Abstract：
:Defensins are naturally occurring antimicrobial peptides that disrupt bacterial membranes and prevent bacterial invasion of the host. Emerging studies indicate that certain defensins also block virus infection; however, the mechanism(s) involved are poorly understood. We demonstrate that human alpha-defensins inhibit adenovirus infection at low micromolar concentrations, and this requires direct association of the defensin with the virus. Moreover, defensins inhibit virus disassembly at the vertex region, thereby restricting the release of an internal capsid protein, pVI, which is required for endosomal membrane penetration during cell entry. As a consequence, defensins hamper the release of adenovirus particles from endocytic vesicles, resulting in virion accumulation in early endosomes and lysosomes. Thus, defensins possess remarkably distinct modes of activity against bacteria and viruses, and their function may provide insights for the development of new antiviral strategies.
journal_name
Cell Host Microbejournal_title
Cell host & microbeauthors
Smith JG,Nemerow GRdoi
10.1016/j.chom.2007.12.001subject
Has Abstractpub_date
2008-01-17 00:00:00pages
11-9issue
1eissn
1931-3128issn
1934-6069pii
S1931-3128(07)00308-3journal_volume
3pub_type
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pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
pub_type： 杂志文章,评审
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pub_type： 杂志文章
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
pub_type： 杂志文章,评审
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2013.11.006
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2017.06.002
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2017.11.002
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2011.01.002
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journal_title：Cell host & microbe
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doi：10.1016/j.chom.2018.02.001
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journal_title：Cell host & microbe
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doi：10.1016/j.chom.2014.03.006
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2013.01.011
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journal_title：Cell host & microbe
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2017.09.012
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
doi：10.1016/j.chom.2009.02.002
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journal_title：Cell host & microbe
pub_type： 评论,杂志文章
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journal_title：Cell host & microbe
pub_type： 杂志文章
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journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2018.12.001
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abstract：:Mounting an effective innate immune response against pathogens requires the rapid and global reprogramming of host cellular processes. Here we employed complementary proteomic methods to identify differentially regulated proteins early during a plant's defense response. Besides defense-related proteins, constituents o...
journal_title：Cell host & microbe
pub_type： 杂志文章
doi：10.1016/j.chom.2009.10.005
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