract：
:Gut-dwelling Prevotella copri (P. copri), the most prevalent Prevotella species in the human gut, have been associated with diet and disease. However, our understanding of their diversity and function remains rudimentary because studies have been limited to 16S and metagenomic surveys and experiments using a single type strain. Here, we describe the genomic diversity of 83 P. copri isolates from 11 human donors. We demonstrate that genomically distinct isolates, which can be categorized into different P. copri complex clades, utilize defined sets of polysaccharides. These differences are exemplified by variations in susC genes involved in polysaccharide transport as well as polysaccharide utilization loci (PULs) that were predicted in part from genomic and metagenomic data. Functional validation of these PULs showed that P. copri isolates utilize distinct sets of polysaccharides from dietary plant, but not animal, sources. These findings reveal both genomic and functional differences in polysaccharide utilization across human intestinal P. copri strains.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Fehlner-Peach H,Magnabosco C,Raghavan V,Scher JU,Tett A,Cox LM,Gottsegen C,Watters A,Wiltshire-Gordon JD,Segata N,Bonneau R,Littman DRdoi
10.1016/j.chom.2019.10.013subject
Has Abstractpub_date
2019-11-13 00:00:00pages
680-690.e5issue
5eissn
1931-3128issn
1934-6069pii
S1931-3128(19)30537-2journal_volume
26pub_type
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