Abstract:
:Recent epidemics of Zika virus (ZIKV) have brought increasing concerns of heightened disease severity and neurotropism. In this issue of Cell Host & Microbe, Lazear et al. (2016) and Bayer et al. (2016) show that innate immunity can restrict ZIKV infection and disease development.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Xie X,Shan C,Shi PYdoi
10.1016/j.chom.2016.04.019subject
Has Abstractpub_date
2016-05-11 00:00:00pages
566-7issue
5eissn
1931-3128issn
1934-6069pii
S1931-3128(16)30155-Xjournal_volume
19pub_type
评论,杂志文章abstract::Lujo virus (LUJV) is an arenavirus that emerged in 2008 associated with a cluster of human cases of severe hemorrhagic fever. In this issue of Cell Host & Microbe, Raaben et al. (2017) identify neuropilin (NRP)-2 as cell surface receptor and the tetraspannin protein CD63 as intracellular entry factor for LUJV. ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2017.10.014
更新日期:2017-11-08 00:00:00
abstract::Overcoming the cellular type I interferon (IFN) host defense response is critical for a virus to ensure successful infection. Investigating the effects of human adenovirus (HAdV) infection on global cellular histone posttranslational modification (hPTM), we discovered that virus infection-induced activation of IFN sig...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2012.05.005
更新日期:2012-06-14 00:00:00
abstract::(+)strand RNA viruses have to overcome various points of restriction in the host to establish successful infection. In plants, this includes RNA silencing. To uncover additional bottlenecks to RNA virus infection, we genetically attenuated the impact of RNA silencing on transgenically expressed Potato virus X (PVX), a...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2014.08.001
更新日期:2014-09-10 00:00:00
abstract::Bacterial CRISPR-Cas systems employ RNA-guided nucleases to destroy phage (viral) DNA. Phages, in turn, have evolved diverse "anti-CRISPR" proteins (Acrs) to counteract acquired immunity. In Listeria monocytogenes, prophages encode two to three distinct anti-Cas9 proteins, with acrIIA1 always present. However, the sig...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2020.04.001
更新日期:2020-07-08 00:00:00
abstract::Blockade of immune checkpoint molecules, a group of molecules normally involved in maintaining self-tolerance and limiting T cell responses, has emerged as a breakthrough in cancer therapy. Two recent studies published in Science show that, in mice, gut commensal microbes promote antitumor immunity and may determine t...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2015.11.014
更新日期:2015-12-09 00:00:00
abstract::Duffy antigen receptor for chemokines (DARC) expressed on red blood cells (RBCs) influences plasma levels of HIV-1-suppressive and proinflammatory chemokines such as CCL5/RANTES. DARC is also the RBC receptor for Plasmodium vivax. Africans with DARC -46C/C genotype, which confers a DARC-negative phenotype, are resista...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2008.06.002
更新日期:2008-07-17 00:00:00
abstract::The type 2 immune response evoked by intestinal nematode parasites contributes to worm expulsion and tolerance to associated tissue damage. We investigated whether this host response is affected by blocking signaling by the putative endogenous danger signal adenosine, which can be released during inflammation and host...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2014.02.001
更新日期:2014-03-12 00:00:00
abstract::Recognition of peptidoglycan is integral to detection of gram-positive bacterial pathogens. In a recent issue of Cell, Wolf et al. (2016) report that detection of the N-acetylglucosamine component of peptidoglycan by the glycolytic enzyme hexokinase activates the NLRP3 inflammasome, revealing an intriguing interplay b...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2016.07.017
更新日期:2016-08-10 00:00:00
abstract::Influenza viruses of animals can cross species and infect humans. In this issue of Cell Host & Microbe, Zhang et al. (2015) and Tzarum et al. (2015) describe crystal structures and receptor-binding properties of hemagglutinins of avian-origin H10N8 and H6N1 influenza viruses. Human infections with these viruses are no...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2015.02.020
更新日期:2015-03-11 00:00:00
abstract::Persistent viral infections are the result of a series of connected events that culminate in diminished immunity and the inability to eliminate infection. By building our understanding of how distinct components of the immune system function both individually and collectively in productive versus abortive responses, n...
journal_title:Cell host & microbe
pub_type: 杂志文章,评审
doi:10.1016/j.chom.2013.05.014
更新日期:2013-06-12 00:00:00
abstract::The presence of bacteria within epithelial-lined compartments, such as the lung, elicits rapid recruitment of innate immune cells. In this issue of Cell Host & Microbe, Chun and Prince (2009) report that epithelial cells facilitate this process by reorganizing their intercellular junctions to enhance immune cell trans...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2008.12.008
更新日期:2009-01-22 00:00:00
abstract::Disruption of homeostasis between the host immune system and the intestinal microbiota leads to inflammatory bowel disease (IBD). Whether IBD is instigated by individual species or disruptions of entire microbial communities remains controversial. We characterized the fecal microbial communities in the recently descri...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2010.08.004
更新日期:2010-09-16 00:00:00
abstract::The Nef protein of HIV-1 mediates immune evasion by relocating major histocompatibility complex (MHC) molecules and the immune costimulatory molecules CD80 and CD86 away from the monocytic cell surface. We describe a two-pronged mechanism by which Nef removes CD80 and CD86 from the cell surface. While MHCI, CD80, and ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2007.01.001
更新日期:2007-03-15 00:00:00
abstract::Efficient nutrient acquisition in the human gut is essential for microbial persistence. Although polysaccharides have been well-studied nutrients for the gut microbiome, other resources such as nucleic acids and nucleosides are less studied. We describe several ribose-utilization systems (RUSs) that are broadly repres...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2019.11.009
更新日期:2020-01-08 00:00:00
abstract::Defensins are naturally occurring antimicrobial peptides that disrupt bacterial membranes and prevent bacterial invasion of the host. Emerging studies indicate that certain defensins also block virus infection; however, the mechanism(s) involved are poorly understood. We demonstrate that human alpha-defensins inhibit ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2007.12.001
更新日期:2008-01-17 00:00:00
abstract::Type I interferons (IFNs-I) fulfil multiple protective functions during pathogenic infections, but they can also cause detrimental effects and enhance immunopathology. Here, we report that IFNs-I promote the dysregulation of iron homeostasis in macrophages during systemic infections with the intracellular pathogen Can...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.01.023
更新日期:2020-03-11 00:00:00
abstract::Many enveloped viruses hijack the cellular ESCRT machinery to catalyze their escape from host cells. One paper in a recent issue of Cell by Kostelansky et al. and another in this issue of Cell Host & Microbe by Morita et al. shed new light on the structure and function of ESCRT-I. Both papers focus on a fourth ESCRT-I...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2007.06.006
更新日期:2007-07-12 00:00:00
abstract::Interactions between the host and its microbiota are of mutual benefit and promote health. Complex molecular pathways underlie this dialog, but the identity of microbe-derived molecules that mediate the mutualistic state remains elusive. Helicobacter hepaticus is a member of the mouse intestinal microbiota that is tol...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2017.11.002
更新日期:2017-12-13 00:00:00
abstract::Influenza A virus hemagglutinin (HA) initiates viral entry by engaging host receptor sialylated glycans via its receptor-binding site (RBS). The amino acid sequence of the RBS naturally varies across avian and human influenza virus subtypes and is also evolvable. However, functional sequence diversity in the RBS has n...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2017.05.011
更新日期:2017-06-14 00:00:00
abstract::Many Rickettsia species are intracellular bacterial pathogens that use actin-based motility for spread during infection. However, while other bacteria assemble actin tails consisting of branched networks, Rickettsia assemble long parallel actin bundles, suggesting the use of a distinct mechanism for exploiting actin. ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2010.04.008
更新日期:2010-05-20 00:00:00
abstract::Microbial CRISPR-Cas acts as a defense, but also as a gatekeeper controlling the flow of new genes into microbial genomes. In a recent Cell paper, Jiang et al. (2016) uncover the functional importance of transcription-dependent RNA targeting in type III-A CRISPR-Cas antiviral defense and provide insight into the co-ev...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2016.01.015
更新日期:2016-02-10 00:00:00
abstract::Intracellular nucleotide-binding leucine-rich repeat (NLR) receptors play central roles in human and plant innate immunity. In this issue of Cell Host & Microbe, Wang et al. (2015) show that a single plant NLR can detect diverse pathogen effectors by partnering with different scaffolding proteins, which can each recog...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2015.08.011
更新日期:2015-09-09 00:00:00
abstract::Alphaviruses infect cells via a low-pH-triggered membrane fusion reaction mediated by the class II virus fusion protein E1, an elongated molecule with three extramembrane domains (DI-III). E1 drives fusion by inserting its fusion peptide loop into the target membrane and refolding to a hairpin-like trimer in which DII...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2008.10.012
更新日期:2008-12-11 00:00:00
abstract::Vibrio cholerae is the causative agent of the diarrheal disease cholera. Although many V. cholerae virulence factors have been studied, the role of interbacterial interactions within the host gut and their influence on colonization are poorly understood. Here, we utilized the conjugative properties of a Vibrio-specifi...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2017.12.006
更新日期:2018-02-14 00:00:00
abstract::Variations in lipopolysaccharide (LPS), a bacterial outer membrane component, determine virulence of the obligate intracellular bacterium Coxiella burnetii, but the underlying mechanisms are unknown. We find that while avirulent C. burnetii LPS (avLPS) stimulates host p38α-MAPK signaling required for proper traffickin...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2012.10.015
更新日期:2012-12-13 00:00:00
abstract::The difficulty in detecting rare infected cells immediately after mucosal HIV transmission has hindered our understanding of the initial cells targeted by the virus. Working with the macaque simian immunodeficiency virus (SIV) vaginal challenge model, we developed methodology to identify discrete foci of SIV (mac239) ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2016.03.005
更新日期:2016-04-13 00:00:00
abstract::Successful viruses must overcome the body's immune defenses. In this issue of Cell Host & Microbe, Goffinet et al. (2009) provide evidence that the host protein CD317, the target of the HIV Vpu protein, is part of an ancient innate immune response directed against budding viruses. ...
journal_title:Cell host & microbe
pub_type: 评论,杂志文章
doi:10.1016/j.chom.2009.02.002
更新日期:2009-03-19 00:00:00
abstract::Mutations in the autophagy gene EPG5 are linked to the multisystem human disease Vici syndrome, which is characterized in part by pulmonary abnormalities, including recurrent infections. We found that Epg5-deficient mice exhibited elevated baseline innate immune cellular and cytokine-based lung inflammation and were r...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2015.12.011
更新日期:2016-01-13 00:00:00
abstract::Trypanosomiasis is a devastating neglected tropical disease affecting livestock and humans. Humans are susceptible to two Trypanosoma brucei subspecies but protected from other trypanosomes by circulating high-density lipoprotein (HDL) complexes called trypanosome lytic factors (TLFs) 1 and 2. TLFs contain apolipoprot...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2020.04.012
更新日期:2020-07-08 00:00:00
abstract::Commensal bacteria are known to provide colonization resistance in the gut. But exactly which ones provide this function? In a recent paper in Science, Kim et al. (2017) revealed that Clostridia added to mouse infant gut microbiota are sufficient to limit colonization of pathogenic Enterobacteriaceae. ...
journal_title:Cell host & microbe
pub_type: 杂志文章
doi:10.1016/j.chom.2017.06.002
更新日期:2017-06-14 00:00:00